LOCUS       NM_001025721            2913 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus collectin sub-family member 12 (Colec12), mRNA.
ACCESSION   NM_001025721 XM_341574
VERSION     NM_001025721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Toma,V.A., Tigu,A.B., Farcas,A.D., Sevastre,B., Taulescu,M.,
            Gherman,A.M.R., Roman,I., Fischer-Fodor,E. and Parvu,M.
  TITLE     New Aspects Towards a Molecular Understanding of the Allicin
            Immunostimulatory Mechanism via Colec12, MARCO, and SCARB1
            Receptors
  JOURNAL   Int J Mol Sci 20 (15), 3627 (2019)
   PUBMED   31344978
  REMARK    GeneRIF: The molecular docking revealed that
            S-allyl-mercapto-glutathione interacting with Colec12, MARCO (class
            A), and SCARB1 (class B) scavenger receptors in in vitro tests
            demonstrates a direct stimulation of immunoglobulin secretion by
            S-allylmercaptoglutathione (GSSA) in CD19+ B lymphocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Fork,C., Hitzel,J., Nichols,B.J., Tikkanen,R. and Brandes,R.P.
  TITLE     Flotillin-1 facilitates toll-like receptor 3 signaling in human
            endothelial cells
  JOURNAL   Basic Res Cardiol 109 (6), 439 (2014)
   PUBMED   25204797
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Ohtani,K., Suzuki,Y., Eda,S., Kawai,T., Kase,T., Keshi,H.,
            Sakai,Y., Fukuoh,A., Sakamoto,T., Itabe,H., Suzutani,T.,
            Ogasawara,M., Yoshida,I. and Wakamiya,N.
  TITLE     The membrane-type collectin CL-P1 is a scavenger receptor on
            vascular endothelial cells
  JOURNAL   J Biol Chem 276 (47), 44222-44228 (2001)
   PUBMED   11564734
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Nakamura,K., Funakoshi,H., Tokunaga,F. and Nakamura,T.
  TITLE     Molecular cloning of a mouse scavenger receptor with C-type lectin
            (SRCL)(1), a novel member of the scavenger receptor family
  JOURNAL   Biochim Biophys Acta 1522 (1), 53-58 (2001)
   PUBMED   11718900
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097495.1.
            
            On Jul 22, 2005 this sequence version replaced XM_341574.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..2913
                     /gene="Colec12"
                     /note="collectin sub-family member 12"
                     /db_xref="GeneID:361289"
                     /db_xref="RGD:735039"
     exon            1..94
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2316
                     /gene="Colec12"
                     /note="CL-P1; collectin placenta protein 1; nurse cell
                     scavenger receptor 2"
                     /codon_start=1
                     /product="collectin-12"
                     /protein_id="NP_001020892.1"
                     /db_xref="GeneID:361289"
                     /db_xref="RGD:735039"
                     /translation="MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLY
                     VLCALLTITVAILGYKVVEKMDTVTDGMETSRQTYDNKLIAVESDLKKLGDQTGKKAL
                     STNSELSTFRSDILDLRQQLQEITEKTSKNKDMLEKLQANGDSLVDRQSQLKETLQNN
                     SFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQSQMYSQNVVIMNLNNLNLTQVQQRN
                     LITNLQRSVDDTSLAIQQIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALA
                     KANNDTLEDMNNQLSSFTGQMDNITTISQANEQSMKDLQDLHKDTENRTAVKFSQLEE
                     RFQVFETDIVNIINNISYTAHHLRTLTSNLNDVRTTCTDTLTRHTDDLTSLNNTLVNI
                     RLDSISLRMQQDMMRSRLDTEVANLSVVMEEMKLVDSKHGQLIKNFTILQGPPGPRGP
                     KGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGTIGPVGPPGERGSKGSKGSQGPK
                     GSRGSPGKPGPQGPSGDPGPPGPPGKDGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPG
                     LPGVPGMPGPKGPPGPPGPSGAMEPLALQNEPTPASEVNGCPPHWKNFTDKCYYFSVE
                     KEIFEDAKLFCEDKSSHLVFINSREEQQWIKKQTMGRESHWIGLTDSEQESEWKWLDG
                     TPVDYKNWKAGQPDNWGSGHGPGEDCAGLIYAGQWNDFQCDEINNFICEKEREAVPSS
                     IL"
     exon            95..145
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            146..268
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            269..367
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1414
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1903
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2040
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2150
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2296
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2889
                     /gene="Colec12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggattgg aactcagaag gctgccatgg gcgtgcagtg agtaacactg gtgcgacttc
       61 tccgggcgga gcgtgtcctc ggtcaccatg aaagacgact ttgcagagga agaggaggtg
      121 cagtccttcg gttacaagag gtttggtatt caggagggga cacaatgtac caaatgtaaa
      181 aataactggg cactgaagtt ttcgattata ttattatatg ttttgtgtgc cttactgacc
      241 atcacagtag ccattttggg atataaagtt gtagagaaaa tggacactgt cacagatggc
      301 atggagacat ctcgccagac ttacgacaac aagctcattg ctgtggaaag tgatctgaag
      361 aaattagggg accaaactgg gaagaaagct ctaagcacca actctgagct ttctaccttc
      421 agatcagata ttctggatct ccgtcagcaa cttcaggaga tcacagaaaa aaccagtaag
      481 aacaaagata tgctagagaa gttgcaagca aatggggact cattggttga tagacaaagt
      541 caactgaagg aaactctgca gaataattct ttcctcatca ccacagtcaa caaaactctc
      601 caggcatata atggctatgt cacgaatctg caacaagata ctagtgtgct ccagggcaat
      661 ctgcagagcc agatgtattc tcagaatgtg gttatcatga acctcaacaa cctgaacctg
      721 acccaggttc agcagaggaa ccttatcaca aatctgcagc gatctgtgga tgacacgagc
      781 ctggctatcc agcaaattaa gaatgacttc caaaatctgc aacaggtttt ccttcaagcc
      841 aagaaggaca ccgattggct aaaggagaaa gtacagagtt tgcagacatt ggctgccaac
      901 aactctgccc tggccaaagc caataatgac accctggagg atatgaataa ccagctcagc
      961 tctttcacag gtcagatgga caacattacc actatctcac aggctaacga gcagagcatg
     1021 aaagaccttc aggacttaca caaggataca gaaaatagga cagctgtcaa gttcagccaa
     1081 cttgaggaac gcttccaggt ctttgagaca gatattgtga acatcattaa caacatcagc
     1141 tacacagccc atcacctgag gacgctgacc agcaatctga atgatgttag gaccacttgc
     1201 acagacacct tgaccagaca cacggatgac ctgacctcct tgaataacac actagtcaac
     1261 atccgcttgg attctatttc tctcaggatg cagcaagaca tgatgaggtc aaggttagac
     1321 actgaagtag ccaacttatc agtggttatg gaagagatga agctggttga ctccaagcat
     1381 ggtcagctca tcaagaactt taccattcta cagggtcctc ctggccccag aggtccaaaa
     1441 ggtgacagag gatctcaggg accgcctggt ccaactggca acaagggaca gaaaggagag
     1501 aagggagagc ctggtccacc tggccctgcg ggtgagcgag gcacaattgg accagtaggc
     1561 cctcctggag agcgtggcag caaaggatcc aaaggctcac agggtcccaa aggatcacgt
     1621 gggtccccag gaaagcctgg ccctcaaggg cctagtggag accctggacc accaggtcca
     1681 ccaggcaagg atggactccc tggccctcag ggccctcctg gcttccaggg actacagggc
     1741 actgtgggtg aacctggagt acctggacct cgggggctac caggcttacc aggggtgcca
     1801 ggcatgcctg ggcccaaggg accacctggc cccccaggtc cctcaggagc aatggagccg
     1861 ttggctctgc agaatgaacc aaccccagca tcagaggtca acggatgtcc gcctcactgg
     1921 aagaacttca cagataaatg ttactatttt tcggtggaga aagaaatttt tgaagatgct
     1981 aagcttttct gtgaagacaa atcttcccat ctcgttttca taaactcaag agaggaacag
     2041 caatggataa aaaagcagac catggggaga gagagccact ggatcggcct cacagactca
     2101 gagcaagaaa gcgagtggaa gtggctagat gggacacctg ttgattacaa aaactggaaa
     2161 gctggacaac ccgacaactg gggcagtggc catgggcctg gagaagactg tgctggattg
     2221 atttatgccg ggcagtggaa tgacttccag tgtgatgaaa tcaataactt catttgcgaa
     2281 aaagaaaggg aggcagtacc atcatccata ttataactgt gatataatag caggaacgta
     2341 ttttctgatg cctctcaaag gtgaagaata ctcgtttctg atgccatcac ttctcaccag
     2401 attgaatgga aaaagacctg aaaagtagtt attcaaagta aatggatacc tactgcacca
     2461 taaccgaagg actagagagc taaaatgctc cccaagttga tactgatttc caatgtgcaa
     2521 atggactgaa tcacatagat ttttctcagc cattaaccat acaatttatg caaattatat
     2581 ctttccaaat atggaatgct ccaatcagaa aaagactatc attggttgtt gagttacagg
     2641 ctctgtgtaa acagtgtgtt tctaaaatcc caaatataga aagaatatgc agacatacac
     2701 atatataggc catcttttag taataatatg aaatatactt aaagagcttt taaacttcat
     2761 atttttgtac aaaatatttg ccttttacaa tcattttact tttttaaatt ttacctatat
     2821 aacacataaa gccaaagaaa acaataattg tactaataaa atttcaatgg agtttctctt
     2881 cagatttaaa aaaaaaaaaa aaaaaaaaaa aaa
//
