LOCUS       NM_001107100            2432 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus collagen type VIII alpha 1 chain (Col8a1), mRNA.
ACCESSION   NM_001107100 XM_001060711 XM_221536
VERSION     NM_001107100.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2432)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   6  (bases 1 to 2432)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   7  (bases 1 to 2432)
  AUTHORS   Cherepanova,O.A., Pidkovka,N.A., Sarmento,O.F., Yoshida,T., Gan,Q.,
            Adiguzel,E., Bendeck,M.P., Berliner,J., Leitinger,N. and Owens,G.K.
  TITLE     Oxidized phospholipids induce type VIII collagen expression and
            vascular smooth muscle cell migration
  JOURNAL   Circ Res 104 (5), 609-618 (2009)
   PUBMED   19168440
  REMARK    GeneRIF: Oxidized phospholipids induce type VIII collagen
            expression and vascular smooth muscle cell migration.
REFERENCE   8  (bases 1 to 2432)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   9  (bases 1 to 2432)
  AUTHORS   Hopfer,U., Fukai,N., Hopfer,H., Wolf,G., Joyce,N., Li,E. and
            Olsen,B.R.
  TITLE     Targeted disruption of Col8a1 and Col8a2 genes in mice leads to
            anterior segment abnormalities in the eye
  JOURNAL   FASEB J 19 (10), 1232-1244 (2005)
   PUBMED   16051690
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473967.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221536.4, XM_001060711.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093050
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2432
                     /gene="Col8a1"
                     /note="collagen type VIII alpha 1 chain"
                     /db_xref="GeneID:304021"
                     /db_xref="RGD:1309361"
     exon            1..78
                     /gene="Col8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..197
                     /gene="Col8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..528
                     /gene="Col8a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2432
                     /gene="Col8a1"
                     /note="procollagen, type VIII, alpha 1; collagen
                     alpha-1(VIII) chain; collagen, type VIII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(VIII) chain precursor"
                     /protein_id="NP_001100570.1"
                     /db_xref="GeneID:304021"
                     /db_xref="RGD:1309361"
                     /translation="MAVPPRPLQLLGILFILSLSSVRLAQAGAYYGIKPLPPQIPPQI
                     PPQIPQYQPLGQQVPHMPLGKDGLSMGKEMPHMQYGKEYPHLPQYMKEIQPVPRVGKE
                     VVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGMPGIKGKPGPQGYPGIGKP
                     GMPGMPGKPGAMGMPGAKGEIGPKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQ
                     PGAKGERGPKGPPGPPGLQGPKGEKGFGMPGLPGLKGPPGMHGPPGPVGLPGVGKPGV
                     TGFPGPQGPLGKPGPPGEPGPQGLIGVPGVQGPPGMPGVGKPGQDGIPGQPGFPGGKG
                     EQGLPGLPGPPGLPGVGKPGFPGPKGDRGIGGVPGALGPRGEKGPVGAPGIGGPPGEP
                     GLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPG
                     MRGLPGPIGPKGEAGHKGLPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIAGPSGP
                     IGPPGIPGPKGEPGLPGPPGFPGVGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPG
                     PPGPPAVMPPTPSPQGEYLPDMGLGIDGVKPPHAYAGKKGKNGGPYEMPAFTAELTVP
                     FPPVGAPVKFDKLLYNGRQNYNPQTGVFTCEVPGVYYFAYHVHCKGGNVWVALFKNNE
                     PMMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLL
                     YPM"
     exon            529..2432
                     /gene="Col8a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagagga tcagagccct tccacggtcc tctccgtggg agcccaagtc cctgtctccc
       61 agatcttaca tgctcaagaa gctgttctgt aaataaagta aaccctgtga agagacggga
      121 cccagcccca ttggtattac aagaagagtc aaacaaggac tttggtcctc aattctactg
      181 gccagccaag cctaaatgtg atggctgtgc cacccaggcc tctacagctg ctgggaatac
      241 tgttcatcct ttccctgagc tccgtcagac tcgctcaggc cggtgcctac tatggaatca
      301 agcctctgcc acctcaaatc cctcctcaga taccaccaca aattccacag taccagccct
      361 tgggccagca agtacctcat atgcctttgg gcaaggatgg cctttccatg ggcaaggaga
      421 tgccccacat gcagtatggc aaagagtacc cacacctacc ccagtatatg aaggaaatcc
      481 aacctgtgcc aagagtgggc aaggaagtgg tgcccaaaaa aggcaaagaa ataccattag
      541 ccagtttgcg aggagaacaa ggtccccgtg gagaacctgg accaagagga ccacctgggc
      601 caccaggttt gccaggtcac ggaatgcctg gaatcaaagg aaagccaggg ccccagggat
      661 acccagggat tggaaagccg ggtatgcctg gaatgcctgg gaagccagga gccatgggaa
      721 tgccgggggc aaaaggcgaa attggaccca aaggggaaat cggacctatg ggaatcccag
      781 ggccacaagg acctccagga ccccatggac ttcctggcat tgggaaaccg ggtgggccag
      841 ggttaccagg gcaaccagga gcaaaaggtg agagagggcc caaaggacca ccaggacctc
      901 ccggcctaca gggtcccaaa ggagagaagg gcttcgggat gcctggcttg ccgggtctca
      961 agggtccgcc aggtatgcat ggccctcctg gcccagttgg gctaccagga gtaggaaaac
     1021 caggagtgac tggctttcct ggaccccagg gtcccttggg gaagccaggg cctccagggg
     1081 aacctggacc acaaggcctt attggtgtgc caggcgttca aggacctcct gggatgcctg
     1141 gagttggaaa gccaggtcag gatgggatcc ctggccaacc aggatttcca ggtggtaaag
     1201 gggaacaggg attaccaggg ttgcctggac ccccaggcct cccaggggtc ggaaaaccag
     1261 gcttcccagg acccaaaggg gaccggggta ttgggggtgt tcctggggct cttgggccaa
     1321 ggggagaaaa ggggccagta ggtgctcctg gaataggggg tccccctgga gagccaggcc
     1381 tacccggaat tccaggtccc atgggccctc caggagctat tggtttccct ggacccaaag
     1441 gagaaggtgg aattgtagga ccacagggtc caccaggtcc caagggagag ccaggcctcc
     1501 agggcttccc tgggaagcca ggttttcttg gtgaagtagg tccccctggc atgaggggtt
     1561 tgcccggtcc tataggaccc aagggagaag ctggtcacaa aggattgcct ggacttcctg
     1621 gtgttccagg gctgcttgga cccaaaggag aacctggcat acccggggat cagggtctac
     1681 aggggccccc aggtattcca gggattgcgg gacctagtgg ccctattgga ccccctggga
     1741 ttccaggccc caaaggagaa ccaggcctcc cagggccccc tgggttccct ggtgtaggga
     1801 agccaggagt agcaggactt catggtcccc cggggaaacc tggtgccctt ggacctcaag
     1861 gccaacctgg ccttcctggg ccaccaggcc ctccaggccc cccaggcccc ccagctgtga
     1921 tgccccctac accatcaccc cagggagagt atctaccaga tatgggacta ggaattgatg
     1981 gagtgaagcc tccacatgcc tatgcgggca aaaagggcaa gaacggaggg ccctatgaga
     2041 tgcccgcgtt tactgccgag ctgactgtac ctttcccacc ggtgggggcc ccagtgaagt
     2101 ttgacaagct cctatacaat ggaagacaga actacaaccc gcagacggga gtcttcacct
     2161 gcgaagtccc gggtgtctac tactttgctt accatgttca ctgcaaggga ggcaacgtct
     2221 gggttgctct cttcaagaac aacgagccca tgatgtacac atacgacgag tacaagaagg
     2281 gctttctgga ccaggcatct ggaagcgcag tactgctgct ccggcccgga gaccgggtgt
     2341 tcctccaaat gccttcagaa caggctgctg gactctatgc tgggcaatat gtccactcct
     2401 ccttttcagg atatttattg tatcccatgt aa
//
