LOCUS       NM_001100741            3626 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus collagen type VI alpha 2 chain (Col6a2), mRNA.
ACCESSION   NM_001100741 XM_001079642 XM_342115
VERSION     NM_001100741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R,
            Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M,
            Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M,
            Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J,
            Kichler A, Otsu K and Mayr M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X,
            Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins
            MT, Misra S, Stoughton J and Mayr M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A,
            Teunissen CE, de Wit H and Jimenez CR.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S,
            Haddock MC, Baxter MA, Knight D, Humphries MJ and Kimber SJ.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Lechner BE, Lim JH, Mercado ML and Fallon JR.
  TITLE     Developmental regulation of biglycan expression in muscle and
            tendon
  JOURNAL   Muscle Nerve 34 (3), 347-355 (2006)
   PUBMED   16810681
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Jobsis GJ, Keizers H, Vreijling JP, de Visser M, Speer MC,
            Wolterman RA, Baas F and Bolhuis PA.
  TITLE     Type VI collagen mutations in Bethlem myopathy, an autosomal
            dominant myopathy with contractures
  JOURNAL   Nat Genet 14 (1), 113-115 (1996)
   PUBMED   8782832
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Dziadek M, Darling P, Bakker M, Overall M, Zhang RZ, Pan TC, Tillet
            E, Timpl R and Chu ML.
  TITLE     Deposition of collagen VI in the extracellular matrix during mouse
            embryogenesis correlates with expression of the alpha 3(VI) subunit
            gene
  JOURNAL   Exp Cell Res 226 (2), 302-315 (1996)
   PUBMED   8806434
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Takahara T, Sollberg S, Muona P and Uitto J.
  TITLE     Type VI collagen gene expression in experimental liver fibrosis:
            quantitation and spatial distribution of mRNAs, and immunodetection
            of the protein
  JOURNAL   Liver 15 (2), 78-86 (1995)
   PUBMED   7791542
REFERENCE   10 (bases 1 to 3626)
  AUTHORS   Muona P, Jaakkola S, Zhang RZ, Pan TC, Pelliniemi L, Risteli L, Chu
            ML, Uitto J and Peltonen J.
  TITLE     Hyperglycemic glucose concentrations up-regulate the expression of
            type VI collagen in vitro. Relevance to alterations of peripheral
            nerves in diabetes mellitus
  JOURNAL   Am J Pathol 142 (5), 1586-1597 (1993)
   PUBMED   8494053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM036514.1, FM048712.1, CK365920.1, DN935075.1, CB616438.1,
            FM093132.1 and BC089923.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_001079642.1, XM_342115.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               FM036514.1         1-414
            415-878             FM048712.1         84-547
            879-1396            CK365920.1         117-634
            1397-1905           DN935075.1         110-618
            1906-2468           CB616438.1         5-567
            2469-3159           FM093132.1         17-707
            3160-3626           BC089923.1         675-1141
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3626
                     /gene="Col6a2"
                     /note="collagen type VI alpha 2 chain"
                     /db_xref="GeneID:361821"
                     /db_xref="RGD:1305585"
     exon            1..66
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..218
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..3163
                     /gene="Col6a2"
                     /note="procollagen, type VI, alpha 2; collagen alpha-2(VI)
                     chain; collagen, type VI, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(VI) chain precursor"
                     /protein_id="NP_001094211.1"
                     /db_xref="GeneID:361821"
                     /db_xref="RGD:1305585"
                     /translation="MTTTTKMLQGSFSVLLLGGLLGVLHAQQQEAISPDISTTDRNNN
                     CPEKADCPVNVYFVLDTSESVAMQSPTDSLLYHMQQFVPQFISQLQNEFYLEQVALSW
                     RYGGLHFSDQVEVFSPPGSDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRQHVGRG
                     VVNFAVVITDGHVTGNPCGGIKMQAERAREEGIRLFAVAPNRNLNEQGLRDIANTPHE
                     LYRNNYATMRPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPHGPKGYRGQKG
                     AKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGSDGRKGAPGLAGK
                     NGTDGQKGKLGRIGPPGCKGDPGSRGPDGYPGEAGSPGEQGDQGAKGDSGRPGRRGPP
                     GNPGDKGSKGYRGNSGAPGSPGVKGGKGGPGPRGPKGEPGRRGDPGTKGGPGSDGPKG
                     EKGDPGPEGPRGLAGEIGSKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGD
                     SGQPGPKGDPGRPGFSYPGPRGTPGEKGEPGPPGPEGGRGDFGLKGAPGRKGEKGEPA
                     DPGPPGEPGPRGPRGIPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDV
                     VFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAI
                     RLDDERVNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIKESRRQKTRVFAVVITD
                     GRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHETHESENLYSIACDKPQQVRNMTLFS
                     DLVAEKFIDDMEDVLCPDPQIVCPELPCQTELYVAQCTQRPVDIVFLLDGSERLGEQN
                     FYKARRFVEEVSRRLTLARRDDDPLNARMALLQYGSQNQQQVAFPLTYNVTTIHEALE
                     RTTYLNSFSHVGTGIVHAINNVVRGARGGARRHAELSFVFLTDGVTGNDSLEESVHSM
                     RKQNVVPTVVAVGGDVDMDVLTKISLGDRAAIFREKDFDSLAQPSFFDRFIRWIC"
     exon            219..817
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..838
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..904
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..958
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1003
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1030
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1057
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1102
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1156
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1219
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1282
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1372
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1435
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1498
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1561
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1624
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1675
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1711
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1774
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1837
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1873
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1919
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2072
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2525
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2564
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..3601
                     /gene="Col6a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcacctc gggccgtcag gacccgagct gtcctcggaa gtacccagac gtcctctcca
       61 agccaggaca tcagggcaca tgacgactac taccaagatg ctccagggtt ctttttctgt
      121 gctcctgctt gggggactct tgggggtcct ccatgcccag cagcaggaag ccatctcacc
      181 tgatatctct actactgaca ggaacaacaa ctgtccagag aaggctgact gcccagtcaa
      241 cgtgtacttc gtgttggaca cctcggagag cgtggccatg cagtccccca cagacagcct
      301 gctttatcac atgcagcagt tcgtaccaca atttatcagc cagctgcaga acgagttcta
      361 cctggagcag gtggccctga gctggcgcta tggtggccta cacttctcgg accaggtgga
      421 ggtgttcagc cccccaggca gcgaccgggc ctccttcact aagagcctac aaggcatccg
      481 ctccttccgc aggggcacct tcactgactg tgccttggcc aacatgaccc agcagatccg
      541 gcagcacgta ggccggggtg tagtcaactt tgccgtggtc atcaccgatg gccacgtcac
      601 aggcaatccc tgtgggggca tcaaaatgca ggctgagcgt gcccgcgagg agggcatccg
      661 gctctttgcc gtggccccca ataggaacct aaatgaacaa ggcctgcggg atatcgccaa
      721 caccccacat gagctatacc gaaacaacta tgccaccatg cgacctgact ctactgagat
      781 tgaccaggac accatcaacc gcatcatcaa ggtcatgaaa catgaagcct acggagagtg
      841 ctacaaggtg agctgcctgg agattccggg accccacgga cccaagggtt accgaggaca
      901 gaagggcgcc aagggcaaca tgggcgagcc aggagaacct ggacagaaag gacgacaggg
      961 agaccctggc attgaaggcc ccattggatt cccaggaccc aagggtgtgc ctggcttcaa
     1021 gggagagaag ggtgaattcg gatcagatgg tcggaaggga gctccgggtc tagcaggcaa
     1081 gaacggaaca gatggacaga agggcaaact gggccgtatt gggcctcctg gttgcaaggg
     1141 agacccggga agtcggggcc ccgatggata ccccggagaa gctggaagcc cgggagagca
     1201 aggagaccaa ggtgccaagg gggactctgg ccgcccagga cgcaggggac caccaggaaa
     1261 tcctggagac aaaggaagca agggatatcg aggcaacagt ggagctcccg gaagtccagg
     1321 agtgaaagga ggcaagggag ggcctggccc ccgtggacca aaaggagagc ctggacgcag
     1381 gggagatcct gggaccaagg gcggcccggg cagtgatggt ccaaaggggg agaagggaga
     1441 ccctggtcct gaggggccac gaggtctggc tggagaaatc ggcagtaaag gagccaaggg
     1501 agacagaggt ttgcctggac ccagaggccc ccagggagct cttggggagc cagggaagca
     1561 gggatctcgg ggagaccctg gggatgctgg gcctcgagga gattcaggac agccaggacc
     1621 caagggagat cctggaaggc ctggattcag ctacccagga ccccgaggga cacccggtga
     1681 aaaaggcgag cccggcccac caggccctga gggaggccga ggagactttg gtctgaaagg
     1741 agcacccgga cggaagggag aaaaaggaga gccagctgat cctggtcccc ctggtgaacc
     1801 tggccctcgg gggccaagag gaatcccagg acctgaggga gaacccggcc ctccaggaga
     1861 tcctggtctc acggaatgtg acgtcatgac ctatgtgagg gagacctgtg ggtgctgtga
     1921 ctgtgagaag cgctgcggtg ccctggatgt ggtcttcgtc atcgacagct ctgagagtat
     1981 tggctacacc aacttcacct tggagaagaa ctttgtcatc aatgtggtca acaggctggg
     2041 cgccattgcc aaggacccca agtctgaaac gggtacacgt gtgggtgtgg tacagtacag
     2101 ccatgagggc acctttgagg ccatccggct ggacgacgag cgggtcaact ccctgtccag
     2161 tttcaaggag gccgtcaaaa accttgagtg gattgccggc ggcacttgga cgccctctgc
     2221 cctcaagttc gcctataatc agctcatcaa agagagccgg cgccagaaga cccgggtgtt
     2281 cgcagtggtc atcacagatg ggcgccatga ccctcgagat gatgacctca atcttcgggc
     2341 actgtgtgac cgagacgtca ccgtgacagc catcggcatc ggtgacatgt tccacgagac
     2401 ccacgagagc gagaacctct actccatcgc ctgtgacaag ccccagcagg tgcgcaacat
     2461 gacgctgttc tctgacctgg tggccgagaa attcatcgat gacatggaag acgtcctttg
     2521 tccggacccc cagatcgtgt gtccagaact tccctgccaa acagagctct atgtggccca
     2581 gtgcacacaa cggcccgtgg acattgtctt cctgctggat ggctcggagc ggctgggcga
     2641 gcagaacttc tacaaggcac ggcgcttcgt ggaggaggtg tcacggcgcc tgactctggc
     2701 acgaagggat gacgacccac tcaatgcccg catggccctg ttgcagtatg gaagccagaa
     2761 ccagcaacag gtggccttcc cgttgaccta caatgtgacc accatccacg aggccctgga
     2821 gagaaccacc tacctcaatt ctttctcgca cgtgggcaca ggcatcgtgc acgccatcaa
     2881 caacgtggtg cggggggcac ggggtggggc ccggcgtcac gcggagctgt ccttcgtctt
     2941 cctcacggac ggcgtcacgg gcaacgacag cctggaggag tccgtacact ccatgcgtaa
     3001 gcagaatgtg gtgcccaccg tggtcgctgt gggtggtgat gtggacatgg atgtacttac
     3061 caagatcagc ctgggtgaca gggcggccat cttccgggag aaagacttcg acagtctagc
     3121 ccagcccagc ttcttcgaca ggttcatccg ctggatctgt tagcgccgcc atgctctacc
     3181 atctcttgac catttcccat ctgtggtgct actaggaccc tagccagtcc cagctagacg
     3241 gtacacttgg gtctttctag aaagtgaaag cccttctccc aaggtcagga cagaaggact
     3301 ctgaacccaa agccccttcc ccaccttcgg ctcccttggc ttcccctccc cacatctcca
     3361 gcctacctat accttgctct caaacactgg aggaccccag agtcttccca ctgcccattt
     3421 cccacagcct ctgcccttcc acttccgttt ctccttcatg catccgctag tcccttctga
     3481 aggcctgcac cagttgtgcc cagggccctg tctttctcta cccgttattt cctatctcag
     3541 gagatcaact ctgagagcac catgtcacat gcccaatggc ccaataaagg ttttgagcct
     3601 caaaaaaaaa aaaaaaaaaa aaaaaa
//
