LOCUS       NM_021760               6076 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus collagen type V alpha 3 chain (Col5a3), mRNA.
ACCESSION   NM_021760
VERSION     NM_021760.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6076)
  AUTHORS   Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R,
            Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M,
            Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M,
            Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J,
            Kichler A, Otsu K and Mayr M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 6076)
  AUTHORS   Chernousov MA, Rothblum K, Stahl RC, Evans A, Prentiss L and Carey
            DJ.
  TITLE     Glypican-1 and alpha4(V) collagen are required for Schwann cell
            myelination
  JOURNAL   J Neurosci 26 (2), 508-517 (2006)
   PUBMED   16407548
  REMARK    GeneRIF: Alpha4(V) collagen has an important role in peripheral
            nerve terminal differentiation.  alpha4(V) collagen coassembles
            with laminin on the surface of polarized Schwann cells to form
            tube-like ECM structures that are sites of myelination.
REFERENCE   3  (bases 1 to 6076)
  AUTHORS   Yamaguchi K, Matsuo N, Sumiyoshi H, Fujimoto N, Iyama KI,
            Yanagisawa S and Yoshioka H.
  TITLE     Pro-alpha3(V) collagen chain is expressed in bone and its basic
            N-terminal peptide adheres to osteosarcoma cells
  JOURNAL   Matrix Biol 24 (4), 283-294 (2005)
   PUBMED   15908193
  REMARK    GeneRIF: N-terminal globular domain of the pro-alpha3(V) chain
            influence bone formation of osteoblasts through proteoglycan on the
            cell surface during development or regeneration
REFERENCE   4  (bases 1 to 6076)
  AUTHORS   Rothblum K, Stahl RC and Carey DJ.
  TITLE     Constitutive release of alpha4 type V collagen N-terminal domain by
            Schwann cells and binding to cell surface and extracellular matrix
            heparan sulfate proteoglycans
  JOURNAL   J Biol Chem 279 (49), 51282-51288 (2004)
   PUBMED   15383532
  REMARK    GeneRIF: alpha4(V)-NTD binding occurs via a mechanism that requires
            the high affinity heparin binding site and that is blocked by
            soluble heparin.
REFERENCE   5  (bases 1 to 6076)
  AUTHORS   Chernousov MA, Rothblum K, Tyler WA, Stahl RC and Carey DJ.
  TITLE     Schwann cells synthesize type V collagen that contains a novel
            alpha 4 chain. Molecular cloning, biochemical characterization, and
            high affinity heparin binding of alpha 4(V) collagen
  JOURNAL   J Biol Chem 275 (36), 28208-28215 (2000)
   PUBMED   10852920
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF272661.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272661.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132265 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6076
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..6076
                     /gene="Col5a3"
                     /note="collagen type V alpha 3 chain"
                     /db_xref="GeneID:60379"
                     /db_xref="RGD:70922"
     exon            1..143
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..5269
                     /gene="Col5a3"
                     /note="collagen, type V, alpha 4; collagen alpha-3(V)
                     chain; procollagen, type V, alpha 3; collagen, type V,
                     alpha 3"
                     /codon_start=1
                     /product="collagen alpha-3(V) chain precursor"
                     /protein_id="NP_068528.1"
                     /db_xref="GeneID:60379"
                     /db_xref="RGD:70922"
                     /translation="MRSCRRLDQLQAGLCLLLASLQLVSWTLAAEPVDVLETLGVHRD
                     KAGVTKGPGFCPQRIPQGDRAFRVGKSSLLSVPTWQLFPDGHFPENFSVLLTLRAQPA
                     NQSVLLSIYDENGVRQMGLALGPALGLLGDSFRSLPKQINLMDGRWHRVAVSISGDKV
                     TLVVDCEPQPPMFGQGPRVISTAGLTVMGTQELGEESFEGDIQELLLIPDPQAALQAC
                     ELYLPDCETPDSTTTGVTKEEPETPAPRRRKGKGKKKDRGRKGKGRKKNKTSRLSPTP
                     GAPENQTSLHTPETEKPSPHLPPTPTPLAITTTVTMGGNATVLQGLDSSTETEQMTPE
                     MDATEESEGGGPTMGPEFRAAEQSLQTEFQIFPGAGEKGAKGEPATIEQGQQFEGPAG
                     APGPRGISGPSGPPGPPGFPGDRGLPGPAGLPGIPGIDGVRGLPGTVIMMPFHFASGS
                     MKGPPVSFQQAQAQAVLQQAQLSMKGPPGPVGLTGRPGPVGLPGYPGLKGELGEAGPQ
                     GPRGLQGPPGPPGREGKTGRAGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFG
                     PVGQPGPPGEDGIKGLQGPPGPTGQAGEPGPRGLIGPRGPPGPLGRPGVTGSDGAPGA
                     KGNVGPPGEPGPPGQQGNHGSQGIPGPQGPIGTPGEKGPPGNPGIPGVPGSEGPPGHP
                     GHEGPTGEKGAQGPPGSAGPQGYPGPRGVKGTSGNRGLQGEKGERGEDGFPGFKGDEG
                     PKGDRGNPGLPGPRGEDGPEGQKGPEGLPGDEGPPGAAGEKGKLGVPGLPGYPGRPGP
                     KGSIGFPGPLGPLGEKGKRGKAGQPGEEGERGTPGTRGDRGQPGATGQPGPKGDVGQN
                     GSPGAPGEKGLPGLQGPPGFPGPKGPPGPQGKDGIPGHPGQRGELGFQGQTGPPGPAG
                     VLGPQGKVGDVGPLGERGPPGPPGPPGEPGLPGIEGREGAKGELGPLGSLGKEGPPGP
                     MGFPGPQGAPGDPGPIGLKGDKGPPGPLGANGSPGERGPVGPSGGIGLPGQSGGQGPI
                     GPAGEKGSPGERGVPGPTGKDGIPGPPGLQGPPGAAGPSGEEGDKGEVGMPGHKGSKG
                     DKGDAGPPGPTGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGL
                     QGLPGPPGEKGEVGDVGSMGPHGAPGPRGPPGPSGSAGSPGLPGGVGQPGAVGEKGEP
                     GNAGDAGPPGVPGIPGPKGEIGEKGDSGPSGAAGPPGKKGPPGEDGAKGNMGPTGLPG
                     DLGPPGDPGVPGTDGIPGEKGNAGDIGGPGPPGASGEPGARGLPGKRGSPGRMGPEGK
                     EGEKGAKGDAGPDGPPGRTGPIGARGPPGRVGPDGLPGIPGPVGEPGLLGPPGLIGPP
                     GPLGPPGLPGLKGDAGLKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGLQGDPG
                     LPGPVGSLGHPGPPGVVGPLGQKGSKGSPGSLGPRGDPGPAGPPGPPGSPAEVHGLRR
                     RRSVLDTPEGGLEEVMASLNSLSLELEQLQRPPGTAESPGLICHELHRNHPHLPDGEY
                     WIDPNQGCARDAFKVFCNFTAGGETCLYPDKKFETVKLASWSREKPGGWYSTFRRGKK
                     FSYVDADGSPVNVVQLTFLKLLSAAAHQRFTYTCQNSAAWLDEASGDHRHSIRFQGTN
                     WEELSFNQTTAATIKVPHDGCRVRKGQAKTLFEFSSSVGFLPLWDVAAVDFGQTNQKF
                     GFELGSVCFSS"
     exon            144..305
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            306..495
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..652
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..757
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..901
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1015
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1156
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1204
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1246
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1309
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1384
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1468
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1525
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1579
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1633
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1687
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1741
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1795
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1840
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1894
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1939
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..1993
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2038
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2092
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2137
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2191
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2236
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2290
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2398
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2452
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2506
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2551
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2605
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2650
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2704
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2758
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2812
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2920
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3010
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3064
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3172
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3280
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3334
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3388
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3496
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3550
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3604
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3658
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3712
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3820
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3874
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3928
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..3982
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4036
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4144
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4198
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4252
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4360
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4414
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4450
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4504
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4703
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4816
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4885
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4886..5125
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
     exon            5126..6052
                     /gene="Col5a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggaaga ccagtccaca tcccccttgg ccttggtgca ccaggccccg ctgggatgag
       61 aagctgccgg agactggacc agcttcaggc cggcctctgc ctgctcctgg cctccctaca
      121 actcgtgtcc tggacgctgg ctgcagaacc tgtggatgta ttggaaacct tgggtgtgca
      181 tagggacaag gctggggtga ccaaagggcc tggcttctgc ccccagagga ttccacaggg
      241 tgaccgagca ttcagggtgg gcaagtccag ccttctcagc gtccccacat ggcagctctt
      301 tccagatgga cattttcctg agaacttttc tgtgctgctc actctgcggg cccagccagc
      361 caatcaatct gtccttctgt ctatatatga cgagaatggt gtccggcaga tggggctggc
      421 actggggcca gctctgggtc tccttggtga ctctttcagg tctcttccca agcagatcaa
      481 ccttatggat ggcaggtggc accgggtggc ggtcagcatc agcggtgaca aggtgaccct
      541 ggtggttgac tgtgaacctc agccccccat gtttggtcag gggcctcggg ttataagtac
      601 agctggactc acggtgatgg gaacccagga gctcggggag gagtcttttg agggagacat
      661 ccaggagctg ctgttaattc cagaccctca ggctgctctc caggcctgtg agctctacct
      721 gcctgactgt gagacccccg attccacaac cacaggggtc actaaagaag aaccagaaac
      781 acctgcccct cgtcgacgaa agggcaaagg aaagaaaaaa gatcggggtc gcaagggcaa
      841 gggaagaaag aaaaacaaga cctcaagact gagtccaacc ccaggtgccc ctgagaacca
      901 gacctccctc cacacccctg agacagagaa gccatcgccc catctgcctc caactcccac
      961 acctttggcc atcaccacca ctgtcacgat gggaggaaat gccacagttt tgcaggggtt
     1021 ggactccagt actgaaactg agcagatgac tccagagatg gacgctactg aagagagtga
     1081 aggaggtggc ccgaccatgg gccccgagtt ccgggcagca gaacagtctt tacagactga
     1141 gttccagatc tttcctggtg ctggagaaaa gggagcgaaa ggagaacctg cgactataga
     1201 gcagggacag cagtttgagg gacctgcagg agctccagga ccccggggaa tatctggtcc
     1261 ttcaggccct cctgggcctc cgggcttccc tggggaccgt ggcctaccgg gccctgctgg
     1321 cctcccagga atcccaggca ttgatggcgt ccggggcctg ccaggcacag tgatcatgat
     1381 gccgttccat tttgcaagcg gctcgatgaa aggaccccca gtctcctttc aacaggcaca
     1441 ggcccaggca gtactgcaac aggctcagct gtccatgaaa gggccccctg gtccagtagg
     1501 gctcactggg cgcccaggcc ctgtgggcct ccctggatat ccaggtctga aaggtgaatt
     1561 gggagaagca gggcctcagg gcccccgagg attgcagggc cctcctgggc ctcctggacg
     1621 ggaaggcaag acaggccgag ctggagcaga tggggctcgg ggtcttccgg gagacacagg
     1681 acctaagggt gaccggggct ttgatggcct gcctggactg cctggtgaga agggccagag
     1741 gggtgacttt ggacctgtag gacaacctgg tcccccagga gaagatggta taaagggcct
     1801 gcagggacct ccaggcccca ctggccaggc tggagagccg ggtccccgag gtctgattgg
     1861 ccccagaggc ccccctggtc ctttaggacg cccgggtgtg acagggagtg atggcgcacc
     1921 gggtgccaaa ggcaacgtgg gtcctcccgg agaaccaggc cccccaggac agcaaggaaa
     1981 ccacggctcc cagggaatcc caggccccca ggggcccatt ggcacacccg gggagaaggg
     2041 tcctcctgga aaccccggaa ttccaggtgt cccaggatct gagggccccc cgggccaccc
     2101 aggccatgag ggtcccaccg gagaaaaggg ggctcagggc ccaccagggt cagcaggccc
     2161 tcagggctat cctggacctc gtggtgtgaa gggtacctct ggtaaccggg gcctccaagg
     2221 agagaaagga gaaaggggag aggatggttt tccaggcttc aagggtgatg agggaccaaa
     2281 aggcgaccgg ggaaacccgg gactcccagg tcccagagga gaggatggcc cagaaggaca
     2341 aaaggggcct gagggactgc ctggtgatga gggcccccca ggagcagcag gggagaaggg
     2401 caagcttggg gtgccaggtc tcccaggtta tccaggacgc ccaggaccta agggatctat
     2461 tggatttcct gggccccttg gaccactggg ggagaaaggc aagcggggca aagcagggca
     2521 gccaggggag gaaggagaac gtggcacacc gggcaccaga ggagacagag gacagccagg
     2581 ggccacaggc cagcctggcc ctaagggaga tgtgggccag aacgggtctc ctggggcccc
     2641 cggagaaaag ggtctacccg gtctgcaagg tcccccagga ttccctgggc caaaaggccc
     2701 cccaggtcct caggggaaag atgggatacc cggacaccct ggacaaagag gagaattggg
     2761 cttccaaggt cagacaggcc cccctggacc agctggtgtc cttggtcctc agggaaaggt
     2821 aggggatgtg ggtcctctag gcgagagagg ccccccaggg cctcctggac cgcctggtga
     2881 accaggtctg ccaggcatag aaggcagaga aggggccaag ggtgagctag gacccctggg
     2941 gtccctcgga aaggaggggc cacctgggcc catgggcttc cctggcccac aaggagcccc
     3001 cggagaccca ggacccattg gtttgaaggg tgacaagggt cccccgggcc ctcttggggc
     3061 aaatggctcc ccaggtgagc gtggtcctgt gggcccctct ggaggcattg ggcttcctgg
     3121 ccagagtggt gggcaaggcc ctattggtcc tgctggtgag aaggggtccc cgggagaacg
     3181 gggtgtgcct ggtcctactg gcaaagatgg tattccaggg cccccgggac ttcaggggcc
     3241 ccctggagct gcagggcctt ctggtgagga aggagacaag ggggaagtag ggatgcctgg
     3301 acacaaggga agcaaagggg ataaaggaga tgcgggccca cctggaccaa caggaataag
     3361 gggtccagcg ggccatccag gccccccggg tgctgatggt gctcagggtc gccggggacc
     3421 ccctggcctc tttgggcaga aaggtgatga tggagtccga ggctttgtag gtgtaattgg
     3481 tcctccaggc ctgcaggggc tgccgggccc tcctggggag aaaggcgagg ttggagacgt
     3541 gggatccatg ggtccccacg gagctccagg ccctcggggt ccccctgggc ccagtggatc
     3601 agcgggttcc ccagggctgc ctggaggagt agggcagcct ggcgctgtgg gcgagaaggg
     3661 tgagccaggg aatgctggag acgctggacc cccaggagtt ccaggcatcc ctgggcccaa
     3721 aggtgaaatt ggtgaaaagg gggattcggg tccatcaggg gctgctggtc ctccaggcaa
     3781 aaagggacct cctggagagg acggagctaa ggggaacatg ggtcccacag gactccctgg
     3841 agatctagga cccccaggag accctggagt tccgggtacg gatggcatcc caggggagaa
     3901 ggggaatgct ggtgatattg ggggaccggg gccacctgga gcttcagggg aacctggtgc
     3961 ccgtgggctc cctggcaaga ggggttcccc tggccgcatg ggtccagaag gaaaagaggg
     4021 agagaaaggc gccaagggag atgctggtcc cgatggcccc ccaggcagaa caggccccat
     4081 tggggctcgg gggccccctg gacgggttgg gcctgatggt cttccaggga tccctggtcc
     4141 tgtgggtgaa ccaggtctcc tgggacctcc tgggctaatc ggccctccag ggcccctggg
     4201 cccacctggc ctccctggcc tgaagggaga cgctggcctc aagggggaaa agggccacat
     4261 tgggctaatc ggcctcattg gtcccccagg ggaggctggg gaaaaaggcg atcaggggtt
     4321 gccaggtgtg cagggccctc caggccttca gggagaccct ggtcttcctg gtcctgttgg
     4381 ctccttaggt caccctgggc ccccaggtgt ggtgggccct ctgggacaga agggttccaa
     4441 ggggtccccg ggatctcttg gacctcgtgg agaccctgga ccagcaggtc ctcctggtcc
     4501 cccgggttcc cctgctgagg tgcacggcct gcgtaggcgc cgctctgtgt tggacacccc
     4561 agaaggtggc ctggaggaag tgatggcctc actcaattca ctgagcttgg agctggagca
     4621 gttgcagcga cccccaggca cagccgagag cccaggcctc atatgccacg agcttcatcg
     4681 aaaccaccca cacctgccgg acggagagta ctggattgac cccaatcagg gctgtgcacg
     4741 ggacgccttc aaggtcttct gcaacttcac tgccggaggt gagacctgtc tctacccaga
     4801 caagaagttt gagacggtga aactggcctc ctggtcccga gaaaagcctg gaggttggta
     4861 cagcaccttc cgccgaggga agaagttctc ctatgtggat gctgacggct ccccggtgaa
     4921 tgtggtccag ttgaccttcc tgaagttgtt gagcgctgca gcccatcaga ggttcactta
     4981 cacctgccag aactccgcag catggctgga cgaagcttca ggtgaccaca ggcactctat
     5041 ccgcttccaa gggaccaact gggaagagtt gtccttcaac cagacaacag cagccaccat
     5101 caaggtcccc catgatggct gccgggtccg gaagggacag gcgaagaccc tctttgaatt
     5161 cagctcttct gtgggctttc tgcctctgtg ggatgtggcc gccgttgact ttggccagac
     5221 gaaccagaag tttgggtttg aacttggctc cgtctgcttt agcagctgag ttttggaggt
     5281 gggaaggaag ctaaagggag ccccatgtgg ggctatgtgg tgctgaggct ttgaggccat
     5341 tctatttatc accagggaac tctagatcca gggttgtgtg actctgagta ttcttcctcc
     5401 cttgtagggg tgagggtgga gagcccagct tcttctgtct attcatcccg ggtggcacac
     5461 ccaactgtcc gctggcttct tccctccacc caaccattca ttgcctactc ccacccccag
     5521 acctccatac agtatagact tataactcag agctgatgaa gccccacccc tgcctctcca
     5581 cccctccacc aggccctttg gtgctatccc tttccatagt taagcactgg atacctcctg
     5641 gtccctggct aggacctttc cctctcattc ctattctttc tttgagtaaa gaggtaaaca
     5701 agatcaacgt gggacgccct cccctgagac gcgccttcct tctgcttcct tgacccagct
     5761 ccgcacaatt ccctctcccc actctgcccc attcccatgt ccccaagcct tctggggacc
     5821 aagatgttgg gcacaaatca ggatcctaaa tggtgctgcc ctgctcgtaa ctgggaactg
     5881 tatgaaatgg ggaatgaatg gtttgtggtc tatttaatct gcttccttct gaaggaagtc
     5941 tgggatatga tgagagattc cagaagggtc tctactctcc ctcccctgtg ctgccctcct
     6001 cccaaggaca cagggcaaaa ctgccatctc aagaataaac caaggaactg tgaaaaaaaa
     6061 aaaaaaaaaa aaaaaa
//
