LOCUS       NM_001399195            6063 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus collagen type V alpha 2 chain (Col5a2), mRNA.
ACCESSION   NM_001399195 XM_039084297
VERSION     NM_001399195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6063)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6063)
  AUTHORS   Meng,Z., Chen,Y., Wu,W., Yan,B., Meng,Y., Liang,Y., Yao,X. and
            Luo,J.
  TITLE     Exploring the Immune Infiltration Landscape and M2
            Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy
  JOURNAL   Front Endocrinol (Lausanne) 13, 841813 (2022)
   PUBMED   35692390
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6063)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 6063)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 6063)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 6063)
  AUTHORS   Ellis,L.R., Warner,D.R., Greene,R.M. and Pisano,M.M.
  TITLE     Interaction of Smads with collagen types I, III, and V
  JOURNAL   Biochem Biophys Res Commun 310 (4), 1117-1123 (2003)
   PUBMED   14559231
REFERENCE   7  (bases 1 to 6063)
  AUTHORS   Wurtz,T., Ellerstrom,C., Lundmark,C. and Christersson,C.
  TITLE     Collagen mRNA expression during tissue development: the
            temporospacial order coordinates bone morphogenesis with collagen
            fiber formation
  JOURNAL   Matrix Biol 17 (5), 349-360 (1998)
   PUBMED   9822201
REFERENCE   8  (bases 1 to 6063)
  AUTHORS   Richards,A.J., Martin,S., Nicholls,A.C., Harrison,J.B., Pope,F.M.
            and Burrows,N.P.
  TITLE     A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type
            II
  JOURNAL   J Med Genet 35 (10), 846-848 (1998)
   PUBMED   9783710
REFERENCE   9  (bases 1 to 6063)
  AUTHORS   Michalickova,K., Susic,M., Willing,M.C., Wenstrup,R.J. and
            Cole,W.G.
  TITLE     Mutations of the alpha2(V) chain of type V collagen impair matrix
            assembly and produce ehlers-danlos syndrome type I
  JOURNAL   Hum Mol Genet 7 (2), 249-255 (1998)
   PUBMED   9425231
REFERENCE   10 (bases 1 to 6063)
  AUTHORS   Andrikopoulos,K., Liu,X., Keene,D.R., Jaenisch,R. and Ramirez,F.
  TITLE     Targeted mutation in the col5a2 gene reveals a regulatory role for
            type V collagen during matrix assembly
  JOURNAL   Nat Genet 9 (1), 31-36 (1995)
   PUBMED   7704020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 5, 2022 this sequence version replaced XM_039084297.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222447.1, SRR26643299.39134.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               JAXUCZ010000009.1  55089907-55090151   c
            246-470             JAXUCZ010000009.1  55006054-55006278   c
            471-484             JAXUCZ010000009.1  55000546-55000559   c
            485-517             JAXUCZ010000009.1  54999218-54999250   c
            518-550             JAXUCZ010000009.1  54998200-54998232   c
            551-604             JAXUCZ010000009.1  54996803-54996856   c
            605-715             JAXUCZ010000009.1  54991168-54991278   c
            716-793             JAXUCZ010000009.1  54988839-54988916   c
            794-838             JAXUCZ010000009.1  54986247-54986291   c
            839-892             JAXUCZ010000009.1  54984911-54984964   c
            893-946             JAXUCZ010000009.1  54984504-54984557   c
            947-1000            JAXUCZ010000009.1  54983824-54983877   c
            1001-1054           JAXUCZ010000009.1  54981122-54981175   c
            1055-1108           JAXUCZ010000009.1  54980168-54980221   c
            1109-1153           JAXUCZ010000009.1  54979512-54979556   c
            1154-1207           JAXUCZ010000009.1  54979018-54979071   c
            1208-1252           JAXUCZ010000009.1  54977801-54977845   c
            1253-1306           JAXUCZ010000009.1  54976228-54976281   c
            1307-1405           JAXUCZ010000009.1  54973749-54973847   c
            1406-1450           JAXUCZ010000009.1  54973371-54973415   c
            1451-1549           JAXUCZ010000009.1  54973169-54973267   c
            1550-1603           JAXUCZ010000009.1  54972689-54972742   c
            1604-1711           JAXUCZ010000009.1  54972399-54972506   c
            1712-1765           JAXUCZ010000009.1  54970980-54971033   c
            1766-1864           JAXUCZ010000009.1  54970385-54970483   c
            1865-1918           JAXUCZ010000009.1  54969856-54969909   c
            1919-2017           JAXUCZ010000009.1  54969084-54969182   c
            2018-2071           JAXUCZ010000009.1  54968923-54968976   c
            2072-2125           JAXUCZ010000009.1  54968780-54968833   c
            2126-2179           JAXUCZ010000009.1  54967795-54967848   c
            2180-2233           JAXUCZ010000009.1  54966840-54966893   c
            2234-2278           JAXUCZ010000009.1  54965176-54965220   c
            2279-2377           JAXUCZ010000009.1  54964778-54964876   c
            2378-2485           JAXUCZ010000009.1  54963466-54963573   c
            2486-2539           JAXUCZ010000009.1  54960170-54960223   c
            2540-2593           JAXUCZ010000009.1  54958869-54958922   c
            2594-2647           JAXUCZ010000009.1  54958652-54958705   c
            2648-2701           JAXUCZ010000009.1  54957966-54958019   c
            2702-2809           JAXUCZ010000009.1  54957473-54957580   c
            2810-2863           JAXUCZ010000009.1  54957312-54957365   c
            2864-2917           JAXUCZ010000009.1  54956738-54956791   c
            2918-3079           JAXUCZ010000009.1  54955699-54955860   c
            3080-3187           JAXUCZ010000009.1  54955083-54955190   c
            3188-3295           JAXUCZ010000009.1  54953919-54954026   c
            3296-3349           JAXUCZ010000009.1  54952807-54952860   c
            3350-3457           JAXUCZ010000009.1  54951229-54951336   c
            3458-3511           JAXUCZ010000009.1  54950678-54950731   c
            3512-3619           JAXUCZ010000009.1  54949907-54950014   c
            3620-3673           JAXUCZ010000009.1  54949471-54949524   c
            3674-3781           JAXUCZ010000009.1  54948425-54948532   c
            3782-4073           JAXUCZ010000009.1  54946156-54946447   c
            4074-4261           JAXUCZ010000009.1  54944524-54944711   c
            4262-4501           JAXUCZ010000009.1  54942952-54943191   c
            4502-6063           JAXUCZ010000009.1  54940768-54942329   c
FEATURES             Location/Qualifiers
     source          1..6063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..6063
                     /gene="Col5a2"
                     /note="collagen type V alpha 2 chain"
                     /db_xref="GeneID:85250"
                     /db_xref="RGD:70921"
     exon            1..245
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4648
                     /gene="Col5a2"
                     /note="procollagen, type V, alpha 2; collagen alpha-2(V)
                     chain; collagen, type V, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(V) chain precursor"
                     /protein_id="NP_001386124.1"
                     /db_xref="GeneID:85250"
                     /db_xref="RGD:70921"
                     /translation="MMANWVVARPLLILFVLLGYCVSIKAQEQENDDYDEEIACTQHG
                     QMYLNRDIWKPSPCQICVCDNGAILCDKIECQEVLNCANPVTPPGECCPACPQTSGGG
                     DTSFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGDRGPKGRPGPRGPQGID
                     GEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPIG
                     PRGPQGLQGQQGGVGPAGPPGEPGEPGPMGPIGARGPEGPPGKPGEDGEPGRNGNTGE
                     VGFSGSPGARGFPGAPGLPGLKGHRGNKGLEGPKGEVGAPGAKGEAGPTGPMGAMGPL
                     GPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGVKGEAGPTG
                     ARGPEGPQGQRGETGPPGPAGSHGLPGAVGTDGTPGAKGPTGSPGTSGPPGLAGPPGS
                     PGPQGSTGPQGIRGQLGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDP
                     GTVGPPGPMGERGAPGNRGFPGSDGLPGPKGAQGERGPIGSSGPKGGQGDPGRPGEPG
                     LPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGD
                     LGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPP
                     GPPGEGGKPGDQGVPGEPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDG
                     PKGNPGPTGTIGDTGPPGLQGMPGERGIAGTPGPKGDRGGVGEKGAEGTAGNDGARGL
                     PGSLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQP
                     GVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLKGGRGTQGPPGATGFPGSAG
                     RVGPPGPAGAPGPAGPIGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGSPGDKGDPGE
                     DGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPP
                     GPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPG
                     PVGAPGDAGQRGEPGSRGPVGPPGRAGKRGLPGPQGPRGDKGDNGDRGDRGQKGHRGF
                     TGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGLLGPIGPPGVRGSV
                     GEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNK
                     TDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHPTKQSGEYWIDPNQGSAE
                     DAIKVYCNLETGETCISANPASVPRKTWWASKSPDNKPVWYGLDMNRGSQFTYGDYKS
                     PNTAITQMTFLRLLSKEASQNLTYICKNTVGYMDDQTKNLKKAVVLKGSNDLEIKGEG
                     NIRFRYTVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDIGPVDIGNADQEFGFEIGP
                     VCFM"
     exon            246..470
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..484
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..517
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..550
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..604
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..715
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..793
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..838
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..892
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..946
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1000
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1054
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1108
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1153
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1207
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1252
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1306
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1405
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1450
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1549
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1603
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1711
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1765
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1864
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1918
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2017
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2071
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2125
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2179
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2233
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2278
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2377
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2485
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2539
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2593
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2647
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2701
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2809
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2863
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2917
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3079
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3187
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3295
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3349
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3457
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3511
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3619
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3673
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3781
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..4073
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4261
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4501
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..6063
                     /gene="Col5a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagactct gctggagctg gtgctgaaac agactgaggc agcccctggg actggtgctg
       61 aaaaagagac cccagccaaa ttcatggtgc tacagtgacc tccatatcta ctcttcgatc
      121 ccaggaggac ccacatgtct catatttagg catgatggca aactgggtgg tagcaagacc
      181 tctcctcatt ctttttgttt tattagggta ctgtgtctca ataaaagccc aggaacaaga
      241 gaatgatgac tatgatgaag aaatagcctg tacacaacat ggccagatgt atttaaatag
      301 agacatttgg aaaccttctc catgccagat ctgtgtctgt gacaatggtg ctatcctctg
      361 tgacaagata gagtgccaag aagtgctcaa ctgtgccaat cctgtaacac ctcctgggga
      421 gtgctgccca gcgtgtccac agacatctgg aggtggagat acaagttttg gtagaggaag
      481 aaagggacaa aaaggagaac caggattagt tcctgttgta acgggcatac gtggtcgtcc
      541 aggacctgca ggccctccag gatcacaagg accaagaggg gaccgaggcc ccaaaggaag
      601 acctggtcct cgtggtcctc agggaattga tggagagcca ggtgttcctg gtcagccagg
      661 tgctccaggg cctcctgggc acccctctca cccaggacct gatggcatga gcaggccctt
      721 ttcagctcaa atggctgggt tggatgaaaa atctggactt ggaagtcaag tgggactcat
      781 gcctggctct gtgggtccta ttggcccaag gggacctcag ggtttacaag gacagcaagg
      841 tggtgtggga cctgcaggac ctcctggtga gcctggcgag cctggaccaa tgggtccaat
      901 tggtgcccgt ggaccagaag gcccacctgg gaagcctgga gaagatggtg aacctggaag
      961 aaatgggaat acaggtgaag tggggttctc aggatcacca ggtgctcgag gctttcctgg
     1021 tgctcctggt ctccctggct tgaaaggtca cagaggaaac aaaggtcttg aaggccccaa
     1081 aggtgaagtt ggagcacctg gtgctaaggg tgaagctggc cccaccggtc caatgggtgc
     1141 tatgggccct ctgggaccaa gaggaatgcc aggagagagg ggaagacttg ggccacaggg
     1201 tgctcctgga caacgaggtg ctcatggcat gcctggaaaa cctggaccaa tgggtcccct
     1261 tgggatacct ggctcttctg gctttccagg aaatcctgga gtgaagggag aagcaggtcc
     1321 tactggggcc cgaggccctg aaggacctca gggacagaga ggtgaaactg ggccacctgg
     1381 tcctgctggc tctcatggcc ttcctggtgc ggtggggact gatggtacac ctggcgctaa
     1441 aggacccaca ggctctcctg gaacctctgg ccctcctggc ttagcagggc cccctgggtc
     1501 tcctgggcct cagggcagca ctggacctca gggaattcga ggacaactgg gtgatccagg
     1561 agttccaggt ttcaaaggag aagctggccc aaaaggagaa ccagggccac atggtattca
     1621 gggtcctatt ggtccacctg gagaagaagg caaaagaggt cctcgagggg acccaggcac
     1681 agttggtcct ccaggaccaa tgggagaaag gggtgctcct ggcaatcgtg gttttccagg
     1741 ttctgatggt ttacctggac caaagggtgc tcagggagag cgtggcccta taggttcttc
     1801 agggcctaaa ggaggccagg gagatccagg acgtccaggc gaacctggac ttccaggtgc
     1861 tcggggcctg acaggaaatc ctggtgttca aggtcctgaa ggaaaacttg ggcctttggg
     1921 tgctcctggc gaagatggcc gaccaggtcc tccaggctcc attggtatta gagggcagcc
     1981 tggaagcatg ggccttccag gccccaaagg tagcagtggt gaccttggga aaccaggaga
     2041 agctgggaat gctggcgtgc ctgggcaaag gggggctcct ggcaaagacg gagaagttgg
     2101 tccttcaggc cccgtgggac ctccgggcct agctggggaa agaggagaac agggacctcc
     2161 aggtcctact ggctttcagg gacttcctgg gcctccaggg ccacctggag aaggtggaaa
     2221 gcctggtgat caaggtgttc ctggagagcc tggagctgtt gggccattag gacctcgggg
     2281 agaaagaggg aatcctggag aaagaggaga gccagggata actggattac ctggggagaa
     2341 aggcatggct ggaggacatg gccctgatgg tccaaagggc aacccaggtc caactgggac
     2401 cattggagac acagggccac caggtcttca aggcatgcca ggagaaagag gaattgcagg
     2461 gacacctggt cctaagggtg acagaggtgg cgtaggagag aaaggtgctg aaggaacagc
     2521 tggaaatgat ggggcaaggg gtcttcctgg ttccttggga cctccaggtc ctgcaggccc
     2581 tactggagaa aagggtgaac ctggtcctag aggattagtt ggccctcctg gctcccgtgg
     2641 caatcctggt tctcgggggg aaaatggtcc aactggagct gttggttttg ctggacccca
     2701 gggtcccgat ggacagcctg gtgtcaaggg tgagcctgga gagccagggc agaagggaga
     2761 tgctgggtct cctggacccc aaggacttgc aggatcacct ggccctcatg gtcctcatgg
     2821 tgttcctgga ctgaaaggtg gtcgaggaac ccagggtcca cctggtgcta caggatttcc
     2881 tggttctgct ggaagagttg ggcctccagg ccccgctgga gctccaggac ctgcagggcc
     2941 cataggagaa cctgggaagg aaggaccacc cggtcttcgt ggggaccctg gctctcatgg
     3001 gagagtgggt gatagaggac cagctggccc acctggtagc ccaggagaca aaggggaccc
     3061 aggggaagat ggacaacctg gtccagatgg cccccctggt cctgctggta ccactgggca
     3121 aagaggaatt gttggaatgc ctggacaacg tggggagcga ggaatgcctg gccttcctgg
     3181 cccagcgggt acaccaggaa aagtaggacc gactggtgca acaggagata aaggtccccc
     3241 tggacccgta ggacctccag gttccaatgg tcctgtgggg gaacctggac cagaaggtcc
     3301 ggctggtaat gatggtaccc caggacggga tggtgctgtt ggagaacggg gtgaccgtgg
     3361 agaccccggg cctgctggtc taccaggttc tcagggtgcc cctgggaccc ctggccctgt
     3421 cggtgcacca ggagatgcag gacaaagagg agagccaggt tcccgaggcc ctgtaggacc
     3481 acctggtcga gctggaaagc gtggtttacc tggaccacaa ggacctcgag gtgataaggg
     3541 tgacaatgga gacagaggtg acagaggtca gaaaggccac agaggcttca ctggcttgca
     3601 gggtcttcct ggccctcctg gtccaaatgg tgaacaagga agtgctggca ttcctggtcc
     3661 ttttggccca agaggtcctc caggaccagt aggtccttca ggaaaagaag gaaaccctgg
     3721 gctacttgga ccaattggac ctcctggtgt gcggggaagt gtaggagaag caggaccaga
     3781 gggccctcct ggtgaacctg gccctcctgg ccctccaggt ccccctggtc atcttactgc
     3841 tgctcttggt gatatcatgg gacactatga tgagaacatg ccagatccac ttccagaatt
     3901 tacagaagac caggcagctc cagatgacac aaacaaaact gaccctggag tccatgctac
     3961 tctgaagtct ctcagtagtc aaattgaaac catgcggagt cctgatggtt ccaagaagca
     4021 cccagcccgc acttgtgatg atttaaagct ttgccatcct acaaagcaga gtggtgaata
     4081 ttggattgat cctaaccagg gatcagctga agacgcaatc aaagtttact gcaatctgga
     4141 gacaggagag acatgcattt ccgcaaaccc agccagtgtt ccacggaaaa cgtggtgggc
     4201 cagcaaatcc cctgacaata agcccgtgtg gtatggtctc gacatgaata gaggatctca
     4261 gttcacatat ggagattaca agtcccctaa cacagctatt actcagatga cctttctgcg
     4321 ccttttatca aaagaagcct cccagaacct tacttatata tgtaagaaca ctgttggtta
     4381 tatggatgat caaactaaaa acctcaagaa agctgtggtt cttaaagggt caaatgactt
     4441 agaaataaaa ggagaaggaa acatcagatt cagatacacc gttcttcaag atacctgttc
     4501 aaagcgaaat ggaaatgtag gcaagactgt ctttgaatac agaacacaga atgtggcccg
     4561 cttgcccatc atagatatcg gtcctgtgga tattggcaat gcagaccagg aatttggctt
     4621 tgaaattggg ccagtttgtt tcatgtaaca gaagtccaga agtatcgaga ctaccatcaa
     4681 tgaccaacac aagaactgtg actgtttgaa gttcatcctg agactcttga agtaatggct
     4741 ggtcctgcat cagctttgta catatgatct gaagtgcctg accaccttat ccttcagaat
     4801 atttatttta cttacaattc tcaagtttaa ttgacttaat ttttttcaat atggcagttt
     4861 agattaaaac aacgacaatg accaccttta caaaaagtaa actgattaaa aaatacatat
     4921 gttttcatca atttatttca ctataatgaa tacgttgctt aggtatttat gaggaaattc
     4981 ttcttagcag gtagcttaca tgatggcaca tgttgagtgt gcttggctgc agtatgaaaa
     5041 gtagagagtt atgccccttt tatcctctta tcgccaaatc atcagtgata aatgaacacc
     5101 tctatacgag tcttaatatt atactaccat tatagaaaaa atttaagttt aatataatat
     5161 atcacttttc cactgtctta aatgatatat ttaaataaca tagtcattga ttttaggagg
     5221 aaaaagaatc catgaaattg cttcagcttt acaatttatt ttgtaaagac tggtagactt
     5281 tgagtttttt ccttgttcaa atttaagagt aacattttcc tttttgttgt aatctttcaa
     5341 tacggataaa ggttatattt gtggtttctt atgtaagaag atactgggta aaaaccccag
     5401 ttgcccacac agttttctaa tacacataca cagtaatgaa tgctgagact ctcccacagg
     5461 cacgtctcat ttcctgaagc tatcacaaag aaaagatcga gaagcccaga gttttgatga
     5521 tcactcaaat aaaattagaa cattcataag aaaatatgac ccaacagttt ttagcatgag
     5581 ctacctcatc tctacaagtt gggatggatt tcctgttttt gtttattctt tttaggtgtt
     5641 gaaaggtact atgcttctgt tgatattcca agactggaga taggcagggc taaaattatt
     5701 acttttaatg atggtgctat aattctttct ataacattct ttagaaataa agaatccatg
     5761 ccatttgtga acacagaact gttaaacatc ctatttctga gagacagatc atgatttcag
     5821 ggtctttaac tgttcctctc atattgtatt tagaatattg tttaatactt gcatgtgtct
     5881 taacccaaaa cacataggtt cccttgtata tcaagacttt ttttcttaat tgcagttgtt
     5941 tgctccactg gtgtttctta ctgagaaata aataacccag gccatcccaa aggacaagcc
     6001 acacacacac aactttggtc atgtatctct gcaaagcatc gaattaaatg cacgcttctg
     6061 tca
//
