LOCUS       NM_134452               5544 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus collagen type V alpha 1 chain (Col5a1), mRNA.
ACCESSION   NM_134452
VERSION     NM_134452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5544)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 5544)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 5544)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 5544)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   5  (bases 1 to 5544)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   6  (bases 1 to 5544)
  AUTHORS   Burrows,N.P., Nicholls,A.C., Richards,A.J., Luccarini,C.,
            Harrison,J.B., Yates,J.R. and Pope,F.M.
  TITLE     A point mutation in an intronic branch site results in aberrant
            splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two
            British families
  JOURNAL   Am J Hum Genet 63 (2), 390-398 (1998)
   PUBMED   9683580
REFERENCE   7  (bases 1 to 5544)
  AUTHORS   Tillet,E., Ruggiero,F., Nishiyama,A. and Stallcup,W.B.
  TITLE     The membrane-spanning proteoglycan NG2 binds to collagens V and VI
            through the central nonglobular domain of its core protein
  JOURNAL   J Biol Chem 272 (16), 10769-10776 (1997)
   PUBMED   9099729
REFERENCE   8  (bases 1 to 5544)
  AUTHORS   Somasundaram,R. and Schuppan,D.
  TITLE     Type I, II, III, IV, V, and VI collagens serve as extracellular
            ligands for the isoforms of platelet-derived growth factor (AA, BB,
            and AB)
  JOURNAL   J Biol Chem 271 (43), 26884-26891 (1996)
   PUBMED   8900172
REFERENCE   9  (bases 1 to 5544)
  AUTHORS   Burrows,N.P., Nicholls,A.C., Yates,J.R., Gatward,G.,
            Sarathachandra,P., Richards,A. and Pope,F.M.
  TITLE     The gene encoding collagen alpha1(V)(COL5A1) is linked to mixed
            Ehlers-Danlos syndrome type I/II
  JOURNAL   J Invest Dermatol 106 (6), 1273-1276 (1996)
   PUBMED   8752669
REFERENCE   10 (bases 1 to 5544)
  AUTHORS   Yaoi,Y., Hashimoto,K., Koitabashi,H., Takahara,K., Ito,M. and
            Kato,I.
  TITLE     Primary structure of the heparin-binding site of type V collagen
  JOURNAL   Biochim Biophys Acta 1035 (2), 139-145 (1990)
   PUBMED   2203476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_134452.3.
            
            On Nov 27, 2020 this sequence version replaced NM_134452.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272662.1, SRR26643429.10893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000003.1  31606880-31606991
            113-280             JAXUCZ010000003.1  31641257-31641424
            281-494             JAXUCZ010000003.1  31647555-31647768
            495-657             JAXUCZ010000003.1  31648894-31649056
            658-789             JAXUCZ010000003.1  31668640-31668771
            790-921             JAXUCZ010000003.1  31669648-31669779
            922-1161            JAXUCZ010000003.1  31670229-31670468
            1162-1341           JAXUCZ010000003.1  31671034-31671213
            1342-1398           JAXUCZ010000003.1  31671862-31671918
            1399-1440           JAXUCZ010000003.1  31677001-31677042
            1441-1503           JAXUCZ010000003.1  31677254-31677316
            1504-1578           JAXUCZ010000003.1  31679305-31679379
            1579-1671           JAXUCZ010000003.1  31680926-31681018
            1672-1728           JAXUCZ010000003.1  31682593-31682649
            1729-1782           JAXUCZ010000003.1  31683782-31683835
            1783-1836           JAXUCZ010000003.1  31684127-31684180
            1837-1890           JAXUCZ010000003.1  31685488-31685541
            1891-1944           JAXUCZ010000003.1  31686719-31686772
            1945-1998           JAXUCZ010000003.1  31688369-31688422
            1999-2043           JAXUCZ010000003.1  31689910-31689954
            2044-2097           JAXUCZ010000003.1  31691532-31691585
            2098-2142           JAXUCZ010000003.1  31692243-31692287
            2143-2196           JAXUCZ010000003.1  31692806-31692859
            2197-2241           JAXUCZ010000003.1  31692959-31693003
            2242-2295           JAXUCZ010000003.1  31693923-31693976
            2296-2340           JAXUCZ010000003.1  31698017-31698061
            2341-2394           JAXUCZ010000003.1  31698575-31698628
            2395-2439           JAXUCZ010000003.1  31702554-31702598
            2440-2493           JAXUCZ010000003.1  31704209-31704262
            2494-2601           JAXUCZ010000003.1  31706553-31706660
            2602-2655           JAXUCZ010000003.1  31707489-31707542
            2656-2709           JAXUCZ010000003.1  31709265-31709318
            2710-2754           JAXUCZ010000003.1  31712849-31712893
            2755-2808           JAXUCZ010000003.1  31712998-31713051
            2809-2853           JAXUCZ010000003.1  31714085-31714129
            2854-2907           JAXUCZ010000003.1  31714848-31714901
            2908-2961           JAXUCZ010000003.1  31716018-31716071
            2962-3015           JAXUCZ010000003.1  31718918-31718971
            3016-3123           JAXUCZ010000003.1  31720151-31720258
            3124-3213           JAXUCZ010000003.1  31721530-31721619
            3214-3267           JAXUCZ010000003.1  31721711-31721764
            3268-3375           JAXUCZ010000003.1  31722859-31722966
            3376-3483           JAXUCZ010000003.1  31725382-31725489
            3484-3537           JAXUCZ010000003.1  31726804-31726857
            3538-3591           JAXUCZ010000003.1  31727716-31727769
            3592-3699           JAXUCZ010000003.1  31727862-31727969
            3700-3753           JAXUCZ010000003.1  31728678-31728731
            3754-3861           JAXUCZ010000003.1  31728833-31728940
            3862-3915           JAXUCZ010000003.1  31730291-31730344
            3916-4023           JAXUCZ010000003.1  31731114-31731221
            4024-4077           JAXUCZ010000003.1  31731708-31731761
            4078-4131           JAXUCZ010000003.1  31731981-31732034
            4132-4185           JAXUCZ010000003.1  31733395-31733448
            4186-4239           JAXUCZ010000003.1  31734045-31734098
            4240-4347           JAXUCZ010000003.1  31734673-31734780
            4348-4401           JAXUCZ010000003.1  31734856-31734909
            4402-4455           JAXUCZ010000003.1  31735000-31735053
            4456-4563           JAXUCZ010000003.1  31735960-31736067
            4564-4617           JAXUCZ010000003.1  31736230-31736283
            4618-4653           JAXUCZ010000003.1  31736993-31737028
            4654-4707           JAXUCZ010000003.1  31739106-31739159
            4708-4963           JAXUCZ010000003.1  31741142-31741397
            4964-5076           JAXUCZ010000003.1  31742100-31742212
            5077-5145           JAXUCZ010000003.1  31744505-31744573
            5146-5379           JAXUCZ010000003.1  31748096-31748329
            5380-5544           JAXUCZ010000003.1  31752461-31752625
FEATURES             Location/Qualifiers
     source          1..5544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..5544
                     /gene="Col5a1"
                     /note="collagen type V alpha 1 chain"
                     /db_xref="GeneID:85490"
                     /db_xref="RGD:70920"
     exon            1..112
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..5526
                     /gene="Col5a1"
                     /note="collagen alpha-1(V) chain; procollagen, type V,
                     alpha 1; collagen alpha 1 (V); collagen, type V, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(V) chain precursor"
                     /protein_id="NP_604447.2"
                     /db_xref="GeneID:85490"
                     /db_xref="RGD:70920"
                     /translation="MDVHTRWKAPRPGAPLLSSPLLLLLLLLWAPPPSRAAQPTDLLE
                     MLDFHNLPSGVTKTTGFCATRRSSKEPDVAYRVSKDAQLSMPTKQLYPESDFPEDFSI
                     LTTVKAKKGSQAFLVSVYNEQGIQQLGLELGRSPVFLYEDHTGKPGPEEYPLFPGINL
                     SDGKWHRIAISVYKKNVTLILDCKKKITKFLNRGDHPIIDVNGIIMFGSRILDDEIFE
                     GDIQQLLFVSDHRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYPEGEGETYYYEYP
                     YYEDPEDPGKEPAPSQKPVEAARETTEVPEEQTQPPSEAPTVPETSDTAGKEDNPGIG
                     DYDYVPTDDYYTTSPYEDFGYGEGVENPDQPTNPDSGAEIPTSTSVTSNSSNPAPSPE
                     EGKDDLGGEFTEETIKNLDENYYDPYFDPDSDSNVSPSEIGPGMPANQDTIYEGIGGP
                     RGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTTGPTGQMGDPGERGPPGRPGL
                     PGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPM
                     GLTGRPGPMGPPGSGGLKGEPGDMGPQGPRGVQGPPGPTGKPGRRGRAGSDGARGMPG
                     QTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGLPGDDGERGDDGEVGPRGLPGEPGP
                     RGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAI
                     GPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKG
                     ADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGD
                     PGPLGPTGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQR
                     GPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPG
                     KDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGL
                     PGAAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGSEGPPGPPGPA
                     GSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGVPGEKGPQGPAGRDGLQGPVGLPG
                     PAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGP
                     RGQQGLFGQKGDEGSRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPS
                     GAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPLGPKGERGEKGEAGPSG
                     AAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGS
                     PGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKP
                     GPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIG
                     PPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPLGPPGPPGLPGPPGPKGAKGSSGP
                     TGPKGEAGHPGLPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGAGESYVDYADGM
                     EEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDS
                     FKVYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVG
                     VVQMTFLRLLSASAQQNITYNCYQSVAWQDAATGSYDKAIRFLGSNDEEMSYDNNPYI
                     RALVDGCATKKGYQKTVLEIDTPKVEQVPIVDIMFTDFGEASQKFGFEVGPACFLG"
     exon            113..280
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..494
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..657
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..789
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..921
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1161
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1341
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1398
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1440
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1503
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1578
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1671
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1728
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1782
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1836
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1890
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1944
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..1998
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2043
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2097
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2142
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2196
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2241
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2295
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2340
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2394
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2439
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2493
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2601
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2655
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2709
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2754
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2808
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2853
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2907
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..2961
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3015
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3123
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3213
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3267
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3375
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3483
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3537
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3591
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3699
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3753
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3861
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3915
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4023
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4077
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4131
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4185
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4239
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..4347
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4401
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4455
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4563
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4617
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4653
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4654..4707
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4963
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4964..5076
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5077..5145
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5379
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5380..5544
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatggacg tacacacccg ctggaaagct ccgcgcccgg gcgccccgct gctgtcctcg
       61 ccgctgctcc tgctcctgct gctgctgtgg gcgccgcctc cgagccgcgc agctcagcca
      121 acagatcttc tggagatgct agattttcac aatttgccct caggcgtaac gaaaaccaca
      181 ggtttctgtg ccactcgacg atcttccaaa gagccggatg ttgcctaccg agtctctaaa
      241 gatgcacagc tcagcatgcc caccaagcag ctgtaccctg agtctgactt tcctgaggac
      301 ttctccatcc tgacaaccgt gaaagccaag aaaggcagtc aggccttcct ggtctccgtt
      361 tacaatgagc agggcatcca gcagttggga ctggagctgg gccgctcccc tgtcttcctc
      421 tatgaggacc acacagggaa gcccgggcct gaagagtatc cactcttccc tggcatcaac
      481 ctgtccgatg gcaagtggca ccgaatcgct atcagtgtat acaagaaaaa tgtcaccttg
      541 atcctcgact gtaaaaagaa gatcacgaag ttcctcaacc gcggcgacca ccccataata
      601 gatgtcaacg gtatcatcat gtttggctcc cggattctgg atgatgaaat atttgagggt
      661 gacatccaac agttgctctt cgtctccgac caccgagctg cctatgatta ctgtgagcac
      721 tacagccccg actgtgacac agcggtccct gacacacctc agtcacagga ccctaaccca
      781 gatgaatatt acccagaagg agagggtgag acctattact atgagtaccc atattatgaa
      841 gaccctgaag acccgggaaa ggagcccgcc ccctctcaga agccagtgga agccgccaga
      901 gaaaccacgg aggttcctga ggagcagacc cagcccccat ccgaagcccc tacagtgcct
      961 gagaccagtg acacggctgg caaggaggac aatccaggga tcggggacta cgactatgtg
     1021 cccactgacg actactacac tacatccccg tatgaagact tcggctatgg cgagggcgtg
     1081 gagaaccccg accagcccac caaccctgac tcaggggccg agatccccac cagcaccagt
     1141 gttacctcca attcctccaa tccggctcca tctccagagg aagggaagga tgacctggga
     1201 ggtgagttca ccgaggagac catcaagaat ctagatgaaa actactatga cccgtacttt
     1261 gacccggact ccgactccaa tgtctctcca tcggagatag ggccaggcat gcctgctaac
     1321 caggacacca tctatgaagg gattggagga ccccgaggtg agaaagggca aaagggagaa
     1381 ccagccatca ttgagccggg aatgctgata gaggggcccc ctggccctga aggccctgct
     1441 ggtcttccag gacctccagg aactacgggt cctactggcc aaatgggtga ccctggagaa
     1501 aggggtcccc ctgggcgccc aggtcttcct ggggctgatg gcttgcctgg tccccccggg
     1561 accatgctca tgctgccgtt ccgttttgga ggtggtggcg acgccggttc taagggcccc
     1621 atggtctctg cccaggaatc ccaggcacag gctatcctcc agcaagccag gttggcacta
     1681 aggggaccag ctggtccaat gggtctcacc gggagacctg gccccatggg tcctcctggg
     1741 agtggaggtt tgaagggtga gccaggagac atgggacctc agggtcctcg aggtgtgcaa
     1801 ggtccacccg gcccaacagg gaagcctgga agacggggcc gtgctgggag tgatggtgcc
     1861 agaggcatgc ctggacaaac aggccccaag ggtgaccgtg gctttgatgg tctggctggg
     1921 ttgccgggag agaaaggcca tagaggtgac cctggtcctt ctggcccgcc gggactccca
     1981 ggagatgatg gagaaagggg tgacgatgga gaagttgggc ccagggggct gcctggggag
     2041 cctggaccac gtggtctgct tgggccaaaa ggcccccctg gcccacctgg acctcctggt
     2101 gtgacgggta tggatggcca gcctggcccc aaaggaaatg tgggtcccca gggagagcct
     2161 gggcccccag gacagcaggg taatcctggt gcccagggtc ttcccggtcc ccagggtgcc
     2221 attggtcctc caggagaaaa gggtcctttg gggaaaccag gtctcccagg aatgcccgga
     2281 gctgatggac ccccggggca ccctggcaaa gaaggtcctc caggagagaa aggaggccag
     2341 ggtcctcccg gcccccaggg tcccattggc tacccaggtc cacgaggagt caagggggca
     2401 gatggcatcc gagggctgaa gggcaccaag ggagagaagg gtgaagacgg cttccctggg
     2461 tttaaaggcg acatgggaat aaagggtgac cggggggaga tcggcccacc cggcccccga
     2521 ggagaagatg gtcctgaagg cccaaaaggt cgaggtggtc ccaatggtga tcctggtccc
     2581 ctggggccca ccggggagaa gggaaagctc ggagtgcctg gattaccagg gtacccagga
     2641 agacaagggc caaagggttc tattggattc cctggcttcc cgggcgccaa cggagagaaa
     2701 ggtggcaggg ggacacctgg aaagccagga ccacggggac agcgaggccc aacgggcccg
     2761 aggggtgaac gaggcccacg gggcatcact gggaagcctg gccctaaggg caactcagga
     2821 ggtgatggcc cagccggccc tcctggtgag cggggaccca atggacccca aggccccacc
     2881 ggcttccctg gacctaaggg tcccccgggt ccaccaggca aggacgggct ccccggacat
     2941 cctgggcaga gaggggagac tggtttccaa ggcaagactg gccctccagg ccctccagga
     3001 gtggttggcc ctcagggtcc cacaggcgag acgggtccca tgggagagcg tggccaccct
     3061 ggtcctccag gcccccctgg tgaacagggc ctcccaggtg ctgctgggaa agaagggacg
     3121 aagggtgacc caggtcctgc tggcctccct gggaaggatg gacctccagg attgcgtgga
     3181 ttccctgggg accgagggct ccccggcccc gtgggagcac tcggactgaa aggcagcgaa
     3241 ggcccccctg gccccccagg tcctgcgggt tctccagggg agagaggacc agctggtgct
     3301 gctggaccca ttggaattcc agggagacct gggcctcagg gacctccggg gcctgctgga
     3361 gagaaagggg ttcctggaga gaaaggtccg caaggcccgg ctggccgaga tggcctgcaa
     3421 ggtcccgtgg ggctccctgg accagccggc cccgtgggtc ctcctggaga agatggagat
     3481 aagggagaga tcggagagcc cgggcagaaa gggagcaagg gcgacaaagg cgagcagggt
     3541 cctcctgggc ctaccggtcc tcaaggcccc attgggcagc caggcccttc gggagcagat
     3601 ggtgaacctg gccctcgtgg acagcagggc ctgtttgggc agaaaggaga tgaaggttca
     3661 agaggtttcc caggaccgcc agggccagtg ggcttgcagg gtttaccagg acctccagga
     3721 gaaaagggtg agacaggaga cgtgggccag atgggccctc ctggtccacc aggcccccga
     3781 ggaccctctg gagctccagg agctgatggg ccacagggtc ctccaggagg gattggcaac
     3841 cctggtgcag tcggagaaaa gggagagcct ggcgaagctg gagagcctgg ccttccagga
     3901 gaaggaggtc ccctgggacc taaaggagaa agaggggaga agggagaggc tggcccctct
     3961 ggtgctgctg gaccccctgg acccaaaggc ccacctggag atgatggccc caaaggcagc
     4021 cccggccccg tgggctttcc tggagaccct gggccccctg gagagccagg cccagcaggt
     4081 caagatggcc cacctggtga caaaggggat gatggagaac ctgggcagac gggatcccca
     4141 ggccctactg gtgaacctgg tccatctggg cctccaggaa agaggggtcc accgggccct
     4201 gcaggccctg aaggcaggca gggggagaaa ggagccaagg gagaagctgg cttagaaggc
     4261 cctcctggga agactggccc cattggtccc caaggggccc ctgggaagcc tggccctgat
     4321 ggtcttcgtg ggatccctgg tcctgtgggt gagcaaggcc tcccaggatc cccaggccct
     4381 gatggtccac ccggccccat gggtcctcca ggactccctg gcctcaaagg agactccggt
     4441 cccaaaggtg aaaagggcca tccgggcctg attggactca tcggacctcc gggcgaacaa
     4501 ggtgaaaaag gtgaccgagg actcccaggc ccccagggct catctggtcc taaaggagaa
     4561 cagggcatta caggtccttc tggcccgctt gggcctcctg gtcccccagg cttgccgggc
     4621 cctccaggtc ccaaaggtgc taaaggttca tcgggtccca ctggcccgaa gggcgaggca
     4681 ggccatccag gactccctgg tccacccggg cctccaggcg aggtcatcca gcccctgcca
     4741 atccaggcgt ccaggactcg gcggaacatt gatgccagtc agctcctgga tgatggggct
     4801 ggggagagct acgtggatta tgcagatggc atggaagaga tctttggttc cctcaactcc
     4861 ctgaagctgg agattgagca gatgaagcgg ccactgggca cacagcagaa cccagcccgt
     4921 acctgcaagg accttcaact ctgccatcct gatttcccag acggcgaata ctgggtcgat
     4981 cccaaccaag ggtgctccag ggactccttc aaagtctact gcaatttcac agctggaggg
     5041 tccacgtgcg tcttccctga caagaagtct gagggagcca gaatcacttc ttggcccaaa
     5101 gaaaacccag gttcctggtt cagtgaattc aagcgtggga aactgctctc ctatgtggat
     5161 gctgaaggca accctgtggg cgtggtacaa atgaccttcc tgcggctgct gagtgcctct
     5221 gcccagcaga acatcaccta caactgctac cagtccgtgg cctggcagga tgccgccaca
     5281 ggcagctacg ataaggctat ccgcttcttg ggctccaacg atgaggaaat gtcttatgat
     5341 aacaacccct acatccgtgc cctggtggat ggctgtgcta ccaagaaagg ctaccagaag
     5401 acggtgctgg agattgacac gcccaaagtt gagcaagtcc ccattgtgga catcatgttc
     5461 accgactttg gtgaagcctc acagaaattt ggatttgaag tagggccagc ttgcttccta
     5521 ggctaggagc tgctgagccc accg
//
