LOCUS       NM_001008332            1190 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus collagen type IV alpha 4 chain (Col4a4), mRNA.
ACCESSION   NM_001008332 XM_217452
VERSION     NM_001008332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Pierides A, Voskarides K, Athanasiou Y, Ioannou K, Damianou L,
            Arsali M, Zavros M, Pierides M, Vargemezis V, Patsias C, Zouvani I,
            Elia A, Kyriacou K and Deltas C.
  TITLE     Clinico-pathological correlations in 127 patients in 11 large
            pedigrees, segregating one of three heterozygous mutations in the
            COL4A3/ COL4A4 genes associated with familial haematuria and
            significant late progression to proteinuria and chronic kidney
            disease from focal segmental glomerulosclerosis
  JOURNAL   Nephrol Dial Transplant 24 (9), 2721-2729 (2009)
   PUBMED   19357112
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Baek JI, Choi SJ, Park SH, Choi JY, Kim CD, Kim YL and Kim UK.
  TITLE     Identification of novel variants in the COL4A4 gene in Korean
            patients with thin basement membrane nephropathy
  JOURNAL   Indian J Med Res 129 (5), 525-533 (2009)
   PUBMED   19675380
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Bai X, Dilworth DJ, Weng YC and Gould DB.
  TITLE     Developmental distribution of collagen IV isoforms and relevance to
            ocular diseases
  JOURNAL   Matrix Biol 28 (4), 194-201 (2009)
   PUBMED   19275937
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Marcocci E, Uliana V, Bruttini M, Artuso R, Silengo MC, Zerial M,
            Bergesio F, Amoroso A, Savoldi S, Pennesi M, Giachino D, Rombola G,
            Fogazzi GB, Rosatelli C, Martinhago CD, Carmellini M, Mancini R, Di
            Costanzo G, Longo I, Renieri A and Mari F.
  TITLE     Autosomal dominant Alport syndrome: molecular analysis of the
            COL4A4 gene and clinical outcome
  JOURNAL   Nephrol Dial Transplant 24 (5), 1464-1471 (2009)
   PUBMED   19129241
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Voskarides K, Damianou L, Neocleous V, Zouvani I, Christodoulidou
            S, Hadjiconstantinou V, Ioannou K, Athanasiou Y, Patsias C,
            Alexopoulos E, Pierides A, Kyriacou K and Deltas C.
  TITLE     COL4A3/COL4A4 mutations producing focal segmental
            glomerulosclerosis and renal failure in thin basement membrane
            nephropathy
  JOURNAL   J Am Soc Nephrol 18 (11), 3004-3016 (2007)
   PUBMED   17942953
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Lu W, Phillips CL, Killen PD, Hlaing T, Harrison WR, Elder FF,
            Miner JH, Overbeek PA and Meisler MH.
  TITLE     Insertional mutation of the collagen genes Col4a3 and Col4a4 in a
            mouse model of Alport syndrome
  JOURNAL   Genomics 61 (2), 113-124 (1999)
   PUBMED   10534397
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Qin P, Piechocki M, Lu S and Kurpakus MA.
  TITLE     Localization of basement membrane-associated protein isoforms
            during development of the ocular surface of mouse eye
  JOURNAL   Dev Dyn 209 (4), 367-376 (1997)
   PUBMED   9264260
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Miner JH and Sanes JR.
  TITLE     Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal
            laminae: sequence, distribution, association with laminins, and
            developmental switches
  JOURNAL   J Cell Biol 127 (3), 879-891 (1994)
   PUBMED   7962065
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   Leinonen A, Mariyama M, Mochizuki T, Tryggvason K and Reeders ST.
  TITLE     Complete primary structure of the human type IV collagen alpha
            4(IV) chain. Comparison with structure and expression of the other
            alpha (IV) chains
  JOURNAL   J Biol Chem 269 (42), 26172-26177 (1994)
   PUBMED   7523402
REFERENCE   10 (bases 1 to 1190)
  AUTHORS   Sanes JR, Engvall E, Butkowski R and Hunter DD.
  TITLE     Molecular heterogeneity of basal laminae: isoforms of laminin and
            collagen IV at the neuromuscular junction and elsewhere
  JOURNAL   J Cell Biol 111 (4), 1685-1699 (1990)
   PUBMED   2211832
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086403.1.
            
            On Dec 16, 2004 this sequence version replaced XM_217452.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..1190
                     /gene="Col4a4"
                     /note="collagen type IV alpha 4 chain"
                     /db_xref="GeneID:301562"
                     /db_xref="RGD:1305355"
     exon            1..90
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     exon            91..247
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..680
                     /gene="Col4a4"
                     /note="procollagen, type IV, alpha 4; collagen, type IV,
                     alpha 4"
                     /codon_start=1
                     /product="collagen type IV alpha 4 chain"
                     /protein_id="NP_001008333.1"
                     /db_xref="GeneID:301562"
                     /db_xref="RGD:1305355"
                     /translation="MRCFFRWTESYGTGPWSLIFILFTIQYEYGSSKKYGSPCGGRNC
                     SVCQCFPEKGSRGHPGPLGPQGPIGPLGPPGPIGIPGEKGLRGDSGLPGPPGEKGDKG
                     PTGVPGFPGVDGVPGHPGPPGPRGKPGMDGYNGSRGDPGYPGERGAPGPGGPPVRHH"
     exon            248..290
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..368
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     exon            369..503
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     exon            504..548
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
     exon            549..1152
                     /gene="Col4a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caactcgcag ccagcacaca gacctgaggc tggacaggct gtgaagagga acacggtcac
       61 gggtggatta cctccagcca caacctcgag ggcactgact cccaactgtc catgagaatc
      121 ttctgggaga gaggagaagg ccggaggagt attttgggca cagaggtcat cccttgaagg
      181 cactagtgct caaggtcttc atgaggtgct ttttcagatg gaccgagtcc tacggcacag
      241 gcccctggtc actgatattt atcctcttta ccatacaata tgaatatggg agcagcaaga
      301 aatatggcag cccctgtgga ggaagaaact gctctgtctg ccagtgtttc cctgaaaagg
      361 gatctcgggg tcacccagga ccactgggac cacagggacc aatagggccc ttgggacccc
      421 caggacccat tgggattcca ggagaaaaag gactgagagg tgacagcggc ctgcctggac
      481 caccaggaga gaaaggagac aagggtccaa ctggtgtgcc cggatttcca ggcgtggatg
      541 gtgtacctgg tcacccaggg cctcctggac ccagaggcaa acctggtatg gacggctaca
      601 atggctcacg aggtgatccg ggctatccag gagagagagg agctcctggc cctggcggcc
      661 cccctgtaag acaccattag cacagtctag agtggtcctg agtgaaaaga ctttatgtac
      721 agcaggaact ggctggtcta ctcgggaatg gcctcactgc acctttgcct gcctgcagca
      781 ggacaactaa actgggtgct tgggggaggg ggagacgagg tgggcagaac cagagcattt
      841 aggggcttca tgggcggtgg aaagggaaga tactgagggt attaagaagg ggtgtgaact
      901 aactggcttc atcaaggagt taaaggagga ggtagtttac caaatcttac aaccccacca
      961 ttcagggcga atttgtattt aaagatagtt tcagcaaggg acatctctta tttccaccac
     1021 ccacctttcc agctgtctta cttgagtaaa aatcagatat ggttttgcct gagtcaaaat
     1081 gcactgtatg gaattctcaa agaactaata aaaattgaga aaattttaaa taaaaaataa
     1141 aattactatt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
