LOCUS       NM_001413988            8238 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus collagen type IV alpha 3 chain (Col4a3), mRNA.
ACCESSION   NM_001413988 XM_039083896
VERSION     NM_001413988.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8238)
  AUTHORS   Papazachariou,L., Papagregoriou,G., Hadjipanagi,D.,
            Demosthenous,P., Voskarides,K., Koutsofti,C., Stylianou,K.,
            Ioannou,P., Xydakis,D., Tzanakis,I., Papadaki,A., Kallivretakis,N.,
            Nikolakakis,N., Perysinaki,G., Gale,D.P., Diamantopoulos,A.,
            Goudas,P., Goumenos,D., Soloukides,A., Boletis,I., Melexopoulou,C.,
            Georgaki,E., Frysira,E., Komianou,F., Grekas,D., Paliouras,C.,
            Alivanis,P., Vergoulas,G., Pierides,A., Daphnis,E. and Deltas,C.
  TITLE     Frequent COL4 mutations in familial microhematuria accompanied by
            later-onset Alport nephropathy due to focal segmental
            glomerulosclerosis
  JOURNAL   Clin Genet 92 (5), 517-527 (2017)
   PUBMED   28632965
  REMARK    GeneRIF: COL4A mutations comprise a frequent cause of Familial
            microscopic hematuria.
REFERENCE   2  (bases 1 to 8238)
  AUTHORS   Xie,X., Li,Z., Pi,M., Wu,J., Zeng,W., Zuo,L. and Zha,Y.
  TITLE     [Down-regulation of p38 MAPK and collagen by 1, 25-(OH)2-VD3 in rat
            models of diabetic nephropathy]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (7), 931-935 (2016)
   PUBMED   27363275
  REMARK    GeneRIF: Data show that collagen type III (Col3), collagen type IV
            (Col4) and p38 mitogen-activated protein kinase (p38 MAPK) are
            up-regulated in models of diabetic nephropathy.
REFERENCE   3  (bases 1 to 8238)
  AUTHORS   Wang,Y., Huang,G., Mo,B. and Wang,C.
  TITLE     Artesunate modulates expression of matrix metalloproteinases and
            their inhibitors as well as collagen-IV to attenuate pulmonary
            fibrosis in rats
  JOURNAL   Genet Mol Res 15 (2) (2016)
   PUBMED   27323108
  REMARK    GeneRIF: These findings suggested that artesunate attenuates
            alveolitis and pulmonary fibrosis by regulating expression of
            collagen-IV, TIMP-1 and 2, as well as MMP-2 and -9, to reduce ECM
            accumulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8238)
  AUTHORS   Deng,B., Molina,J., Aubry,M.C., Sun,Z., Wang,L., Eckloff,B.W.,
            Vasmatzis,G., You,M., Wieben,E.D., Jen,J., Wigle,D.A. and Yang,P.
  TITLE     Clinical biomarkers of pulmonary carcinoid tumors in never smokers
            via profiling miRNA and target mRNA
  JOURNAL   Cell Biosci 4, 35 (2014)
   PUBMED   25105010
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8238)
  AUTHORS   Ha,T.S., Hong,E.J., Ahn,E.M. and Ahn,H.Y.
  TITLE     Regulation of type IV collagen alpha chains of glomerular
            epithelial cells in diabetic conditions
  JOURNAL   J Korean Med Sci 24 (5), 837-843 (2009)
   PUBMED   19794980
  REMARK    GeneRIF: Glomerular collagen alpha3(IV) protein was higher and more
            intense in immunofluorescence staining according to diabetic
            durations.
REFERENCE   6  (bases 1 to 8238)
  AUTHORS   Ryan,J.J., Reynolds,J., Norgan,V.A. and Pusey,C.D.
  TITLE     Expression and characterization of recombinant rat alpha 3(IV)NC1
            and its use in induction of experimental autoimmune
            glomerulonephritis
  JOURNAL   Nephrol Dial Transplant 16 (2), 253-261 (2001)
   PUBMED   11158397
REFERENCE   7  (bases 1 to 8238)
  AUTHORS   Bhatt,R.S., Tomoda,T., Fang,Y. and Hatten,M.E.
  TITLE     Discoidin domain receptor 1 functions in axon extension of
            cerebellar granule neurons
  JOURNAL   Genes Dev 14 (17), 2216-2228 (2000)
   PUBMED   10970885
REFERENCE   8  (bases 1 to 8238)
  AUTHORS   Maeshima,Y., Colorado,P.C., Torre,A., Holthaus,K.A.,
            Grunkemeyer,J.A., Ericksen,M.B., Hopfer,H., Xiao,Y., Stillman,I.E.
            and Kalluri,R.
  TITLE     Distinct antitumor properties of a type IV collagen domain derived
            from basement membrane
  JOURNAL   J Biol Chem 275 (28), 21340-21348 (2000)
   PUBMED   10766752
REFERENCE   9  (bases 1 to 8238)
  AUTHORS   Ryan,J.J., Katbamna,I., Mason,P.J., Pusey,C.D. and Turner,A.N.
  TITLE     Sequence analysis of the 'Goodpasture antigen' of mammals
  JOURNAL   Nephrol Dial Transplant 13 (3), 602-607 (1998)
   PUBMED   9550634
REFERENCE   10 (bases 1 to 8238)
  AUTHORS   Lemmink,H.H., Mochizuki,T., van den Heuvel,L.P., Schroder,C.H.,
            Barrientos,A., Monnens,L.A., van Oost,B.A., Brunner,H.G.,
            Reeders,S.T. and Smeets,H.J.
  TITLE     Mutations in the type IV collagen alpha 3 (COL4A3) gene in
            autosomal recessive Alport syndrome
  JOURNAL   Hum Mol Genet 3 (8), 1269-1273 (1994)
   PUBMED   7987301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 10, 2022 this sequence version replaced XM_039083896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000009.1  91323990-91324231
            243-299             JAXUCZ010000009.1  91379540-91379596
            300-389             JAXUCZ010000009.1  91380966-91381055
            390-434             JAXUCZ010000009.1  91384661-91384705
            435-479             JAXUCZ010000009.1  91385960-91386004
            480-542             JAXUCZ010000009.1  91386940-91387002
            543-596             JAXUCZ010000009.1  91387623-91387676
            597-623             JAXUCZ010000009.1  91388398-91388424
            624-701             JAXUCZ010000009.1  91389294-91389371
            702-764             JAXUCZ010000009.1  91391055-91391117
            765-800             JAXUCZ010000009.1  91391227-91391262
            801-842             JAXUCZ010000009.1  91392946-91392987
            843-920             JAXUCZ010000009.1  91393153-91393230
            921-983             JAXUCZ010000009.1  91395686-91395748
            984-1043            JAXUCZ010000009.1  91396261-91396320
            1044-1088           JAXUCZ010000009.1  91397601-91397645
            1089-1142           JAXUCZ010000009.1  91398282-91398335
            1143-1184           JAXUCZ010000009.1  91399975-91400016
            1185-1272           JAXUCZ010000009.1  91401776-91401863
            1273-1308           JAXUCZ010000009.1  91402162-91402197
            1309-1473           JAXUCZ010000009.1  91403751-91403915
            1474-1566           JAXUCZ010000009.1  91404396-91404488
            1567-1662           JAXUCZ010000009.1  91404837-91404932
            1663-1733           JAXUCZ010000009.1  91405965-91406035
            1734-1916           JAXUCZ010000009.1  91407185-91407367
            1917-2085           JAXUCZ010000009.1  91408490-91408658
            2086-2178           JAXUCZ010000009.1  91410443-91410535
            2179-2280           JAXUCZ010000009.1  91411139-91411240
            2281-2378           JAXUCZ010000009.1  91413190-91413287
            2379-2529           JAXUCZ010000009.1  91413724-91413874
            2530-2643           JAXUCZ010000009.1  91414188-91414301
            2644-2811           JAXUCZ010000009.1  91415314-91415481
            2812-2901           JAXUCZ010000009.1  91416750-91416839
            2902-3036           JAXUCZ010000009.1  91417172-91417306
            3037-3135           JAXUCZ010000009.1  91422925-91423023
            3136-3225           JAXUCZ010000009.1  91423834-91423923
            3226-3365           JAXUCZ010000009.1  91424242-91424381
            3366-3492           JAXUCZ010000009.1  91426342-91426468
            3493-3573           JAXUCZ010000009.1  91428510-91428590
            3574-3672           JAXUCZ010000009.1  91428922-91429020
            3673-3720           JAXUCZ010000009.1  91429947-91429994
            3721-3906           JAXUCZ010000009.1  91432736-91432921
            3907-4037           JAXUCZ010000009.1  91433418-91433548
            4038-4110           JAXUCZ010000009.1  91437703-91437775
            4111-4182           JAXUCZ010000009.1  91439877-91439948
            4183-4308           JAXUCZ010000009.1  91440036-91440161
            4309-4407           JAXUCZ010000009.1  91441149-91441247
            4408-4620           JAXUCZ010000009.1  91446628-91446840
            4621-4798           JAXUCZ010000009.1  91447379-91447556
            4799-4913           JAXUCZ010000009.1  91447679-91447793
            4914-5086           JAXUCZ010000009.1  91449149-91449321
            5087-8238           JAXUCZ010000009.1  91449937-91453088
FEATURES             Location/Qualifiers
     source          1..8238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..8238
                     /gene="Col4a3"
                     /note="collagen type IV alpha 3 chain"
                     /db_xref="GeneID:363265"
                     /db_xref="RGD:71085"
     exon            1..242
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..5171
                     /gene="Col4a3"
                     /note="collagen, type IV, alpha 3 (Goodpasture antigen);
                     procollagen, type IV, alpha 3; collagen alpha-3(IV) chain;
                     collagen alpha-3(IV) chain-like"
                     /codon_start=1
                     /product="collagen alpha-3(IV) chain precursor"
                     /protein_id="NP_001400917.1"
                     /db_xref="GeneID:363265"
                     /db_xref="RGD:71085"
                     /translation="MHSETAPRFLALLLPILLLLLAAPPVVSKGCVCEGKGKCLCWGT
                     KGEKGEIGFPGPPGFPGQKGFPGPEGLPGPQGPKGSPGLPGLTGPKGIRGITGLPGFA
                     GPPGLPGIPGYPGPPGLAGLPGCNGSKGEQGFPGIPGTPGYAGLPGPDGLKGQKGKPA
                     QGEDGEFNGKGDPGPPGAPGFQGLPGPPGFPGPAGPPGPPGFFGFPGAMGPRGPKGRM
                     GDSTIGQEGEKGVKGLTGPPGLPGPVIFTLRHPYRKSDFQGQKGDEGERGEPGPPGPS
                     GPPGDSYGSEKGAPGEPGPRGKPGKDGAPGFPGTEGAKGTRGFPGLRGEAGIKGWKGD
                     IGPPGFPGPTEECYDAHLQKGDKGMPGPPGPKGVRGPRGPSGPPGVPGSPGPSRPGLR
                     GPVGWPGLKGSKGERGPPGIDTVGPPGSLGCPGSPGPPGPPGPPGRPGDTVFQPGPPG
                     DHGAPGDIGPPGVPGVDGPKGEPGQPCTECHCIPGPPGVPGVPGLDGVKGIPGGRGAP
                     GVKGNPGSPGNAGLPGFAGFPGDQGHPGLKGDKGDTPLPWGQVGDPGDPGHRGLPGRK
                     GFDGSPGGPGAKGPRGPRGEPALSGRKGDQGPPGAPGSPGPPGPAGPAGPPGYGPQGE
                     PGPKGAQGVPGALGPPGEAGLKGESSASIPVLGPPGPPGPPGQAGPRGLPGLPGPVGT
                     CDPGHPGPDGEPGIPEVGFPGARGPKGDQGFPGTIGLPGYPGETGRPGYPGEMGVPGA
                     KGEPSVGRPGEPGKPGFPGERGNSGENGDIGLPGLPGPPGTPGKDGFDGPPGDPGQSG
                     PPGAKGPPGRCIPGPRGTQGLPGLNGLKGQPGRRGDTGPKGDPGIPGMDRSGVPGERG
                     PPGTPGLPGEMGPPGQKGYPGPPGFPGLPGEKGEVGIMGYPGTTGLPGLPGKPGSQGQ
                     RGNLGIPGVKGERGRPGVKGERGEKGKPGPPHAPHLKGDKGEPGLKGFVGNPGEKGNR
                     GNPGLPGPKGLEGVPGLPGSPGPRGDTGSSGDPGRPGPQGLPGSMGNMGVPGPKGRKG
                     TSGFPGVAGRPGLPGIPGPQGDKGEPGYSEGASPGPPGPKGDPGLPGDKGKKGERGLP
                     GPPGHSGPAGPDGAPGSPGSPGHPGRPGPDGDSGLKGQKGFPGPPGSTGPPGPPGLPG
                     LPGPMGMRGDQGQDGIPGPPGEKGETGLLGAHPGQKGSPGVPGVKGDRGVPGLSGLPG
                     RKGTMGDVGPQGPPGTTGLPGPPGLPGTIVPGPKGNRGLPGLRGNPGEPGPPGPPGPV
                     GEGIKGDKGFMGLPGSRGLPGMVGDTGAPGQPGAPGIPGLPGVRGDPGFPGFPGVKGE
                     KGNPGFLGSIGHPGPVGPKGPPGPQGKPGTLKVISLPGSPGPPGAPGQPGVKGDPGPL
                     GPPGIPGPCGPRGQPGKDGKPGAPGPPGVKGSKGSKGEQGPPGLDGLPGLKGKPGDRG
                     TPANGTRMRGFIFTRHSQTTANPSCPEGTQPLYSGFSLLFVQGNEHAHGQDLGTLGSC
                     LQRFTTMPFLFCNVDNVCNFASRNDYSYWLSTPAPMPMDMAPITGRALEPYVSRCTVC
                     EGPAMAIAVHSQTTAIPPCPQGWVSLWKGFSFVMFTSAGSEGAGQALASPGSCLEEFR
                     ASPFIECHGRGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGDLEKIISRCQVCMK
                     KRH"
     exon            243..299
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            300..389
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            390..434
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..479
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..542
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..596
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..623
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..701
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..764
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..800
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..842
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..920
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            921..983
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1043
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1088
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1142
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1184
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1272
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1308
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1473
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1566
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1662
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1733
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1916
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2085
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2178
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2280
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2378
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2529
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2643
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2811
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2901
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3036
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3135
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3225
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3365
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3492
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3573
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3672
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3720
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3906
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4037
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..4110
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4182
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4308
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4309..4407
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4620
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4621..4798
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4799..4913
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            4914..5086
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..8238
                     /gene="Col4a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtgggtc cagcccttac gaaactcgtc ccagtgagcc agcaaggcga gcttcactgc
       61 gggatttctc caatctatgc cccgcgggga acatggaggc ctgagagccc gtggatccca
      121 taggtcactg aaaacaccag ggaccgtcgc ccatcatgca ctcagagact gctccaaggt
      181 tcttggcgct cctgctgcct atcctgttgc tgctcctggc tgccccgcct gtggttagca
      241 agggctgtgt ctgcgaaggc aaaggaaaat gcctctgctg gggaactaaa ggggagaagg
      301 gggagatcgg cttccctggg ccccctggat ttcctggcca gaaaggattc ccaggccctg
      361 aaggcttgcc tggaccacag ggacccaagg gctccccagg acttccagga ctcactggcc
      421 ccaaaggcat caggggaata actggattac cagggtttgc aggtcctcct ggacttccag
      481 gcatcccagg ctaccctggg cctcctgggc tggctggttt accaggatgc aatggctcta
      541 agggtgaaca aggattccca ggcattcctg gcacaccagg ctatgcaggg ctcccaggtc
      601 ctgatggctt aaaaggacaa aagggcaagc ctgctcaagg agaagacgga gaattcaatg
      661 gaaaaggtga ccctggtcct ccgggggctc caggcttcca gggtttacca ggacccccag
      721 gtttcccagg gcctgccggc ccaccagggc ccccaggatt ttttggtttc ccaggagcga
      781 tgggacccag aggacccaaa ggtcgcatgg gcgatagcac gataggacaa gaaggagaaa
      841 agggtgtgaa aggattaaca ggacctcctg ggctgccagg accagtgatt tttacactcc
      901 gacacccata cagaaaatcg gactttcagg gacagaaagg cgatgaggga gagaggggtg
      961 aacctggacc tcctggaccc tcgggaccac ctggagactc ctatggatca gaaaagggtg
     1021 ctcctggaga gcctggtcct cggggaaaac ctggaaaaga cggtgctccc ggcttccctg
     1081 gcactgaggg agccaaggga accagaggct ttcctgggtt gaggggtgaa gccggcatta
     1141 agggatggaa aggagacatt ggccccccag gatttcctgg tccaacagaa gaatgttatg
     1201 atgcacatct gcaaaaggga gataaaggaa tgccaggccc gcctgggccc aaaggagtcc
     1261 gtggcccacg gggtcccagt ggtccccctg gagttcctgg aagtcctgga ccgtcaaggc
     1321 ctggcctcag aggacctgtc ggatggccag gcttgaaagg gagtaaaggg gagaggggac
     1381 cccctgggat agacaccgtg ggccctcctg gatccctggg atgtcctgga tcaccaggtc
     1441 caccaggccc accaggacct ccaggacgtc caggtgacac tgtttttcag ccaggtccac
     1501 ctggtgacca tggagcacca ggcgatatag gacctccagg agttccagga gtcgatggac
     1561 ccaaaggaga accaggccaa ccttgtactg agtgtcactg catcccaggg cccccaggag
     1621 tcccaggagt tccaggatta gatggtgtca aaggaatccc aggaggacga ggtgcgcctg
     1681 gtgtgaaggg aaacccaggg tccccaggaa atgcaggtct cccaggattt gcaggattcc
     1741 caggcgacca agggcatcca ggacttaaag gggacaaagg ggacacacct ctaccctggg
     1801 gacaagtggg cgatccaggt gatcctggac acagaggcct gccagggaga aagggcttcg
     1861 atggaagtcc tggaggtcca ggagcaaaag ggccacgagg acctaggggc gaaccggctc
     1921 tgagtggaag gaaaggggac cagggacctc caggagctcc tggatcccct ggacccccag
     1981 gacctgcagg accagctgga ccaccgggct atggacccca aggagagcca ggtccaaagg
     2041 gagcccaagg agtccctgga gccctgggac caccaggaga agccggtctt aaaggagaat
     2101 ccagtgcatc aataccagtt ctaggtcccc caggccctcc agggccccct ggtcaggctg
     2161 gccccagagg tctacctggt ttgcctggac ctgtgggaac atgtgatcct ggtcatcctg
     2221 gacctgatgg tgaaccagga atcccagaag ttggattccc aggggccaga ggacctaagg
     2281 gagatcaagg tttcccagga acaataggat tacctggtta tcctggggaa acgggaagac
     2341 ctggctatcc cggggagatg ggcgtcccag gagccaaggg agaaccatca gtaggcaggc
     2401 ctggggagcc aggaaaacca ggctttccag gagaaagagg caattctggg gaaaatggag
     2461 atattggact ccctggactt ccaggccccc ctggaactcc aggaaaagac gggtttgacg
     2521 ggcctccagg agacccaggg cagtctggac ctccaggagc aaaaggaccc ccagggaggt
     2581 gcataccagg acccaggggc acccaaggac ttccaggttt aaatggattg aaaggacaac
     2641 caggtagaag aggtgatacc gggccaaaag gagaccctgg catcccaggg atggacagat
     2701 ctggagtccc tggagagcga ggaccaccag gaacaccagg tcttccgggt gagatgggac
     2761 cgcctggcca aaaaggatat ccaggacctc caggattccc agggttacca ggagagaaag
     2821 gagaggttgg aatcatgggc tatcctggaa ccactggcct tccggggctt cctgggaaac
     2881 caggctcaca ggggcagagg ggtaacctcg gaatcccagg agtaaaaggg gaaagaggac
     2941 gcccgggagt caaaggcgaa cgaggcgaga aggggaaacc tgggcctccc catgcaccac
     3001 acttaaaggg ggacaaagga gagcctggac ttaaagggtt cgtaggaaat ccaggtgaaa
     3061 agggaaacag aggcaatcca gggttaccag gccccaaagg cctcgaggga gtgcctgggc
     3121 taccaggatc tccaggccct agaggagata cggggagcag tggggatcct ggaagaccag
     3181 gaccacaagg cttgccagga agcatgggga acatgggggt gccaggccct aaagggagaa
     3241 aaggaacttc aggatttcca ggtgtagctg gaagaccagg cctgccaggg atccctggcc
     3301 cccagggaga taagggggag ccaggttatt cagaaggtgc aagcccagga ccaccaggac
     3361 cgaagggtga tccaggattg ccaggtgaca aagggaagaa aggagagaga ggactacctg
     3421 ggccacctgg acattcgggg cctgctggac ctgacggagc ccctgggagt cctgggagtc
     3481 ctggccaccc aggaagacca ggtcctgatg gtgattccgg tcttaaagga cagaaaggtt
     3541 tccccggccc tccaggaagc actggccctc caggccctcc aggactccca ggacttcctg
     3601 gaccaatggg tatgagaggc gaccaaggac aagatggaat tcctggtcct ccgggagaaa
     3661 aaggagaaac aggcttgctg ggggcccatc caggccaaaa agggagccct ggtgtaccag
     3721 gtgtcaaagg agacagggga gttccaggct tgtctggcct tcctggcagg aaggggacca
     3781 tgggggatgt tggacctcaa ggacccccag gcaccactgg actcccaggt ccaccaggtc
     3841 tgcctgggac cattgtccct ggcccaaaag gaaacagagg tctccccggc ttacgaggaa
     3901 atccaggtga gccaggtccc cctggacctc caggacctgt cggagaaggc ataaagggtg
     3961 acaaaggatt tatgggcctc cctggctcca gaggtctgcc tggaatggta ggggacacgg
     4021 gtgcaccagg tcaaccggga gcaccaggca tccccggtct tcccggtgtc agaggtgatc
     4081 caggattccc cgggtttcca ggtgtaaaag gagagaaggg taatcccgga tttcttgggt
     4141 caattggaca tccaggacca gttgggccaa aaggaccacc aggtccacaa ggaaaacctg
     4201 gcacacttaa ggtcatctcc cttccaggaa gcccagggcc tcctggtgca cctggacagc
     4261 caggagtgaa aggagatcct ggacccctgg gaccaccagg aattccaggg ccctgtgggc
     4321 caagaggtca accaggcaag gacggaaaac caggagctcc aggaccaccg ggagtaaagg
     4381 gcagcaaggg ctcgaaagga gaacaaggcc cacctggtct ggatggattg ccaggtttaa
     4441 agggaaaacc tggagacaga gggacacctg ccaacgggac aagaatgaga ggcttcatct
     4501 tcactcgaca cagtcaaacc acagccaatc cttcatgccc tgaaggaaca cagccactct
     4561 acagtgggtt ttcccttctt ttcgtacaag gaaatgagca cgcccatgga caagaccttg
     4621 gtactctggg cagctgccta cagcgattca ccacaatgcc attcttattc tgtaacgtcg
     4681 ataacgtgtg taactttgca tcacgaaatg actattcata ctggctgtcg acaccagccc
     4741 cgatgcccat ggacatggcc ccaattactg gcagagctct cgaaccctac gttagcagat
     4801 gcaccgtctg cgaaggtcct gcaatggcta tagctgttca cagtcaaact actgctatcc
     4861 ccccatgtcc ccagggctgg gtttctctct ggaaaggttt ttccttcgtt atgtttacaa
     4921 gtgcaggctc tgagggtgct ggacaagcac ttgcctcgcc cggctcctgc ctggaggaat
     4981 tccgagccag tccgtttata gaatgccatg gacgagggac ctgcaactac tactcaaact
     5041 cctacagctt ctggctggct tcactaaatc cagaaagaat gttcagaaaa cctattccat
     5101 caactgtgaa agctggagac ttggagaaaa tcataagccg ctgtcaggtg tgcatgaaga
     5161 aaagacactg atgaaatctt ttgctccttc ttaagtatca aaatcatgac ttacaacatg
     5221 catttattta ggtctttctc tctaacctta aaggcgtagt agtgcaaagt ttcaccacac
     5281 aagaaagcat ttcattcaag ttagtctgtg gtgtgggcaa cgctttccac agaatattac
     5341 tgatatccca tcccagctgt gtctaacgta ctgactaaat gatgattgag tgaggcttga
     5401 actacaagct gaaagagatc tggtcctgtg gatccacaat gtgttccttg tctcccactc
     5461 ctgagagaag gagtgtgttt ccttccacct ccttcctgag acctcagact tcagctagag
     5521 aaggagatgg gggcatacag aattcaagca ccctgtgaaa agaactggag ggtcagagct
     5581 gttaagtggt tatgagggct aaaaacacag gataaaggtg ccaggactca tttaaatatg
     5641 cccaaagcta ggaccaaagg aaacttccca gagggaatca taacatgcgt agatatatgg
     5701 tttcgttcta tgttttgttg actgtgtcca tttgcttctt cacggagctc tttttactat
     5761 gtcagtaggc tcaaaatggg taaaacgttt acccttaggg aactaatctt tactaggatg
     5821 acatacacat ccatcgaaac atttctcttt attattttca atgtacttac aagtaacaag
     5881 gacaccactt aacaaatgtg cactttatcc ccactcctat aaacactgac cttaaataat
     5941 ttcaccagga aataatggaa ggtacttgct ggtttatcag actcaaacca ttcgtgggtt
     6001 tacagatttg ttcctttgtt agttttttaa cttctccttt agaaaacaca cacgtacccc
     6061 ccctgttttt aatgttatat attcctaaca atcatatgga gagaaaccac tgggtaaaaa
     6121 ccttaccgta ctgtacacag ctgctctatg tcttaaaatg tggtcttaag tatatagata
     6181 cattccaaag ttacttaatt cagcttaagt tattttcttc agtaccaaaa tgtgtcccca
     6241 tatactgtac tggggttgag ggtatgtgca gcgggtagtg agagagactt gcttctgatc
     6301 taacctcaag ggcaacaaac tttgtttgta aagactgtca catgtgcaag acacccatcc
     6361 ccaacctctt cccggtcttc ccacaccaaa accaaagagt ctcatatatg ggtgtggctc
     6421 tcctgctttt gcttttcctt taccactgtc tctgtgtttc ctcacaattc agcagcctaa
     6481 gagaaggttt aaaagtacct gttgctcttt aagcagcccc tggttcagtt cccagtaccc
     6541 acactggtac tggttcacgg tctcctgctc cagatgatcc gacatccact tctggcctct
     6601 gcacccgcac tcagccagat acacaaaagt tttaaaattt ttaaaataag atctacaccc
     6661 aggctaagtt caagacttct aacttctctt cggcacccca gaagccgatg tctggaaact
     6721 attaagaaat caagactatt ttaaaatcaa acagtgtggt actattcgat gactcagagg
     6781 gtccaggcac tgtgaggcaa agctttgagt atatctctct atccactgaa gtggacgtga
     6841 tggtgctgat acttaggtcc aggccggtgc tgtaaactca actgctttgt attggaatgt
     6901 gtggcccaag agcacagaca aaggtggtca cgcttcgaca ctcctgtgac tgcaacgaga
     6961 cattctcaca cctcagctga gatgtgtaac atctcattac aaggatgtgt ttcggctaac
     7021 attgaaaaat atccaactgt cccagataca ttccagtagt gaaaacaagg gcttgatctc
     7081 cttggccagt gggatcagga gtaggagcgg cagccacggc acccaggagc ttgtcataaa
     7141 cgcccgttcg agagcattct aaacctgcga aattagaagc cgtaattaga aaacagatat
     7201 ctgtgttttg tttcgatgag aagcatctca ctgtatagcc caggctgacc cccaaatcac
     7261 cacaattttc tgcctcagac atccagaatt ttgttttaaa tgttttcctc atcctctggt
     7321 gttctccact tactaggcac acacccaaga aactggccac aatcctttca cctttgcctc
     7381 ttaaaaactc accggtggct gtcagggtaa tctgtttcac caccagactg gtgctaatgt
     7441 caaacacctg cccttcattt ggccattggc ctcgttcttc tcccgtcctc gtatcaggat
     7501 ctaaggcacg taatactgaa caccttaatg tccaaagaag ccattaccaa caatcagcca
     7561 tctgtacttc tagggatgac caacaaaatg cagcccatgc atattacttc ccagatgttt
     7621 atgagtaaat tataattcta aaattcaact tcatatgtga ctggaaaaat ttggttcagt
     7681 agtcaagaat gctggcttct ctgcagagga cccaaggaca gttcccaata cccaggtcag
     7741 gcagctcagg actgctcaaa gggatccaac tggcctccaa ggacacccac acataggtgg
     7801 cattcgctag ctcaggctct gccacatgaa taaaaataga tctttaaaca tctttaactg
     7861 atttacaaaa catttctttc aaatttggtg cttcagcttt ggaaatttca cagtgtgcta
     7921 aaacaaccaa cttgtcaatt gtcctctttg gcgagataaa acgttattaa tttatttata
     7981 aaagtattaa aaatgtttaa atttgaattt tattgctgat tttacaaagt ttttctatat
     8041 ttcaaatgta acttactacc actaaactta atttaatatt tttctctata accacttgaa
     8101 atttatttaa aatatatcga atattttata cagtaatatc ttgtcaaaat tatgatatat
     8161 tataatgtac taatatttct gtaaatataa ctaaagttct attgttttgc caaaataaaa
     8221 taaaaggaaa aactctac
//
