LOCUS       NM_001135009            6579 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus collagen type IV alpha 1 chain (Col4a1), mRNA.
ACCESSION   NM_001135009 XM_214400
VERSION     NM_001135009.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6579)
  AUTHORS   Zhu,M.M., Ma,Y., Tang,M., Pan,L. and Liu,W.L.
  TITLE     Hypoxia-induced upregulation of matrix metalloproteinase 9
            increases basement membrane degradation by downregulating collagen
            type IV alpha 1 chain
  JOURNAL   Physiol Res 71 (6), 825-834 (2022)
   PUBMED   36281728
  REMARK    GeneRIF: Hypoxia-induced upregulation of matrix metalloproteinase 9
            increases basement membrane degradation by downregulating collagen
            type IV alpha 1 chain.
REFERENCE   2  (bases 1 to 6579)
  AUTHORS   Bukosza,E.N., Kaucsar,T., Godo,M., Lajtar,E., Tod,P., Koncsos,G.,
            Varga,Z.V., Baranyai,T., Nguyen,M.T., Schachner,H., Soti,C.,
            Ferdinandy,P., Giricz,Z., Szenasi,G. and Hamar,P.
  TITLE     Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early
            Signs of Renal Injury in Prediabetic Obese Rats
  JOURNAL   Int J Mol Sci 20 (17), 4266 (2019)
   PUBMED   31480394
  REMARK    GeneRIF: glomerular collagen deposition and increased lipocalin-2
            expression were the early signs of kidney injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6579)
  AUTHORS   Dower,K., Zhao,S., Schlerman,F.J., Savary,L., Campanholle,G.,
            Johnson,B.G., Xi,L., Nguyen,V., Zhan,Y., Lech,M.P., Wang,J.,
            Nie,Q., Karsdal,M.A., Genovese,F., Boucher,G., Brown,T.P.,
            Zhang,B., Homer,B.L. and Martinez,R.V.
  TITLE     High resolution molecular and histological analysis of renal
            disease progression in ZSF1 fa/faCP rats, a model of type 2
            diabetic nephropathy
  JOURNAL   PLoS One 12 (7), e0181861 (2017)
   PUBMED   28746409
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6579)
  AUTHORS   Peng,F.F., Xiao,Z.L., Chen,H.M., Chen,Y., Zhou,J., Yu,H. and
            Zhang,B.F.
  TITLE     Parathyroid hormone inhibits TGF-beta/Smad signaling and
            extracellular matrix proteins upregulation in rat mesangial cells
  JOURNAL   Biochem Biophys Res Commun 478 (3), 1093-1098 (2016)
   PUBMED   27530924
  REMARK    GeneRIF: PTH pretreatment prevented TGF-beta1 and high
            glucose-induced Smad2/3 phosphorylation and consequent upregulation
            of fibronectin and type IV collagen within 4 h.
REFERENCE   5  (bases 1 to 6579)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 6579)
  AUTHORS   Lozanoff,S., Johnston,J., Ma,W. and Jourdan-Le Saux,C.
  TITLE     Immunohistochemical localization of Pax2 and associated proteins in
            the developing kidney of mice with renal hypoplasia
  JOURNAL   J Histochem Cytochem 49 (9), 1081-1097 (2001)
   PUBMED   11511678
REFERENCE   7  (bases 1 to 6579)
  AUTHORS   Bhatt,R.S., Tomoda,T., Fang,Y. and Hatten,M.E.
  TITLE     Discoidin domain receptor 1 functions in axon extension of
            cerebellar granule neurons
  JOURNAL   Genes Dev 14 (17), 2216-2228 (2000)
   PUBMED   10970885
REFERENCE   8  (bases 1 to 6579)
  AUTHORS   Grande,J.P., Melder,D.C., Kluge,D.L. and Wieben,E.D.
  TITLE     Structure of the rat collagen IV promoter
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 85-88 (1996)
   PUBMED   8950183
REFERENCE   9  (bases 1 to 6579)
  AUTHORS   Somasundaram,R. and Schuppan,D.
  TITLE     Type I, II, III, IV, V, and VI collagens serve as extracellular
            ligands for the isoforms of platelet-derived growth factor (AA, BB,
            and AB)
  JOURNAL   J Biol Chem 271 (43), 26884-26891 (1996)
   PUBMED   8900172
REFERENCE   10 (bases 1 to 6579)
  AUTHORS   Davenport,E.A. and Nettesheim,P.
  TITLE     Type I collagen gel modulates extracellular matrix synthesis and
            deposition by tracheal epithelial cells
  JOURNAL   Exp Cell Res 223 (1), 155-162 (1996)
   PUBMED   8635488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 16, 2008 this sequence version replaced XM_214400.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.53363.1,
                                           SRR26643294.54494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAXUCZ010000016.1  84885597-84885882
            287-346             JAXUCZ010000016.1  84927455-84927514
            347-436             JAXUCZ010000016.1  84949386-84949475
            437-481             JAXUCZ010000016.1  84949567-84949611
            482-526             JAXUCZ010000016.1  84950302-84950346
            527-589             JAXUCZ010000016.1  84950436-84950498
            590-643             JAXUCZ010000016.1  84950918-84950971
            644-670             JAXUCZ010000016.1  84951099-84951125
            671-754             JAXUCZ010000016.1  84951646-84951729
            755-817             JAXUCZ010000016.1  84951814-84951876
            818-853             JAXUCZ010000016.1  84953347-84953382
            854-895             JAXUCZ010000016.1  84954036-84954077
            896-982             JAXUCZ010000016.1  84955080-84955166
            983-1009            JAXUCZ010000016.1  84956563-84956589
            1010-1060           JAXUCZ010000016.1  84956727-84956777
            1061-1105           JAXUCZ010000016.1  84957424-84957468
            1106-1159           JAXUCZ010000016.1  84957552-84957605
            1160-1201           JAXUCZ010000016.1  84958916-84958957
            1202-1286           JAXUCZ010000016.1  84960320-84960404
            1287-1322           JAXUCZ010000016.1  84960741-84960776
            1323-1487           JAXUCZ010000016.1  84961534-84961698
            1488-1583           JAXUCZ010000016.1  84962828-84962923
            1584-1667           JAXUCZ010000016.1  84964448-84964531
            1668-1738           JAXUCZ010000016.1  84964975-84965045
            1739-1930           JAXUCZ010000016.1  84967249-84967440
            1931-2099           JAXUCZ010000016.1  84967912-84968080
            2100-2192           JAXUCZ010000016.1  84970300-84970392
            2193-2297           JAXUCZ010000016.1  84970753-84970857
            2298-2395           JAXUCZ010000016.1  84971784-84971881
            2396-2546           JAXUCZ010000016.1  84972589-84972739
            2547-2660           JAXUCZ010000016.1  84972923-84973036
            2661-2828           JAXUCZ010000016.1  84973644-84973811
            2829-2918           JAXUCZ010000016.1  84973939-84974028
            2919-3071           JAXUCZ010000016.1  84974750-84974902
            3072-3170           JAXUCZ010000016.1  84975053-84975151
            3171-3260           JAXUCZ010000016.1  84975250-84975339
            3261-3400           JAXUCZ010000016.1  84975966-84976105
            3401-3527           JAXUCZ010000016.1  84976457-84976583
            3528-3608           JAXUCZ010000016.1  84976673-84976753
            3609-3707           JAXUCZ010000016.1  84977208-84977306
            3708-3758           JAXUCZ010000016.1  84979446-84979496
            3759-3944           JAXUCZ010000016.1  84980364-84980549
            3945-4078           JAXUCZ010000016.1  84981316-84981449
            4079-4151           JAXUCZ010000016.1  84983460-84983532
            4152-4223           JAXUCZ010000016.1  84984430-84984501
            4224-4352           JAXUCZ010000016.1  84985086-84985214
            4353-4451           JAXUCZ010000016.1  84986341-84986439
            4452-4664           JAXUCZ010000016.1  84987291-84987503
            4665-4842           JAXUCZ010000016.1  84988312-84988489
            4843-4957           JAXUCZ010000016.1  84992134-84992248
            4958-5130           JAXUCZ010000016.1  84993283-84993455
            5131-6579           JAXUCZ010000016.1  84995034-84996482
FEATURES             Location/Qualifiers
     source          1..6579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6579
                     /gene="Col4a1"
                     /note="collagen type IV alpha 1 chain"
                     /db_xref="GeneID:290905"
                     /db_xref="RGD:1307148"
     exon            1..286
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..5212
                     /gene="Col4a1"
                     /note="procollagen, type IV, alpha 1; collagen alpha-1(IV)
                     chain; alpha 1 type IV collagen; collagen, type IV, alpha
                     1"
                     /codon_start=1
                     /product="collagen alpha-1(IV) chain precursor"
                     /protein_id="NP_001128481.1"
                     /db_xref="GeneID:290905"
                     /db_xref="RGD:1307148"
                     /translation="MGPRLSVWLLLPLAALLLHEERSRAAAKGDCGGSGCGKCDCHGV
                     KGQKGERGFPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYP
                     GNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPG
                     EILGHVPGTLLKGERGFPGIPGAPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKG
                     QMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFQGTPGYGE
                     KGEPGKPGPRGKPGKDGEKGEKGSPGFPGESGYPGLPGRQGPQGEKGEPGLPGPPGTV
                     VGTRPLGEKGERGYPGSPGLRGEPGPKGYPGSPGQPGPPGFAVPGQTGAPGFPGERGE
                     KGERGSPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGIPGQ
                     PGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGL
                     EGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGH
                     PGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPIGEKGQAGLPG
                     GPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGNPGEKG
                     AVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPG
                     LKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGV
                     PGIGPPGAMGPPGGQGPPGSSGPPGVKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQ
                     SGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGAPGLPGEKGDHGFPGSS
                     GPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPG
                     TPGVPGKDGQAGHPGQPGPKGDPGLSGIPGSPGLPGPKGSVGGMGLPGSPGEKGVPGI
                     PGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAG
                     TPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGP
                     AGQKGEPGSDGIPGSAGEKGEQGLPGRGFPGFPGTKGDKGSKGEVGFPGLAGSPGIPG
                     AKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGID
                     GPKGDKGNPGWPGAPGAPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGQKG
                     LPGLQGVKGDQGDQGIPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPG
                     PKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGP
                     PGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCL
                     RKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCE
                     APAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRS
                     APFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRR
                     T"
     exon            287..346
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..436
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..481
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..526
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..589
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..670
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..754
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..817
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..853
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..895
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..982
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1009
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1060
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1105
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1159
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1201
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1286
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1322
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1487
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1583
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1667
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1738
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1930
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2099
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2192
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2297
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2395
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2546
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2660
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2828
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2918
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3071
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3170
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3260
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3400
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3527
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3608
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3707
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3758
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..3944
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4078
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4151
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4223
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4352
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4451
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4452..4664
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4842
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..4957
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5130
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5131..6579
                     /gene="Col4a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggggaggg ggcagcgcca acaaattggg gagctcctcg ggcggcgcgc tcaggtctct
       61 gctcagagcc accgcacccg ggacggtgag cagggctcac gcccgggccc tccgagactg
      121 agcacctcgc cgcggcccac gggagacggg ctgcagttcc ccgccgtctc tgttggtccc
      181 ccgccgcccc gggcgcgcca ccatggggcc ccggctcagc gtctggcttc tgctgccgct
      241 cgccgccctt ctgctccacg aggagcgcag ccgggccgct gcgaagggtg attgtggtgg
      301 ctctggctgt ggaaaatgtg actgtcatgg tgtgaaggga caaaagggag agagaggctt
      361 tccagggtta caaggtgtca ttggatttcc tgggatgcaa ggacctgagg ggccacatgg
      421 accaccagga caaaagggtg atgctggaga acctggactt cctggaacga aagggacacg
      481 aggaccccct ggagcagctg gctaccctgg gaatcccgga cttcctggta ttcctggcca
      541 ggatggtcct ccaggtcccc caggtatccc aggatgcaat ggtacaaagg gagagagagg
      601 gccactcggt cctcctggct tgcctggatt cagcgggaat cctggaccac cggggttacc
      661 aggaatgaag ggagatcccg gtgaaattct cggccatgtt cctgggaccc tgctgaaagg
      721 agagagagga tttcctggta tccctggggc gccgggctca ccagggttgc caggactcca
      781 gggacctgtc ggtcctccgg gatttactgg accaccgggt cctccaggcc ctcctggacc
      841 tcctggagaa aaggggcaga tgggatccag cttccaagga ccaaaaggcg acaagggaga
      901 acaaggggtc agtggtcccc cgggagtacc tggacaggca caagttaagg aaaaaggaga
      961 ctttgcccca acaggagaaa agggtcagaa aggtgaacct ggattccagg gaacaccagg
     1021 atatggagag aaaggtgaac ctggcaagcc aggacctcgg ggaaaacctg gaaaagatgg
     1081 tgaaaaagga gaaaagggga gcccgggctt tcctggtgaa tccggatacc caggtcttcc
     1141 aggccggcag ggccctcagg gagagaaggg tgaacctgga cttccaggcc cccctggaac
     1201 tgtggtaggc accaggccat tgggagagaa aggagagcga ggctacccgg gatccccagg
     1261 gttaagagga gagcccggtc ctaaaggtta ccctggatcg ccaggccaac caggccctcc
     1321 aggtttcgct gttccaggcc agactggtgc tccgggcttc ccaggtgaaa gaggagaaaa
     1381 aggtgaaagg ggatctccag gtgtgtcttt accaggacca agtggaagag atggagcccc
     1441 agggcctcct ggccctcctg gcccccctgg gcaaccaggc cacacgaacg gcattgtgga
     1501 gtgtcaacct ggaccacctg gggaccaggg tcctccagga attccaggac agccaggttt
     1561 gacaggcgaa gttggacaga aaggtcagaa aggagagagc tgccttgcct gtgacacaga
     1621 aggacttcga ggccccccag ggccacaggg gcctccagga gagattggtt tccctggaca
     1681 gccaggggct aaaggtgacc gaggcctgcc aggcagagat ggtcttgaag gattgccggg
     1741 tccacaaggt tcaccggggc tcataggcca gcctggagct aagggagagc ccggcgagat
     1801 attttttgac atgcgactca aaggtgacaa aggagaccca ggttttccag gacagccagg
     1861 gatgccagga agagcaggaa ctccgggaag agacggccac ccaggactcc ccggacccaa
     1921 aggctccccg ggttcaatag gattgaaggg agagagaggt ccccctggag gagttggctt
     1981 tcctggtagt cgtggagaca ttggccctcc tggaccccca ggagtcggtc ccatcggtcc
     2041 cattggtgaa aaaggacaag caggccttcc tgggggcccc gggtccccag gtcttccagg
     2101 tccaaagggt gaagcaggaa aggttgtccc actccccggc ccccctggag ctgcaggact
     2161 tccaggatcc cctgggttcc cagggccaca aggtgaccga ggcttcccag gaaccccagg
     2221 acggccaggc aacccaggag agaagggtgc tgtgggccaa ccaggaattg gatttcccgg
     2281 gcttcctggc cccaaaggtg ttgatggctt gcctggagag ataggacgac cggggagtcc
     2341 aggtcgccct ggatttaatg gcttacctgg caacccagga ccgcaaggcc aaaagggaga
     2401 acctggcatt gggcttccag gactcaaagg gcagccaggt cttccaggta tccctggcac
     2461 acccggagag aaaggcagca tcgggggacc tggcgttcca ggagaacagg ggttgactgg
     2521 ccctcccgga ctccagggga tcagaggtga cccaggacct cctggggttc aaggccctgc
     2581 aggtccacca ggggttccag gaataggacc acccggagct atgggccctc ccggagggca
     2641 aggaccacca ggttcatcag gtccacctgg agttaaagga gagaagggat tccctggatt
     2701 cccaggactg gatatgcctg gccccaaagg agataaaggc tctcaaggac ttcctggcct
     2761 cacaggacag tcagggctcc ctggcctccc tggacagcag gggactcctg gagttccagg
     2821 gttcccaggt tctaaaggtg aaatgggcgt catgggaacc ccgggacaac caggctcacc
     2881 aggaccagca ggcgccccag ggttacccgg agagaaagga gaccatggct ttccgggctc
     2941 ctcgggaccc aggggcgacc ctggcttcaa aggtgataaa ggtgatgtcg ggcttcctgg
     3001 catgccagga tccatggagc acgtggacat gggcagcatg aaggggcaga aaggagacca
     3061 gggagagaaa ggacaaattg gacccactgg tgataaaggt tcccgaggag accccggaac
     3121 accaggagtg cccgggaagg atgggcaggc agggcaccct ggacagccag gacctaaagg
     3181 tgacccaggc cttagtggaa taccaggatc ccctggactt cctggaccca aaggatcggt
     3241 tggaggaatg ggcttgccag gttcgcccgg agagaaaggc gttccgggca tccctggctc
     3301 acagggtgtc cctggctcac ctggagagaa aggagctaag ggagagaaag ggcagtcagg
     3361 tctccctggc attggaattc ctggacggcc tggtgacaag ggagatcagg ggcttgcagg
     3421 tttcccaggc agccctggtg agaagggaga gaaaggcagt gccggaaccc cagggatgcc
     3481 agggtcccca ggcccaagag gctctccagg gaacatcggc catccaggaa gcccaggcct
     3541 gcctggagaa aaaggagaca aaggcctccc aggactggat ggtgttcccg gtgtcaaagg
     3601 agaagcaggt cttcctggga ctcctggccc cacaggccca gctggccaga agggagaacc
     3661 tggcagtgat ggaatcccgg ggtcggcagg agagaagggt gaacaaggtt tgccaggaag
     3721 aggcttccca ggcttccccg gcaccaaagg agacaaaggt tccaagggtg aagtgggttt
     3781 ccctggcctt gccggaagtc ctgggattcc tggagccaaa ggcgagcaag gattcatggg
     3841 tcctcccggc cctcaaggac agccgggctt acctggcact cctggccacc ctgtggaggg
     3901 gcccaaagga gaccgaggac ctcagggtca acccggcctg ccagggcatc cgggacctat
     3961 ggggccacca gggttccctg gaatcgatgg gccaaaaggt gacaagggaa atccaggttg
     4021 gccaggagct cctggggctc caggccctaa gggagaccca ggattccaag gcatgccggg
     4081 cattggcggc tctccaggga tcacaggttc aaagggagat atgggaccgc ctggcgttcc
     4141 aggattccaa ggtcagaaag gtcttcctgg cttgcaggga gtgaagggag atcagggaga
     4201 tcaaggcata cccggcccta aaggtctcca aggtccccct gggcccccag gtccctacga
     4261 tgtcatcaaa ggagaaccag ggctcccagg tcctgagggt cctcctggtc tcaaaggact
     4321 tcaaggacca ccaggtccaa aaggacagca aggtgtgaca ggctccgtgg gcttgcctgg
     4381 acctccaggt gtccctgggt ttgatggtgc ccctggccag aaaggagaga ctggaccatt
     4441 tggaccacct ggtccgagag ggtttcctgg tccaccaggc cccgatgggc tgccaggatc
     4501 catgggtccc ccgggtaccc catctgtgga ccatggcttc cttgtgacca ggcatagtca
     4561 gacaacagat gacccgctgt gtcccccagg gaccaaaatt ctttaccatg ggtactctct
     4621 gctctatgtc caaggaaacg agcgggccca tggtcaggac ttgggtacgg ctggcagctg
     4681 tctgcgcaag ttcagcacca tgcccttcct cttctgcaac atcaacaacg tctgcaactt
     4741 cgcctccagg aacgactact cctactggct gtccactccg gagcccatgc ccatgtccat
     4801 ggcacctatc tctggggaca acatccggcc cttcattagc aggtgtgcag tttgcgaagc
     4861 gcccgccatg gtgatggcgg tgcacagtca gaccatccag atcccgcagt gccccaacgg
     4921 ttggtcctca ctgtggattg gctattcctt tgtgatgcac accagcgctg gtgctgaagg
     4981 ttctggccaa gcccttgcat ctcccgggtc ctgtctggaa gagtttagaa gtgccccatt
     5041 catcgagtgc catggcagag gaacgtgcaa ttactacgcg aatgcttaca gcttttggct
     5101 cgccaccata gagagaagcg agatgttcaa gaagcccacg ccgtccacct tgaaggcagg
     5161 ggagctgcgc acgcatgtca gccgctgcca agtgtgcatg agaagaacat agtgatgccc
     5221 ccctctgccg ccgtcacaac atggtgctac tccctccttg tcctcctctc ccctcctgtt
     5281 gtattgttaa cagcaacgaa ccctagaatt atatcctatg tacctcactg tccactatga
     5341 aaaccgtaaa gtgccttaca gggatttgcg taactaacac accccgcttc gttggcctct
     5401 gtttgctgaa ggagaaggac agacagctac gagcctccca taatggcaca ctccaaatgg
     5461 cgctcctgat ccaataaaag atgaattgcc ttttgcaatc cagtgcactg atgtctgggg
     5521 cgagaactcc acaagaaacc caaaggtgct aggggtgcac ggtgctccac acagcccaca
     5581 gcccgcttca tcctgtcacc ccagacgtga gcgccgcctg acccactgtc cagggtttgc
     5641 cacctcaggt ccctcgatgg gctgtgcaga tagcaatcaa ggaaactggt ttcttccacc
     5701 ctctacacag aattccatct ttccgggccc caaaacacaa acttacgccc tgtgtggcac
     5761 tacgtagctg cttccgtgga agtcatggct ttctgtggaa taaagatggt ccaaaggtag
     5821 acggaaaata aataagtaaa taaatatata tatattagta atttatatag gtgtcagcaa
     5881 ttaggcaggt caagttctag tgtagaaccc gttgttaaat aaagcatact ccgtttgcct
     5941 ctctcgagaa actgtactgt cctttcacag ggtttccaac accaggccac cgaatgtgaa
     6001 aacaccagcc tttctcactc actcccacat cagaggaggt gcataaccaa agccaaaacc
     6061 attccgaaac atggtgtcta tgatagtgcg ccctgtgcct ggcgcttcct gctttccgct
     6121 ctgcgcggag tattttcagg gtttgccaca ctatccgcag actgaatgac tgacttccag
     6181 tatgacagcc aaggcctttc atcctgcaat cctggggcag gcagttcaca cctgagcaca
     6241 cacaggccac ttcccagccc ctctcgagct gtgtcacagc ccctgcaggg agccgacagg
     6301 tcaggcgcag gaggggaaga tcactatgct tgaagtggcg ttacactaaa agtccccctt
     6361 accccacccc ctttttaaaa aaaagttttt aagactacta aggccttctg tgtaatttct
     6421 ttaaatgtgt tatttcttaa gaattcaaat ttgtaataaa actatttgta taaaaattaa
     6481 gctttttatg aatttgttgc cagaactgcc actgaaacgt tgaaagagaa gttgccacac
     6541 agaccgctaa taaacctgta agctttgctg tgtatctta
//
