LOCUS       NM_053304               5843 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus collagen type I alpha 1 chain (Col1a1), mRNA.
ACCESSION   NM_053304 XM_001081230 XM_213440
VERSION     NM_053304.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5843)
  AUTHORS   Cao,Y., Huang,W., Wu,F., Shang,J., Ping,F., Wang,W., Li,Y., Zhao,X.
            and Zhang,X.
  TITLE     ZFP36 protects lungs from intestinal I/R-induced injury and
            fibrosis through the CREBBP/p53/p21/Bax pathway
  JOURNAL   Cell Death Dis 12 (7), 685 (2021)
   PUBMED   34238924
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5843)
  AUTHORS   Lin,G., Wan,X., Liu,D., Wen,Y., Yang,C. and Zhao,C.
  TITLE     COL1A1 as a potential new biomarker and therapeutic target for type
            2 diabetes
  JOURNAL   Pharmacol Res 165, 105436 (2021)
   PUBMED   33497804
  REMARK    GeneRIF: COL1A1 as a potential new biomarker and therapeutic target
            for type 2 diabetes.
REFERENCE   3  (bases 1 to 5843)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   4  (bases 1 to 5843)
  AUTHORS   Yuan,Y., Naito,H., Kitamori,K., Hashimoto,S., Asano,T. and
            Nakajima,T.
  TITLE     The antihypertensive agent hydralazine reduced extracellular matrix
            synthesis and liver fibrosis in nonalcoholic steatohepatitis
            exacerbated by hypertension
  JOURNAL   PLoS One 15 (12), e0243846 (2020)
   PUBMED   33315911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5843)
  AUTHORS   Kananykhina,E.Y., Shmakova,T.V., Bolshakova,G.B., Rusanov,F.S.,
            Elchaninov,A.V., Nikitina,M.P., Lokhonina,A.V., Makarov,A.V. and
            Fatkhudinov,T.K.
  TITLE     Expression of Metalloproteinases and Type I and III Collagens
            during Healing of Excisional Skin Wound on the Abdomen and Back in
            Rats
  JOURNAL   Bull Exp Biol Med 168 (6), 812-816 (2020)
   PUBMED   32328952
  REMARK    GeneRIF: Expression of Metalloproteinases and Type I and III
            Collagens during Healing of Excisional Skin Wound on the Abdomen
            and Back in Rats.
REFERENCE   6  (bases 1 to 5843)
  AUTHORS   Federspiel,S.J., DiMari,S.J., Howe,A.M., Guerry-Force,M.L. and
            Haralson,M.A.
  TITLE     Extracellular matrix biosynthesis by cultured fetal rat lung
            epithelial cells. IV. Effects of chronic exposure to retinoic acid
            on growth, differentiation, and collagen biosynthesis
  JOURNAL   Lab Invest 65 (4), 441-450 (1991)
   PUBMED   1921334
REFERENCE   7  (bases 1 to 5843)
  AUTHORS   Tsuneyoshi,T., Westerhausen,A., Constantinou,C.D. and Prockop,D.J.
  TITLE     Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of
            type I procollagen in lethal osteogenesis imperfecta. The
            conformational strain on the triple helix introduced by a glycine
            substitution can be transmitted along the helix
  JOURNAL   J Biol Chem 266 (24), 15608-15613 (1991)
   PUBMED   1874719
REFERENCE   8  (bases 1 to 5843)
  AUTHORS   Federspiel,S.J., DiMari,S.J., Howe,A.M., Guerry-Force,M.L. and
            Haralson,M.A.
  TITLE     Extracellular matrix biosynthesis by cultured fetal rat lung
            epithelial cells. III. Effects of chronic exposure to epidermal
            growth factor on growth, differentiation, and collagen biosynthesis
  JOURNAL   Lab Invest 64 (4), 463-473 (1991)
   PUBMED   2016852
REFERENCE   9  (bases 1 to 5843)
  AUTHORS   Annoni,G., Arosio,B., Santambrogio,D., Gagliano,N. and Zern,M.A.
  TITLE     Albumin and procollagen type I gene regulation in alcohol and
            viral-induced human liver disease
  JOURNAL   Boll Ist Sieroter Milan 70 (1-2), 391-397 (1991)
   PUBMED   1670041
REFERENCE   10 (bases 1 to 5843)
  AUTHORS   Kulozik,M., Hogg,A., Lankat-Buttgereit,B. and Krieg,T.
  TITLE     Co-localization of transforming growth factor beta 2 with alpha
            1(I) procollagen mRNA in tissue sections of patients with systemic
            sclerosis
  JOURNAL   J Clin Invest 86 (3), 917-922 (1990)
   PUBMED   1697606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB693258.1, BC133728.1, CB579389.1, CO397981.1 and BQ206338.1.
            
            On or before Oct 27, 2007 this sequence version replaced
            XM_213440.4, XM_001081230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z78279.1, BC133728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB693258.1         9-24
            17-4742             BC133728.1         1-4726
            4743-5275           CB579389.1         85-617
            5276-5752           CO397981.1         173-649
            5753-5843           BQ206338.1         1-91                c
FEATURES             Location/Qualifiers
     source          1..5843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5843
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="collagen type I alpha 1 chain"
                     /db_xref="GeneID:29393"
                     /db_xref="RGD:61817"
     exon            1..187
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..4473
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="procollagen type I, alpha 1; collagen alpha-1(I)
                     chain; collagen, type I, alpha 1; alpha-1 type I collagen;
                     collagen, type 1, alpha 1; procollagen, type 1, alpha 1;
                     type I-alpha 1 collagen"
                     /codon_start=1
                     /product="collagen alpha-1(I) chain precursor"
                     /protein_id="NP_445756.1"
                     /db_xref="GeneID:29393"
                     /db_xref="RGD:61817"
                     /translation="MFSFVDLRLLLLLGATALLTHGQEDIPEVSCIHNGLRVPNGETW
                     KPDVCLICICHNGTAVCDGVLCKEDLDCPNPQKREGECCPFCPEEYVSPDAEVIGVEG
                     PKGDPGPQGPRGPVGPPGQDGIPGQPGLPGPPGPPGPPGPPGLGGNFASQMSYGYDEK
                     SAGVSVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKN
                     GDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDTGPAGPKG
                     EPGSPGENGAPGQMGPRGLPGERGRPGPPGSAGARGNDGAVGAAGPPGPTGPTGPPGF
                     PGAAGAKGEAGPQGARGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAP
                     GIAGAPGFPGARGPSGPQGPSGAPGPKGNSGEPGAPGNKGDTGAKGEPGPAGVQGPPG
                     PAGEEGKRGARGEPGPSGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGP
                     KGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPAGPPGARGQA
                     GVMGFPGPKGTAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGAPGPAGPAGERGEQG
                     PAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGP
                     AGPRGNNGAPGNDGAKGDTGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPK
                     GADGSPGKDGVRGLTGPIGPPGPAGAPGDKGETGPSGPAGPTGARGAPGDRGEPGPPG
                     PAGFAGPPGADGQPGAKGEPGDTGVKGDAGPPGPAGPAGPPGPIGNVGAPGPKGSRGA
                     AGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPVGKEGGKGPRGETGPAGRPGEVGPP
                     GPPGPAGEKGSPGADGPAGSPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPG
                     KQGPSGASGERGPPGPMGPPGLAGPPGESGREGSPGAEGSPGRDGAPGAKGDRGETGP
                     AGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRGDKGET
                     GEQGDRGIKGHRGFSGLQGPPGSPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNG
                     LPGPIGPPGPRGRTGDSGPAGPPGPPGPPGPPGPPSGGYDFSFLPQPPQEKSQDGGRY
                     YRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGE
                     YWIDPNQGCNLDAIKVYCNMETGQTCVFPTQPSVPQKNWYISPNPKEKKHVWFGESMT
                     DGFQFEYGSEGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKSLL
                     LQGSNEIELRGEGNSRFTYSTLVDGCTSHTGTWGKTVIEYKTTKTSRLPIIDVAPLDI
                     GAPDQEFGMDIGPACFV"
     exon            188..382
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..414
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..450
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..552
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..621
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..666
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..720
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..774
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..828
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..882
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..936
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..981
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1035
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1080
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1134
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1233
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1278
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1377
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1431
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1539
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1593
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1692
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1746
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1845
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1899
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1953
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2007
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2061
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2106
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2205
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2313
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2421
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2475
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2529
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2637
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2691
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2745
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2907
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3015
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3123
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3177
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3285
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3339
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3447
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3501
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3609
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3892
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4083
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4326
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..5826
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagtttc acctccggac ggagcaggag gcacacggag tgaggccacg catgagccga
       61 agctaacccc ccaccccagc cgcaaagagt ctacatgtct agggtctaga catgttcagc
      121 tttgtggacc tccggctcct gctcctctta ggggccactg ccctcctgac gcatggccaa
      181 gaagacatcc ctgaagtcag ctgcatacac aatggcctaa gggtccctaa tggtgagacg
      241 tggaaacctg atgtatgctt gatctgtatc tgccacaatg gcacggctgt gtgcgatggc
      301 gtgctatgca aagaagactt ggactgtccc aacccccaaa aacgggaggg cgagtgctgt
      361 cctttctgcc cagaagaata tgtatcacca gacgcagaag tcataggagt cgagggaccc
      421 aagggagacc ctggccccca aggcccacgg ggacctgttg gcccccctgg acaagatggc
      481 atccctggac agcctggact tcctggtcct cctggtcccc ccggcccccc cggaccccct
      541 ggtcttggag gaaactttgc ttcccagatg tcctatggct atgatgagaa atcagctgga
      601 gtttccgtgc ctggccccat gggtccttct ggtcctcgtg gtctccctgg cccccctggt
      661 gcacctggtc ctcaaggttt ccaaggcccc cctggtgaac ctggcgagcc tggcgcttca
      721 ggtccaatgg gtccccgagg tccccctggc cctcctggca agaacggaga tgatggggaa
      781 gctggtaagc ctggccgccc tggtgagcgt ggacctcctg gacctcaggg tgctcgtgga
      841 ttgcctggaa cagctggcct ccccggaatg aagggacaca gaggtttcag tggtttggat
      901 ggtgccaaag gagatactgg tcctgctggt cctaagggag agcctggcag tcctggtgaa
      961 aatggagctc ccggccagat gggtccccga ggtctgcctg gtgagagagg tcgccctgga
     1021 ccccctggca gtgctggtgc tcgtggtaac gatggtgctg tcggtgcagc tgggcccccc
     1081 ggtcccaccg gccctactgg ccctcctggc ttccctggtg cagctggtgc taagggtgaa
     1141 gctggtcccc agggagcccg aggctctgaa ggtccccagg gtgtgcgtgg tgagcccgga
     1201 ccccctggcc ctgctggtgc tgctggtcct gctggaaacc ctggtgctga tggacaacct
     1261 ggtgctaaag gtgccaatgg tgctcctggt attgctggtg ctcctggctt ccctggtgcc
     1321 cgaggcccct ctggacctca gggccccagc ggcgctcctg gtcccaaagg caacagtggt
     1381 gaacctggtg cccctggcaa caaaggagac actggtgcca aaggagaacc cggccctgct
     1441 ggagttcaag gtccccctgg ccctgctgga gaagaaggaa aacgaggagc ccgtggtgag
     1501 cctggaccta gcggcctgcc cggacctcct ggcgagcgcg gtggacctgg tagccgtggt
     1561 ttccctggtg ctgatggtgt tgctggcccc aagggtcctg ctggtgaacg tggttctcct
     1621 ggccctgctg gtcccaaagg ttctcctggt gaagctggtc gccctggtga agctggtctc
     1681 cctggtgcca agggtctcac tggcagtcct ggcagccctg gtcctgatgg caaaaccggc
     1741 ccccctggtc ccgctggtca agatggtcgc cctggacccg caggtcctcc tggagcccgt
     1801 ggacaggctg gtgtgatggg attccctgga cctaagggta ctgctggaga acctggaaag
     1861 gctggagaac gaggtgtccc cggaccccct ggcgctgttg gtcccgctgg caaagatggc
     1921 gaagctggag ctcaaggagc ccccggccct gctggtcctg ctggtgagag aggtgaacaa
     1981 ggtcccgctg gctcccctgg attccagggt cttcctggtc ccgctggtcc tcctggtgaa
     2041 gcaggcaagc ctggtgaaca gggtgttcct ggagaccttg gtgcccctgg accctctggc
     2101 gcaagaggcg agagaggttt ccctggtgaa cgtggtgtac aaggtccccc aggtcctgct
     2161 ggtccccgag gaaacaatgg tgcccccggc aacgatggtg ccaagggtga tactggtgcc
     2221 cccggagctc ctggtagcca gggtgccccc ggtcttcagg gaatgcctgg tgaacgtggt
     2281 gcagctggtc ttccaggtcc taagggtgac agaggtgatg ctggtcccaa aggtgctgat
     2341 ggttctcctg gcaaagatgg cgtccgtggt ctgactggtc ccattggtcc tcctggccct
     2401 gctggtgccc ctggtgacaa gggtgaaact ggtcccagtg gtcctgctgg ccccaccgga
     2461 gcccgtggtg cccccggaga ccgtggtgag cctggtcccc ctggtcctgc tggcttcgct
     2521 ggcccccctg gtgctgatgg ccaacctggt gcgaaaggtg aacctggtga tactggtgtg
     2581 aaaggtgacg ctggtcctcc tggccctgct ggtcccgctg gaccccctgg ccccattggt
     2641 aacgttggtg ctcctggacc caaaggttct cgtggtgctg ctggtccccc tggtgctact
     2701 ggtttccctg gtgctgctgg tcgtgttggt ccccctggtc cctctggaaa tgctggaccc
     2761 cctggccctc ccggtcccgt tggcaaagaa gggggcaaag gtccccgtgg tgagactggt
     2821 cccgctggac gtcctggtga agttggtccc ccaggtcccc ctggccctgc tggtgagaaa
     2881 ggatctcctg gtgctgatgg acctgctggc tctcctggta cccctggacc tcagggtatt
     2941 gctggacagc gtggtgtggt cggtcttccc ggtcagagag gagaaagagg cttccctggt
     3001 cttcctggac cctctggtga acccggcaaa caaggtcctt ctggagcaag tggtgaacgt
     3061 ggtccccctg gccctatggg cccccctgga ttggctggcc cccctggtga atctggtcgt
     3121 gagggatccc ctggtgctga aggctcccct ggaagagatg gtgctcctgg tgccaagggt
     3181 gaccgtggtg agactggccc tgctggcccc cctggtgctc ctggtgctcc tggtgctccc
     3241 ggccctgttg gtcctgctgg caagaatggc gaccgtggtg agactggtcc tgctggtcct
     3301 gctggtccca ttggccctgc tggtgcccgt ggtcctgctg gaccccaagg cccccgtggt
     3361 gacaagggtg agacaggcga acaaggtgac agaggcataa agggtcatcg tggcttctct
     3421 ggtctccagg gtcctcctgg ctctcctggc tctcctggtg aacaaggccc ctctggagct
     3481 tctggtcctg caggtccccg gggtccccct ggctctgctg gttctcctgg caaagatgga
     3541 ctcaacggtc tccctggccc cattggtccc cctggtcctc gaggtcgcac tggcgatagt
     3601 ggtcctgctg gtccccccgg acctcctgga ccccctggcc ctcccggtcc tcccagcggt
     3661 ggttatgact tcagcttcct gcctcagcca cctcaagaga agtctcaaga tggtggccgt
     3721 tactaccggg ccgatgatgc caacgtggtc cgtgaccgtg accttgaggt ggacactacc
     3781 ctcaagagcc tgagccagca gattgagaac atccgcagcc ctgagggcag ccgcaagaac
     3841 cccgcccgca catgccgtga cctcaagatg tgccactctg actggaagag cggagagtac
     3901 tggatcgacc ctaaccaagg ctgcaacctg gatgccatca aggtctactg caacatggag
     3961 acaggtcaga cctgtgtgtt ccccactcag ccctctgtgc ctcagaagaa ctggtacatc
     4021 agcccaaacc ccaaggagaa gaagcatgtc tggtttggag agagcatgac cgatggattc
     4081 cagttcgagt atggaagcga aggttccgat cctgccgatg tcgctatcca gctgaccttc
     4141 ctgcgcctga tgtccaccga ggcctcccag aacatcacct atcactgcaa gaacagcgta
     4201 gcctacatgg accaacagac tggcaacctc aagaagtccc tgctcctcca gggctccaac
     4261 gagatcgagc tcaggggcga aggcaacagt cgattcacct acagcacgct tgtggatggc
     4321 tgcacgagtc acaccggaac ttggggcaag acagtcatcg aatacaaaac caccaagacc
     4381 tcccgcctgc ccatcatcga tgtggctccc ttggacattg gtgccccaga ccaggaattc
     4441 ggaatggaca ttggccctgc ctgcttcgtg taaactccct ccatcccaat ctggttccct
     4501 cccacccagc ccactttccc ccaaccctgg aaacagacca acaacccaaa ctcaatttcc
     4561 ccaaaagcca aaaattggga gacaatttca catggacttt ggaaaacatt tttttccttt
     4621 gcattcatct ctcaaactta gtttttatct ttgaccaact gaacgtgacc aaaaaccaaa
     4681 agtgcattca accttaccaa aaagaaaaaa aaataagaat aaataaataa ctttttaaaa
     4741 aaggaagctt ggtcctcttg cttgaagacc tatgtgggta taagtccctt tctgcccact
     4801 gggcttatga taccccaaat gctgcctttt ctgttccttt ctccaccccc tcttggggcc
     4861 tctcctccat tgctccccaa atttaagtct cccccaaaga cacaggaaat aatgcattgt
     4921 ctgcccagcc agcaaaggca atgctgaatc gtcccaccag cccctcaacc cccagcctac
     4981 ttccctaccc agcaccttca aatcctgccg ggacatgggg ttctcggact attgaaggag
     5041 cctaaccatc tggcatctcc atggcctctg caacaaatcc ccacacacac tttgtttttg
     5101 agggcctgtg ctgggggagc cacctgcccc tcgcaggggt ttggagccag gcagggtcac
     5161 agcagactgg aaacatcggc cacacatgtg caggctgggt gggagagact gttctgttcc
     5221 ttgtgtaatt gtgttgctga aagactacct cgttcttgtc tttgtgtgtc accggggcaa
     5281 ctgtgtgggg gcggggatgg gggcagggtg gcagcgcgcc cagtttggta tcaaaggtgc
     5341 tacatctctg tgaaggggtg gggtgggaag gaatttctgg tgctatagaa tctgagatgc
     5401 tcccctagac cagcaaatgt tccttttgtt caaagtattt ttttattctt ttttttttaa
     5461 tggataggga cttgtgtgaa ttttcttttc ctgacggtgc tatttaacaa gggaggagag
     5521 agtgccaact ccagcctgct ctctctctac ccccctcttc actcttccag ctcctgggcc
     5581 tatctgatga tctctctctc ttctgaaacc ctcccctctt gctgctgctc cctaccctca
     5641 gcttctctct ctctctgtcc tgcatcaggg tttcagagca ccattttcca aagcacaaag
     5701 cagtttttat ccctggggtg ggaggaagca agagactctg tacctatttt gtatgtgtat
     5761 aataatttga gatgttttta attattttga ttgctggaat aaagcatgtg gaaatgaccc
     5821 aacgcaaaaa aaaaaaaaaa aaa
//
