LOCUS       NM_053489               5007 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus collagen type XVIII alpha 1 chain (Col18a1),
            mRNA.
ACCESSION   NM_053489 XM_001079576 XM_241632
VERSION     NM_053489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5007)
  AUTHORS   Ambade,A.S., Naranjo,M., Tuhy,T., Yu,R., Marimoutou,M.,
            Everett,A.D., Shimoda,L.A., Zimmerman,S.L., Cubero Salazar,I.M.,
            Simpson,C.E., Tedford,R.J., Hsu,S., Hassoun,P.M. and Damico,R.L.
  TITLE     Collagen 18A1/Endostatin Expression in the Progression of Right
            Ventricular Remodeling and Dysfunction in Pulmonary Arterial
            Hypertension
  JOURNAL   Am J Respir Cell Mol Biol 71 (3), 343-355 (2024)
   PUBMED   38861354
  REMARK    GeneRIF: Collagen 18A1/Endostatin Expression in the Progression of
            Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial
            Hypertension.
REFERENCE   2  (bases 1 to 5007)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 5007)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 5007)
  AUTHORS   Aikio,M., Elamaa,H., Vicente,D., Izzi,V., Kaur,I., Seppinen,L.,
            Speedy,H.E., Kaminska,D., Kuusisto,S., Sormunen,R., Heljasvaara,R.,
            Jones,E.L., Muilu,M., Jauhiainen,M., Pihlajamaki,J.,
            Savolainen,M.J., Shoulders,C.C. and Pihlajaniemi,T.
  TITLE     Specific collagen XVIII isoforms promote adipose tissue accrual via
            mechanisms determining adipocyte number and affect fat deposition
  JOURNAL   Proc Natl Acad Sci U S A 111 (30), E3043-E3052 (2014)
   PUBMED   25024173
  REMARK    GeneRIF: Specific collagen XVIII isoforms promote adipose tissue
            accrual via mechanisms determining
REFERENCE   5  (bases 1 to 5007)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 5007)
  AUTHORS   Fukai,N., Eklund,L., Marneros,A.G., Oh,S.P., Keene,D.R.,
            Tamarkin,L., Niemela,M., Ilves,M., Li,E., Pihlajaniemi,T. and
            Olsen,B.R.
  TITLE     Lack of collagen XVIII/endostatin results in eye abnormalities
  JOURNAL   EMBO J 21 (7), 1535-1544 (2002)
   PUBMED   11927538
REFERENCE   7  (bases 1 to 5007)
  AUTHORS   Jia,J.D., Bauer,M., Sedlaczek,N., Herbst,H., Ruehl,M., Hahn,E.G.,
            Riecken,E.O. and Schuppan,D.
  TITLE     Modulation of collagen XVIII/endostatin expression in lobular and
            biliary rat liver fibrogenesis
  JOURNAL   J Hepatol 35 (3), 386-391 (2001)
   PUBMED   11592600
REFERENCE   8  (bases 1 to 5007)
  AUTHORS   Ma,L., Elliott,S.N., Cirino,G., Buret,A., Ignarro,L.J. and
            Wallace,J.L.
  TITLE     Platelets modulate gastric ulcer healing: role of endostatin and
            vascular endothelial growth factor release
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6470-6475 (2001)
   PUBMED   11353854
REFERENCE   9  (bases 1 to 5007)
  AUTHORS   Perletti,G., Concari,P., Giardini,R., Marras,E., Piccinini,F.,
            Folkman,J. and Chen,L.
  TITLE     Antitumor activity of endostatin against carcinogen-induced rat
            primary mammary tumors
  JOURNAL   Cancer Res 60 (7), 1793-1796 (2000)
   PUBMED   10766159
REFERENCE   10 (bases 1 to 5007)
  AUTHORS   Muragaki,Y., Timmons,S., Griffith,C.M., Oh,S.P., Fadel,B.,
            Quertermous,T. and Olsen,B.R.
  TITLE     Mouse Col18a1 is expressed in a tissue-specific manner as three
            alternative variants and is localized in basement membrane zones
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8763-8767 (1995)
   PUBMED   7568013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473988.1.
            
            On or before Oct 21, 2010 this sequence version replaced
            XM_001079576.2, XM_241632.5, NM_053489.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132291, SAMD00132293
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..5007
                     /gene="Col18a1"
                     /note="collagen type XVIII alpha 1 chain"
                     /db_xref="GeneID:85251"
                     /db_xref="RGD:70936"
     exon            1..100
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..4025
                     /gene="Col18a1"
                     /note="procollagen, type XVIII, alpha 1; collagen
                     alpha-1(XVIII) chain; collagen, type XVIII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XVIII) chain precursor"
                     /protein_id="NP_445941.2"
                     /db_xref="GeneID:85251"
                     /db_xref="RGD:70936"
                     /translation="MAPRWHLLDMLTSLVLLLVARVSWAEPENVAEDVGLLQLLGDPL
                     PQKISQVEDPHVGLAYVFGPYSKSSQMAQYHFPKLFFRDFSLLFEVRPTTEAAGVLFA
                     ITDAAQVVVSLGVKLSEVRDGQQNISLLYTEPGASQTQTGASFRLPAFVGQWTHFALS
                     VDGSSVALYVDCEEFQRVPFARSPHGLELERGAGLFVGQAGAADPDKFQGMISELRVR
                     KTPRVSPVHCLDEEDDDDDRASGDFGSGLEESSNLHRQETYLRPGLPQPPPVTSPPLA
                     GGSATEDSRTEEKEEEATVDSKGADTLPVTDSSGVWDGDVQNPGGGLIKGGLKGQKGE
                     PGAQGPPGPAGPQGPAGPAVQSPSSQPVPGAQGPPGPQGPPGKDGIPGRDGEPGDPGE
                     DGRPGDTGPQGFPGTPGDVGPKGEKGDPGIGPRGPPGPPGPPGPSFRQDKLTFIDMEG
                     SGGFSGDLESLRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSYAPGPAGLPGVPGKEGP
                     PGFPGPPGPPGKEGPPGVAGQKGSVGDAGSPGPKGSKGDLGPIGMPGKSGLPGLPGPV
                     GPPGPPGPPGPPGPGFAAGFDDMEGSGTPLWSTARSSDGLQGDPGVTGPPGAKGEVGA
                     DGVQGIPGLPGREGVAGPPGPKGEKGTQGEKGNPGKDGVGRPGLPGPPGPPGPVIYVS
                     NEDRAVVSTPGPEGKPGYAGFPGPAGPKGDLGSKGEQGLPGPKGEKGEPGSIFSPDGT
                     ALGQAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGTNGLKGEKGEPGEASLG
                     FSMRGLPGPPGPPGPPGPPGVPVYDSNAFVESGRPGLPGQQGVQGPPGPKGDKGEVGP
                     PGPPGQFPIDLFHLEAEMKGDKGDRGDAGRKGERGEPGAPGGGFFSSSVPGPPGPPGY
                     PGIPGPKGESIRGPPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTVSVPG
                     PPGPPGPPGPPGAMGASAGQVRIWATYQTMLDKIREVPEGWLIFVAEREELYVRVRNG
                     FRKVLLEARTALPHGTDNEVAALQPPLVQLHEGSSYTRREHSYPTARPWRADDILANP
                     PRLPDRQPYPGVPHHHHHHHHHHSSHEHRPPAHPSPSPAHTHQDFHPVLHLVALNTPL
                     SGGMRGIRGADFQCFQQARAVGLSGTFRAFLSSRLQDLYSIVRRADRSSVPIVNLKDE
                     VLSPSWDTLFSGSQGQLHSGARIFSFDGRDVLRHPAWPQKSVWHGSDPSGRRLMESYC
                     ETWRTEATGVTGQASSLLSGRLLEQKAESCHNSYIVLCIENSFMTSFSK"
     exon            101..171
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..716
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..803
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..857
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..987
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1064
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1250
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1277
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1340
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1418
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1475
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1634
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1688
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1715
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1847
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1910
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1946
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2018
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2054
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2144
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2174
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2201
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2264
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2339
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2366
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2420
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2495
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2564
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2607
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2670
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2714
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2843
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2988
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3062
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3194
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3227
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3497
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..3695
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3811
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..5007
                     /gene="Col18a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcagcag cggtcgggag cgctgtgggc aagcggctca cggaggagct gggtgcagca
       61 tccgggcgca gacggcctgg cctggggaga tggcgcccag gtggcacctc ctggacatgc
      121 tcaccagttt ggtcttgctg ctggtggcac gcgtctcctg ggcagagcca gagaatgttg
      181 ctgaagatgt ggggctcctg cagctcctcg gagaccccct accccagaag atctcccaag
      241 tcgaagaccc tcatgtcggg ctggcctacg tctttggacc atactccaaa agtagtcaga
      301 tggcccagta tcacttccct aaactcttct tccgggactt ttcgctgctg ttcgaagtcc
      361 ggccaaccac agaggccgca ggggtgctgt ttgctatcac agatgccgcc caggtggtgg
      421 tctcgctagg cgtgaagctc tcagaggtcc gagatggaca acagaacatc tcattgctct
      481 acacggagcc cggggccagc cagacccaga cgggagccag cttccgccta cctgcgtttg
      541 ttggccagtg gacacacttc gcgctcagcg tggatggaag ctccgtggct ctctacgtag
      601 actgtgaaga gttccagaga gtgccgttcg ctcggtcccc acacggtctg gagctagagc
      661 gtggcgctgg cctctttgtg ggtcaggctg gagcagcgga ccctgacaag ttccagggaa
      721 tgatctcaga gctgagagta cgcaaaaccc cccgggtgag ccctgtgcac tgcctggatg
      781 aagaagatga tgatgacgac cgggcatctg gagattttgg aagtggcctc gaagaaagca
      841 gcaatttaca caggcaggag acatatctac gacccgggct cccccagcca cctcctgtca
      901 cttccccgcc cttggctgga ggcagtgcca ccgaagattc taggacagaa gaaaaggagg
      961 aagaagccac ggtagattct aaaggagctg atacccttcc tgtcacagat tcaagcggtg
     1021 tgtgggacgg ggatgtccag aaccctggag gtggcttgat aaagggaggt ctcaaaggac
     1081 aaaagggaga gccaggtgct caaggcccac ctggcccagc tgggccccag ggtcctgccg
     1141 gtccagcggt acagagcccc agctcacaac ctgtccctgg agcacaagga cccccgggac
     1201 ctcagggacc accagggaag gatggcatcc cgggaaggga tggtgaacca ggcgaccctg
     1261 gtgaagacgg gaggccgggt gacactggac ctcaaggctt cccggggacc ccaggagatg
     1321 tgggccctaa gggtgagaag ggagatcctg gtattgggcc tcgaggacct ccaggacctc
     1381 cgggaccacc aggaccctcc ttcagacagg acaagctgac cttcattgac atggagggat
     1441 ctggtggttt cagcggagac ctagagagcc tcagaggccc acgaggcttc cctggtcccc
     1501 caggtccccc tggtgtccca ggactgcctg gtgaaccagg gcgctttgga gtcaacagtt
     1561 cctacgcacc aggacctgca ggccttcctg gtgtgcctgg gaaggaaggg ccccctggtt
     1621 ttcctggtcc cccaggacct ccaggcaaag agggcccacc aggagtggcc ggccagaaag
     1681 gcagtgttgg cgatgcaggc agcccaggac ccaaggggag caaaggagac cttgggccca
     1741 ttggtatgcc tgggaagtct ggcttgccgg gactccctgg gccagttgga cccccaggac
     1801 ctccagggcc tccagggcca ccaggaccag gatttgctgc tggatttgat gacatggaag
     1861 gttctggaac acctctctgg tcaacagccc gaagctccga tgggctgcag ggggatcctg
     1921 gagtgactgg gccacctggg gccaagggag aagttggagc agacggagtc cagggcatcc
     1981 ctggtctccc aggaagagag ggtgtagctg ggcccccggg acccaaagga gagaaaggga
     2041 cccagggaga aaagggaaac ccaggaaaag atggagtagg tcggccaggc ctccctggcc
     2101 ctccaggccc cccagggcct gtgatctatg tgtcaaatga ggatagagct gtagtaagca
     2161 cgccgggacc tgagggcaag ccagggtacg caggctttcc tggacctgct ggaccgaagg
     2221 gtgacctggg ttccaaaggc gagcagggtc ttccagggcc caagggtgag aagggagaac
     2281 caggcagtat ctttagccct gatggcacag ccctgggcca ggcccagaag ggagccaagg
     2341 gagaaccagg cttccgagga cccccgggtc cttatggacg gcctgggtac aagggtgaaa
     2401 ttggcttccc tggacggccg ggtcgtcccg gaacaaatgg cttaaaggga gagaaagggg
     2461 agcctggaga ggccagcctt gggttcagca tgaggggact gcctggcccc cctgggcctc
     2521 caggcccccc aggtcctccc ggagtgcccg tctatgacag caatgcattt gtggagtctg
     2581 gccgacctgg actaccagga cagcaaggtg tgcaggggcc tccaggacca aagggtgaca
     2641 aaggagaggt gggcccaccc gggccaccag ggcagttccc cattgacctc ttccacctgg
     2701 aagccgaaat gaagggggac aagggagacc gaggggatgc tggacggaag ggagagaggg
     2761 gagagcctgg ggctcctggt ggtggattct tcagctcaag tgtacctgga ccacctggcc
     2821 cacctggata ccctggaatt ccgggtccaa aaggagagag cattcggggt ccgcctggcc
     2881 ctcctggccc gcagggacct cctggcattg gatatgaggg gcgccagggc cccccaggac
     2941 ctccaggacc tccaggacct ccctcattcc ctggccctca tagacagact gtcagtgttc
     3001 ctggtcctcc aggcccacct ggccccccag gtcccccagg agccatgggt gcctctgctg
     3061 ggcaggtaag gatctgggct acataccaga ccatgttgga caagatacgt gaggtgccag
     3121 agggctggct catctttgtg gccgagaggg aagagctcta cgtacgggtt agaaatggct
     3181 tccgtaaggt gctgctggag gcccggacag ccctcccgca cgggacggac aacgaggtag
     3241 ctgccttgca acctccattg gtacagcttc atgagggcag ttcatatacc cggagggagc
     3301 actcctatcc cacggcacga ccctggcgag cagatgacat cttggccaac ccaccacgtc
     3361 tgccggaccg ccagccttac ccgggagttc cacaccacca ccaccaccac caccaccacc
     3421 acagttctca tgaacaccgg ccgccagccc acccctcccc ctcacctgcc catactcacc
     3481 aggactttca cccagtgctc cacctggtgg cactgaacac ccctctgtct ggaggcatgc
     3541 gtggtatccg tggggctgac ttccagtgct tccagcaagc ccgagccgtg gggctgtctg
     3601 gcacctttcg ggccttcctg tcctctaggc tgcaggacct ctacagcatt gtacgccgtg
     3661 ctgaccgcag ctctgtgccc atcgtcaacc tgaaggatga ggtactatct cccagctggg
     3721 acaccctgtt ctccggctcc cagggtcaac tgcactctgg ggcccgcatc ttttctttcg
     3781 acggcagaga cgtcctgaga cacccagcct ggccacagaa gagcgtatgg catggctcag
     3841 accccagtgg gcgcaggctg atggagagct actgtgagac gtggaggact gaagctactg
     3901 gggttacagg tcaggcctct tccctgctgt cgggcaggct cctggaacag aaggccgaga
     3961 gctgccacaa cagctatatc gtcctgtgca ttgagaatag cttcatgacc tctttctcca
     4021 aatagggcct ctgccagcta agagggcgga cagaggcgat gcagaacttt gacacagtgc
     4081 agggagcatc cagccagcac ccagggtctg gctaggatac gaccctgtgt agttcacatt
     4141 ttatgtaatc gtcaagaaat aaaaggaagc caaagagtat atttttttaa acatttacag
     4201 tagacttcct gcccttcctc tcctacttga actggctagc ctgtcacggt tcctttttcc
     4261 tccatgcttg gcgggaccat agctggacca tagctgggtc tcggcagaag gctgatgacc
     4321 tagagttact gtctaagacc tgcagacttt gctctagcct ggcgtctttc tgtgcagaca
     4381 cttcacagag cagtcacacg cacgtgctgg ggagagcaca gggcagttca ggctcccctc
     4441 tcaccgtcca gtggctgtgg ccagttgtac aggcgggcac ctgctcatcc atgtggtaac
     4501 tggctctcct catgcttgag gagtgggacc caactctccc gactccccca cttcctgcca
     4561 gagcaggttt ccaagttcac agtgacccca tatctgaccc tgtttcctgt caccgtgggc
     4621 agagaccagg aatgtggcca gattcagcct ggtgctcatt ttttttcctg agggccatac
     4681 acgacatggg gcttgtcact cagagtggct tctctggtga cccctgagat cccatccaga
     4741 gcagaaccca accccagcca agcccaagaa gagccttgtc ctcgctcttc agtctgaagt
     4801 ccgcaaatct ctcagcagcc gcgcaaaggc acttgtcctg tggagggact tgtgtgctca
     4861 gggccacaag tggtcaatca aagccactgt gcctgcctcg ggctctgcgt ccaaggattg
     4921 ggacaatcca atggggctgg ttctgtgaca atgtgtgatc tgaagccatt tcaaagaggc
     4981 accaaataaa aatgaccttt tatacag
//
