LOCUS       NP_001388231            1736 aa            linear   ROD 30-MAR-2024
DEFINITION  collagen alpha-2(XI) chain isoform 1 precursor [Rattus norvegicus].
ACCESSION   NP_001388231 XP_006255990
VERSION     NP_001388231.1
DBSOURCE    REFSEQ: accession NM_001401302.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1736)
  AUTHORS   Lace,B., Kempa,I., Piekuse,L., Grinfelde,I., Klovins,J., Pliss,L.,
            Krumina,A. and Vieira,A.R.
  TITLE     Association studies of candidate genes and cleft lip and palate
            taking into consideration geographical origin
  JOURNAL   Eur J Oral Sci 119 (6), 413-417 (2011)
   PUBMED   22112025
REFERENCE   2  (residues 1 to 1736)
  AUTHORS   Nikopensius,T., Jagomagi,T., Krjutskov,K., Tammekivi,V., Saag,M.,
            Prane,I., Piekuse,L., Akota,I., Barkane,B., Krumina,A.,
            Ambrozaityte,L., Matuleviciene,A., Kucinskiene,Z.A., Lace,B.,
            Kucinskas,V. and Metspalu,A.
  TITLE     Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to
            nonsyndromic cleft palate
  JOURNAL   Birth Defects Res A Clin Mol Teratol 88 (9), 748-756 (2010)
   PUBMED   20672350
REFERENCE   3  (residues 1 to 1736)
  AUTHORS   Fernandes,R.J., Weis,M., Scott,M.A., Seegmiller,R.E. and Eyre,D.R.
  TITLE     Collagen XI chain misassembly in cartilage of the chondrodysplasia
            (cho) mouse
  JOURNAL   Matrix Biol 26 (8), 597-603 (2007)
   PUBMED   17683922
REFERENCE   4  (residues 1 to 1736)
  AUTHORS   Chen,W., Kahrizi,K., Meyer,N.C., Riazalhosseini,Y., Van Camp,G.,
            Najmabadi,H. and Smith,R.J.
  TITLE     Mutation of COL11A2 causes autosomal recessive non-syndromic
            hearing loss at the DFNB53 locus
  JOURNAL   J Med Genet 42 (10), e61 (2005)
   PUBMED   16033917
REFERENCE   5  (residues 1 to 1736)
  AUTHORS   Melkoniemi,M., Koillinen,H., Mannikko,M., Warman,M.L.,
            Pihlajamaa,T., Kaariainen,H., Rautio,J., Hukki,J., Stofko,J.A.,
            Cisneros,G.J., Krakow,D., Cohn,D.H., Kere,J. and Ala-Kokko,L.
  TITLE     Collagen XI sequence variations in nonsyndromic cleft palate, Robin
            sequence and micrognathia
  JOURNAL   Eur J Hum Genet 11 (3), 265-270 (2003)
   PUBMED   12673280
REFERENCE   6  (residues 1 to 1736)
  AUTHORS   Melkoniemi,M., Brunner,H.G., Manouvrier,S., Hennekam,R.,
            Superti-Furga,A., Kaariainen,H., Pauli,R.M., van Essen,T.,
            Warman,M.L., Bonaventure,J., Miny,P. and Ala-Kokko,L.
  TITLE     Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is
            associated with loss-of-function mutations in the COL11A2 gene
  JOURNAL   Am J Hum Genet 66 (2), 368-377 (2000)
   PUBMED   10677296
REFERENCE   7  (residues 1 to 1736)
  AUTHORS   McGuirt,W.T., Prasad,S.D., Griffith,A.J., Kunst,H.P., Green,G.E.,
            Shpargel,K.B., Runge,C., Huybrechts,C., Mueller,R.F., Lynch,E.,
            King,M.C., Brunner,H.G., Cremers,C.W., Takanosu,M., Li,S.W.,
            Arita,M., Mayne,R., Prockop,D.J., Van Camp,G. and Smith,R.J.
  TITLE     Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13)
  JOURNAL   Nat Genet 23 (4), 413-419 (1999)
   PUBMED   10581026
REFERENCE   8  (residues 1 to 1736)
  AUTHORS   van Steensel,M.A., Buma,P., de Waal Malefijt,M.C., van den
            Hoogen,F.H. and Brunner,H.G.
  TITLE     Oto- spondylo-megaepiphyseal dysplasia (OSMED): clinical
            description of three patients homozygous for a missense mutation in
            the COL11A2 gene
  JOURNAL   Am J Med Genet 70 (3), 315-323 (1997)
   PUBMED   9188673
REFERENCE   9  (residues 1 to 1736)
  AUTHORS   Walter,L., Fischer,K. and Gunther,E.
  TITLE     Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and
            RT1.Hb genes in the rat major histocompatibility complex
  JOURNAL   Immunogenetics 44 (3), 218-221 (1996)
   PUBMED   8662089
REFERENCE   10 (residues 1 to 1736)
  AUTHORS   Vikkula,M., Mariman,E.C., Lui,V.C., Zhidkova,N.I., Tiller,G.E.,
            Goldring,M.B., van Beersum,S.E., de Waal Malefijt,M.C., van den
            Hoogen,F.H., Ropers,H.H. et al.
  TITLE     Autosomal dominant and recessive osteochondrodysplasias associated
            with the COL11A2 locus
  JOURNAL   Cell 80 (3), 431-437 (1995)
   PUBMED   7859284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 8, 2022 this sequence version replaced XP_006255990.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..1736
                     /product="collagen alpha-2(XI) chain isoform 1 precursor"
                     /note="procollagen, type XI, alpha 2; type XI collagen
                     alpha2 chain; collagen alpha-2(XI) chain-like; collagen,
                     type XI, alpha 2"
                     /calculated_mol_wt=168764
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2977
     Region          32..213
                     /region_name="TSPN"
                     /note="Thrombospondin N-terminal -like domains;
                     smart00210"
                     /db_xref="CDD:214560"
     Region          <377..>592
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          <508..>774
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          <754..>1003
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          <900..>1168
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          <1222..>1444
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          <1408..>1505
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          1540..1735
                     /region_name="COLFI"
                     /note="Fibrillar collagens C-terminal domain; smart00038"
                     /db_xref="CDD:197483"
     CDS             1..1736
                     /gene="Col11a2"
                     /coded_by="NM_001401302.1:178..5388"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:294279"
                     /db_xref="RGD:2373"
ORIGIN      
        1 mercsrchrl llllplvlgl saapgwagap svdvlralrf pslpdgvrks kgvcpadvay
       61 rvarpaqlsa ptrqlfpggf pkdfslltvv rtrsglqapl ltlysaqgvq qlglelgrpv
      121 rflyedqrgr pqasaqpifr glsladgkwh hvavavkgqs vtlivdckkr vtrplprsvh
      181 pvldthgvvi fgahvlddev fegdvqelli vpgvqaayqs cgqkdlecer eqrdgpqtqk
      241 phraqrspkk eparlhkpqn qepqqqptes lyydyeppyy dvmttetspd yqyptpgeee
      301 gvlessllps leeeqtdlqv pptadsfqae eygeggtepp agfydytygy gddyreetel
      361 gpalsaetdh tgavahgprg lkgekgepav lepgmfvegp pgpegpagla gppgiqgnpg
      421 pvgdpgergp pgraglpgsd gppgppgtsl mlpfrfgssg gdkgpvvaaq eaqaqailqq
      481 arlalrgppg pmgytgrpgp lgqpgspglk gesgdlgpqg prgpqgltgp pgkagrrgra
      541 gadgargmpg epgvkgdrgf dglpglpgek gqrgdtgaqg lpgppgedge rgddgeigpr
      601 glpgesgprg llgpkgppgi pgppgvrgmd gphgpkgslg pqgepgppgq qgtpgtqglp
      661 gpqgaigphg ekgprgkpgl pgmpgsdglp ghpgkegppg tkgnqgpsgp qgplgypgpr
      721 gvkgvdgirg lkghkgekge dgfpgfkgdi gvkgdrgevg vpgsrgedgp egpkgrtgpt
      781 gdpgptglmg ekgklgvpgl pgypgrqgpk gslgfpgfpg asgekgargl sgksgprger
      841 gptgprgqrg prgatgksga kgtsggdgph gppgerglpg pqgpngfpgp kgppgpagkd
      901 glpghpgqrg evgfqgktgp pgppgvvgpq gaagesgpmg erghpgppgp pgeqglpgta
      961 gkdgtkgdpg ppgapgkdgp aglrgfpger glpgtaggpg lkgnegpagp pgpagspger
     1021 gaagsggpig ppgrpgpqgp pgaagekgvp gekgpigptg rdgvqgpvgl pgpagppgva
     1081 gedgdkgevg dpgqkgtkgn kgehgppgpp gpigpvgqpg aagadgepga rgpqghfgak
     1141 gdegtrgfng ppgpiglqgl pgpfgekget gdvgpmgppg ppgprgpagp ngadgpqgpp
     1201 ggvgnlgppg ekgepgesgs pgvqgepgvk gprgergekg esgqageagp pgpkgptgdd
     1261 gpkgnpgpvg fpgdpgppge agprgqdgak gsqgedgepg qpgspgptge ngppgplgkr
     1321 gpagtpgpeg rqgekgakgd pgavgapgkt gpvgpagpag kpgpdglrgl pgsvgqqgrp
     1381 gatgqagppg pvgppglpgl rgdagakgek ghpgliglig ptgeqgekgd rglpgpqgsp
     1441 gqkgetgipg asgpigpggp pglpgpsgpk gakgatgpag pkgekgvqgp pghpgppgev
     1501 iqplpiqmpk ktrrsvdgsk lmqdeeatpt ggapgspagl eeifgsldsl reeieqmrrp
     1561 tgtqdspart cqdlklchpe lpdgeywvdp nqgcardafr vfcnftagge tcvtprddvt
     1621 qfsyvdsegs pvgvvqltfl rllsvsahqd vsypcsgvsq dgplklrgan edelspetsp
     1681 yvkefrdgcq tqqgrtvlev rtpvleqlpv ldasfsdlga ptrrggvllg pvcfmg
//
