LOCUS       NM_013117               7673 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus collagen type XI alpha 1 chain (Col11a1), mRNA.
ACCESSION   NM_013117 XM_002726064 XM_002729104
VERSION     NM_013117.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7673)
  AUTHORS   Katayama,K., Kuriki,M., Kamiya,T., Tochigi,Y. and Suzuki,H.
  TITLE     Giantin is required for coordinated production of aggrecan, link
            protein and type XI collagen during chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 499 (3), 459-465 (2018)
   PUBMED   29577904
  REMARK    GeneRIF: giantin plays a pivotal role in coordinated production of
            aggrecan, link protein and type XI collagen in chondrocytes.
REFERENCE   2  (bases 1 to 7673)
  AUTHORS   Hering,T.M., Wirthlin,L., Ravindran,S. and McAlinden,A.
  TITLE     Changes in type II procollagen isoform expression during
            chondrogenesis by disruption of an alternative 5' splice site
            within Col2a1 exon 2
  JOURNAL   Matrix Biol 36, 51-63 (2014)
   PUBMED   24735995
REFERENCE   3  (bases 1 to 7673)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 7673)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   5  (bases 1 to 7673)
  AUTHORS   Wenstrup,R.J., Smith,S.M., Florer,J.B., Zhang,G., Beason,D.P.,
            Seegmiller,R.E., Soslowsky,L.J. and Birk,D.E.
  TITLE     Regulation of collagen fibril nucleation and initial fibril
            assembly involves coordinate interactions with collagens V and XI
            in developing tendon
  JOURNAL   J Biol Chem 286 (23), 20455-20465 (2011)
   PUBMED   21467034
REFERENCE   6  (bases 1 to 7673)
  AUTHORS   Cho,H., Yamada,Y. and Yoo,T.J.
  TITLE     Ultrastructural changes of cochlea in mice with hereditary
            chondrodysplasia (cho/cho)
  JOURNAL   Ann N Y Acad Sci 630, 259-261 (1991)
   PUBMED   1952599
REFERENCE   7  (bases 1 to 7673)
  AUTHORS   Seegmiller,R.E., Brown,K. and Chandrasekhar,S.
  TITLE     Histochemical, immunofluorescence, and ultrastructural differences
            in fetal cartilage among three genetically distinct
            chondrodystrophic mice
  JOURNAL   Teratology 38 (6), 579-592 (1988)
   PUBMED   3070812
REFERENCE   8  (bases 1 to 7673)
  AUTHORS   Bernard,M., Yoshioka,H., Rodriguez,E., Van der Rest,M., Kimura,T.,
            Ninomiya,Y., Olsen,B.R. and Ramirez,F.
  TITLE     Cloning and sequencing of pro-alpha 1 (XI) collagen cDNA
            demonstrates that type XI belongs to the fibrillar class of
            collagens and reveals that the expression of the gene is not
            restricted to cartilagenous tissue
  JOURNAL   J Biol Chem 263 (32), 17159-17166 (1988)
   PUBMED   3182841
REFERENCE   9  (bases 1 to 7673)
  AUTHORS   Seegmiller,R.E. and Fraser,F.C.
  TITLE     Mandibular growth retardation as a cause of cleft palate in mice
            homozygous for the chondrodysplasia gene
  JOURNAL   J Embryol Exp Morphol 38, 227-238 (1977)
   PUBMED   886247
REFERENCE   10 (bases 1 to 7673)
  AUTHORS   Seegmiller,R., Fraser,F.C. and Sheldon,H.
  TITLE     A new chondrodystrophic mutant in mice. Electron microscopy of
            normal and abnormal chondrogenesis
  JOURNAL   J Cell Biol 48 (3), 580-593 (1971)
   PUBMED   4100752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_002726064.2, XM_002729104.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.9843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               JAXUCZ010000002.1  204509136-204509590
            456-623             JAXUCZ010000002.1  204533752-204533919
            624-837             JAXUCZ010000002.1  204540470-204540683
            838-1000            JAXUCZ010000002.1  204546100-204546262
            1001-1126           JAXUCZ010000002.1  204570159-204570284
            1127-1243           JAXUCZ010000002.1  204576834-204576950
            1244-1336           JAXUCZ010000002.1  204577519-204577611
            1337-1591           JAXUCZ010000002.1  204579354-204579608
            1592-1654           JAXUCZ010000002.1  204580199-204580261
            1655-1696           JAXUCZ010000002.1  204581406-204581447
            1697-1759           JAXUCZ010000002.1  204582068-204582130
            1760-1834           JAXUCZ010000002.1  204584039-204584113
            1835-1918           JAXUCZ010000002.1  204585092-204585175
            1919-1975           JAXUCZ010000002.1  204587960-204588016
            1976-2029           JAXUCZ010000002.1  204590857-204590910
            2030-2083           JAXUCZ010000002.1  204593917-204593970
            2084-2137           JAXUCZ010000002.1  204594075-204594128
            2138-2191           JAXUCZ010000002.1  204594290-204594343
            2192-2245           JAXUCZ010000002.1  204595515-204595568
            2246-2290           JAXUCZ010000002.1  204595683-204595727
            2291-2344           JAXUCZ010000002.1  204596549-204596602
            2345-2389           JAXUCZ010000002.1  204597095-204597139
            2390-2443           JAXUCZ010000002.1  204597332-204597385
            2444-2488           JAXUCZ010000002.1  204597894-204597938
            2489-2542           JAXUCZ010000002.1  204602957-204603010
            2543-2587           JAXUCZ010000002.1  204605209-204605253
            2588-2641           JAXUCZ010000002.1  204605600-204605653
            2642-2686           JAXUCZ010000002.1  204605734-204605778
            2687-2740           JAXUCZ010000002.1  204611650-204611703
            2741-2848           JAXUCZ010000002.1  204613728-204613835
            2849-2902           JAXUCZ010000002.1  204616608-204616661
            2903-2956           JAXUCZ010000002.1  204624978-204625031
            2957-3001           JAXUCZ010000002.1  204625155-204625199
            3002-3055           JAXUCZ010000002.1  204625308-204625361
            3056-3100           JAXUCZ010000002.1  204625476-204625520
            3101-3154           JAXUCZ010000002.1  204630146-204630199
            3155-3208           JAXUCZ010000002.1  204634251-204634304
            3209-3262           JAXUCZ010000002.1  204640283-204640336
            3263-3370           JAXUCZ010000002.1  204641483-204641590
            3371-3460           JAXUCZ010000002.1  204641981-204642070
            3461-3514           JAXUCZ010000002.1  204642328-204642381
            3515-3622           JAXUCZ010000002.1  204648443-204648550
            3623-3730           JAXUCZ010000002.1  204653627-204653734
            3731-3784           JAXUCZ010000002.1  204654526-204654579
            3785-3838           JAXUCZ010000002.1  204656209-204656262
            3839-3946           JAXUCZ010000002.1  204656673-204656780
            3947-4000           JAXUCZ010000002.1  204663217-204663270
            4001-4054           JAXUCZ010000002.1  204665143-204665196
            4055-4108           JAXUCZ010000002.1  204666402-204666455
            4109-4162           JAXUCZ010000002.1  204668650-204668703
            4163-4270           JAXUCZ010000002.1  204669394-204669501
            4271-4324           JAXUCZ010000002.1  204669781-204669834
            4325-4378           JAXUCZ010000002.1  204670378-204670431
            4379-4432           JAXUCZ010000002.1  204671557-204671610
            4433-4486           JAXUCZ010000002.1  204675031-204675084
            4487-4594           JAXUCZ010000002.1  204675208-204675315
            4595-4648           JAXUCZ010000002.1  204675859-204675912
            4649-4702           JAXUCZ010000002.1  204684907-204684960
            4703-4810           JAXUCZ010000002.1  204685791-204685898
            4811-4864           JAXUCZ010000002.1  204688146-204688199
            4865-4900           JAXUCZ010000002.1  204688299-204688334
            4901-4954           JAXUCZ010000002.1  204688428-204688481
            4955-5204           JAXUCZ010000002.1  204689818-204690067
            5205-5317           JAXUCZ010000002.1  204695151-204695263
            5318-5386           JAXUCZ010000002.1  204696666-204696734
            5387-5620           JAXUCZ010000002.1  204698507-204698740
            5621-7673           JAXUCZ010000002.1  204700212-204702264
FEATURES             Location/Qualifiers
     source          1..7673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..7673
                     /gene="Col11a1"
                     /note="collagen type XI alpha 1 chain"
                     /db_xref="GeneID:25654"
                     /db_xref="RGD:2372"
     exon            1..455
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..5767
                     /gene="Col11a1"
                     /note="procollagen type XI alpha 1; collagen alpha-1(XI)
                     chain; collagen type a1(XI)6B-7; collagen type
                     a1(XI)6A-7-8; collagen, type XI, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XI) chain precursor"
                     /protein_id="NP_037249.1"
                     /db_xref="GeneID:25654"
                     /db_xref="RGD:2372"
                     /translation="MEPWSRWKTKRWIWDLTISTLVLTFLFQAREVRGAAPVDILKAL
                     DFHNSPVGISKTTGFCTSRKNSKDPDIAYRVTEEAQISAPTKQLFPGGIFPQDFSILF
                     TIKPKKGTQAFLLSLYNEHGIQQLGVEVGRSPVFLFEDHTGKPTPENYPLFSTVNIAD
                     GKWHRVAISVEKKTVTMIVDCKKKITKPLDRSERSIVDTNGIMVFGTRILETDVFQGD
                     IQQFLITGDPKAAYDYCDHYSPDCDLTSKAAQAQEPHIDEYAPEDIIEYDYEYGETDY
                     KEAESVTEMPTVTEETVAQTEANIVDDFQDYNYGTMETYQTESPRRVSGSNEPNPVEE
                     GFTEEYLTGEDYDVQRNISEDILYGNKGIDGRDSDLLVDGDLGEYDFYEYKEYEERTT
                     TSPNEEFGPGVPAETDFTETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGL
                     MGPPGLQGPSGLPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTIS
                     AQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSAGAKGESGDPGPQGPRGVQG
                     PPGPTGKPGKRGRPGADGGRGMPGEPGSKGDRGFDGLPGLPGDKGHRGERGPQGPPGL
                     PGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPPGQPGIGGIDGPQGPKGNMGPQ
                     GEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSG
                     EKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGE
                     VGQVGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFP
                     GFPGANGEKGARGIAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPG
                     ERGPQGPQGPVGFPGPKGPPGPAGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGP
                     TGETGPIGERGHPGTPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGIRGFPGER
                     GLPGAQGAPGLKGGEGPQGPQGPIGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKG
                     APGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGP
                     PGPPGLQGPVGAPGIAGGDGEAGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPP
                     GEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPG
                     PPGEAGSGGPKGERGEKGEAGPPGAAGPPGIKGPPGDDGPKGNPGPVGFPGDPGPPGE
                     PGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGASGSEGRQGEKGAK
                     GEAGAEGPPGKTGPVGPQGPSGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPG
                     LPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGP
                     IGPPGPPGLPGPAGPKGNKGSSGPTGQKGDSGMPGPPGPPGPPGEVIQPLPILSPKKT
                     RRHTESIQADAGDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQL
                     SHPDFPDGEYWIDPNQGCSGDSFKVYCNFTAGGETCIYPDKKSEGVRLSSWPKEKPGS
                     WYSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYNCHQSTAWYDVLSGSY
                     DKALRFLGSNDEEMSYENNPHIKALYDGCASRKGYEKTVIEINTPKIDQVPIIDVMIN
                     DFGDQNQKFGFEVGPACFLG"
     exon            456..623
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..837
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1000
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1126
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1243
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1336
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1591
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1654
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1696
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1759
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1834
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1918
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1975
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2029
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2083
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2137
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2191
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2245
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2290
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2344
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2389
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2443
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2488
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2542
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2587
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2641
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2686
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2740
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2848
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2902
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..2956
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3001
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3055
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3100
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3154
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3208
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3262
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3370
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3460
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3514
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3622
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3730
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3784
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3838
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3946
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4000
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4054
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4108
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4162
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4270
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4324
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4378
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4432
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4486
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4594
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4648
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..4702
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4703..4810
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4811..4864
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..4900
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..4954
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5204
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5317
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5386
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5620
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5621..7673
                     /gene="Col11a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagcctct tgtccagccc acccacagca tgaagccttt agtggtgctc agtgctttca
       61 gctttttttc ttgaaaccct tcatctaccc tcagtctgaa ggcagggtca ggcgtaggac
      121 gggtctcagg gtcgcagtct tctgcgggcc accccagagg gagaggaggg ggcgagagac
      181 aggaaggaag caaaccatca aattgaaaaa aaaatagagc cctttgactt tttttcactc
      241 cctctccctt ccggatggct gtgtagcaaa cgtaggcgac accttggaag ggacgaagtt
      301 ggtctgcact ggcaatttcg tgggttcaca gttgtgagcg ccgggcttgg agatggagcc
      361 ctggtccagg tggaaaacga aacggtggat ctgggatctc accatctcaa ccctcgtctt
      421 gacttttctc ttccaagcca gagaggtcag aggagctgct ccagttgata tactgaaagc
      481 attagatttt cacaattctc cagtgggaat atctaaaaca acaggatttt gcacaagcag
      541 aaagaattct aaagatccag atatcgctta tagagttacc gaggaagccc agatcagtgc
      601 cccaacgaag cagttatttc caggaggaat ttttccgcaa gatttttcaa tactatttac
      661 aataaaaccc aaaaaaggaa ctcaagcttt cctcttgtct ctctacaatg aacatggcat
      721 tcagcaactc ggtgttgagg ttgggagatc acctgttttt ctatttgaag accacactgg
      781 aaaacccaca ccagaaaact atcctctctt ctcaacagtt aacattgctg atggaaagtg
      841 gcaccgggta gcaatcagtg tggagaagaa aactgtgaca atgattgtcg attgtaagaa
      901 gaaaatcaca aaacccctcg atagaagcga gagatcgata gtcgatacca acggaatcat
      961 ggtatttgga acaagaattt tagaaacaga tgttttccag ggtgatattc agcagttcct
     1021 gatcactggt gaccccaagg cagcatatga ctactgtgac cattacagtc ccgactgtga
     1081 cttaacatcc aaggccgctc aggcccagga gccgcacata gatgagtatg cacctgagga
     1141 tataatcgag tatgactatg aatatgggga gacagactat aaagaggctg agagtgtaac
     1201 agagatgccc actgtcactg aagaaacagt agcacaaact gaggcaaata ttgtggatga
     1261 ctttcaagac tataactatg gaacgatgga aacttaccag actgagtctc ctcggcgggt
     1321 atcaggatca aatgagccaa atccagttga agaaggtttt actgaagaat atctaaccgg
     1381 agaggattat gatgtccaga gaaacatttc cgaggatatt ctgtatggaa acaaaggaat
     1441 agacggcagg gattctgatc tgctggtaga tggagattta ggtgaatatg atttttatga
     1501 atacaaagaa tatgaagaaa ggactacgac ctcccctaat gaagaatttg gcccaggtgt
     1561 cccagcagaa actgatttca cagaaacaag catcaatggc catggcgcat atggagagaa
     1621 agggcagaag ggggaacctg ctgtagttga acccggaatg cttgttgaag gaccacctgg
     1681 gccagctgga ccagcgggtc ttatgggtcc tccaggacta caaggtcctt ctgggctccc
     1741 cggcgaccct ggtgataggg gcccaccagg acgccctggc ttaccagggg ctgatggctt
     1801 acccggtcct ccaggaacca tgttaatgtt accattccgc tatgggggtg acggctccaa
     1861 aggaccaacc atctctgcgc aggaagccca ggctcaggcg attcttcagc aggctcggat
     1921 tgctctgaga ggccctcctg gcccaatggg tcttaccgga agaccaggtc ctgtgggggg
     1981 tcctggttca gctggagcca aaggtgagag tggggatcca ggtcctcagg gtcctcgagg
     2041 tgtccaaggt cctcctggtc caaccggaaa acctggaaag aggggccgtc caggtgccga
     2101 tggaggaaga ggcatgccag gagaacctgg gtctaaggga gaccgagggt ttgatggact
     2161 tccaggtctg ccaggtgaca aaggtcacag gggggaaaga ggtccacaag gtccacctgg
     2221 cctccccggc gatgatggaa tgaggggaga agatggagag atcgggccca ggggtcttcc
     2281 aggggaagct ggtccacgag gcttgctggg accaaggggc actccaggac ctcctgggca
     2341 gcctggtatt ggaggtatag atggccccca aggaccaaaa ggaaacatgg gtcctcaagg
     2401 ggagcctgga ccaccaggtc agcaaggaaa tccaggacct caaggacttc ctggtccaca
     2461 aggcccaatt ggtcctcctg gagaaaaagg accacaagga aaaccagggc ttgcaggact
     2521 tcctggtgcc gatggacctc ctggtcatcc tgggaaagaa ggccagtctg gagaaaaggg
     2581 tgccctgggt cctcctggtc ctcagggacc tattggctat cccggtcccc gtggagtaaa
     2641 gggagcagat ggtgtcagag gtctcaaggg ctctaaagga gaaaagggtg aagatggctt
     2701 tccaggattc aaaggtgaca tgggtcttaa aggtgacaga ggcgaagtgg gtcaagttgg
     2761 tccaagagga gaagatggcc ctgaaggccc caaaggccgt gcaggcccaa ctggagaccc
     2821 aggtccctct ggccaagcag gagagaaggg aaaacttggg gttccaggat tgccaggata
     2881 tccaggaaga caaggtccaa agggatccac tggatttcct ggatttccag gtgccaacgg
     2941 ggagaaaggt gcccggggaa ttgctggcaa accaggcccc cgaggacaac gtggtccaac
     3001 gggtcctcga ggttccagag gcgccagagg tcccacagga aaacctgggc cgaagggtac
     3061 atcaggtggt gatggccctc ctggcccacc aggcgaaagg ggccctcaag gacctcaagg
     3121 tccagttgga ttccctggac caaaaggccc ccctggccct gctgggaaag atgggctacc
     3181 aggacaccct ggacaacgtg gagagactgg atttcaagga aagaccggtc cccctgggcc
     3241 aggaggtgtg gtaggaccac agggaccaac tggtgagact ggcccgatag gtgaacgtgg
     3301 gcatcctggc actcctggtc ctccgggcga gcaaggactt cctggtgctg cagggaaaga
     3361 aggtgcaaag ggtgatcctg gtcctcaagg tatctcaggg aaagatggac cagcaggaat
     3421 ccgtggtttc ccaggtgaaa gaggccttcc tggagcccag ggcgcacctg ggttgaaagg
     3481 aggagaaggt ccccaaggcc cgcagggtcc aattggctct cctggagagc gaggctctgc
     3541 aggcacagca ggcccaattg gtttgccagg acgtccaggc cctcagggcc ctcctggtcc
     3601 agctggagaa aaaggtgctc cgggagaaaa gggtcctcag gggcctgcag gtagagatgg
     3661 ggtccaaggc cctgtgggtc tcccagggcc tgctggtcct gctggctctc ctggagaaga
     3721 tggagacaag ggtgaaattg gtgaaccagg ccaaaagggc agcaaaggtg acaaaggcga
     3781 aaatggtcct cctggtcccc cgggtcttca aggccctgtt ggtgctcctg gaattgctgg
     3841 aggagatggt gaggcaggtc cccgaggaca gcagggaatg tttggacaaa aaggtgatga
     3901 gggtgcacga ggtttcccag gacctcctgg gcccataggt cttcaggggt tgccaggccc
     3961 accaggtgaa aagggcgaaa acggagacgt tggccctatg ggtccaccag gtcctcctgg
     4021 cccacgaggc cctcaaggtc ccaatggagc tgatggacca caaggacccc caggctctat
     4081 tggttcagtt ggtggtgtgg gagaaaaggg tgaaccagga gaagcaggga acccaggacc
     4141 ccctggagaa gccggatcag gtggtcccaa aggagagaga ggagagaaag gagaagctgg
     4201 gccccctggt gctgcgggtc ctcctggtat taaggggcca ccaggtgatg atggacccaa
     4261 ggggaatccg ggacctgttg ggtttcctgg agatcctggt ccacctggag aacctggtcc
     4321 tgcagggcaa gatggtgttg gaggtgacaa gggtgaagat ggagatccag gacaaccagg
     4381 tccccctggt ccatccggtg aagctggccc tccaggtcca cctggaaaga gaggtccgcc
     4441 tggagcttcc ggttccgaag gaaggcaagg agagaaaggt gctaagggag aagctggagc
     4501 tgaaggacct cctgggaaaa ctggcccggt cggacctcag ggtccttctg gaaagcctgg
     4561 tccagaaggt cttcgaggca tccctggtcc tgtgggagaa caaggtctcc ccggtgctgc
     4621 tggccaagat ggaccccctg gtcctctggg acctcctggt ttacctggtc tcaaaggtga
     4681 tcctggctcc aagggtgaaa agggacatcc tggtttaatt ggattgattg gccctccagg
     4741 agaacaaggg gaaaagggtg acagaggact tcctgggact caaggttctc caggagccaa
     4801 aggtgatggg ggcatcccag gtcctgctgg tcccataggt cctcctggtc ctccaggatt
     4861 accaggtcct gctggtccga agggtaacaa aggatcttct ggacctactg gccagaaggg
     4921 tgacagtggt atgccaggac ctcctgggcc tccaggtcct cctggagaag tcatacagcc
     4981 attacctatt ttgtcaccga agaaaacaag aagacacact gaaagcatcc aggccgacgc
     5041 aggtgataat attcttgact actcagatgg catggaggaa atatttggtt ccctcaattc
     5101 tctgaaacaa gacattgaac acatgaagtt tcccatgggt acacagacca acccagcacg
     5161 aacatgcaaa gacctgcagc tcagccaccc cgacttccca gatggtgaat attggattga
     5221 tcctaaccaa ggctgctcag gtgattcctt caaagtttac tgtaatttca cagctggtgg
     5281 tgagacgtgc atctatccag acaaaaaatc tgagggagta agactttcat cttggccgaa
     5341 ggagaaacca ggaagttggt acagtgaatt taagagagga aaactgcttt cctatttaga
     5401 tgtggaaggc aattccatca atatggtaca aatgacattc ctgaaactcc tgactgcctc
     5461 tgccagacaa aacttcacct acaattgcca ccagtcaact gcttggtatg acgtcttatc
     5521 aggaagttat gacaaagcac ttcggtttct gggatctaat gatgaggaaa tgtcctacga
     5581 gaacaaccca cacatcaaag ctttgtatga cggctgtgcg tcccgaaaag gctatgaaaa
     5641 gacagtgatt gagatcaata ctccgaaaat tgatcaagta cccatcattg atgtaatgat
     5701 caatgatttt ggtgatcaga atcagaagtt tggatttgaa gttggtccag cttgctttct
     5761 tggctaagat taggatgaag accatatgaa accaacagaa aaaatacctt ggtgccgcca
     5821 atccatttta tgccacatgc aagttttgaa taaggacggt ataggaaacc tgtttaggaa
     5881 tcactgatgc ctgacggagg cacagtccaa ggaaagaagt tctggtagtc ataaccatgt
     5941 aaggtagtgg ctgagatggc aacagggctc attcttgatt ctcaaccctc atctctcctt
     6001 ttcctatttg gattttgttg gtgctgtaga aaacaaaaag agagaaaata tatattcgta
     6061 aaaaaaaatg gtgctcattc ccatccatca aagatatagt aaaagtgtct ttaataaatt
     6121 gtaattattt tatgtacagt tctacactgt cttccctgtg tccatttcca aaacttgcac
     6181 gtgactctga atcccaccta tctcgaattt tgtgacagtt gtgcaactgt gatgacaata
     6241 aatattgtga tacaaaatct caagttgtat ttctgcagac tctaattgcc tttctttgat
     6301 tgataataaa atgcctttgt atgtgttgat gttgaagagt tcagttattt gatgtcattg
     6361 acgaatttca cagtggtcaa acccagacac gcccatcatc cctgttctgc taagagtaac
     6421 tttttgagtt tcagcaagaa atgtcacgca ttttaaaaat taattaagtg ctatacctcg
     6481 aaaattttct tctcagaacc cagacttcac caaatacttg tatatatgga aaacaagaaa
     6541 atttatattt ttggacagga aagtatgtat gagaaactgt ttttaacatc cacccaggaa
     6601 ttaagttttt gtacaattat ttctctacct aatctttcat tgccttcagt gtgcttcagt
     6661 aatgcaaact gatattaaag atggaaaata agcaattgtt tatgaatttg tgcaatgtta
     6721 ggtttttaac aatggacttt taaaatctga tacaagtggc atagtccaaa atattatttt
     6781 acttgcccaa tgaatacagt tcctttattt taaagtaatt attttcaaca tctgaccaac
     6841 ctagtagcta aatacatagg gtggactgtt tcaaaagtca tatttgctca agacaatcaa
     6901 ttcctctctt tttttccact aaggtatttt tctttaacat accttggagt agcaataaaa
     6961 ttttaaaatc accaactgaa ttttgtatct attttaagta atatatgtaa gacttgaaaa
     7021 taaatgtttt attataattt cttatatgaa gtgttaaatt aattgatacc agataccact
     7081 ggaacattta tcaactgata atttatctca aagaacataa tctgtaatct tgacatttaa
     7141 aagtgaacat ttgtaattcg gaatttcttt atttctgaaa ccaagtttgt aaatgtcctt
     7201 tggaggaagg agatatgaat tttatcaata aatcaagtct tgtctacctg gattggtcat
     7261 tttctttctt aagcaggttg caattcactc ttatctacaa aaagactttt gattgtcaca
     7321 cttgaccatc cagaagaaaa atctataacc cttgcatgtt aaccttcaaa gataagttct
     7381 caaatatagt tgatgatggc atacatttcc aaaaaaatga taacttatat ttagcatttc
     7441 aaaatggcct ttacaggtaa atattttaca aagtctcata caggttcatg acttcaaaac
     7501 taaaaatatt tcccagcaaa ttattaattc tttaaatcat aatgagataa tgttagttta
     7561 ggaagaaagt tttcatagaa cagttaaatt acatgcatta aagaaagaat atgttgtata
     7621 ttaacttatg ccaaagtagt tgtcttttta atgaaataaa tttgatagct aag
//
