LOCUS       NM_001401101            5626 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cordon-bleu WH2 repeat protein (Cobl), transcript
            variant 1, mRNA.
ACCESSION   NM_001401101 XM_039092056
VERSION     NM_001401101.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5626)
  AUTHORS   Izadi,M., Seemann,E., Schlobinski,D., Schwintzer,L., Qualmann,B.
            and Kessels,M.M.
  TITLE     Functional interdependence of the actin nucleator Cobl and
            Cobl-like in dendritic arbor development
  JOURNAL   Elife 10, e67718 (2021)
   PUBMED   34264190
  REMARK    GeneRIF: Functional interdependence of the actin nucleator Cobl and
            Cobl-like in dendritic arbor development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5626)
  AUTHORS   Mahuzier,A., Shihavuddin,A., Fournier,C., Lansade,P., Faucourt,M.,
            Menezes,N., Meunier,A., Garfa-Traore,M., Carlier,M.F.,
            Voituriez,R., Genovesio,A., Spassky,N. and Delgehyr,N.
  TITLE     Ependymal cilia beating induces an actin network to protect
            centrioles against shear stress
  JOURNAL   Nat Commun 9 (1), 2279 (2018)
   PUBMED   29891944
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5626)
  AUTHORS   Hou,W., Izadi,M., Nemitz,S., Haag,N., Kessels,M.M. and Qualmann,B.
  TITLE     The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin
  JOURNAL   PLoS Biol 13 (9), e1002233 (2015)
   PUBMED   26334624
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5626)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   5  (bases 1 to 5626)
  AUTHORS   Schwintzer,L., Koch,N., Ahuja,R., Grimm,J., Kessels,M.M. and
            Qualmann,B.
  TITLE     The functions of the actin nucleator Cobl in cellular morphogenesis
            critically depend on syndapin I
  JOURNAL   EMBO J 30 (15), 3147-3159 (2011)
   PUBMED   21725280
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5626)
  AUTHORS   Ahuja,R., Pinyol,R., Reichenbach,N., Custer,L., Klingensmith,J.,
            Kessels,M.M. and Qualmann,B.
  TITLE     Cordon-bleu is an actin nucleation factor and controls neuronal
            morphology
  JOURNAL   Cell 131 (2), 337-350 (2007)
   PUBMED   17956734
  REMARK    GeneRIF: Cobl is an actin nucleator controlling neuronal morphology
            and development.
REFERENCE   7  (bases 1 to 5626)
  AUTHORS   Carroll,E.A., Gerrelli,D., Gasca,S., Berg,E., Beier,D.R., Copp,A.J.
            and Klingensmith,J.
  TITLE     Cordon-bleu is a conserved gene involved in neural tube formation
  JOURNAL   Dev Biol 262 (1), 16-31 (2003)
   PUBMED   14512015
REFERENCE   8  (bases 1 to 5626)
  AUTHORS   Gasca,S., Hill,D.P., Klingensmith,J. and Rossant,J.
  TITLE     Characterization of a gene trap insertion into a novel gene,
            cordon-bleu, expressed in axial structures of the gastrulating
            mouse embryo
  JOURNAL   Dev Genet 17 (2), 141-154 (1995)
   PUBMED   7586755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 2, 2022 this sequence version replaced XM_039092056.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.30841.1,
                                           SRR26643299.55587.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000014.1  91273934-91274201   c
            269-472             JAXUCZ010000014.1  91192907-91193110   c
            473-683             JAXUCZ010000014.1  91184256-91184466   c
            684-912             JAXUCZ010000014.1  91182133-91182361   c
            913-1010            JAXUCZ010000014.1  91176099-91176196   c
            1011-1085           JAXUCZ010000014.1  91171856-91171930   c
            1086-1259           JAXUCZ010000014.1  91150102-91150275   c
            1260-1398           JAXUCZ010000014.1  91116494-91116632   c
            1399-1569           JAXUCZ010000014.1  91113854-91114024   c
            1570-1879           JAXUCZ010000014.1  91077554-91077863   c
            1880-1977           JAXUCZ010000014.1  91067432-91067529   c
            1978-3854           JAXUCZ010000014.1  91064153-91066029   c
            3855-3974           JAXUCZ010000014.1  91062148-91062267   c
            3975-4238           JAXUCZ010000014.1  91060777-91061040   c
            4239-5626           JAXUCZ010000014.1  91041721-91043108   c
FEATURES             Location/Qualifiers
     source          1..5626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5626
                     /gene="Cobl"
                     /note="cordon-bleu WH2 repeat protein"
                     /db_xref="GeneID:305497"
                     /db_xref="RGD:1312002"
     exon            1..268
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..4256
                     /gene="Cobl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein cordon-bleu; cordon-bleu homolog"
                     /codon_start=1
                     /product="protein cordon-bleu isoform 1"
                     /protein_id="NP_001388030.1"
                     /db_xref="GeneID:305497"
                     /db_xref="RGD:1312002"
                     /translation="MDAPRALAAKPPTGRKMKARAPPPPGKPAAQNVHSEQKLPHDAT
                     LGSQQSLVHLKEALHNSTLDITVVLPSGLEKQSVVSGSRAVMDLLVELCLQNHLNPSH
                     HVLEIWSSETQQPLSFKPNTLIGSLNAHTVFLKEKVPEEKGKPGLTKAPEKSVRLVVN
                     YLRTQKAVMRVSPEVPLQNILPVICAKCEVSPDHVVLLRDNIAGEELELSKSLNELGI
                     KELYAWDNRREMLRKSSLGNDETDKEKKKFLGFFKVNKRSNSKAEHLGLSGADSDEDP
                     SKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGMSMKSDMKKRRAPPPPSPG
                     LLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQPPPPSPVVPNRKEDKEENRKSTVGV
                     GRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVTEPVTFPGEGAGSETSELRPKLSL
                     PLGPGSHCSMGGVSQVPAEAEETASVGSCFASEDTTEDSGVMSSPSDVISLDSQQDSM
                     RSKDKWSTDQEDCSDQDLAGTPELGPQKSPSWGKHGSGSSILRTEKAAMPGNDDEDLS
                     ITGLFHQTRAELDKDLGGMEENYETDTSSLTSSVNGVSNHSLQEAIIPDSGVDDIPVT
                     FIGEVSDEPFDSGLFFSGSNNAAALNQGGIASQRSHLPPYQTEQSQPFIRTNRKEPDP
                     SLPSQDYRKRNQPILANTSENENPVGIDPRVTSFVSKPSTDDPKAKDKDKMCGSGPSE
                     KTQTGHRVNSLPVNPRVGEDENSNSALPPWSHHGQASGGSYGLKYGLTTYKIVPPKPE
                     MRCYDRDVSLSTGAIKIDELGNLMSPHMNGSRTISKPSAVAETEAPPIGKVKEFWRRN
                     SMEKYLNGPAECTVKKAPSTTITATSEKPQRDETKAGFTLTTPEQQPASQEYGAPPEE
                     DRSRPHSAVSCPVKVPAPNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPH
                     KKTAEQGHEEAKLARPPPAWKDSAVPNLCSEAGQCEHGTNQGSVRLPSNPGGQLPADH
                     PKVEVNSTYGKSATHNSPAAVHRNSYFLPGRSSQRDRVSVGQSCGFHEKQTISNQKMN
                     STSNPSQALDKAHPAPLLLTEARDSGRILVNGSAQTPGNCEPPHSQKESTLTSYIILQ
                     TEEKPSPLSADGQNSDDALPSSIFGPKKKFKPVVQRPLPKDISLHSALMEAIHTSGGR
                     DKLRKTAEQASEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFR
                     DAALMAPGVDKPQQEDRGLPPPPALPPPSTPASQVPSASIPVSRFSIGTLSNPVNARQ
                     ALMDAIRSGTGAARLRKVPLLV"
     exon            269..472
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            473..683
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            684..912
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1010
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1085
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1259
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1398
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1569
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1879
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1977
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..3854
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..3974
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4238
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..5626
                     /gene="Cobl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcacctt gctcccgcgc ccgggctagc cgcgtcggtc cctccccgcg cgcccccgcc
       61 cgcccggacg cctccggtcg cttctgtcct tttcggcacg gctgctgtcc tcgctagccc
      121 cgcgtgggag gaggatgggt cagcgcggaa aaagtgaatg aggacggcgg cgccgcagcc
      181 agcgccccag tcggccggca gagcctggtg cgcagcccgc cggctccatg gacgcaccgc
      241 gcgcactggc ggccaagccc cccacaggaa ggaagatgaa ggcccgcgct ccaccacctc
      301 ctggaaagcc tgctgcccag aatgtccaca gcgaacagaa actgcctcat gacgccacac
      361 tgggttcaca gcaaagcctg gtccacttga aggaggcact tcacaacagt accttggaca
      421 tcactgtggt tctgcccagt ggactggaga agcagagcgt ggttagtggg agccgtgcgg
      481 tgatggacct cctggttgaa ctctgccttc agaaccacct gaatccttct caccacgtct
      541 tagagatctg gtcttcggag acccaacagc ctttgagttt taagccaaat acgttgattg
      601 gctccttgaa tgcacatacg gtatttctga aagaaaaagt ccctgaagag aaagggaagc
      661 ctggcctaac caaggcccct gagaaatccg tacgcctggt agtgaactac ctgagaactc
      721 agaaggctgt catgcgggtg agccctgagg tgcctctgca gaacattctg cctgtcatct
      781 gtgcgaagtg tgaggtcagc ccagatcacg tggtgctgct cagggacaat attgctgggg
      841 aagagctgga gctgtccaag tccctgaatg aactagggat caaggagcta tatgcgtggg
      901 acaacagaag agaaatgctc aggaaatcat cccttggcaa tgatgagaca gataaggaga
      961 agaaaaaatt tcttgggttt ttcaaagtta ataagaggag caacagtaag gctgagcatc
     1021 ttgggctgtc gggcgcagat agcgacgagg atccctcgaa gtcagcgtct ggaggggact
     1081 tgaacggctg tgtaacaaca cccaactcac catccttgca ttctcggtcc ctgacactgg
     1141 gtccctccct ctcactgggc aacatctctg gaatgtctat gaagtcagac atgaagaagc
     1201 gcagagcccc tcctcctcca agtcccgggc tgctgggtca agacaaggta tcagaaaagg
     1261 cctccctcag ctcgcaggcc gatcttcaga agaagaagag gcgggcgcca gctcctcctc
     1321 caccacagcc gccaccacca agtcctgtgg ttcccaaccg caaggaagat aaggaagaga
     1381 acaggaagag cacagtgggt gttggacgtc aggtgccaca aaagcctccc agaggcacag
     1441 ctcggggccc accccagtta gtgctccccc cgcccccacc ctatcctcct cctgacacag
     1501 atgtaacaga gcctgtcacc tttcctgggg aaggcgctgg ttccgagacc tcagagctga
     1561 gacctaaact gagtctgcct ctggggcctg gcagccactg cagcatgggt ggagtctcac
     1621 aggtgcccgc ggaggctgag gagacggcat ctgtgggcag ctgttttgca tcggaggaca
     1681 caaccgaaga ctcaggggtc atgagctctc cctcagatgt catctccctg gactcacaac
     1741 aagatagcat gagatctaag gataaatggt ccacagacca ggaggactgc agtgaccagg
     1801 acctggctgg aacaccagaa ctgggtcccc aaaagagccc atcatggggg aaacatggct
     1861 caggaagctc aattttaagg actgagaaag ccgccatgcc tgggaatgat gatgaagatc
     1921 tgtccatcac gggactcttc catcagactc gagcagagct tgacaaagac ctgggaggga
     1981 tggaagaaaa ttatgaaaca gataccagct ctctaaccag ctctgtaaat ggggtatcca
     2041 accacagtct gcaagaagcc ataatccctg atagtggtgt ggacgacatc cctgtcactt
     2101 ttatcgggga agtttctgac gagcctttcg actcggggct gttcttcagt ggaagtaaca
     2161 atgctgctgc tttgaaccaa gggggcattg ccagccaaag atcccacctg cccccatatc
     2221 agactgagca gagccagcca ttcataagga caaacagaaa agagcctgac ccctcccttc
     2281 cttcccaaga ttacagaaag agaaatcagc caatcttagc caacacatct gaaaatgaga
     2341 atccagttgg aatagacccc agagttacat catttgtttc aaagccttcg acagatgacc
     2401 caaaggcaaa ggataaagac aagatgtgcg gttctggtcc cagtgagaag acacagaccg
     2461 gtcacagagt aaactccctg ccagtgaatc ccagagttgg tgaggatgaa aactccaact
     2521 cagccctgcc cccatggtct caccatggcc aggcctcggg gggaagctat ggactcaagt
     2581 atggcctcac tacatataaa atcgttcctc ccaaaccaga gatgaggtgt tatgacaggg
     2641 atgtgtccct ctccactggt gccattaaga ttgatgaact agggaatctg atgagtcctc
     2701 acatgaatgg aagcaggacc atatccaagc catcagctgt tgccgaaaca gaggctccac
     2761 ctattggaaa agtcaaagag ttctggaggc gcaactcgat ggaaaagtac ctgaatgggc
     2821 cagccgagtg cacggtcaaa aaggccccct ccaccaccat cactgccaca tccgaaaaac
     2881 cacagcgaga tgagacgaag gcaggcttta cgctgaccac tccggagcag cagcctgcct
     2941 cacaggaata cggggcaccc ccggaggaag acagaagccg gccacattca gccgtctcct
     3001 gtcctgtgaa agtgccagca cctaatccca cagacatcac attcctcaag cctcagagaa
     3061 gaacatccag ccagtatgtg gcttctgcta ttgccaagaa gatgggacct ccaaaagtcc
     3121 atgctgatgt ggtgagacca cataagaaga ctgccgaaca aggccacgag gaagcaaagc
     3181 tcgctagacc acctccagcc tggaaagaca gtgcagtccc caacctgtgt tcagaggccg
     3241 gccagtgtga gcatggcaca aaccagggct ctgtccgcct tcccagcaac cctggtgggc
     3301 agttgccagc ggaccatccc aaagtagagg tcaacagcac atatgggaag tcagcgactc
     3361 acaactctcc tgctgctgtc cacagaaact cctatttcct cccaggcaga tcttcccagc
     3421 gggatcgtgt ttctgtagga cagagctgtg gtttccatga aaagcaaact ataagtaacc
     3481 aaaagatgaa ttcaacatct aacccctcgc aggcactgga caaggcacac ccagcccccc
     3541 tgctcttgac agaagcccgt gactctggga ggatactggt gaatggctct gcacagaccc
     3601 caggaaattg tgagcctccc cactctcaga aagagtccac cctgactagc tatattatct
     3661 tacagacaga ggaaaagccc agtccgttat ctgcagatgg tcaaaactca gatgatgctc
     3721 taccgtcgag catttttggg ccaaagaaaa aattcaagcc tgtcgttcaa aggccacttc
     3781 caaaagatat atccctgcac agtgccctga tggaagccat ccacacctca ggagggaggg
     3841 acaagctccg aaagactgca gaacaggcct cagaaggaag gccaaagaaa ccatcctacg
     3901 tggaggcgga gagcgagcga tctgcccttc tggcagccat ccggggccac agtgggactc
     3961 tcagcctgag gaaggtgtca tccctggcct ctgaggagct ccagagcttc cgagatgctg
     4021 cactcatggc tccaggtgtg gacaagcctc agcaagaaga ccgtggcctt ccacccccac
     4081 ctgccctgcc accaccatcc actccagcat cccaggttcc ctcagcctcc ataccggttt
     4141 ctaggttcag catcggcacc ctcagcaacc cagtaaatgc taggcaagcc ttgatggatg
     4201 ctatccgctc gggcacagga gctgcaagac tcagaaaggt tcccttgctc gtgtgaggtt
     4261 caaccactgc agaaaccacc tgtacagctc caaggatcat ccctaaagaa atccacatga
     4321 caggaaatga aaccatcaag aagtggcggt actttcctgt ctccaggcca acttgcccgc
     4381 ggtggatttt cagtgttcct acataatggt caaaggggag atgctgcttt gctgtgtgac
     4441 ttgtgtgcca aggacatatg atctgcctct gaatgctcac agttgccaat aaactgctct
     4501 tgttggcaga gtaatgggaa tacacaggct ggagcccaac actcacacat gattatagct
     4561 atgggcacaa ggaattatgc cttaagttga tttttggatc tttgagactt tgaccacata
     4621 cacatggtta aaatcattta tgatcttttg aattctaggt ggacaaaaac ataaatcaac
     4681 agaaatagtc agaatctatc acatgctcca agacactctg ttcctggagt aagaagcaca
     4741 atggagaaag cctgctgaga tggcttttgc aggacagcaa aagcttcaga ttcatgtttg
     4801 tattcctcac acagtgaggc ctcacacctc acagatgatc ttggactgtg atctgaccaa
     4861 ctaagctttt aaaattccac tactgctgcc cagagtagca gccctacttg accgtgttag
     4921 caagacattc ctggctcctt agaaggtgat gggaagcaga gatcagaaca ctggaagggc
     4981 tgcccttttt tgtatagatt gtgtccccct tgtatatctt ccccctatgt cccagcaggc
     5041 tatgacatgc atcggttcac tgtgaaggga tcttgcatgg agcccaggac ttcaccagta
     5101 gccttctgaa atcctgcaga gggccagaga gcagggtgtt gaggacctac atgtcacagc
     5161 ggtccacatt gtgctgtgtg ttctgtggct tacatttccc tgacacactt tggcatggtc
     5221 cagcagctgc cctggtatta tatgacattc ttatagtaca ttgtgggtag acaccatctt
     5281 taaagaattt aaactcagca ggaagttttg tgtttttttt ttactgtgtc tctaaaacct
     5341 tttcttatat ggagaaaatc aagaaagcaa tagaagtcaa aatgagttca tgatataaaa
     5401 tctctgcctt actgaaaaga aaaaaagcaa aaaagaaacc atgaaatcct ttaactgttt
     5461 cgctctgttt taaatctagg catcgggtag agtgggagct tggtaccgtg tgattaacat
     5521 tgctaaagtt tctcagtgag gcaagagcta ccagccaatt actcttagtc acagctgtct
     5581 actctttctc ttagtgccac aaataaatgc aaatccaatg ctgtaa
//
