LOCUS       NM_001006954            2060 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus Coenzyme A synthase (Coasy), mRNA.
ACCESSION   NM_001006954 XM_213464
VERSION     NM_001006954.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Dusi,S., Valletta,L., Haack,T.B., Tsuchiya,Y., Venco,P.,
            Pasqualato,S., Goffrini,P., Tigano,M., Demchenko,N., Wieland,T.,
            Schwarzmayr,T., Strom,T.M., Invernizzi,F., Garavaglia,B.,
            Gregory,A., Sanford,L., Hamada,J., Bettencourt,C., Houlden,H.,
            Chiapparini,L., Zorzi,G., Kurian,M.A., Nardocci,N., Prokisch,H.,
            Hayflick,S., Gout,I. and Tiranti,V.
  TITLE     Exome sequence reveals mutations in CoA synthase as a cause of
            neurodegeneration with brain iron accumulation
  JOURNAL   Am J Hum Genet 94 (1), 11-22 (2014)
   PUBMED   24360804
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Nemazanyy,I., Panasyuk,G., Breus,O., Zhyvoloup,A., Filonenko,V. and
            Gout,I.T.
  TITLE     Identification of a novel CoA synthase isoform, which is primarily
            expressed in the brain
  JOURNAL   Biochem Biophys Res Commun 341 (4), 995-1000 (2006)
   PUBMED   16460672
  REMARK    GeneRIF: description of the existence of a novel CoA synthase
            isoform, which is the product of alternative splicing and possesses
            a 29aa extension at the N-terminus; isoform is termed CoASy beta.
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   Nemazanyy,I., Panasyuk,G., Zhyvoloup,A., Panayotou,G., Gout,I.T.
            and Filonenko,V.
  TITLE     Specific interaction between S6K1 and CoA synthase: a potential
            link between the mTOR/S6K pathway, CoA biosynthesis and energy
            metabolism
  JOURNAL   FEBS Lett 578 (3), 357-362 (2004)
   PUBMED   15589845
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Aghajanian,S. and Worrall,D.M.
  TITLE     Identification and characterization of the gene encoding the human
            phosphopantetheine adenylyltransferase and dephospho-CoA kinase
            bifunctional enzyme (CoA synthase)
  JOURNAL   Biochem J 365 (Pt 1), 13-18 (2002)
   PUBMED   11994049
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Zhyvoloup,A., Nemazanyy,I., Babich,A., Panasyuk,G., Pobigailo,N.,
            Vudmaska,M., Naidenov,V., Kukharenko,O., Palchevskii,S.,
            Savinska,L., Ovcharenko,G., Verdier,F., Valovka,T., Fenton,T.,
            Rebholz,H., Wang,M.L., Shepherd,P., Matsuka,G., Filonenko,V. and
            Gout,I.T.
  TITLE     Molecular cloning of CoA Synthase. The missing link in CoA
            biosynthesis
  JOURNAL   J Biol Chem 277 (25), 22107-22110 (2002)
   PUBMED   11980892
REFERENCE   8  (bases 1 to 2060)
  AUTHORS   Daugherty,M., Polanuyer,B., Farrell,M., Scholle,M., Lykidis,A., de
            Crecy-Lagard,V. and Osterman,A.
  TITLE     Complete reconstitution of the human coenzyme A biosynthetic
            pathway via comparative genomics
  JOURNAL   J Biol Chem 277 (24), 21431-21439 (2002)
   PUBMED   11923312
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083781.1.
            
            On Nov 22, 2004 this sequence version replaced XM_213464.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2060
                     /gene="Coasy"
                     /note="Coenzyme A synthase"
                     /db_xref="GeneID:287711"
                     /db_xref="RGD:1549767"
     exon            1..15
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            16..723
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1718
                     /gene="Coasy"
                     /note="bifunctional coenzyme A synthase; CoA synthase"
                     /codon_start=1
                     /product="bifunctional coenzyme A synthase precursor"
                     /protein_id="NP_001006955.1"
                     /db_xref="GeneID:287711"
                     /db_xref="RGD:1549767"
                     /translation="MAVFRSGLLVLTTPLATLAARLPPILTSASHLVNHTLYVHLQPG
                     MNLGGPAQPQPSPVQATFEVLDFITHLYTGADLHRHLDVRILLTNIQTKSTLIPVLSS
                     VQNLAHPPEVVLTDFQTLDGSQYNPVKQQLERYATSCYSCSPQLSSVLLYPDYGTGEM
                     PLELPNALLPSTIRPASPVARSPRQPVRGYRRGAVGGTFDRLHNAHKVLLSVACVLAQ
                     EQLVVGVADKDLLKSKLLPELLQPYSERVGHLNEFLVDIKPSLTFELIPLLDPYGPAG
                     SDPTLEFLVVSEETYRGGMAVNRFRLENGKEELALYQIQLLKDQSHKENEEEKVSSSS
                     FRQRILGNLLQPPNERPELPSGIYVLGLTGISGSGKSSVAQRLKNLGAYIIDSDHLGH
                     RAYAPGGPAYQPVVEAFGTDILHQDGTINRKVLGSRVFGNKKQLKMLTDIVWPVIAKL
                     AREEMDVAVAKGKTLCVIDAAMLLEAGWQNMVHEVWTVVIPESEAVRRIVERDGLSEA
                     AAQSRLQNQMSGQQLVEQSHVVLCTLWESHVTQRQVEKAWDLLQKRLPKAHQTRN"
     exon            724..938
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1070
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1260
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1325
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1410
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1508
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1655
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2029
                     /gene="Coasy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctcctcg gcggtgcctg gatagcatgg ccgtattccg ctcaggcctc ctggtgctga
       61 caacgccgct ggccaccctg gccgcacgcc tgcctcccat cctgacctcg gcgtcacacc
      121 tggtgaatca caccctctat gtgcacctgc agccgggcat gaacctgggg ggacccgctc
      181 agccccagcc cagccctgtg caggccacat ttgaggttct ggatttcatc acgcacctct
      241 acactggtgc cgacctgcac aggcacctgg acgtcagaat tctactgacc aatatccaaa
      301 ccaagagtac cttaatccct gtgctttcct cagtccagaa tctggcccac cctccagaag
      361 tagttctgac ggacttccag accctggatg ggagccagta caaccctgtt aaacaacagc
      421 tagagcgtta tgccaccagc tgctacagct gttctccaca gttgtcttcc gtattgctgt
      481 atccggatta tgggactgga gagatgcctt tggaactccc gaatgccctc ttaccctcca
      541 ccataaggcc agcttccccg gtggccagat ctccgaggca gcctgtgcgt ggctaccgcc
      601 gtggggccgt gggtggcact tttgaccgct tgcacaatgc ccacaaagtg ttgctcagtg
      661 ttgcatgtgt actggcccag gagcagcttg tggtgggagt agcggacaaa gatctgttga
      721 agagcaagtt gctccctgag ctgctccagc cttattcaga gcgtgtgggg catctgaatg
      781 agttcctggt ggacatcaag ccctccctga cttttgaact catccccctg ctggatccct
      841 atgggcctgc tgggtctgac cccactttgg agttcctggt ggtcagcgag gagacctacc
      901 gtggggggat ggccgtcaac cgcttccgcc ttgagaatgg caaagaggag ctcgccttat
      961 accagataca gctgctgaag gaccagagtc acaaggaaaa cgaggaggaa aaggtcagct
     1021 cctccagctt tcgccagcga attctgggaa acctgcttca gcctccgaat gagaggcccg
     1081 agctcccgtc aggtatctat gtgctggggc tgacaggcat cagcggctct gggaaaagct
     1141 cagtggctca gcggctgaag aacttggggg catacatcat tgacagtgac catctgggcc
     1201 accgggccta tgctcccggg ggccctgcct accagcctgt ggtggaggcc tttggaacag
     1261 atattctcca tcaagatggg accatcaata ggaaggtcct aggcagccgg gtgtttggga
     1321 ataagaagca gctgaagatg ctcacagata ttgtgtggcc agttatcgca aagctggccc
     1381 gagaggagat ggatgtggct gtggctaagg gaaagactct gtgtgtgatt gatgctgcta
     1441 tgctgcttga agctggctgg cagaatatgg tacacgaggt gtggaccgtc gtcatccctg
     1501 agtctgaggc tgtacgtcgc attgttgaga gggatggact gagtgaggca gccgctcaaa
     1561 gccggctgca gaaccagatg agtgggcagc agctggtaga gcagagccac gtggttctgt
     1621 gcaccttgtg ggaatcacat gtcacacagc gccaggtgga aaaggcttgg gatcttctac
     1681 agaaacgcct ccccaaggct caccagacca ggaactgaca gtggattttc tgtggcgcca
     1741 cactggccct tggaactaac aaatctaatg gtgaggagga atgggggcct cgatgtttac
     1801 cctatgtcag gcctcagggg cttcaagctg agctgtgcag gacacagaga gaagcttgga
     1861 agtcggccta gcatgctgga atttggccag caatgaggac acagcaatgg ggagcggccc
     1921 cctcttgggt tctgtctgct ttttggtggt ggagatttga tgtctaacta gtgttatggg
     1981 ttgtagtgaa gactggaccc agtaactaaa ttaaagatgt ttccaagtga aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa
//
