LOCUS       NP_001006955             563 aa            linear   ROD 19-SEP-2024
DEFINITION  bifunctional coenzyme A synthase precursor [Rattus norvegicus].
ACCESSION   NP_001006955 XP_213464
VERSION     NP_001006955.1
DBSOURCE    REFSEQ: accession NM_001006954.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 563)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 563)
  AUTHORS   Dusi,S., Valletta,L., Haack,T.B., Tsuchiya,Y., Venco,P.,
            Pasqualato,S., Goffrini,P., Tigano,M., Demchenko,N., Wieland,T.,
            Schwarzmayr,T., Strom,T.M., Invernizzi,F., Garavaglia,B.,
            Gregory,A., Sanford,L., Hamada,J., Bettencourt,C., Houlden,H.,
            Chiapparini,L., Zorzi,G., Kurian,M.A., Nardocci,N., Prokisch,H.,
            Hayflick,S., Gout,I. and Tiranti,V.
  TITLE     Exome sequence reveals mutations in CoA synthase as a cause of
            neurodegeneration with brain iron accumulation
  JOURNAL   Am J Hum Genet 94 (1), 11-22 (2014)
   PUBMED   24360804
REFERENCE   3  (residues 1 to 563)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (residues 1 to 563)
  AUTHORS   Nemazanyy,I., Panasyuk,G., Breus,O., Zhyvoloup,A., Filonenko,V. and
            Gout,I.T.
  TITLE     Identification of a novel CoA synthase isoform, which is primarily
            expressed in the brain
  JOURNAL   Biochem Biophys Res Commun 341 (4), 995-1000 (2006)
   PUBMED   16460672
  REMARK    GeneRIF: description of the existence of a novel CoA synthase
            isoform, which is the product of alternative splicing and possesses
            a 29aa extension at the N-terminus; isoform is termed CoASy beta.
REFERENCE   5  (residues 1 to 563)
  AUTHORS   Nemazanyy,I., Panasyuk,G., Zhyvoloup,A., Panayotou,G., Gout,I.T.
            and Filonenko,V.
  TITLE     Specific interaction between S6K1 and CoA synthase: a potential
            link between the mTOR/S6K pathway, CoA biosynthesis and energy
            metabolism
  JOURNAL   FEBS Lett 578 (3), 357-362 (2004)
   PUBMED   15589845
REFERENCE   6  (residues 1 to 563)
  AUTHORS   Aghajanian,S. and Worrall,D.M.
  TITLE     Identification and characterization of the gene encoding the human
            phosphopantetheine adenylyltransferase and dephospho-CoA kinase
            bifunctional enzyme (CoA synthase)
  JOURNAL   Biochem J 365 (Pt 1), 13-18 (2002)
   PUBMED   11994049
REFERENCE   7  (residues 1 to 563)
  AUTHORS   Zhyvoloup,A., Nemazanyy,I., Babich,A., Panasyuk,G., Pobigailo,N.,
            Vudmaska,M., Naidenov,V., Kukharenko,O., Palchevskii,S.,
            Savinska,L., Ovcharenko,G., Verdier,F., Valovka,T., Fenton,T.,
            Rebholz,H., Wang,M.L., Shepherd,P., Matsuka,G., Filonenko,V. and
            Gout,I.T.
  TITLE     Molecular cloning of CoA Synthase. The missing link in CoA
            biosynthesis
  JOURNAL   J Biol Chem 277 (25), 22107-22110 (2002)
   PUBMED   11980892
REFERENCE   8  (residues 1 to 563)
  AUTHORS   Daugherty,M., Polanuyer,B., Farrell,M., Scholle,M., Lykidis,A., de
            Crecy-Lagard,V. and Osterman,A.
  TITLE     Complete reconstitution of the human coenzyme A biosynthetic
            pathway via comparative genomics
  JOURNAL   J Biol Chem 277 (24), 21431-21439 (2002)
   PUBMED   11923312
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083781.1.
            
            On Nov 22, 2004 this sequence version replaced XP_213464.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     Protein         1..563
                     /product="bifunctional coenzyme A synthase precursor"
                     /note="bifunctional coenzyme A synthase; CoA synthase"
                     /calculated_mol_wt=60231
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1974
     Region          192..338
                     /region_name="PPAT_CoAS"
                     /note="phosphopantetheine adenylyltransferase domain of
                     eukaryotic and archaeal bifunctional enzymes; cd02164"
                     /db_xref="CDD:173915"
     Site            order(197..198,226,286)
                     /site_type="active"
                     /db_xref="CDD:173915"
     Site            203..206
                     /site_type="other"
                     /note="(T/H)XGH motif"
                     /db_xref="CDD:173915"
     Region          358..551
                     /region_name="CoaE"
                     /note="Dephospho-CoA kinase [Coenzyme transport and
                     metabolism]; COG0237"
                     /db_xref="CDD:440007"
     CDS             1..563
                     /gene="Coasy"
                     /coded_by="NM_001006954.1:27..1718"
                     /db_xref="GeneID:287711"
                     /db_xref="RGD:1549767"
ORIGIN      
        1 mavfrsgllv lttplatlaa rlppiltsas hlvnhtlyvh lqpgmnlggp aqpqpspvqa
       61 tfevldfith lytgadlhrh ldvrilltni qtkstlipvl ssvqnlahpp evvltdfqtl
      121 dgsqynpvkq qleryatscy scspqlssvl lypdygtgem plelpnallp stirpaspva
      181 rsprqpvrgy rrgavggtfd rlhnahkvll svacvlaqeq lvvgvadkdl lkskllpell
      241 qpyservghl neflvdikps ltfeliplld pygpagsdpt leflvvseet yrggmavnrf
      301 rlengkeela lyqiqllkdq shkeneeekv ssssfrqril gnllqppner pelpsgiyvl
      361 gltgisgsgk ssvaqrlknl gayiidsdhl ghrayapggp ayqpvveafg tdilhqdgti
      421 nrkvlgsrvf gnkkqlkmlt divwpviakl areemdvava kgktlcvida amlleagwqn
      481 mvhevwtvvi peseavrriv erdglseaaa qsrlqnqmsg qqlveqshvv lctlweshvt
      541 qrqvekawdl lqkrlpkahq trn
//
