LOCUS       NM_001037769             820 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor 8 (Coa8),
            mRNA.
ACCESSION   NM_001037769 XM_008764981 XM_216787
VERSION     NM_001037769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Signes,A., Cerutti,R., Dickson,A.S., Beninca,C., Hinchy,E.C.,
            Ghezzi,D., Carrozzo,R., Bertini,E., Murphy,M.P., Nathan,J.A.,
            Viscomi,C., Fernandez-Vizarra,E. and Zeviani,M.
  TITLE     APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS
            and ROS
  JOURNAL   EMBO Mol Med 11 (1) (2019)
   PUBMED   30552096
REFERENCE   2  (bases 1 to 820)
  AUTHORS   Melchionda,L., Haack,T.B., Hardy,S., Abbink,T.E.,
            Fernandez-Vizarra,E., Lamantea,E., Marchet,S., Morandi,L.,
            Moggio,M., Carrozzo,R., Torraco,A., Diodato,D., Strom,T.M.,
            Meitinger,T., Tekturk,P., Yapici,Z., Al-Murshedi,F., Stevens,R.,
            Rodenburg,R.J., Lamperti,C., Ardissone,A., Moroni,I., Uziel,G.,
            Prokisch,H., Taylor,R.W., Bertini,E., van der Knaap,M.S., Ghezzi,D.
            and Zeviani,M.
  TITLE     Mutations in APOPT1, encoding a mitochondrial protein, cause
            cavitating leukoencephalopathy with cytochrome c oxidase deficiency
  JOURNAL   Am J Hum Genet 95 (3), 315-325 (2014)
   PUBMED   25175347
REFERENCE   3  (bases 1 to 820)
  AUTHORS   Sun,X., Yasuda,O., Takemura,Y., Kawamoto,H., Higuchi,M., Baba,Y.,
            Katsuya,T., Fukuo,K., Ogihara,T. and Rakugi,H.
  TITLE     Akt activation prevents Apop-1-induced death of cells
  JOURNAL   Biochem Biophys Res Commun 377 (4), 1097-1101 (2008)
   PUBMED   18977203
REFERENCE   4  (bases 1 to 820)
  AUTHORS   Yasuda,O., Fukuo,K., Sun,X., Nishitani,M., Yotsui,T., Higuchi,M.,
            Suzuki,T., Rakugi,H., Smithies,O., Maeda,N. and Ogihara,T.
  TITLE     Apop-1, a novel protein inducing cyclophilin D-dependent but
            Bax/Bak-related channel-independent apoptosis
  JOURNAL   J Biol Chem 281 (33), 23899-23907 (2006)
   PUBMED   16782708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1 and BC107661.1.
            
            On or before Sep 4, 2014 this sequence version replaced
            XM_008764981.1, NM_001037769.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107661.1, DN936417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 JAXUCZ010000006.1  136593399-136593403
            6-817               BC107661.1         1-812
            818-820             JAXUCZ010000006.1  136618235-136618237
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..820
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /note="cytochrome c oxidase assembly factor 8"
                     /db_xref="GeneID:299341"
                     /db_xref="RGD:1304719"
     exon            1..136
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..595
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /note="UPF0671 protein C14orf153 homolog; apoptogenic
                     protein 1, mitochondrial; apoptogenic 1, mitochondrial"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor 8"
                     /protein_id="NP_001032858.1"
                     /db_xref="GeneID:299341"
                     /db_xref="RGD:1304719"
                     /translation="MAALRPGSKALRRLLCRSFSGGGVRLARERATERRDAASSRVSR
                     FCPPRQSCHDWIGPPDKYSNLRPVHFHVPENESPLEQRLRELRQETQEWNQQFWAKQN
                     LSFNKEKEEFIYSRLQAKGSGPRTESGQRATLDAEEMADFYKDFLSKNFQKHMCYNRD
                     WYKRNFAITFFMGKVALERMWSKLKQKPKKTSG"
     exon            137..334
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /inference="alignment:Splign:2.1.0"
     exon            335..398
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /inference="alignment:Splign:2.1.0"
     exon            399..489
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /inference="alignment:Splign:2.1.0"
     exon            490..820
                     /gene="Coa8"
                     /gene_synonym="APOP-1; Apop1; Apopt1; RGD1304719"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgcgcgg gccatggcgg ctttgcggcc cggaagcaaa gctcttcgcc ggctgctctg
       61 ccggtccttc tccggcggcg gcgttcggct ggcccgtgag cgcgctacgg agcgcaggga
      121 tgctgcgtcc agccgggtct caagattctg ccctccgaga cagtcttgcc atgattggat
      181 aggcccccca gacaaatact ccaaccttcg tcctgttcat tttcatgtcc ctgaaaatga
      241 gtctcctttg gagcaaaggc ttagggaatt gaggcaagaa acgcaggaat ggaatcagca
      301 gttctgggcc aagcagaatc tgtcctttaa taaggaaaag gaagagttca tttactcaag
      361 gctacaagct aaaggctcag gcccgcgaac cgagtcaggc caaagagcaa cgctggatgc
      421 cgaggagatg gctgacttct ataaggactt tctgagcaag aatttccaga agcacatgtg
      481 ctataaccga gactggtaca agcgcaattt tgccatcact ttcttcatgg ggaaggtggc
      541 cctggagagg atgtggagca agctgaagca gaagccaaag aagacaagcg gttagaggag
      601 cccaccggac ctgacccaca gcaccaggtc catttacgag gcctggaaac taagtgagca
      661 caggttcctg acctgcgctc agacctttgc tgactgtgtg tccccagcgg ctcagtccca
      721 tcagcagact gtatgcttgt tgtctgtatc ttgaattatg tcagttcaga agatagcagg
      781 gtaaaaatgt gaataaagtt ttgctgtaag aatttaatcc
//
