LOCUS       NM_001401093             673 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor 6 (Coa6),
            mRNA.
ACCESSION   NM_001401093 XM_039098286
VERSION     NM_001401093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 673)
  AUTHORS   Stroud,D.A., Maher,M.J., Lindau,C., Vogtle,F.N., Frazier,A.E.,
            Surgenor,E., Mountford,H., Singh,A.P., Bonas,M., Oeljeklaus,S.,
            Warscheid,B., Meisinger,C., Thorburn,D.R. and Ryan,M.T.
  TITLE     COA6 is a mitochondrial complex IV assembly factor critical for
            biogenesis of mtDNA-encoded COX2
  JOURNAL   Hum Mol Genet 24 (19), 5404-5415 (2015)
   PUBMED   26160915
REFERENCE   2  (bases 1 to 673)
  AUTHORS   Pacheu-Grau,D., Bareth,B., Dudek,J., Juris,L., Vogtle,F.N.,
            Wissel,M., Leary,S.C., Dennerlein,S., Rehling,P. and Deckers,M.
  TITLE     Cooperation between COA6 and SCO2 in COX2 maturation during
            cytochrome c oxidase assembly links two mitochondrial
            cardiomyopathies
  JOURNAL   Cell Metab 21 (6), 823-833 (2015)
   PUBMED   25959673
REFERENCE   3  (bases 1 to 673)
  AUTHORS   Baertling,F., A M van den Brand,M., Hertecant,J.L., Al-Shamsi,A., P
            van den Heuvel,L., Distelmaier,F., Mayatepek,E., Smeitink,J.A.,
            Nijtmans,L.G. and Rodenburg,R.J.
  TITLE     Mutations in COA6 cause cytochrome c oxidase deficiency and
            neonatal hypertrophic cardiomyopathy
  JOURNAL   Hum Mutat 36 (1), 34-38 (2015)
   PUBMED   25339201
REFERENCE   4  (bases 1 to 673)
  AUTHORS   Ghosh,A., Trivedi,P.P., Timbalia,S.A., Griffin,A.T., Rahn,J.J.,
            Chan,S.S. and Gohil,V.M.
  TITLE     Copper supplementation restores cytochrome c oxidase assembly
            defect in a mitochondrial disease model of COA6 deficiency
  JOURNAL   Hum Mol Genet 23 (13), 3596-3606 (2014)
   PUBMED   24549041
REFERENCE   5  (bases 1 to 673)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000019.1.
            
            On Feb 2, 2022 this sequence version replaced XM_039098286.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR474051.1, BQ211011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000019.1  71293066-71293360
            296-673             JAXUCZ010000019.1  71295291-71295668
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..673
                     /gene="Coa6"
                     /note="cytochrome c oxidase assembly factor 6"
                     /db_xref="GeneID:102556031"
                     /db_xref="RGD:7559315"
     exon            1..295
                     /gene="Coa6"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..391
                     /gene="Coa6"
                     /note="cytochrome c oxidase assembly factor 6 homolog"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor 6"
                     /protein_id="NP_001388022.1"
                     /db_xref="GeneID:102556031"
                     /db_xref="RGD:7559315"
                     /translation="MAAPSMKERQACWGARDLYWRCLDDNAEDAARCQKLRSSFEASC
                     PQQWIKYFDKRRDYLKFKEKFEAGEFQSSPSTENS"
     exon            296..673
                     /gene="Coa6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatccgtggc gggcactttc gcagtgagct tccctgtacg gttggtggac ctgcagggcg
       61 acagtgcagc acgcacagtc cgcaccgcgc tcccacgtgg gctgatcccc gggtcgcacg
      121 tcacgtggct ccccgcgtga cccctgcagg aatggcagcc ccgtccatga aggaaaggca
      181 ggcgtgctgg ggcgcgcgcg acctgtactg gcgctgcctc gacgacaacg cagaggacgc
      241 ggcccggtgc cagaagctga ggagctcgtt cgaggccagc tgcccccagc agtggataaa
      301 atattttgac aaaagaagag actacttaaa atttaaggaa aaatttgaag caggagaatt
      361 ccagtcttca ccgtcgactg aaaattccta gccctctttc tggactttca cacaagtggt
      421 aattattcct ctggactttc agaaatgatt cccgggcttg aatcacagtg cacatcatgt
      481 tctctgtaaa caagttacta aaatggtgga aaaaagcata agatctcatc attcaaacta
      541 tgaaggactg ctttaattta gtgagagatc cattttaaga aaaagcataa agttattata
      601 taaaaagttt attataaaaa aatacattgt tcatcttcct ttcccccttt ggaataaaag
      661 ctgaatagta agc
//
