LOCUS       NP_001128117             897 aa            linear   ROD 26-FEB-2024
DEFINITION  centrobin [Rattus norvegicus].
ACCESSION   NP_001128117 XP_001078458 XP_220600
VERSION     NP_001128117.1
DBSOURCE    REFSEQ: accession NM_001134645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 897)
  AUTHORS   Chang CW, Hsu WB, Tsai JJ, Tang CJ and Tang TK.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (residues 1 to 897)
  AUTHORS   Liska F, Gosele C, Popova E, Chylikova B, Krenova D, Kren V, Bader
            M, Tres LL, Hubner N and Kierszenbaum AL.
  TITLE     Overexpression of full-length centrobin rescues limb malformation
            but not male fertility of the hypodactylous (hd) rats
  JOURNAL   PLoS One 8 (4), e60859 (2013)
   PUBMED   23577170
  REMARK    GeneRIF: centrobin is essential for normal patterning of the limb
            autopod
REFERENCE   3  (residues 1 to 897)
  AUTHORS   Gudi R, Zou C, Li J and Gao Q.
  TITLE     Centrobin-tubulin interaction is required for centriole elongation
            and stability
  JOURNAL   J Cell Biol 193 (4), 711-725 (2011)
   PUBMED   21576394
REFERENCE   4  (residues 1 to 897)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (residues 1 to 897)
  AUTHORS   Liska F, Gosele C, Rivkin E, Tres L, Cardoso MC, Domaing P, Krejci
            E, Snajdr P, Lee-Kirsch MA, de Rooij DG, Kren V, Krenova D,
            Kierszenbaum AL and Hubner N.
  TITLE     Rat hd mutation reveals an essential role of centrobin in spermatid
            head shaping and assembly of the head-tail coupling apparatus
  JOURNAL   Biol Reprod 81 (6), 1196-1205 (2009)
   PUBMED   19710508
  REMARK    GeneRIF: Cntrob may represent a novel candidate gene for presently
            unexplained hereditary forms of teratozoospermia and the 'easily
            decapitated sperm syndrome' in humans.
            Erratum:[Biol Reprod. 2010 Apr;82(4):804. Rooij, Dirk G de
            [corrected to de Rooij, Dirk G]]
REFERENCE   6  (residues 1 to 897)
  AUTHORS   Zou C, Li J, Bai Y, Gunning WT, Wazer DE, Band V and Gao Q.
  TITLE     Centrobin: a novel daughter centriole-associated protein that is
            required for centriole duplication
  JOURNAL   J Cell Biol 171 (3), 437-445 (2005)
   PUBMED   16275750
REFERENCE   7  (residues 1 to 897)
  AUTHORS   Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y,
            Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS and
            Kingsmore SF.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF532342.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XP_001078458.1, XP_220600.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF532342.1, EF532344.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..897
                     /product="centrobin"
                     /note="LYST-interacting protein 8; centrobin, centrosomal
                     BRCA2 interacting protein; centrobin-like"
                     /calculated_mol_wt=100206
     Region          <200..>554
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <568..766
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..897
                     /gene="Cntrob"
                     /gene_synonym="Lip8; RGD1307488"
                     /coded_by="NM_001134645.1:225..2918"
                     /db_xref="GeneID:303240"
                     /db_xref="RGD:1307488"
ORIGIN      
        1 mataapspns plrpedlltd sseppglnqv ssevtsqlyt slhlsrqaea taraqlylas
       61 tssppnegid slaqelsrsl svglennlkk kdgskhifem esvrgqlqtm lhtsrdmayr
      121 tgserreeds fdsdstatll ntrplqdlsp sssaqaleel fprytslrpg pptnppdcqg
      181 lrdaldselt rrkhcerhiq slqtrvlelq qqlavavaad hkkdlmieql dktlarvveg
      241 wnrheaerte vlrglqeerq aaeltrskqq etvtrleqsl seamealnre qestrlqqre
      301 realeeerqa lamrleveqq qcqalqqerd eakagqlseh rrlealqval qeerqawvkq
      361 eqqlkerlqa lqeegqaqle rekgtsqrea qaareaqqql allqsevrrl egdldtvrre
      421 rdalqlemsl vqaryesqri qmeselavql eqrvterlae vqenslrqaa slrdhhrkql
      481 qelsgqhqqe laaqlaqfkv emaereerqq qvaqdyelrl areqarvrdl ksgnqqleeq
      541 rvelverlqa mlqahwdean qllsttllpp npqaplaeps spgplepekg erriwamppm
      601 avalkpvlqq gregradlpg apsvlcstsp dlslllgpsf qsqnsfqple pkpdvappav
      661 gpfsaleaft adhraehpfp eedpgpegdg plkaglppas qleglknflq qlletapqsn
      721 enpsvdllap ksgsravssw eeapqvprlp ppvhktkvpl amasslfrvh elpssnlqgs
      781 gvstgspekg tdglspprql mevsellrly qargwgalpa edlllylkrl ehggtdgqge
      841 lvprrntdsr lgeitrkeip sqavprrlas apktekpark ksghpgpsmr srggiwr
//
