LOCUS       NM_013225               3405 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus contactin 6 (Cntn6), mRNA.
ACCESSION   NM_013225 XM_346713
VERSION     NM_013225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Wong,C.M., Wang,Y., Lee,J.T., Huang,Z., Wu,D., Xu,A. and Lam,K.S.
  TITLE     Adropin is a brain membrane-bound protein regulating physical
            activity via the NB-3/Notch signaling pathway in mice
  JOURNAL   J Biol Chem 289 (37), 25976-25986 (2014)
   PUBMED   25074942
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Sakurai,K., Toyoshima,M., Ueda,H., Matsubara,K., Takeda,Y.,
            Karagogeos,D., Shimoda,Y. and Watanabe,K.
  TITLE     Contribution of the neural cell recognition molecule NB-3 to
            synapse formation between parallel fibers and Purkinje cells in
            mouse
  JOURNAL   Dev Neurobiol 69 (12), 811-824 (2009)
   PUBMED   19672956
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Cui,X.Y., Hu,Q.D., Tekaya,M., Shimoda,Y., Ang,B.T., Nie,D.Y.,
            Sun,L., Hu,W.P., Karsak,M., Duka,T., Takeda,Y., Ou,L.Y., Dawe,G.S.,
            Yu,F.G., Ahmed,S., Jin,L.H., Schachner,M., Watanabe,K.,
            Arsenijevic,Y. and Xiao,Z.C.
  TITLE     NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell
            differentiation into oligodendrocytes
  JOURNAL   J Biol Chem 279 (24), 25858-25865 (2004)
   PUBMED   15082708
  REMARK    GeneRIF: NB-3/Notch1 pathway promotes neural progenitor cell
            differentiation into oligodendrocytes via Deltex1.
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Takeda,Y., Akasaka,K., Lee,S., Kobayashi,S., Kawano,H.,
            Murayama,S., Takahashi,N., Hashimoto,K., Kano,M., Asano,M.,
            Sudo,K., Iwakura,Y. and Watanabe,K.
  TITLE     Impaired motor coordination in mice lacking neural recognition
            molecule NB-3 of the contactin/F3 subgroup
  JOURNAL   J Neurobiol 56 (3), 252-265 (2003)
   PUBMED   12884264
  REMARK    GeneRIF: Immunohistochemistry of the cerebellum from 3-month-old
            rats demonstrates that lobules 1-8 are distinct from lobules 9 and
            10 with respect to localization of NB-3 protein.
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Ogawa,J., Kaneko,H., Masuda,T., Nagata,S., Hosoya,H. and
            Watanabe,K.
  TITLE     Novel neural adhesion molecules in the Contactin/F3 subgroup of the
            immunoglobulin superfamily: isolation and characterization of cDNAs
            from rat brain
  JOURNAL   Neurosci Lett 218 (3), 173-176 (1996)
   PUBMED   8945756
  REMARK    Erratum:[Neurosci Lett 1997 Jan 17;221(2-3):217]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013225.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87248.1, SRR26643298.24321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000004.1  138911567-138911668
            103-242             JAXUCZ010000004.1  138993956-138994095
            243-369             JAXUCZ010000004.1  139079718-139079844
            370-545             JAXUCZ010000004.1  139086532-139086707
            546-641             JAXUCZ010000004.1  139147843-139147938
            642-845             JAXUCZ010000004.1  139172199-139172402
            846-948             JAXUCZ010000004.1  139174372-139174474
            949-1133            JAXUCZ010000004.1  139209688-139209872
            1134-1270           JAXUCZ010000004.1  139214494-139214630
            1271-1400           JAXUCZ010000004.1  139216456-139216585
            1401-1551           JAXUCZ010000004.1  139218267-139218417
            1552-1679           JAXUCZ010000004.1  139247028-139247155
            1680-1855           JAXUCZ010000004.1  139272524-139272699
            1856-1973           JAXUCZ010000004.1  139273052-139273169
            1974-2132           JAXUCZ010000004.1  139273792-139273950
            2133-2282           JAXUCZ010000004.1  139275732-139275881
            2283-2353           JAXUCZ010000004.1  139279197-139279267
            2354-2588           JAXUCZ010000004.1  139292173-139292407
            2589-2704           JAXUCZ010000004.1  139292541-139292656
            2705-2891           JAXUCZ010000004.1  139294711-139294897
            2892-3004           JAXUCZ010000004.1  139305196-139305308
            3005-3173           JAXUCZ010000004.1  139306105-139306273
            3174-3405           JAXUCZ010000004.1  139307063-139307294
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..3405
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="contactin 6"
                     /db_xref="GeneID:27256"
                     /db_xref="RGD:62008"
     exon            1..102
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            103..242
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..3274
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /note="neural recognition molecule NB-3; neural adhesion
                     molecule"
                     /codon_start=1
                     /product="contactin-6 precursor"
                     /protein_id="NP_037357.1"
                     /db_xref="GeneID:27256"
                     /db_xref="RGD:62008"
                     /translation="MRLLWKLVILLPLINSCAGESRFTRPIFIQEPQDVIFPLDLSRS
                     EIILSCTASGYPSPHYRWKQNGTDIDFSMTYHYRLDGGSLAISSPRTDQDIGIYQCLA
                     TNPVGTILSRKAKLQFAYIEDFETKSRSTVSVREGQGVVLLCGPPPHFGELSYDWTFN
                     DNPLYVQEDKRRFVSQNTGNLYIAKVEPSDVGNYTCFVTNKEAHRSVQGPPTPLVQRT
                     DGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPMPGKVKYS
                     NSQATLEIPKFQQEDEGFYECVAGNLRGRNLAKGQLIFYAPPEWEQKIQNTYLSIYDS
                     LFWECKASGNPNPSYTWLKNGERLNTEERIQTENGTLIITMLNVSDSGIYQCAAENKY
                     QTIYANAELRVLASAPDFSKNPIKKISVVQVGGDISIECKPNAFPKASISWKRGTENL
                     KQSKRVFFLEDGSLKICNVTRSDAGSYTCVATNQFGNGKSSGSLIVKERTVITVPPSK
                     MDVTVGESIVLPCQVSHDPTMEVLFVWYFNGDVIDLKKGVAHFERIGGESVGDLMIRN
                     IQLGHSGKYLCTVQTTLERLSAVADIIVRGPPGPPEDVKVEHISSTTSQLSWRPGPDN
                     NSPIQIFTIQTRTPFSVGWQAVATVPEILNGQTYNATVIGLSPWVEYEFRVVAGNNIG
                     IGEPSKPSELLRTKASIPNVAPVNINGGGGSRSELVITWEPIPEELQNGEGFGYIIMF
                     RPVGSTTWMKEKVALVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSLSTVSIVYSG
                     EDEPRLAPRGTSVQSFSASDMEVSWNAIAWNRNTGRVLGYEVLYWTDNSKESMIGKIR
                     VSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKL
                     SNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHVLETNNTSAELLVPFEEDYLI
                     EIRTVSDGGDGSSSEEIRIPKMSSLSSVGVQILKPSTQFLTMVGFFYCFVIQPLSR"
     exon            243..369
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..545
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            546..641
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..845
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..948
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1133
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1270
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1400
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1551
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1679
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1855
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1973
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2132
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2282
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2353
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2588
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2704
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2891
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3004
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3173
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3405
                     /gene="Cntn6"
                     /gene_synonym="NB-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccatacg gcttggttct gcctggatgc acagcatgcc tgactgaggg ctccagacag
       61 agttctgcag gaaaattcta aagatcccga gacatttccc tgatagattg tgaacatact
      121 gactagaaga tacaatcttc tttcctgctg attgcatggg agaaattttt gaccttcgaa
      181 cgtggagatg aggttgctat ggaaactggt aattctgctg ccactcataa actcttgtgc
      241 aggtgagagt cgttttactc gtcctatttt tatccaggag ccacaggatg tcatttttcc
      301 gttggattta tctagatctg aaattattct gagttgtact gcaagtggat acccttctcc
      361 ccactacagg tggaaacaga atggtacaga cattgacttc agcatgactt atcactatag
      421 gttggatgga ggcagtttgg ccatcagcag ccccagaaca gatcaagata ttggcatata
      481 ccagtgtctg gccaccaatc cggtgggcac cattctgagt agaaaagcca aactacagtt
      541 tgcatatatt gaagactttg aaaccaaatc cagaagcacg gtctctgtcc gggaaggtca
      601 aggagtggta ctcctctgtg gcccaccacc acattttgga gaattatcat atgattggac
      661 cttcaatgat aaccctttgt atgttcaaga ggacaagcga cgatttgtat ctcaaaacac
      721 agggaacttg tacattgcca aagtagaacc gtctgatgtg ggcaattata cttgctttgt
      781 cacaaacaaa gaggcccaca gaagtgtcca aggaccacct actcctttag tgcagcgcac
      841 tgatggtgtc atgggggaat atgagccaaa gattgaagtg cgttttcctg aaacaataca
      901 agctgcaaag gattcatctg taaaactgga atgctttgcc cttggaaatc cagtccctga
      961 tattagttgg aggcggttgg atggaagccc gatgccaggg aaagtcaagt acagcaactc
     1021 ccaagctacc cttgaaatcc ccaagtttca acaagaggat gaaggcttct atgagtgcgt
     1081 tgcaggtaac cttcgaggaa gaaaccttgc aaagggtcaa ctcattttct atgctcctcc
     1141 agaatgggaa cagaaaatcc aaaatacata cctttctatc tatgacagct tgttttggga
     1201 atgcaaagct agtggaaacc caaatccttc gtacacgtgg ctaaagaatg gtgaacgtct
     1261 caacacagaa gagagaattc agactgaaaa tgggactctt atcatcacca tgctgaacgt
     1321 gtcagactct gggatctacc agtgtgctgc agaaaacaag tatcagacaa tttatgcaaa
     1381 tgcagaattg agagttttag cctcagctcc agatttctca aaaaatccca ttaaaaaaat
     1441 ttcagttgtt caagttggtg gtgacatttc aatcgaatgc aaaccaaacg ctttccccaa
     1501 agcatctatt tcctggaaaa gaggaacgga gaacctgaag caaagtaaaa gagttttttt
     1561 cttggaggat ggtagcctta agatatgcaa tgttaccaga tcagatgctg gatcttatac
     1621 ttgcgtagcc acaaatcaat ttggcaatgg gaaaagcagt ggtagtctca tcgtaaaaga
     1681 gcgaacggtc attacagtac caccgtctaa aatggatgtt acagttggag agagcattgt
     1741 cttaccctgc caggtgtctc atgatcccac catggaagtt ctctttgttt ggtacttcaa
     1801 tggagatgtc atagatttaa agaaaggagt ggctcatttt gaacgaattg ggggtgaatc
     1861 tgttggggat ttgatgataa ggaatattca attaggccat tcgggaaaat atctatgcac
     1921 agtacaaaca acactagaac gcttgtctgc tgtcgctgat atcattgtga gaggtcctcc
     1981 tggtccccca gaagatgtaa aagtggagca catctctagt accacgtccc agctcagctg
     2041 gagacctggt cctgataata acagccccat tcaaattttt accattcaga ctcggacacc
     2101 cttctctgtg ggctggcaag ctgttgccac agtccctgaa attctcaatg gacagacata
     2161 caatgcaaca gtcattggtt tgagtccttg ggtggaatat gaatttcgtg ttgttgctgg
     2221 gaacaacatt ggaattggag agccaagcaa accatcagag ttgctgagaa ccaaagcatc
     2281 aatccccaat gtggcaccag taaatatcaa tggaggtggt gggagcagat cggaacttgt
     2341 cattacgtgg gagcctattc cagaagaact acagaatgga gaggggtttg gatatatcat
     2401 catgttccgg ccagtgggct caacaacctg gatgaaagaa aaggtggctc ttgtagaatc
     2461 ttcaaagttc atctacagaa atgaaagcat catgcctttg tctccctttg aagtcaaagt
     2521 gggagtgtac aacaatgaag gcgaaggttc cctgagtacc gtgtctattg tctactctgg
     2581 ggaagatgaa cctcggctgg ctccaagagg aacttctgtc cagagttttt ctgcttctga
     2641 catggaggtt tcctggaatg ccattgcttg gaatagaaac actggaagag tgctgggcta
     2701 tgaggtctta tactggactg acaactccaa agaatctatg attgggaaaa ttagagtcag
     2761 tggaaatgtc acaaccaaga atattacagg gctaagagct aatacgattt actttgcttc
     2821 tgtgagagcc tacaacactg cagggacagg accctcaagt ccaccagtta atgtcaccac
     2881 gaaaaagtcc ccacctagcc aaccaccagc aaacattgcc tggaagctgt caaattccaa
     2941 attatgcctg aactgggagc atgtaaaaac tatggaaaat gagtctgaag tgctgggcta
     3001 caagatcctc tatcggcaga accgacagag taaaactcat gtcttggaaa caaataatac
     3061 atcagctgag ctactggttc catttgaaga agactatttg atcgaaatca gaacagtcag
     3121 tgatggtgga gacggaagca gtagtgagga aatcagaatt ccaaaaatgt caagtttgag
     3181 ttccgtggga gttcagatct tgaagcccag tacccagttc ctgacaatgg ttggattttt
     3241 ttactgtttt gttattcagc cactttcacg atgaatcaat ctatggatct ttgggaattt
     3301 tctgagagca aatcattctg taaatacgtt ctccagcctc catcacgaga catattctta
     3361 atacagactt gtttggaaag aaaatgtata ttactaagct cttgt
//
