LOCUS       NM_057118               3210 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus contactin 1 (Cntn1), mRNA.
ACCESSION   NM_057118
VERSION     NM_057118.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Cai,Q., Patel,M., Coling,D. and Hu,B.H.
  TITLE     Transcriptional changes in adhesion-related genes are site-specific
            during noise-induced cochlear pathogenesis
  JOURNAL   Neurobiol Dis 45 (2), 723-732 (2012)
   PUBMED   22044737
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Czopka,T., von Holst,A., ffrench-Constant,C. and Faissner,A.
  TITLE     Regulatory mechanisms that mediate tenascin C-dependent inhibition
            of oligodendrocyte precursor differentiation
  JOURNAL   J Neurosci 30 (37), 12310-12322 (2010)
   PUBMED   20844127
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Dobbertin,A., Czvitkovich,S., Theocharidis,U., Garwood,J.,
            Andrews,M.R., Properzi,F., Lin,R., Fawcett,J.W. and Faissner,A.
  TITLE     Analysis of combinatorial variability reveals selective
            accumulation of the fibronectin type III domains B and D of
            tenascin-C in injured brain
  JOURNAL   Exp Neurol 225 (1), 60-73 (2010)
   PUBMED   20451518
  REMARK    GeneRIF: Expression of alternatively spliced FnIII domains of
            tenascin-C is differentially regulated after brain injury, with
            strong increases of domains B and D that may well influence axonal
            regeneration and repair processes in the damaged nervous system.
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Lieberoth,A., Splittstoesser,F., Katagihallimath,N.,
            Jakovcevski,I., Loers,G., Ranscht,B., Karagogeos,D., Schachner,M.
            and Kleene,R.
  TITLE     Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1,
            Contactin, and L1 mediate CD24-dependent neurite outgrowth
  JOURNAL   J Neurosci 29 (20), 6677-6690 (2009)
   PUBMED   19458237
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Compton,A.G., Albrecht,D.E., Seto,J.T., Cooper,S.T., Ilkovski,B.,
            Jones,K.J., Challis,D., Mowat,D., Ranscht,B., Bahlo,M.,
            Froehner,S.C. and North,K.N.
  TITLE     Mutations in contactin-1, a neural adhesion and neuromuscular
            junction protein, cause a familial form of lethal congenital
            myopathy
  JOURNAL   Am J Hum Genet 83 (6), 714-724 (2008)
   PUBMED   19026398
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Xiao,Z.C., Taylor,J., Montag,D., Rougon,G. and Schachner,M.
  TITLE     Distinct effects of recombinant tenascin-R domains in neuronal cell
            functions and identification of the domain interacting with the
            neuronal recognition molecule F3/11
  JOURNAL   Eur J Neurosci 8 (4), 766-782 (1996)
   PUBMED   9081628
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S.,
            Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D., Grumet,M. and
            Schlessinger,J.
  TITLE     The carbonic anhydrase domain of receptor tyrosine phosphatase beta
            is a functional ligand for the axonal cell recognition molecule
            contactin
  JOURNAL   Cell 82 (2), 251-260 (1995)
   PUBMED   7628014
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Hosoya,H., Shimazaki,K., Kobayashi,S., Takahashi,H., Shirasawa,T.,
            Takenawa,T. and Watanabe,K.
  TITLE     Developmental expression of the neural adhesion molecule F3 in the
            rat brain
  JOURNAL   Neurosci Lett 186 (2-3), 83-86 (1995)
   PUBMED   7777204
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Berglund,E.O. and Ranscht,B.
  TITLE     Molecular cloning and in situ localization of the human contactin
            gene (CNTN1) on chromosome 12q11-q12
  JOURNAL   Genomics 21 (3), 571-582 (1994)
   PUBMED   7959734
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Faivre-Sarrailh,C., Gennarini,G., Goridis,C. and Rougon,G.
  TITLE     F3/F11 cell surface molecule expression in the developing mouse
            cerebellum is polarized at synaptic sites and within granule cells
  JOURNAL   J Neurosci 12 (1), 257-267 (1992)
   PUBMED   1729438
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D38492.1.
            
            On Aug 31, 2012 this sequence version replaced NM_057118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3210              D38492.1           5-3214
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..3210
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /note="contactin 1"
                     /db_xref="GeneID:117258"
                     /db_xref="RGD:621300"
     exon            1..59
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            60..191
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3196
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /function="cell adhesion molecule"
                     /note="neural cell surface protein F3"
                     /codon_start=1
                     /product="contactin-1 precursor"
                     /protein_id="NP_476459.1"
                     /db_xref="GeneID:117258"
                     /db_xref="RGD:621300"
                     /translation="MKTPLLVSHLLLISLTSCLGEFTWHRRYGHGVSEEDKGFGPIFE
                     EQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTNDRYSMVGGNLVINN
                     PDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEDRPEVKVKEGKGMVLLCDP
                     PYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSI
                     TKSVFSKFIPLIPIPERTTKPYPADIVVQFKDIYTMMGQNVTLECFALGNPVPDIRWR
                     KVLEPMPTTAEISTSGAVLKIFNIQLEDEGLYECEAENIRGKDKHQARIYVQAFPEWV
                     EHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCI
                     AENAYGTIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK
                     GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITNPTRII
                     LAPINADITVGENATMQCAASFDPSLDLTFVWSFNGYVIDFNKEITNIHYQRNFMLDA
                     NGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVAL
                     TWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMESAKAVDLIPWMEYEFR
                     VVATNTLGTGEPSIPSNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYHYGN
                     NFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYS
                     LIAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIRYWAGHDKEAAA
                     HRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKAPPSQPPRII
                     SSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGKLFSTHKHSIEVPIPRDG
                     EYVVEVRAHSDGGDGVVSQVKISGVSTLSSGLLSLLLPSLGFLVFYSEF"
     exon            192..224
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            225..357
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..530
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..833
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..933
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1115
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1240
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1358
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1509
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1637
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1819
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1940
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2099
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2249
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2320
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2555
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2659
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2846
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2959
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3116
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3210
                     /gene="Cntn1"
                     /gene_synonym="F3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaggggca atttgaagca gatattatac cgagaccggc agatgattca acacatacgg
       61 tctttcatag ttgtcaactg ccataaagct cccattcctt ctggaaactg acccatctat
      121 tcaacagaag atgaaaaccc cattgctggt cagtcatctc ctgctaatct ccttaacatc
      181 ctgtctagga gagtttacat ggcacagaag atatggtcat ggagtttctg aggaggataa
      241 aggatttgga cccatttttg aagagcaacc aatcaatacc atttacccag aagagtcact
      301 ggaaggcaaa gtgtcgctca actgccgggc acgggcaagc ccatttccgg tttacaagtg
      361 gagaatgaat aacggggacg ttgacctgac gaacgatcga tacagcatgg tcggagggaa
      421 ccttgttatc aataaccctg acaaacagaa agacgcagga atatactact gcttggcgtc
      481 caacaactac gggatggtca gaagcaccga ggccaccctg agctttgggt atcttgaccc
      541 ctttcctcct gaggatcgtc ctgaagtgaa ggtgaaggaa gggaagggca tggtgcttct
      601 ctgcgaccct ccctaccact tcccagacga tcttagctac cgctggcttc tgaatgaatt
      661 tcccgtcttt atcacaatgg ataagcgaag attcgtgtct cagaccaacg gtaatctcta
      721 catcgcgaac gttgagtctt ctgatagagg caactattcc tgcttcgtgt ccagcccttc
      781 tattacaaag agcgtgttca gcaaatttat acccctcatt ccgatacctg agcgaacaac
      841 gaagccatat cctgctgaca ttgtagtgca gttcaaggac atatacacca tgatgggcca
      901 aaatgtgacc ttagagtgct tcgctcttgg aaaccctgtt cctgatattc ggtggcggaa
      961 ggtgctagaa cccatgccta ccacagctga gatcagcacc tcaggggctg tcctcaagat
     1021 cttcaacatc cagctagaag atgaagggct ctacgagtgc gaggctgaga acattagggg
     1081 aaaggacaag caccaggcaa gaatttatgt tcaagcattt cctgaatggg tagagcatat
     1141 caatgacact gaagtggaca taggcagtga cctctactgg ccttgtgtgg ccacagggaa
     1201 gcccatccct accatcaggt ggctgaaaaa tgggtacgcg tatcacaaag gggaactgag
     1261 gctgtatgac gtgacttttg aaaacgccgg gatgtaccag tgcatagcag aaaacgcgta
     1321 tgggaccatt tatgcaaatg ctgaactcaa gatcctggct ttagctccaa cttttgaaat
     1381 gaatcccatg aagaagaaga tcctggctgc gaaaggagga agggttatca ttgagtgcaa
     1441 acccaaggct gcaccaaaac ccaagttttc atggagcaaa gggacagagt ggcttgtcaa
     1501 cagcagcaga atactcatat gggaagatgg tagcttggaa atcaataata ttacaagaaa
     1561 tgatggagga atctatacat gctttgcaga aaacaacaga gggaaagcta atagcaccgg
     1621 gactctggtg atcacaaatc ccacacgaat cattttggcc ccaatcaatg ctgatatcac
     1681 tgttggagaa aacgctacca tgcagtgtgc tgcctccttt gatccttcct tggatctcac
     1741 gttcgtctgg tctttcaatg gctacgtgat tgactttaac aaggaaatta caaatattca
     1801 ttaccagagg aattttatgc tcgacgccaa tggggaactg ctcatccgaa acgcgcagct
     1861 gaaacacgca ggacggtaca cgtgcacagc gcagacaatc gtggacaatt cttcagcttc
     1921 agctgacctt gtcgtacgag gccccccagg ccctccaggt ggcctgagaa tagaagacat
     1981 cagagctacc tctgtggcac tgacttggag ccgtggttca gacaatcaca gccctatctc
     2041 taaatacact atccagacca agacgattct ctcagatgac tggaaagacg caaagacgga
     2101 tcccccaatc attgaaggaa acatggagtc agcaaaagca gtcgatttga tcccatggat
     2161 ggagtacgaa tttcgagtgg tagcaaccaa tactttgggg actggagagc ccagcatacc
     2221 ctcaaacagg atcaaaaccg atggcgctgc accaaatgtg gctccctcag acgtaggtgg
     2281 tgggggcgga accaacagag agctgacaat aacgtgggcg cctttgtcca gagaatacca
     2341 ttatggtaac aattttggtt acatagtggc attcaagcca ttcgatggag aagagtggaa
     2401 gaaagtgacc gttaccaatc cggatactgg ccgctacgtc cacaaggacg aaaccatgac
     2461 cccttccacc gcgtttcaag tcaaagtgaa ggcattcaac aataaaggag acgggcccta
     2521 cagcctcata gctgtcatca actcagcaca agacgctccc agtgaagccc ccacagaagt
     2581 aggggtcaaa gtgctatcgt cctctgagat ctctgtccat tggaagcacg ttctagagaa
     2641 gattgtggaa agctatcaaa ttcggtactg ggccggtcac gacaaagaag cagcggcgca
     2701 cagagttcaa gtcaccagcc aggagtactc agccaggctg gagaaccttc tgccggacac
     2761 tcagtacttc atagaggtgg gagcctgtaa cagcgcgggg tgcggacctt ccagcgacgt
     2821 gatcgagacc ttcaccagaa aagcccctcc cagccaacca ccaaggatca tcagttccgt
     2881 gaggtctggc tcccgataca taatcacgtg ggatcatgtc gtggcactat ccaatgaatc
     2941 tacagtgaca ggctacaaga tactctatag acctgacggc caacatgacg gtaagctgtt
     3001 ctccacgcac aagcactcca tagaagtccc catccccaga gacggagagt acgtagtcga
     3061 agttcgagca cacagtgatg gaggagatgg ggtagtgtcc caagtcaaaa tttcaggtgt
     3121 gtccacgctg tcatcgggtc tcctcagctt gctcctgccc tcccttggct ttcttgtctt
     3181 ctattcggaa ttctgaacgt tgtgacattt
//
