LOCUS       NM_001003929            2024 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus ciliary neurotrophic factor receptor (Cntfr),
            mRNA.
ACCESSION   NM_001003929 XM_017593357 XM_242848
VERSION     NM_001003929.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Askvig,J.M. and Watt,J.A.
  TITLE     Absence of axonal sprouting following unilateral lesion in
            125-day-old rat supraoptic nucleus may be due to age-dependent
            decrease in protein levels of ciliary neurotrophic factor receptor
            alpha
  JOURNAL   J Comp Neurol 527 (14), 2291-2301 (2019)
   PUBMED   30861131
  REMARK    GeneRIF: Absence of axonal sprouting following unilateral lesion in
            125-day-old rat supraoptic nucleus may be due to age-dependent
            decrease in protein levels of ciliary neurotrophic factor receptor
            alpha.
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   El-Deeb,O.S., Ghanem,H.B., El-Esawy,R.O. and Sadek,M.T.
  TITLE     The modulatory effects of luteolin on cyclic AMP/Ciliary
            neurotrophic factor signaling pathway in experimentally induced
            autoimmune encephalomyelitis
  JOURNAL   IUBMB Life 71 (9), 1401-1408 (2019)
   PUBMED   31185137
  REMARK    GeneRIF: Compared with the EAE group, luteolin-treated EAE group
            showed upregulation of CNTF expression and significant increase in
            cAMP and TAC levels, while it showed significant decrease in
            cleaved caspase 3, NF-kappaB, and MIP-1alpha levels.
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Jeong,K.H., Nam,J.H., Jin,B.K. and Kim,S.R.
  TITLE     Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H)
            transduction of dopaminergic neurons in vivo
  JOURNAL   PLoS One 10 (3), e0121803 (2015)
   PUBMED   25799580
  REMARK    GeneRIF: Activation of CNTF/CNTFRalpha signaling pathway by
            hRheb(S16H) transduction of dopaminergic neurons
            Erratum:[PLoS One. 2015 Apr 17;10(4):e0126450. doi:
            10.1371/journal.pone.0126450.. PMID: 25886143]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Lee,N., Batt,M.K., Cronier,B.A., Jackson,M.C., Bruno Garza,J.L.,
            Trinh,D.S., Mason,C.O., Spearry,R.P., Bhattacharya,S., Robitz,R.,
            Nakafuku,M. and MacLennan,A.J.
  TITLE     Ciliary neurotrophic factor receptor regulation of adult forebrain
            neurogenesis
  JOURNAL   J Neurosci 33 (3), 1241-1258 (2013)
   PUBMED   23325260
  REMARK    GeneRIF: the data suggest that endogenous CNTF receptor signaling
            in type B stem cells inhibits adult neurogenesis, and further
            suggest that the regulation may occur in a neuron subtype-specific
            manner.
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Couvreur,O., Aubourg,A., Crepin,D., Degrouard,J., Gertler,A.,
            Taouis,M. and Vacher,C.M.
  TITLE     The anorexigenic cytokine ciliary neurotrophic factor stimulates
            POMC gene expression via receptors localized in the nucleus of
            arcuate neurons
  JOURNAL   Am J Physiol Endocrinol Metab 302 (4), E458-E467 (2012)
   PUBMED   22146310
  REMARK    GeneRIF: The data strongly suggested that intracellular ciliary
            neurotrophic factor may directly modulate proopiomelanocortin gene
            expression via the activation of ciliary neurotrophic factor
            receptors in the cell nucleus.
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   DeChiara,T.M., Vejsada,R., Poueymirou,W.T., Acheson,A., Suri,C.,
            Conover,J.C., Friedman,B., McClain,J., Pan,L., Stahl,N., Ip,N.Y.
            and Yancopoulos,G.D.
  TITLE     Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit
            profound motor neuron deficits at birth
  JOURNAL   Cell 83 (2), 313-322 (1995)
   PUBMED   7585948
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Stahl,N., Davis,S., Wong,V., Taga,T., Kishimoto,T., Ip,N.Y. and
            Yancopoulos,G.D.
  TITLE     Cross-linking identifies leukemia inhibitory factor-binding protein
            as a ciliary neurotrophic factor receptor component
  JOURNAL   J Biol Chem 268 (11), 7628-7631 (1993)
   PUBMED   8385113
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Clatterbuck,R.E., Price,D.L. and Koliatsos,V.E.
  TITLE     Ciliary neurotrophic factor prevents retrograde neuronal death in
            the adult central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2222-2226 (1993)
   PUBMED   8460125
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Ip,N.Y., McClain,J., Barrezueta,N.X., Aldrich,T.H., Pan,L., Li,Y.,
            Wiegand,S.J., Friedman,B., Davis,S. and Yancopoulos,G.D.
  TITLE     The alpha component of the CNTF receptor is required for signaling
            and defines potential CNTF targets in the adult and during
            development
  JOURNAL   Neuron 10 (1), 89-102 (1993)
   PUBMED   8381290
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Davis,S., Aldrich,T.H., Valenzuela,D.M., Wong,V.V., Furth,M.E.,
            Squinto,S.P. and Yancopoulos,G.D.
  TITLE     The receptor for ciliary neurotrophic factor
  JOURNAL   Science 253 (5015), 59-63 (1991)
   PUBMED   1648265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jan 4, 2023 this sequence version replaced
            XM_017593357.2, NM_001003929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1937165.1,
                                           SRR26643299.22446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000005.1  61656754-61656918   c
            166-255             JAXUCZ010000005.1  61648275-61648364   c
            256-340             JAXUCZ010000005.1  61636885-61636969   c
            341-574             JAXUCZ010000005.1  61632759-61632992   c
            575-692             JAXUCZ010000005.1  61625344-61625461   c
            693-859             JAXUCZ010000005.1  61625006-61625172   c
            860-1023            JAXUCZ010000005.1  61623810-61623973   c
            1024-1204           JAXUCZ010000005.1  61620561-61620741   c
            1205-1373           JAXUCZ010000005.1  61620070-61620238   c
            1374-2024           JAXUCZ010000005.1  61619326-61619976   c
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2024
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /note="ciliary neurotrophic factor receptor"
                     /db_xref="GeneID:313173"
                     /db_xref="RGD:1303100"
     exon            1..165
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            166..255
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1374
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /note="ciliary neurotrophic factor receptor alpha; ciliary
                     neurotrophic factor receptor subunit alpha; CNTF receptor
                     subunit alpha; CNTFR alpha"
                     /codon_start=1
                     /product="ciliary neurotrophic factor receptor subunit
                     alpha precursor"
                     /protein_id="NP_001003929.2"
                     /db_xref="GeneID:313173"
                     /db_xref="RGD:1303100"
                     /translation="MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTL
                     PCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVL
                     LHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPAL
                     KNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSN
                     PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEY
                     IIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKI
                     CDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI"
     exon            256..340
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            341..574
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            575..692
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            693..859
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1023
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1204
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1373
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2024
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagcggg cggcggcggc ggcagtggag gcggcggctc cagccggcgc ggcgcggggt
       61 tcggcagtgg gatccggccg cagtgctcac tccgcgctcc tgcctccctc accgcctgca
      121 gcggccgaag ggcgcggcgc ggagcccgag tggcccgagg gcgcgaaccc ggtcccaaca
      181 catcatccca ggaagacttt ggtctgcaga ggaggataat attgatgtgc ttggagagca
      241 tctggtggta acgagatggc tgcttctgtc ccttgggcct gctgtgctgt gcttgccgct
      301 gccgctgccg ctgtctacac ccagaaacac agtccacagg aggcacccca tgttcagtat
      361 gagcgtctgg gcacagatgt gacgctgcca tgtgggacag caagttggga cgcagctgtg
      421 acctggaggg taaatggaac agatctggcc cctgacctgc tcaatggctc tcagctgata
      481 ctacgaagct tagaactggg ccacagtggc ctgtatgcct gtttccaccg tgactcctgg
      541 cacctgcgcc accaagtcct tctgcatgtg ggtttgccgc ctcgggaacc cgtgctcagc
      601 tgccgttcca acacttaccc caagggcttc tactgcagct ggcacctgtc cgcccccacc
      661 tacatcccca ataccttcaa tgtgactgta ctgcatggct ccaaaatgat ggtctgtgag
      721 aaggacccag ccctcaagaa ccgctgtcac attcggtaca tgcacctgtt ctcaaccatc
      781 aagtacaagg tctccataag tgtcagcaac gccttgggtc acaacaccac ggctatcacc
      841 ttcgacgaat tcaccattgt gaagcccgat cctccagaaa atgtggtggc ccggccagtg
      901 cccagcaacc cccgtcgact ggaggtgaca tggcagacgc cctcaacttg gcctgatccc
      961 gaatcctttc cactcaagtt ttttctgcgc taccggcctc tcatcctgga ccaatggcag
     1021 catgtggagc tctcggatgg cacagcccac accatcacgg atgcctatgc tggaaaggag
     1081 tacatcatcc aggtggccgc caaggacaat gagattggga catggagtga ctggagtgtg
     1141 gctgctcacg ccacaccctg gactgaggaa ccacggcatc tcaccactga agcccaggcc
     1201 cccgagacca cgaccagcac caccagctcc ttggcacccc cacccaccac gaagatctgt
     1261 gaccccgggg agctcagcag cggcggagga ccctccatac ccttcttgac cagtgtccct
     1321 gtcactctgg tcctggctgc cgctgctgcc acagccaaca atctcctgat ctgagccctg
     1381 catcccatga ggacacgcca gacgcctaca gaggagcagg aggccggagc tgagcctgca
     1441 gaccccggtt tctattttgc acacgggcag gaggaccttt tgcattctct tcagacacaa
     1501 tttgtagaga ccccggcagg cccgggcctg ccgtccgtcc ccctagcctc atcacaccaa
     1561 gccggctctc ctttccaccc agagaggagg gccatgcagc taacccaccc accaaagacc
     1621 cctctcatct tacccctcgg gctggaccct ccaacgccag cgactcccag gagcccttgg
     1681 gggaacctga ggggagcccc caccccatat ctacagtttc cccctcctgc cccagcctcc
     1741 tgtctgtccc agggtctctg ttgcaccatc agattataag ctcctgacac tgggggggcc
     1801 cagccatccc cttccccccg gtgcccacac ttttcagtcc ctccacctct gcccctgttt
     1861 tgtacgaccc tccattggcc ctttcctact cccagtattt aatgtcctgt cagtcccttc
     1921 tagtctgact caatggtaac ttgctgtatt tgaatttttt atagatgtat atacatggga
     1981 gggaggggta gggagttctc attaaacgtc accatttcat gaga
//
