LOCUS       NP_001003929             372 aa            linear   ROD 14-FEB-2025
DEFINITION  ciliary neurotrophic factor receptor subunit alpha precursor
            [Rattus norvegicus].
ACCESSION   NP_001003929 XP_017448846 XP_242848
VERSION     NP_001003929.2
DBSOURCE    REFSEQ: accession NM_001003929.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Askvig,J.M. and Watt,J.A.
  TITLE     Absence of axonal sprouting following unilateral lesion in
            125-day-old rat supraoptic nucleus may be due to age-dependent
            decrease in protein levels of ciliary neurotrophic factor receptor
            alpha
  JOURNAL   J Comp Neurol 527 (14), 2291-2301 (2019)
   PUBMED   30861131
  REMARK    GeneRIF: Absence of axonal sprouting following unilateral lesion in
            125-day-old rat supraoptic nucleus may be due to age-dependent
            decrease in protein levels of ciliary neurotrophic factor receptor
            alpha.
REFERENCE   2  (residues 1 to 372)
  AUTHORS   El-Deeb,O.S., Ghanem,H.B., El-Esawy,R.O. and Sadek,M.T.
  TITLE     The modulatory effects of luteolin on cyclic AMP/Ciliary
            neurotrophic factor signaling pathway in experimentally induced
            autoimmune encephalomyelitis
  JOURNAL   IUBMB Life 71 (9), 1401-1408 (2019)
   PUBMED   31185137
  REMARK    GeneRIF: Compared with the EAE group, luteolin-treated EAE group
            showed upregulation of CNTF expression and significant increase in
            cAMP and TAC levels, while it showed significant decrease in
            cleaved caspase 3, NF-kappaB, and MIP-1alpha levels.
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Jeong,K.H., Nam,J.H., Jin,B.K. and Kim,S.R.
  TITLE     Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H)
            transduction of dopaminergic neurons in vivo
  JOURNAL   PLoS One 10 (3), e0121803 (2015)
   PUBMED   25799580
  REMARK    GeneRIF: Activation of CNTF/CNTFRalpha signaling pathway by
            hRheb(S16H) transduction of dopaminergic neurons
            Erratum:[PLoS One. 2015 Apr 17;10(4):e0126450. doi:
            10.1371/journal.pone.0126450.. PMID: 25886143]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Lee,N., Batt,M.K., Cronier,B.A., Jackson,M.C., Bruno Garza,J.L.,
            Trinh,D.S., Mason,C.O., Spearry,R.P., Bhattacharya,S., Robitz,R.,
            Nakafuku,M. and MacLennan,A.J.
  TITLE     Ciliary neurotrophic factor receptor regulation of adult forebrain
            neurogenesis
  JOURNAL   J Neurosci 33 (3), 1241-1258 (2013)
   PUBMED   23325260
  REMARK    GeneRIF: the data suggest that endogenous CNTF receptor signaling
            in type B stem cells inhibits adult neurogenesis, and further
            suggest that the regulation may occur in a neuron subtype-specific
            manner.
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Couvreur,O., Aubourg,A., Crepin,D., Degrouard,J., Gertler,A.,
            Taouis,M. and Vacher,C.M.
  TITLE     The anorexigenic cytokine ciliary neurotrophic factor stimulates
            POMC gene expression via receptors localized in the nucleus of
            arcuate neurons
  JOURNAL   Am J Physiol Endocrinol Metab 302 (4), E458-E467 (2012)
   PUBMED   22146310
  REMARK    GeneRIF: The data strongly suggested that intracellular ciliary
            neurotrophic factor may directly modulate proopiomelanocortin gene
            expression via the activation of ciliary neurotrophic factor
            receptors in the cell nucleus.
REFERENCE   6  (residues 1 to 372)
  AUTHORS   DeChiara,T.M., Vejsada,R., Poueymirou,W.T., Acheson,A., Suri,C.,
            Conover,J.C., Friedman,B., McClain,J., Pan,L., Stahl,N., Ip,N.Y.
            and Yancopoulos,G.D.
  TITLE     Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit
            profound motor neuron deficits at birth
  JOURNAL   Cell 83 (2), 313-322 (1995)
   PUBMED   7585948
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Stahl,N., Davis,S., Wong,V., Taga,T., Kishimoto,T., Ip,N.Y. and
            Yancopoulos,G.D.
  TITLE     Cross-linking identifies leukemia inhibitory factor-binding protein
            as a ciliary neurotrophic factor receptor component
  JOURNAL   J Biol Chem 268 (11), 7628-7631 (1993)
   PUBMED   8385113
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Clatterbuck,R.E., Price,D.L. and Koliatsos,V.E.
  TITLE     Ciliary neurotrophic factor prevents retrograde neuronal death in
            the adult central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2222-2226 (1993)
   PUBMED   8460125
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Ip,N.Y., McClain,J., Barrezueta,N.X., Aldrich,T.H., Pan,L., Li,Y.,
            Wiegand,S.J., Friedman,B., Davis,S. and Yancopoulos,G.D.
  TITLE     The alpha component of the CNTF receptor is required for signaling
            and defines potential CNTF targets in the adult and during
            development
  JOURNAL   Neuron 10 (1), 89-102 (1993)
   PUBMED   8381290
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Davis,S., Aldrich,T.H., Valenzuela,D.M., Wong,V.V., Furth,M.E.,
            Squinto,S.P. and Yancopoulos,G.D.
  TITLE     The receptor for ciliary neurotrophic factor
  JOURNAL   Science 253 (5015), 59-63 (1991)
   PUBMED   1648265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jan 4, 2023 this sequence version replaced
            XP_017448846.1, NP_001003929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1937165.1,
                                           SRR26643299.22446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..372
                     /product="ciliary neurotrophic factor receptor subunit
                     alpha precursor"
                     /note="ciliary neurotrophic factor receptor alpha; ciliary
                     neurotrophic factor receptor subunit alpha; CNTF receptor
                     subunit alpha; CNTFR alpha"
                     /calculated_mol_wt=38730
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2112
     mat_peptide     23..342
                     /product="Ciliary neurotrophic factor receptor subunit
                     alpha. /id=PRO_0000010995"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08406.2)"
                     /calculated_mol_wt=35899
     Region          38..>90
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          42..46
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          54..58
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q08406.2)"
     Site            70
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q08406.2)"
     Region          72..76
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          86..90
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            142
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q08406.2)"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q08406.2)"
     Region          204..300
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(204,272,289)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            261
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q08406.2)"
     Region          290..294
                     /region_name="WSXWS motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08406.2)"
     Site            order(290..291,293..294)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          301..339
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08406.2)"
     CDS             1..372
                     /gene="Cntfr"
                     /gene_synonym="CNTFR-alpha"
                     /coded_by="NM_001003929.2:256..1374"
                     /db_xref="GeneID:313173"
                     /db_xref="RGD:1303100"
ORIGIN      
        1 maasvpwacc avlaaaaaav ytqkhspqea phvqyerlgt dvtlpcgtas wdaavtwrvn
       61 gtdlapdlln gsqlilrsle lghsglyacf hrdswhlrhq vllhvglppr epvlscrsnt
      121 ypkgfycswh lsaptyipnt fnvtvlhgsk mmvcekdpal knrchirymh lfstikykvs
      181 isvsnalghn ttaitfdeft ivkpdppenv varpvpsnpr rlevtwqtps twpdpesfpl
      241 kfflryrpli ldqwqhvels dgtahtitda yagkeyiiqv aakdneigtw sdwsvaahat
      301 pwteeprhlt teaqapettt sttsslappp ttkicdpgel ssgggpsipf ltsvpvtlvl
      361 aaaaatannl li
//
