LOCUS       NM_013166               1094 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ciliary neurotrophic factor (Cntf), mRNA.
ACCESSION   NM_013166
VERSION     NM_013166.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1094)
  AUTHORS   Guo,Y., Mehrabian,Z., Milbrandt,J., DiAntonio,A. and Bernstein,S.L.
  TITLE     Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1
            Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior
            Ischemic Optic Neuropathy
  JOURNAL   Cells 13 (3), 202 (2024)
   PUBMED   38334594
  REMARK    GeneRIF: Synergistic Protection of Retinal Ganglion Cells (RGCs) by
            SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic
            Anterior Ischemic Optic Neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1094)
  AUTHORS   Ceyzeriat,K., Nicolaides,A., Amosse,Q., Fossey,C., Cailly,T.,
            Fabis,F., Garibotto,V., Escartin,C., Tournier,B.B. and Millet,P.
  TITLE     Reactive astrocytes mediate TSPO overexpression in response to
            sustained CNTF exposure in the rat striatum
  JOURNAL   Mol Brain 16 (1), 57 (2023)
   PUBMED   37408083
  REMARK    GeneRIF: Reactive astrocytes mediate TSPO overexpression in
            response to sustained CNTF exposure in the rat striatum.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1094)
  AUTHORS   Lee,K., Choi,J.O., Hwang,A., Bae,H.W. and Kim,C.Y.
  TITLE     Ciliary Neurotrophic Factor Derived From Astrocytes Protects
            Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK
            Pathways
  JOURNAL   Invest Ophthalmol Vis Sci 63 (9), 4 (2022)
   PUBMED   35925584
  REMARK    GeneRIF: Ciliary Neurotrophic Factor Derived From Astrocytes
            Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and
            MAPK/ERK Pathways.
REFERENCE   4  (bases 1 to 1094)
  AUTHORS   Wang,Y., Rhee,K.D., Pellegrini,M. and Yang,X.J.
  TITLE     Impacts of ciliary neurotrophic factor on the retinal transcriptome
            in a mouse model of photoreceptor degeneration
  JOURNAL   Sci Rep 10 (1), 6593 (2020)
   PUBMED   32313077
  REMARK    GeneRIF: Impacts of ciliary neurotrophic factor on the retinal
            transcriptome in a mouse model of photoreceptor degeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1094)
  AUTHORS   Zheng,K., Zhang,Q., Sheng,Z., Li,Y. and Lu,H.H.
  TITLE     Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from
            Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of
            Akt-Nrf2 Signaling
  JOURNAL   Cell Physiol Biochem 51 (4), 1852-1862 (2018)
   PUBMED   30504707
  REMARK    GeneRIF: CNTF activates Akt-Nrf2 signaling to protect myocardial
            cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation.
REFERENCE   6  (bases 1 to 1094)
  AUTHORS   Unoki,K. and LaVail,M.M.
  TITLE     Protection of the rat retina from ischemic injury by brain-derived
            neurotrophic factor, ciliary neurotrophic factor, and basic
            fibroblast growth factor
  JOURNAL   Invest Ophthalmol Vis Sci 35 (3), 907-915 (1994)
   PUBMED   8125754
REFERENCE   7  (bases 1 to 1094)
  AUTHORS   Stahl,N., Davis,S., Wong,V., Taga,T., Kishimoto,T., Ip,N.Y. and
            Yancopoulos,G.D.
  TITLE     Cross-linking identifies leukemia inhibitory factor-binding protein
            as a ciliary neurotrophic factor receptor component
  JOURNAL   J Biol Chem 268 (11), 7628-7631 (1993)
   PUBMED   8385113
REFERENCE   8  (bases 1 to 1094)
  AUTHORS   Calcutt,N.A., Muir,D., Powell,H.C. and Mizisin,A.P.
  TITLE     Reduced ciliary neuronotrophic factor-like activity in nerves from
            diabetic or galactose-fed rats
  JOURNAL   Brain Res 575 (2), 320-324 (1992)
   PUBMED   1571789
REFERENCE   9  (bases 1 to 1094)
  AUTHORS   Davis,S., Aldrich,T.H., Valenzuela,D.M., Wong,V.V., Furth,M.E.,
            Squinto,S.P. and Yancopoulos,G.D.
  TITLE     The receptor for ciliary neurotrophic factor
  JOURNAL   Science 253 (5015), 59-63 (1991)
   PUBMED   1648265
REFERENCE   10 (bases 1 to 1094)
  AUTHORS   Stockli,K.A., Lottspeich,F., Sendtner,M., Masiakowski,P.,
            Carroll,P., Gotz,R., Lindholm,D. and Thoenen,H.
  TITLE     Molecular cloning, expression and regional distribution of rat
            ciliary neurotrophic factor
  JOURNAL   Nature 342 (6252), 920-923 (1989)
   PUBMED   2594085
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013166.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17457.1, FQ214544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000001.1  219314345-219314535 c
            192-1094            JAXUCZ010000001.1  219312512-219313414 c
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1094
                     /gene="Cntf"
                     /note="ciliary neurotrophic factor"
                     /db_xref="GeneID:25707"
                     /db_xref="RGD:2370"
     exon            1..191
                     /gene="Cntf"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..680
                     /gene="Cntf"
                     /note="ciliary neurotropic factor"
                     /codon_start=1
                     /product="ciliary neurotrophic factor"
                     /protein_id="NP_037298.2"
                     /db_xref="GeneID:25707"
                     /db_xref="RGD:2370"
                     /translation="MAFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGL
                     NKNINLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTE
                     GDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEADGMPATVGDGGLFEKKLWGLK
                     VLQELSQWTVRSIHDLRVISSHQMGIPALESHYGAKDKQM"
     exon            192..1094
                     /gene="Cntf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcacattt cttatttgga ctagtgaaga cagaagcaaa ccagctcact tgtttcctgg
       61 gacagttgat ttaggggatg gctttcgcag agcaaacacc tctgaccctt caccgccggg
      121 acctctgtag ccgttctatc tggctagcaa ggaagattcg ttcagacctg actgctctta
      181 tggaatctta tgtaaaacat cagggcctga ataaaaatat caaccttgac tcagtggatg
      241 gtgtaccagt ggcaagcact gatcgttgga gtgagatgac tgaggcagag cgactccaag
      301 agaacctcca ggcttaccgt accttccaag ggatgttaac caagctctta gaagaccaga
      361 gagtacattt caccccaact gaaggtgact tccatcaggc aatacatact cttatgctcc
      421 aagtttctgc ctttgcctac cagctagagg agttaatggt gcttctggaa cagaagatcc
      481 ctgaaaatga ggctgatggg atgcctgcca cagttggaga tggtggtctc tttgagaaga
      541 agctatgggg cttgaaggtc cttcaagagc tctcacagtg gactgtgagg tctatccatg
      601 accttcgtgt catttcttct catcagatgg gaatcccagc acttgagagc cattatgggg
      661 ccaaagataa gcagatgtag ccattcgctc atacctctgt ctcccttttt gatctaatga
      721 aatattgata gttccctgga gcctagtttt ctcagcatca attttggaac actttagacc
      781 acatgcattt catcaagtag ggttggccca catatgaata gatagatata catggttatt
      841 ctggctatgc aaatgtgtgc acccattttg tttgcattgg tggtataata aatgatgcca
      901 ctatcctttc accatagtag tgctttaacc ttcctgatac taagtaacct tttcaggtgt
      961 ttaacagtct tacaggcaga agagaaattg taactcgttt tggttgactt ctgaaaagac
     1021 tgaataaaca aattggaagt cctagactat cttcattcaa actacccgaa taaaaagagt
     1081 attgttgtac agag
//
