LOCUS       NM_001014232            1621 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cannabinoid receptor interacting protein 1
            (Cnrip1), mRNA.
ACCESSION   NM_001014232 XM_344268
VERSION     NM_001014232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Blume,L.C., Patten,T., Eldeeb,K., Leone-Kabler,S., Ilyasov,A.A.,
            Keegan,B.M., O'Neal,J.E., Bass,C.E., Hantgan,R.R., Lowther,W.T.,
            Selley,D.E. and Howlett,A.L.
  TITLE     Cannabinoid Receptor Interacting Protein 1a Competition with
            beta-Arrestin for CB1 Receptor Binding Sites
  JOURNAL   Mol Pharmacol 91 (2), 75-86 (2017)
   PUBMED   27895162
  REMARK    GeneRIF: CRIP1a can compete with beta-arrestins for interaction
            with C-terminal CB1R domains that could affect agonist-driven,
            beta-arrestin-mediated internalization of the CB1R.
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Smith,T.H., Blume,L.C., Straiker,A., Cox,J.O., David,B.G.,
            McVoy,J.R., Sayers,K.W., Poklis,J.L., Abdullah,R.A., Egertova,M.,
            Chen,C.K., Mackie,K., Elphick,M.R., Howlett,A.C. and Selley,D.E.
  TITLE     Cannabinoid receptor-interacting protein 1a modulates CB1 receptor
            signaling and regulation
  JOURNAL   Mol Pharmacol 87 (4), 747-765 (2015)
   PUBMED   25657338
  REMARK    GeneRIF: CRIP1a appears to act as a broad negative regulator of CB1
            receptor function
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Blume,L.C., Bass,C.E., Childers,S.R., Dalton,G.D., Roberts,D.C.,
            Richardson,J.M., Xiao,R., Selley,D.E. and Howlett,A.C.
  TITLE     Striatal CB1 and D2 receptors regulate expression of each other,
            CRIP1A and delta opioid systems
  JOURNAL   J Neurochem 124 (6), 808-820 (2013)
   PUBMED   23286559
  REMARK    GeneRIF: Increased expression of CRIP1a in corpus striatum occurs
            after knockdown of CB1 receptor or dopamine D2 receptor.
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Bojnik,E., Turunc,E., Armagan,G., Kanit,L., Benyhe,S., Yalcin,A.
            and Borsodi,A.
  TITLE     Changes in the cannabinoid (CB1) receptor expression level and
            G-protein activation in kainic acid induced seizures
  JOURNAL   Epilepsy Res 99 (1-2), 64-68 (2012)
   PUBMED   22079489
  REMARK    GeneRIF: Gene expression levels of both cannabinoid receptor
            interacting protein 1 and CB1 receptor were elevated following
            kainic acid induced seizures.
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Malinen,H. and Hyytia,P.
  TITLE     Ethanol self-administration is regulated by CB1 receptors in the
            nucleus accumbens and ventral tegmental area in alcohol-preferring
            AA rats
  JOURNAL   Alcohol Clin Exp Res 32 (11), 1976-1983 (2008)
   PUBMED   18782338
  REMARK    GeneRIF: Replication of the suppressive effects by CB1 antagonism
            in the nucleus accumbens and ventral tegmental area suggests that
            endocannabinoids and their receptors mediate ethanol reinforcement
            through interaction with the mesolimbic dopamine pathway.
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Accorsi-Mendonca,D., Almado,C.E., Dagostin,A.L., Machado,B.H. and
            Leao,R.M.
  TITLE     Inhibition of spontaneous neurotransmission in the nucleus of
            solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is
            not via CB1 or CB2 receptors
  JOURNAL   Brain Res 1200, 1-9 (2008)
   PUBMED   18308297
  REMARK    GeneRIF: We conclude WIN inhibits the neurotransmission in the NTS
            of young rats via a receptor distinct from CB1 or CB2.
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Niehaus,J.L., Liu,Y., Wallis,K.T., Egertova,M., Bhartur,S.G.,
            Mukhopadhyay,S., Shi,S., He,H., Selley,D.E., Howlett,A.C.,
            Elphick,M.R. and Lewis,D.L.
  TITLE     CB1 cannabinoid receptor activity is modulated by the cannabinoid
            receptor interacting protein CRIP 1a
  JOURNAL   Mol Pharmacol 72 (6), 1557-1566 (2007)
   PUBMED   17895407
  REMARK    GeneRIF: Cnrip gene product, CRIP1a, inhibits basal activity of the
            CB1 cannabinoid receptor (cnr1).
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001014232.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088754.1, AY883936.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               JAXUCZ010000014.1  95664512-95665014
            504-654             JAXUCZ010000014.1  95667831-95667981
            655-1621            JAXUCZ010000014.1  95693406-95694372
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1621
                     /gene="Cnrip1"
                     /gene_synonym="Crip1a; RGD1308373"
                     /note="cannabinoid receptor interacting protein 1"
                     /db_xref="GeneID:364208"
                     /db_xref="RGD:1308373"
     exon            1..503
                     /gene="Cnrip1"
                     /gene_synonym="Crip1a; RGD1308373"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..819
                     /gene="Cnrip1"
                     /gene_synonym="Crip1a; RGD1308373"
                     /note="CB1 cannabinoid receptor interacting; CRIP-1"
                     /codon_start=1
                     /product="CB1 cannabinoid receptor-interacting protein 1"
                     /protein_id="NP_001014254.1"
                     /db_xref="GeneID:364208"
                     /db_xref="RGD:1308373"
                     /translation="MGDLPGIVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGS
                     SYKVEVKIKPTTLQVENISIGGVLVPLELKCKEPDGERVVYTGIYDTEGVAPTKSGER
                     QPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNK
                     ESFL"
     exon            504..654
                     /gene="Cnrip1"
                     /gene_synonym="Crip1a; RGD1308373"
                     /inference="alignment:Splign:2.1.0"
     exon            655..1621
                     /gene="Cnrip1"
                     /gene_synonym="Crip1a; RGD1308373"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgcggggc agcctgccag tccagtcact gcgagccctc gcgtgcgcgc agggccctgc
       61 gtggggagcg ggggatgggg cagcctgctg cctccgtgct gtctctggtg cccgctcctt
      121 gtctgagtgt ggtggagggc cacagcctcg cctgctgctt ctcaaaatct ggggtgtaca
      181 gaggcgaccg ctcctagctg tggcctgcat ccatcggctc tctcttcctc cctgcttgtc
      241 cctgccgccc atcgcgctgc agcagctgcc cacagcccgc actgtccacg actccggtca
      301 cggttgccag cccctctgcc agctatgggg gatctaccgg ggatcgtgcg cctttccatc
      361 gcgctgcgca tccaacccaa tgatggccct gttttcttca aggtggacgg gcagcgcttt
      421 gggcagaacc gtacaatcaa gctgctcacc ggttcctcct acaaggtgga ggtgaagatt
      481 aagcccacaa cactgcaggt cgagaacatt tccattggtg gtgtgcttgt cccactggag
      541 ctgaagtgta aagagcctga tggggaaaga gttgtctaca ccggcatata cgatacagaa
      601 ggggtagccc caaccaaaag tggagagcga caacccatcc agatcaccat gccgttcaca
      661 gacattggga ccttcgagac ggtgtggcaa gtcaagttct acaattacca caagcgagac
      721 cactgccagt ggggaagccc gttctccgtc attgagtatg aatgcaagcc caatgagacg
      781 cgcagcctca tgtgggtgaa taaggagtcc ttcctctgaa aatggctcct cctgacagtt
      841 gctagacaat ctccggaaat cgatgcttag acaaaccagc acaagcctta accaaggcac
      901 accataccat ggctgtttcc caacgacctc ctatccccaa ttactgtgaa agtgtgattc
      961 cctcctgagg cagtacctgt gacatcgcgt gggatgtcac gtccctgaaa gttctccttc
     1021 cactattgta tactggtgtt cccgcatctc tcttgtctgc cagtgtgaat ggagctcagt
     1081 gatagtatca ggtttgtcct ataccagaaa gttccacaga aggaccatag tgttttgttt
     1141 ccgggacaag aaatttctcc cttttgtgtt cattgtcaaa ttaagataac agtgtgctgg
     1201 agtcccccat gtgtgatttg taacatgtag catgcaatgt ttgtgagcac ccaaagaaga
     1261 agtaataaca taaacagcgg taaacgggac ccaaatattg tgcttcccat cagcagctgt
     1321 cagcttcttc agaggaagaa agatgatgaa gaaataaaaa gatgagtata taaataagag
     1381 tttataatgt atcaatggtc tttcaggtag cggggcattt tgctgtgatc tagtagaaac
     1441 aggggaaaga cactgttgta gaatcggagc tgtggctcgc ccctttgaca aactcccata
     1501 gactttaaac caacatagag atggcgcccc tgcacaccct ttcacttgaa ctttgtacaa
     1561 ctgtgtatgg aatgggtaat caacttttga tatttcttaa taaagacatt gaaaagcatg
     1621 g
//
