LOCUS       NM_001164142            3198 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant
            2, mRNA.
ACCESSION   NM_001164142
VERSION     NM_001164142.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Kang,H., Jiang,S., Song,Q. and Zhang,Y.
  TITLE     [Activation of cannabinoid receptor 2 alleviates acute lung injury
            in rats with lipopolysaccharide-induced sepsis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1374-1380 (2022)
   PUBMED   36210711
  REMARK    GeneRIF: [Activation of cannabinoid receptor 2 alleviates acute
            lung injury in rats with lipopolysaccharide-induced sepsis].
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Karan,A.A., Spivak,Y.S., Gerasimov,K.A., Suleymanova,E.M.,
            Volobueva,M.N., Kvichansky,A.A., Vinogradova,L.V. and
            Bolshakov,A.P.
  TITLE     CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex
  JOURNAL   Mol Neurobiol 58 (8), 4028-4037 (2021)
   PUBMED   33907944
  REMARK    GeneRIF: CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex.
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Gigante,I., Tutino,V., Russo,F., De Nunzio,V., Coletta,S.,
            Armentano,R., Crovace,A., Caruso,M.G., Orlando,A. and
            Notarnicola,M.
  TITLE     Cannabinoid Receptors Overexpression in a Rat Model of Irritable
            Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
  JOURNAL   Int J Mol Sci 22 (6), 2880 (2021)
   PUBMED   33809047
  REMARK    GeneRIF: Cannabinoid Receptors Overexpression in a Rat Model of
            Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic
            Diet.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Rojo-Bustamante,E., Inigo-Marco,I., Abellanas,M.A.,
            Vinueza-Gavilanes,R., Baltanas,A., Luquin,E., Arrasate,M. and
            Aymerich,M.S.
  TITLE     CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity
            Generated by MAGL Inhibition
  JOURNAL   Biomolecules 10 (8), 1198 (2020)
   PUBMED   32824740
  REMARK    GeneRIF: CB2 Receptors and Neuron-Glia Interactions Modulate
            Neurotoxicity Generated by MAGL Inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Esposito,G., Ligresti,A., Izzo,A.A., Bisogno,T., Ruvo,M., Di
            Rosa,M., Di Marzo,V. and Iuvone,T.
  TITLE     The endocannabinoid system protects rat glioma cells against HIV-1
            Tat protein-induced cytotoxicity. Mechanism and regulation
  JOURNAL   J Biol Chem 277 (52), 50348-50354 (2002)
   PUBMED   12388547
  REMARK    GeneRIF: protects rat glioma cells against HIV-1 Tat
            protein-induced cytotoxicity
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Brown,S.M., Wager-Miller,J. and Mackie,K.
  TITLE     Cloning and molecular characterization of the rat CB2 cannabinoid
            receptor
  JOURNAL   Biochim Biophys Acta 1576 (3), 255-264 (2002)
   PUBMED   12084572
  REMARK    GeneRIF: The rat peripheral cannabinoid receptor (rCB2) was cloned
            from a Sprague-Dawley rat spleen cDNA library and when translated,
            encodes a protein of 410 amino acids.
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Clayton,N., Marshall,F.H., Bountra,C. and O'Shaughnessy,C.T.
  TITLE     CB1 and CB2 cannabinoid receptors are implicated in inflammatory
            pain
  JOURNAL   Pain 96 (3), 253-260 (2002)
   PUBMED   11972997
  REMARK    GeneRIF: CB1 and CB2 cannabinoid receptors are implicated in
            inflammatory pain.
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Carlisle,S.J., Marciano-Cabral,F., Staab,A., Ludwick,C. and
            Cabral,G.A.
  TITLE     Differential expression of the CB2 cannabinoid receptor by rodent
            macrophages and macrophage-like cells in relation to cell
            activation
  JOURNAL   Int Immunopharmacol 2 (1), 69-82 (2002)
   PUBMED   11789671
  REMARK    GeneRIF: levels of the cannabinoid receptor type 2 in cells of
            macrophage lineage undergo major modulatory changes in relation to
            cell activation
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Griffin,G., Tao,Q. and Abood,M.E.
  TITLE     Cloning and pharmacological characterization of the rat CB(2)
            cannabinoid receptor
  JOURNAL   J Pharmacol Exp Ther 292 (3), 886-894 (2000)
   PUBMED   10688601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ694960.1, JAXUCZ010000005.1 and BC107941.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_001164142.4.
            
            On Oct 7, 2014 this sequence version replaced NM_001164142.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.8170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1252              FJ694960.1         1-1252
            1253-1335           JAXUCZ010000005.1  153433147-153433229
            1336-3198           BC107941.1         1-1863
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3198
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
     exon            1..118
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            119..3198
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1251
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C"
                     /note="isoform 1 is encoded by transcript variant 2;
                     peripheral cannabinoid receptor; rCB2; CB2 receptor;
                     cannabinoid receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2 isoform 1"
                     /protein_id="NP_001157614.1"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
                     /translation="MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMG
                     LLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDS
                     RNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQ
                     HVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDK
                     VKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPK
                     SSVTETEAEVKTTTGPGSRTPGCSNC"
ORIGIN      
        1 cctttcctac tcactctgga caggaacagc tgtctgcagc cacgccgcgc ctgagtgagg
       61 agaggcgtag gcaccagccg aggccaccca gcaaacatct atgctgactc tgaatgggcc
      121 cagtcctccg gaacagctcc ggtagaagca gccaaagcct gtctgtccat ggcgggatgc
      181 cgggagctgg agttgaccaa cggctccaat ggcggcttgg agttcaaccc tatgaaggag
      241 tacatgatct tgagtgatgc gcagcagatc gctgtggcgg tgctgtgtac cctgatgggg
      301 ctgctgagtg ccctggagaa cgtggctgtg ctctatctca tcctgtcctc gcagcggctc
      361 cgcaggaagc cctcgtacct gttcatcggc agcttggccg gagctgactt cctggccagc
      421 gtgatctttg cctgcaactt cgtcatcttc catgtctttc acggtgtgga ctccaggaat
      481 atcttcctgt tgaagatcgg cagcgtgacc atgaccttca cggcctctgt gggcagcctg
      541 ctgctgaccg ctgttgaccg atacctatgt ctgtgctacc cacctaccta caaagctctc
      601 gtcacccgtg ggagggcact ggtggccctt ggtgtcatgt gggtcctctc ggcgttgatc
      661 tcctacctac cgctcatggg gtggacttgt tgtcctagtc cctgttctga acttttcccc
      721 ctgatcccca acgactacct cctgggctgg cttcttttca ttgccatcct cttttctggc
      781 atcatctata cctatgggta tgtcctctgg aaagcacacc aacatgtagc cagcttggct
      841 gagcaccagg acaggcaggt gcctgggata gctcggatgc ggctagacgt gaggttggcc
      901 aagactctgg gcctggtcat ggctgttctg ctcatatgct ggttccctgc actggctctc
      961 atgggccata gcctggtcac cacactgagt gacaaggtca aggaggcctt cgccttctgc
     1021 tccatgctgt gccttgttaa ctccatgatc aatcctatca tttatgccct gcggagtgga
     1081 gagatccgct ctgctgccca gcactgcctg acaggctgga agaaatatct ccagggcctc
     1141 ggatctgagg ggaaagaaga agccccaaag tcctcagtta cagagacaga ggctgaggtg
     1201 aaaaccacca cagggccggg atccagaaca ccaggctgct ccaattgctg atacggcctg
     1261 tctttctttc tttctttttt tttttttttt aaagatttat ttatttatta tatataagta
     1321 cactgtagct gtcttcagat acaccagaag agggcatcag atctctttac agatggttgt
     1381 gagccaccat gtggttgctg ggatttgaac tcaggacctc tggaaaagca gtcgggtgct
     1441 cttaaccact gagccatctc tccagcccac ggcctgtctt tctatggaag cagtccgact
     1501 cagaagtcag gtcactccct ccagaagaga ggggtcctgg accctgaata tttctgaagc
     1561 cagctctagg gtaatggaaa cagaacttcc cacccccttt tttgctaagg agtgctgggg
     1621 ttcatggctg gaagacggcc tggtcttgcc taccttacgc agtctgtgga gaggggcctg
     1681 taaaaatggc gggctctgtt cacatcaaat cgggaaaccc tcctgactcc agagacctag
     1741 aggccagagg ggcctccagg gacgataatg aaggactcag gggatctgtg aagacaaggg
     1801 acctgttctc ctggaatcta ggctaccccg gctgtgaggc ctctgcccac aacttcacag
     1861 atgtccatat cttccacagt gtgggttcta ggccgccctg ctgaagatgg atagcaagac
     1921 cagctatttc tggttcctgc ttcactgatt ggaactctgt ggctgtagag cgatgtgacc
     1981 ttcaggccac ccttgcctct tgaggatcaa gaattatgat gtgctgagga ccaaggaggt
     2041 tcactctctc ccttcagaca gagccatgtg ctgtcagctc agggtatctt gttgttggaa
     2101 caggaccctc ctgatagccc gataagcctt gaaaatcatt atgactttag gtccttgggg
     2161 acccacggga agccaggttc acttgaggta cagagtcctc agagaactgt atggaccttg
     2221 tgaccttctg ctgtgtctcc catagcacta tcccagtcca gcctagcttc agtaaaaatc
     2281 aaggtattca caaagagtct ttgggttcta gattgttcct agtgatgctc aactcagctt
     2341 cccttgcctc ttccagactc tggtcctgaa ggataagcag gagttgggag gagactgcct
     2401 gctgcggaca tcctcgatcc acagccccat gctgtctctg ggtacctgca ttttaccttc
     2461 agcaaaggtt gcattcccaa cagacggagg ttcaaggcgc tgctggtggt aggggtaggt
     2521 agcactgggg accgaagaca cggtgaaagg aaaaccctca aacactttct acttttgctt
     2581 ttagcagatt cagccaacag acaagacgtc cgtccccatt gcccagagga actaacatgg
     2641 tggtgttcag tgagaagacc aatcagcctc cctaataaag cagggcagtc cactctgcta
     2701 taaaccctct cacatgcctc tgcaggagga cattttgttt tctctgttaa ggtcaagtga
     2761 aggtcacagt gtctcatttt attcttccca agacaagttc tgtgcatcaa aagctgctgc
     2821 aaattctact ctaatcgcta tgtgggagga ctcggggaag aagttgattc gtctgggctt
     2881 tgtgttttag accgtatttc aacatacact tgggaaggaa gaaacagaaa atacattgtg
     2941 tttccttgtt actccccaaa ggaggaagtg cttggttctg tcaacttcaa cagatttctc
     3001 caaggtgcca gacagagaag gtggagatac ggtttccgca gctgtgaatt ccggcaccac
     3061 ctttggccct cacttgcttg tgtgatcttg ggcaacccct gccctttgcc ttgctttggt
     3121 ttcctccttg gtacatcggg aatggtagga aagaagatgc cttcaagggg cattcattaa
     3181 aacctggtat tgctctaa
//
