LOCUS       NM_012784               5473 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus cannabinoid receptor 1 (Cnr1), mRNA.
ACCESSION   NM_012784
VERSION     NM_012784.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5473)
  AUTHORS   Zeng,X., Mai,J., Xie,H., Yang,L. and Liu,X.
  TITLE     Activation of CB1R alleviates central sensitization by regulating
            HCN2-pNR2B signaling in a chronic migraine rat model
  JOURNAL   J Headache Pain 24 (1), 44 (2023)
   PUBMED   37085778
  REMARK    GeneRIF: Activation of CB1R alleviates central sensitization by
            regulating HCN2-pNR2B signaling in a chronic migraine rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5473)
  AUTHORS   Migliaro,M., Sanchez-Zavaleta,R., Soto-Tinoco,E.,
            Ruiz-Contreras,A.E., Mendez-Diaz,M., Herrera-Solis,A., Perez de la
            Mora,M. and Prospero-Garcia,O.E.
  TITLE     Dominance status is associated with a variation in cannabinoid
            receptor 1 expression and amphetamine reward
  JOURNAL   Pharmacol Biochem Behav 221, 173483 (2022)
   PUBMED   36270348
  REMARK    GeneRIF: Dominance status is associated with a variation in
            cannabinoid receptor 1 expression and amphetamine reward.
REFERENCE   3  (bases 1 to 5473)
  AUTHORS   Alptekin,I.M., Cakiroglu,F.P., Kiremitci,S., Recber,T. and
            Nemutlu,E.
  TITLE     Inulin may prevent steatosis by suppressing cannabinoid receptor-1
            and patatin-like phospholipase-3 expression in liver
  JOURNAL   Nutrition 103-104, 111742 (2022)
   PUBMED   35908495
  REMARK    GeneRIF: Inulin may prevent steatosis by suppressing cannabinoid
            receptor-1 and patatin-like phospholipase-3 expression in liver.
REFERENCE   4  (bases 1 to 5473)
  AUTHORS   Yao,F. and Abdel-Rahman,A.A.
  TITLE     Estrogen dampens central cannabinoid receptor 1-mediated
            neuroexcitation and pressor response in conscious female rats
  JOURNAL   Biochem Pharmacol 201, 115102 (2022)
   PUBMED   35617998
  REMARK    GeneRIF: Estrogen dampens central cannabinoid receptor 1-mediated
            neuroexcitation and pressor response in conscious female rats.
REFERENCE   5  (bases 1 to 5473)
  AUTHORS   Cheng,J., Chen,X., Xia,H., Kong,F., Wang,L., Zhong,L. and Wu,J.
  TITLE     Endogenous Cannabinoid Receptors Modulate Plasticity at Immature
            Synapses
  JOURNAL   J Integr Neurosci 21 (4), 121 (2022)
   PUBMED   35864772
  REMARK    GeneRIF: Endogenous Cannabinoid Receptors Modulate Plasticity at
            Immature Synapses.
REFERENCE   6  (bases 1 to 5473)
  AUTHORS   Murphy,W.J., Eizirik,E., Johnson,W.E., Zhang,Y.P., Ryder,O.A. and
            O'Brien,S.J.
  TITLE     Molecular phylogenetics and the origins of placental mammals
  JOURNAL   Nature 409 (6820), 614-618 (2001)
   PUBMED   11214319
REFERENCE   7  (bases 1 to 5473)
  AUTHORS   Comings,D.E., Muhleman,D., Gade,R., Johnson,P., Verde,R.,
            Saucier,G. and MacMurray,J.
  TITLE     Cannabinoid receptor gene (CNR1): association with i.v. drug use
  JOURNAL   Mol Psychiatry 2 (2), 161-168 (1997)
   PUBMED   9106242
REFERENCE   8  (bases 1 to 5473)
  AUTHORS   Ho,B.Y. and Zhao,J.
  TITLE     Determination of the cannabinoid receptors in mouse x rat hybridoma
            NG108-15 cells and rat GH4C1 cells
  JOURNAL   Neurosci Lett 212 (2), 123-126 (1996)
   PUBMED   8832654
REFERENCE   9  (bases 1 to 5473)
  AUTHORS   Shire,D., Carillon,C., Kaghad,M., Calandra,B., Rinaldi-Carmona,M.,
            Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     An amino-terminal variant of the central cannabinoid receptor
            resulting from alternative splicing
  JOURNAL   J Biol Chem 270 (8), 3726-3731 (1995)
   PUBMED   7876112
  REMARK    Erratum:[J Biol Chem 1996 Dec 27;271(52):33706]
REFERENCE   10 (bases 1 to 5473)
  AUTHORS   Matsuda,L.A., Lolait,S.J., Brownstein,M.J., Young,A.C. and
            Bonner,T.I.
  TITLE     Structure of a cannabinoid receptor and functional expression of
            the cloned cDNA
  JOURNAL   Nature 346 (6284), 561-564 (1990)
   PUBMED   2165569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012784.6.
            
            On Sep 15, 2018 this sequence version replaced NM_012784.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55812.1, SRR26643298.26831.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000005.1  53208357-53208446
            91-5473             JAXUCZ010000005.1  53225009-53230391
FEATURES             Location/Qualifiers
     source          1..5473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5473
                     /gene="Cnr1"
                     /gene_synonym="CB1R; SKR6R"
                     /note="cannabinoid receptor 1"
                     /db_xref="GeneID:25248"
                     /db_xref="RGD:2369"
     exon            1..90
                     /gene="Cnr1"
                     /gene_synonym="CB1R; SKR6R"
                     /inference="alignment:Splign:2.1.0"
     exon            91..5473
                     /gene="Cnr1"
                     /gene_synonym="CB1R; SKR6R"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1574
                     /gene="Cnr1"
                     /gene_synonym="CB1R; SKR6R"
                     /note="CB1; CB-R; brain-type cannabinoid receptor;
                     cannabinoid receptor 1 (brain); Cannabinoid CB1 receptor"
                     /codon_start=1
                     /product="cannabinoid receptor 1"
                     /protein_id="NP_036916.1"
                     /db_xref="GeneID:25248"
                     /db_xref="RGD:2369"
                     /translation="MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYF
                     PQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGEN
                     FMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSL
                     AVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYIS
                     IHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETY
                     LMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPD
                     QARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNST
                     VNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESC
                     IKSTVKIAKVTMSVSTDTSAEAL"
ORIGIN      
        1 ttaggtcgtt aggagaactt actgtgaaca ggctctttta tttcttcaaa agatgtctcc
       61 catttcaagc aaggagcacc catggctgag ggttccctcc cggcatctct ttctcagtca
      121 ccttgagtct ggcctaatca aagactgagg ttatgaagtc gatcctagat ggccttgcag
      181 acaccacctt ccgtaccatc accacagacc tcctctacgt gggctcgaat gacattcagt
      241 atgaagatat caaaggagac atggcatcca aattaggata cttcccacag aaattccctc
      301 taacttcctt caggggtagt cccttccaag aaaagatgac cgcaggagac aactccccgt
      361 tggtcccagc aggagacaca acaaacatta cagagttcta taacaagtct ctctcgtcgt
      421 tcaaggagaa tgaggagaac atccagtgtg gggagaactt tatggacatg gagtgcttta
      481 tgattctgaa tcccagccag cagctggcca tcgctgtact gtccctcaca ctgggcacct
      541 tcacggttct ggagaaccta ctggtgctgt gtgtcatcct gcactcccgc agtctccgat
      601 gcaggccttc ctaccacttc atcggcagcc tggcagtggc cgacctcctg ggaagtgtca
      661 tttttgtgta cagctttgtt gacttccatg tattccaccg taaagacagc cccaatgtgt
      721 ttctgttcaa actgggtggg gttacagcct ccttcacagc ttctgtgggc agcctgttcc
      781 tcacagccat cgacaggtac atatccattc acaggcctct ggcctataag aggatcgtca
      841 ccaggcccaa ggccgttgtg gccttttgcc tgatgtggac tatcgcaata gtaatcgctg
      901 tgttgcctct cctgggctgg aactgcaaga agctgcaatc tgtttgctcg gacattttcc
      961 cactcattga cgagacctac ctgatgttct ggattggggt gaccagtgtg ctgctgctgt
     1021 tcattgtgta cgcgtacatg tacattctct ggaaggctca cagccatgcg gtccgcatga
     1081 ttcagcgtgg gacccagaag agcatcatca tccacacgtc agaagacggc aaggtgcagg
     1141 tgacccggcc tgaccaagcc cgcatggaca ttaggctggc caaaaccctg gttctgatcc
     1201 tggtggtgtt gatcatctgc tggggccctc tgcttgcgat catggtgtat gacgtcttcg
     1261 ggaagatgaa caagcttatc aagacggtgt ttgccttctg cagtatgctc tgcctgctga
     1321 actccaccgt gaaccccatc atctatgctc tgaggagcaa ggacctgaga catgctttcc
     1381 gaagcatgtt cccttcgtgc gaaggcaccg cacagcctct agacaacagc atgggggact
     1441 cagactgcct gcacaagcac gccaacaaca cagccagcat gcacagggcc gcggagagct
     1501 gcatcaagag caccgttaag atcgcgaagg tgaccatgtc tgtgtccaca gacacgtccg
     1561 ccgaggctct gtgagcctgc tgcttttgtg gctgcacaga aaaagaaaaa aagtttttct
     1621 ttagcttaaa acttagaagt ctgttgtctc atcggttaca tatatatttt taagtttacc
     1681 gtgtttagta aaatagtgac tgtcaccgtg cttactgagt ttgctgacat ctcaatagct
     1741 taggtactta aactccattt cccaggggtt tacagtgtag aaagcctatt gcttcagtta
     1801 ctcggtggtc cttcaaagtc tctgaaatag aagggaaaac tttggcttcc aaatccgaag
     1861 cctaactatc catagaaaat caccatgaaa tgagtaataa cctttgtaac cacaactttc
     1921 atgatgctgt gtctgtccac agtattaaag aggtacattt ttaccataag tatagtgcta
     1981 aagtagagaa actttgtaac ctgttttctg tcccctgtta gttgtgtgtt gtgtcagtgt
     2041 ttaatatgtc agtttattta tttatttatt tttgtctagc ttagcaaaac cagaatgtag
     2101 ccctcataag agcgatggca tacaagagtg attgtgtagc agggcgaccc ctgtttagat
     2161 agtattactg tccatgatac gattttagaa accttagtat ttcttccaat atccgtatct
     2221 aaagttaata ttgacataag cataaaggtt tatttttctg ttaaaacaac aagaagaatt
     2281 tgaagactgt tcaaagtatt gagcagaatt catggacact taaaactgtg ttaggcctgc
     2341 attttcgtag gaggacattt caatatcttc tggaccacag ctgttcagtt gggtaatgga
     2401 ttgtgatcag aatggaaaag agaaagtaac actgactttc aaagctgacg ccctgacttt
     2461 ctgcagtcgt tagctataac tggacctctt aagacagcat gtgtcaacct tagtgtatac
     2521 tgttatcact gtggagttgc tgttcacctg ccgtgtatcg catcgttatg ttctggattt
     2581 aaatagattt caggcccgga tggccaaaag acagtttgtc ttctccttaa ttgagaagag
     2641 acattgtctg gcttagtaaa attgtgagtg tgattgtaaa tgtgtatgtg tgtgtatgtg
     2701 tgtgtatgtg tgtgtgtgca tgtgtgtgta ttctatcttg caactgttac agccatgtcc
     2761 ccacaggaga aaaaccgacc aagtgtgaga cgtacccctt gctgcaccct tgcacatgga
     2821 tttagttgct gcaattgagc tctttgtgaa atcctgttta taaaaattct gactgaaact
     2881 tctcaggagt cttcccacct aggagattgg gttgagaatt ctcgtgacgt ttaggtgttc
     2941 tgtaaggcca gcagcgttca gcaagaagta atcagtaaga ggtgctggaa agtagaggag
     3001 tctcccaggg agaggagagt gtgggggatg gtgggcgcct actattaatc aaagtccttg
     3061 caaatggaaa tcagtaaagg gggatggttc tacggccttc ttcaacccca cccccacccc
     3121 cacagtagca agtttcaatg gtgcacatca gcagtgcaat ctcaggttaa ggagcaccat
     3181 gccagttacc agggccaggc catttcatga cagaggatga gtaggacaga ggatatatat
     3241 aacaaatggg cagtgaaaac ctggtgacgg cccagtacct ggctctgttt agatgtttgg
     3301 gcaaagcaaa aggcagtgcc tctgcctgct ggtaccaaga tgtgccaaaa cataaggaca
     3361 agggtggcta gcttcggttc gacatctctg ccatggtgct caaaatttgg gccctttttc
     3421 cgataaagag aagtattgct tttaagaagc cactcactcc tgataaattc tatgtagagt
     3481 ctctcctcat acaggttctc ccccgtcctg aggactgcat agcatgaagt ggagagctag
     3541 tatatgcctg tgatttctag tgtttggggt tcccagtctg atggggcagt gccccttctt
     3601 gcaatcaatg tgacctgagg gccaagctag gatatatcta gatttttttt ccagctgagt
     3661 ctcttgcttt tcttctctgt gcacagagga ggactcaaga tgctggagga ttagtaactc
     3721 catagagaag ggtattgata gaataccacc aggggctagg aattgccagc ctcatcctac
     3781 atccacctga atatcaatca tgtctctagc taccaggctg taccacctct tctcacagct
     3841 acaaagacct ggtaggacat tctaggtata gttattaaaa aaaaaatcca agattcactt
     3901 ttagaactgt atttgtgtaa atgccatttt agtgataaga ttttatagtg tattgaactt
     3961 tcaagaccta actcatattt aataagctaa gggacaatgg ggctgatagc actaaacttg
     4021 gtgcttattg atactctaag aaatatctgt gaaatatcat catgtgtgcg ttaagctacc
     4081 ttcatttaaa gggacttaaa attaggtgga tccactttgg cttttcccat atcatttcct
     4141 aaccatattg accaaaacct tttccccagt gagtattagt cattagaatt acattcatta
     4201 gtatcattca ttaaccagcc ccttaattag attcattaat ttaaatgatt ttaatttaat
     4261 catttataca ctctggcatc agggttatct acttccctct gacgtttgtc cttaacatgc
     4321 attcttcggc cattgctcat ctttaaaggg ggctaattcc caaactactt aactttgtcc
     4381 aaataaagac tgagtcctag actatcagta tcatttaaac aaagaaagca gtctctaaga
     4441 gctcctagat ttacccctat gtattaaata tatgtaaaaa taaatgtgca tctgggcagc
     4501 ttagacataa gtctgtgcca gatgtctcca aagctgtctg atacttaact ttcaggctta
     4561 gctggtatca aatgccaagg aatttttgct acctaaaccc atctgcagga aataggccca
     4621 actaccagat gagaactagg tctctagtta ccattcattt cattcatttc tgccattcca
     4681 tatccataaa cagcaccact aacatcatgc acaagattag attcctaata ttcttgactg
     4741 tatatttgta tgatatttta aaacctccta aatggccatt cacagttgct ttgcactggc
     4801 cttctgataa aatgttaaca cacctattgt aatatacaaa aaacattcta tctactgatt
     4861 tggactgaat gtatgtacat aggctttaca aaaaagtcag acgtcgaagc agtggtttac
     4921 agatcagtga ttttcagata gagtttcttt cagttgccgt ggaatctttc aaaagcactc
     4981 ttagtgtgaa cttaatgaac tctaggggtc ctggtgatca gagtcgccta gagaggaaac
     5041 ctttcctttt attaatatga agcaagatac cagactatct tgattctcac ttccagtgtt
     5101 tcaagtggaa aacgtatttc cttgttgtct ctgtaaatgg aacatcctta attttcctct
     5161 taaagaatat tgtactgtta gatgtttgtt gaactggtag catcattgag actgctgtga
     5221 tgtctttgtc agtaatctgt ataatatttt gtatacaagt actggtaaga ttgttattaa
     5281 gtgtagctcc agtcattaaa ttactatagc aaagtagtac ttctgtaata tttacaatgt
     5341 attaagccta cagtatattt tatttcattg atgtaatttt attgttattt attcaagaga
     5401 aagcagttca tcatgtctat tgtctaaaat tacctggaat caaataaaag ttctagatta
     5461 tcacgaaaaa cca
//
