LOCUS       NM_012809               2326 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 2',3'-cyclic nucleotide 3' phosphodiesterase
            (Cnp), mRNA.
ACCESSION   NM_012809 XM_340904
VERSION     NM_012809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Wang,D., Tan,K.S., Arias-Moreno,X., Tan,W. and Cheng,G.
  TITLE     Sirt3 increases CNPase enzymatic activity through deacetylation and
            facilitating substrate accessibility
  JOURNAL   Biochem Biophys Res Commun 571, 181-187 (2021)
   PUBMED   34330062
  REMARK    GeneRIF: Sirt3 increases CNPase enzymatic activity through
            deacetylation and facilitating substrate accessibility.
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Oberoi,R., Chu,T., Mellen,N., Jagadapillai,R., Ouyang,H.,
            Devlin,L.A. and Cai,J.
  TITLE     Diverse changes in myelin protein expression in rat brain after
            perinatal methadone exposure
  JOURNAL   Acta Neurobiol Exp (Wars) 79 (4), 367-373 (2019)
   PUBMED   31885393
  REMARK    GeneRIF: All pups with exposure to methadone demonstrated decreased
            expression of CNP in the cerebral cortex and hippocampus.In the
            cerebellum, PLP expression was downregulated without apparent
            alteration of CNP and MBP expression. PLP and MBP expression, but
            not CNP expression, were significantly inhibited in the brainstem.
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Baburina,Y., Odinokova,I., Azarashvili,T., Akatov,V., Sotnikova,L.
            and Krestinina,O.
  TITLE     Possible Involvement of 2',3'-Cyclic
            Nucleotide-3'-Phosphodiesterase in the Protein
            Phosphorylation-Mediated Regulation of the Permeability Transition
            Pore
  JOURNAL   Int J Mol Sci 19 (11), 3499 (2018)
   PUBMED   30405014
  REMARK    GeneRIF: the role of CNPase, serine/threonine kinases, and MEL in
            the mPTP opening was examined.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Ottestad-Hansen,S., Hu,Q.X., Follin-Arbelet,V.V., Bentea,E.,
            Sato,H., Massie,A., Zhou,Y. and Danbolt,N.C.
  TITLE     The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in
            significant concentrations in a subpopulation of astrocytes in the
            mouse brain
  JOURNAL   Glia 66 (5), 951-970 (2018)
   PUBMED   29350434
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K.,
            Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
  TITLE     The balance between cathepsin C and cystatin F controls
            remyelination in the brain of Plp1-overexpressing mouse, a chronic
            demyelinating disease model
  JOURNAL   Glia 65 (6), 917-930 (2017)
   PUBMED   28251676
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Bifulco,M., Laezza,C., Stingo,S. and Wolff,J.
  TITLE     2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound,
            microtubule-associated protein and membrane anchor for tubulin
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 1807-1812 (2002)
   PUBMED   11842207
  REMARK    GeneRIF: CNP is a membrane-bound microtubule-associated protein
            that can link tubulin to membranes and may regulate cytoplasmic
            microtubule distribution
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Degano,A.L. and Roth,G.A.
  TITLE     Passive transfer of experimental autoimmune encephalomyelitis in
            Wistar rats: dissociation of clinical symptoms and biochemical
            alterations
  JOURNAL   J Neurosci Res 59 (2), 283-290 (2000)
   PUBMED   10650887
REFERENCE   8  (bases 1 to 2326)
  AUTHORS   Yao,D.L., Liu,X., Hudson,L.D. and Webster,H.D.
  TITLE     Insulin-like growth factor I treatment reduces demyelination and
            up-regulates gene expression of myelin-related proteins in
            experimental autoimmune encephalomyelitis
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 6190-6194 (1995)
   PUBMED   7541143
REFERENCE   9  (bases 1 to 2326)
  AUTHORS   Gravel,M., DeAngelis,D. and Braun,P.E.
  TITLE     Molecular cloning and characterization of rat brain 2',3'-cyclic
            nucleotide 3'-phosphodiesterase isoform 2
  JOURNAL   J Neurosci Res 38 (3), 243-247 (1994)
   PUBMED   7932861
REFERENCE   10 (bases 1 to 2326)
  AUTHORS   Bernier,L., Alvarez,F., Norgard,E.M., Raible,D.W., Mentaberry,A.,
            Schembri,J.G., Sabatini,D.D. and Colman,D.R.
  TITLE     Molecular cloning of a 2',3'-cyclic nucleotide
            3'-phosphodiesterase: mRNAs with different 5' ends encode the same
            set of proteins in nervous and lymphoid tissues
  JOURNAL   J Neurosci 7 (9), 2703-2710 (1987)
   PUBMED   3040924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098066.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098066.1, L16532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2326
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /note="2',3'-cyclic nucleotide 3' phosphodiesterase"
                     /db_xref="GeneID:25275"
                     /db_xref="RGD:2368"
     exon            1..83
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1343
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /EC_number="3.1.4.37"
                     /note="CNPase"
                     /codon_start=1
                     /product="2',3'-cyclic-nucleotide 3'-phosphodiesterase"
                     /protein_id="NP_036941.1"
                     /db_xref="GeneID:25275"
                     /db_xref="RGD:2368"
                     /translation="MSTSFARKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVA
                     TLHECKTLFILRGLPGSGKSTLARLIVEKYHNGTKMVSADAYKIIPGSRADFSEEYKR
                     LDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQL
                     KEKNQWQLSLDDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAF
                     KKELRHFISGDEPKEKLDLVSYFGKRPPGVLHCTTKFCDYGKATGAEEYAQQDVVRRS
                     YGKAFKLSISALFVTPKTAGAQVVLNEQELQLWPSDLDKPSSSESLPPGSRAHVTLGC
                     AADVQPVQTGLDLLEILQQVKGGSQGEEVGELPRGKLYSLGKGRWMLSLAKKMEVKAI
                     FTGYYGKGKPVPVHGSRKGGAMQICTII"
     exon            84..753
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /inference="alignment:Splign:2.1.0"
     exon            754..893
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /inference="alignment:Splign:2.1.0"
     exon            894..2302
                     /gene="Cnp"
                     /gene_synonym="Cnp1; CNPF; CNPI; CNPII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgtgtc cctcgcgcag gcgggcggcc ccggagacat agtgcccgca aaggcggtga
       61 cggcggtgcg cccactcatc atgagcacaa gctttgcccg aaaaagccac acattcctgc
      121 ccaagatctt cttcagaaaa atgtcatcct caggagctaa ggacaagcca gagctgcagt
      181 tccctttcct tcaagatgag gacacggtgg ctacgctgca cgagtgcaag acgctgttca
      241 tcctgcgtgg cctgccgggc agcggcaagt ccactctggc tcggctcatc gtggagaagt
      301 accacaacgg caccaagatg gtgtctgctg atgcttacaa gatcattcct ggctctcggg
      361 cagacttctc cgaggagtac aagcgtctgg acgaggacct ggctggctac tgccgccggg
      421 acatcagggt tcttgtgctc gatgacacca accatgagcg ggaacggctg gaccagcttt
      481 ttgaaatggc agaccagtac cagtaccagg tggtgctggt ggagcccaag acggcgtggc
      541 gactagactg tgcccagctc aaggagaaga accaatggca gctgtcgctc gatgacctga
      601 agaagctgaa gcccgggctg gagaaggact tcctgccact ttactttggc tggttcctga
      661 ccaaaaagag ttccgagacc ctccgaaaag ccggccaggt ctttctggag gagctgggaa
      721 atcacaaggc tttcaagaaa gagcttcgac acttcatttc tggggatgaa cccaaggaga
      781 agcttgacct ggtcagctat tttggcaaga gacctccagg cgtgctgcac tgtacaacca
      841 aattctgtga ctacgggaag gccaccgggg cagaagaata tgcccaacag gatgtggtga
      901 ggagatctta cggcaaggcc ttcaaactgt ccatctctgc cctctttgtg acacccaaga
      961 cagctggggc ccaggtggtg cttaatgagc aggagctgca gttgtggcca agtgacctgg
     1021 acaagccctc atcctccgag agcctgcccc cagggagccg agctcacgtc accctaggct
     1081 gtgcagccga cgtgcagcca gtgcagacag gccttgacct tttagagatt ttacagcagg
     1141 tgaagggggg cagccaaggt gaggaggtgg gtgagctccc ccggggcaag ctctattcct
     1201 tgggcaaagg gcgttggatg ctgagcttgg cgaagaagat ggaagtcaag gccatcttca
     1261 cggggtacta tgggaagggc aaacctgtac ccgtacacgg cagccggaag gggggtgcca
     1321 tgcagatctg caccatcatc tgagggttca cgccactgtg ccaccgctgt ggacacagca
     1381 acatgccttc cacttgattt ttaagatttt ttttttttac tcaaagctaa tctacctata
     1441 actttttaga agtctgtaaa ataaccatca gttccttcac ccaccctctt ccccttaaca
     1501 ctcagctcaa cacaggcagg tgggcagagg aagacaccat tcaggaacct ggaccagagg
     1561 tggtaattaa agggctgggt cattgggcct ggagcggcca cctagatgca cccaggacct
     1621 tgttaaccct cccttagccg ctgcccatgc agagctgggc acacacacct cagagccacc
     1681 acacatcatg caagggacaa atgctactgc cacaggaaaa cagtggtagc tttgagaggg
     1741 gacagacccc tgggtgccaa tcttaatcac tgtagcccca aggaaggctt gggctactta
     1801 ctgggctgta aaaggggctt atctctcacc gttggtcatt cccaactccc tctctccttc
     1861 actggcacta ggttaatggt gtgaccacta ggggagaaaa tggcattacc ggaagccaca
     1921 tctctggttc cggtctggct atctagcctt aacagctgtc tctgctaagg tcagagagat
     1981 gctttaagaa actccagctt tgctttctgc ccagcccatc ttgcctccgt ggtgcctctg
     2041 ggcctcctct aaaggatggt ggtgggtacc aagagccaac ggagggggcc ctgagccagc
     2101 aagagtaagc cccatctgct ctggggaagt ctgaacacgc gcgtgtgctg tggttcctgg
     2161 agtacctcac tctgctcagt aacaggacct tgctaattgg gttgtcaccc aagcatctgg
     2221 gatttatgtt cctaccctca ccctgtgttg cccacctcag caacaactaa gactgatact
     2281 gaaataaatc gtgttaatcc caaaaaaaaa aaaaaaaaaa aaaaaa
//
