LOCUS       NM_001009357            3399 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex subunit 9 (Cnot9),
            mRNA.
ACCESSION   NM_001009357 XM_217431
VERSION     NM_001009357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3399)
  AUTHORS   Chen,Y., Boland,A., Kuzuoglu-Ozturk,D., Bawankar,P., Loh,B.,
            Chang,C.T., Weichenrieder,O. and Izaurralde,E.
  TITLE     A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct
            links between miRNA target recognition and silencing
  JOURNAL   Mol Cell 54 (5), 737-750 (2014)
   PUBMED   24768540
REFERENCE   2  (bases 1 to 3399)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   3  (bases 1 to 3399)
  AUTHORS   Ajiro,M., Nishidate,T., Katagiri,T. and Nakamura,Y.
  TITLE     Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary
            carcinogenesis
  JOURNAL   Int J Oncol 37 (5), 1085-1093 (2010)
   PUBMED   20878056
REFERENCE   4  (bases 1 to 3399)
  AUTHORS   Suzuki,A., Igarashi,K., Aisaki,K., Kanno,J. and Saga,Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   5  (bases 1 to 3399)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3399)
  AUTHORS   Lau,N.C., Kolkman,A., van Schaik,F.M., Mulder,K.W., Pijnappel,W.W.,
            Heck,A.J. and Timmers,H.T.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3399)
  AUTHORS   Garapaty,S., Mahajan,M.A. and Samuels,H.H.
  TITLE     Components of the CCR4-NOT complex function as nuclear hormone
            receptor coactivators via association with the NRC-interacting
            Factor NIF-1
  JOURNAL   J Biol Chem 283 (11), 6806-6816 (2008)
   PUBMED   18180299
REFERENCE   8  (bases 1 to 3399)
  AUTHORS   Winkler,G.S., Mulder,K.W., Bardwell,V.J., Kalkhoven,E. and
            Timmers,H.T.
  TITLE     Human Ccr4-Not complex is a ligand-dependent repressor of nuclear
            receptor-mediated transcription
  JOURNAL   EMBO J 25 (13), 3089-3099 (2006)
   PUBMED   16778766
REFERENCE   9  (bases 1 to 3399)
  AUTHORS   Gregory,R.C., Lord,K.A., Panek,L.B., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     Subtraction cloning and initial characterization of novel
            epo-immediate response genes
  JOURNAL   Cytokine 12 (7), 845-857 (2000)
   PUBMED   10880228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087134.1.
            
            On Jan 7, 2005 this sequence version replaced XM_217431.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087134.1, FQ225078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..3399
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /note="CCR4-NOT transcription complex subunit 9"
                     /db_xref="GeneID:301513"
                     /db_xref="RGD:1311495"
     exon            1..441
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..1317
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /note="cell differentiation protein RCD1 homolog; rcd-1;
                     rcd1 (required for cell differentiation) homolog 1; cell
                     differentiation protein RQCD1 homolog"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 9"
                     /protein_id="NP_001009357.1"
                     /db_xref="GeneID:301513"
                     /db_xref="RGD:1311495"
                     /translation="MHSLATAAPVPTALAQVDREKIYQWINELSSPETRENALLELSK
                     KRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVAS
                     HPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLT
                     TEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVL
                     QLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWL
                     AQLVKNLQEGQVTDPRGIPLPPQ"
     exon            442..621
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..737
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..847
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..957
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1056
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1148
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..3359
                     /gene="Cnot9"
                     /gene_synonym="Rqcd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccatttt cctctcgctc agcctgcttg agcatgcgca gtttttgtcc ttccaagact
       61 gctggccttt tcccgccctt ctctggcctt aggaggaaag tcagagttca cgtttcttag
      121 gggatatact tgcgatgccg gggggatacg aggaccagta gtttgcagac gtcattttga
      181 tcctgaacct gaaggttcaa gggacatact ttgggactat ttgttaggcc gaggtccagg
      241 aggcgggaaa gggctgtgtg ggcggagggt cggaggtgag aggtcaaagg gctgcgaaga
      301 gggaggagcg agccggagac ggatggcggc tcttcatctt cggctgcaga gccactaaag
      361 ctgggacgcg ggtccggcgc gtccagcgga agaagtagag cggcccccgc tcccaacatg
      421 cacagcctgg caacggcagc gcctgtgcct actgcactgg cccaggtgga cagagagaag
      481 atctatcagt ggatcaatga actgtccagt cctgaaacaa gggaaaatgc tttgctggag
      541 ctgagcaaga agcgagagtc tgtccctgac cttgcgccca tgctgtggca ttcattcggt
      601 actattgcag cacttttaca ggaaattgta aatatttatc catctatcaa ccctccaacc
      661 ttgacagcac accaatctaa cagggtttgc aatgctctag cattgctaca gtgtgtggcc
      721 tcacacccag agaccaggtc agcctttctt gcagcacaca tcccactctt tttgtacccc
      781 tttttgcaca cagtcagcaa aactcgtccc tttgaatatc ttcggctcac cagccttgga
      841 gttattgggg ccttggttaa aacagatgag caagaagtaa tcaacttttt attgacaaca
      901 gaaatcatcc ctttgtgttt gcgcatcatg gaatctggaa gtgaactgtc taaaacggtt
      961 gccacattca tcctccagaa gatcctctta gatgacactg gtctggctta tatatgtcag
     1021 acatatgagc gtttttccca tgttgccatg atcttgggta aaatggtcct gcagctatcc
     1081 aaagaaccat ctgcccgtct gctgaagcat gtagtaagat gttaccttcg actctcagat
     1141 aatcccaggg cacgtgaagc actcagacag tgcctccctg accagctgaa ggacacaacc
     1201 tttgcccagg tgctaaaaga tgacaccacc accaaacgct ggcttgcaca actggtgaag
     1261 aacctgcagg agggccaagt caccgatccc cggggaattc ccctgccccc tcagtgatcc
     1321 tcgacattcc ctctcactac tcccctacgt tggggagtaa gggtggaacc tatgaggaaa
     1381 acagctcagg ttttattgcc gactgggaat agacaacctc aatgctgaac tgtactggag
     1441 aaaaggggca aggtacccca ctgaggtgtg tgggctgact ggaggtcctg gatcccccta
     1501 ctgctcccag gaattgggct cctgacagca gtctgctacc acagccccag gagggtgtca
     1561 acaccagcaa atgctgtatt tgcagcatgc ccaagatgac cctgctcccc aacctctgcc
     1621 tagccactgg tagagagagg agaggtggta atcacagtaa cactgtaggc atggagagca
     1681 cctgggacca aaccatgtgg ctttttttta aaaaaaaaaa aacaaaaaac aaaaaacttt
     1741 gccttcctgg acgactcaag gtgtgtctct taattctctc tcacacagta tttgtttact
     1801 ttggattttt gtttttaatc tcaaaagaga gagatgtgtt taatggacac aagctgtagt
     1861 tttcagcaaa actttgtcag ttggcactgt ttacacgtct cttagctgca taagctcaat
     1921 aaaagttggt ctgggcattg catcccctcg ggcagaccga tggcgctatc aggctgttgg
     1981 gtggaatggg aggcagggga agaggaaagc aaagccaagc aaaaacacta ccaaccattc
     2041 ccctctgccc ctgttgtttc cctcgcaagc ctggctgctg tgaggacatt cactttggct
     2101 ctggcttcgg ctgctagccc acccaaatct cagcgcttgc ccctttccta ccacttagac
     2161 ttaaagcagg cgtcttaatt tacccagcct tccttagaga gttgtactgg ggtggaggga
     2221 ggcagttctt caggttcaag tcttcacagg tagtttccag gtgtcttctc aaatggaaca
     2281 agcacctaga tccaaatggg gccctgaccc cgttcttctc gtgtgggttt cagtagtgcc
     2341 atctcctcat gattatactt gaagcagtat tagctgaatg agttttttca gagttaaaca
     2401 gctgcactct gctgtctcag tcccctctcc ctttaacact ttctttggtc tatggaaact
     2461 acagggctac cactggaatg ttttttactt gttgatagtg tcagagttcc ctttccatct
     2521 ccatgggctt gacttaacct gttactgtaa actgcctttc tgagatcctt ccactgtcaa
     2581 cctttgtttt ctcatcctca tcccaaagat ggggttatta atccaactct agagagagcc
     2641 caaatcttca gcccatgtct cacacacttg aaggtatctt tattaaattt gaagagacta
     2701 taaagggaca gatgctcata gaaacctttg cagaggcagt tgtgccaaac caagggctct
     2761 ttaagctgac tttcacacag ggagccagcc ttgtttgttg gcttctgtct tcagagacaa
     2821 gaaagtgcta attaagtaac ctagatttag ggagggtaga ataagcattt attcccctgc
     2881 cttccaaatt gaagaggaga ccatggcctc aaggctgaag aaggaaagtc ttagaaagca
     2941 aagaacagca ttgcctgata aacgtctcga ctcactctgc aactgtgatc tggaaagttc
     3001 actagggtac cctgattttt gaaatccgcc ttcctgatga gctgaagtct ctcattccgc
     3061 ctcactgggg aagcagctga gacttggagc cttgctccct gggacattgt ctccatcttt
     3121 cggtgcactg gccatgttac tgtgccaata gtgtcttaat tcatgtccca tctgtcctca
     3181 gctggccttg gacctacata ggagttgaat gaggaggagt gcaacgggtc ttaattcctg
     3241 tggttggtcc tgatgttata tgtactatat aaagaggctc ctccctttat tttgtgtttt
     3301 ccatccctca ccctcaacag gattaaaata aaacatgctc tggtttttta aaaaaaaaaa
     3361 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
