LOCUS       NM_001008382            2171 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex, subunit 8
            (Cnot8), mRNA.
ACCESSION   NM_001008382 XM_343898
VERSION     NM_001008382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Wahle E and Winkler GS.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S,
            Izaurralde E and Weichenrieder O.
  TITLE     The structural basis for the interaction between the CAF1 nuclease
            and the NOT1 scaffold of the human CCR4-NOT deadenylase complex
  JOURNAL   Nucleic Acids Res 40 (21), 11058-11072 (2012)
   PUBMED   22977175
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Piao X, Zhang X, Wu L and Belasco JG.
  TITLE     CCR4-NOT deadenylates mRNA associated with RNA-induced silencing
            complexes in human cells
  JOURNAL   Mol Cell Biol 30 (6), 1486-1494 (2010)
   PUBMED   20065043
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Aslam A, Mittal S, Koch F, Andrau JC and Winkler GS.
  TITLE     The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping
            roles and modulate cell proliferation
  JOURNAL   Mol Biol Cell 20 (17), 3840-3850 (2009)
   PUBMED   19605561
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ
            and Timmers HT.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2171)
  AUTHORS   Bianchin C, Mauxion F, Sentis S, Seraphin B and Corbo L.
  TITLE     Conservation of the deadenylase activity of proteins of the Caf1
            family in human
  JOURNAL   RNA 11 (4), 487-494 (2005)
   PUBMED   15769875
REFERENCE   7  (bases 1 to 2171)
  AUTHORS   Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA,
            Corjay MH, Stoltenborg JK and Dicker IB.
  TITLE     Human carbon catabolite repressor protein (CCR4)-associative factor
            1: cloning, expression and characterization of its interaction with
            the B-cell translocation protein BTG1
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 471-481 (1998)
   PUBMED   9820826
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085856.1.
            
            On Dec 16, 2004 this sequence version replaced XM_343898.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085856.1, SRR8487231.17600.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2171
                     /gene="Cnot8"
                     /note="CCR4-NOT transcription complex, subunit 8"
                     /db_xref="GeneID:363603"
                     /db_xref="RGD:1306401"
     exon            1..40
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            41..136
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            137..342
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1104
                     /gene="Cnot8"
                     /EC_number="3.1.13.4"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 8"
                     /protein_id="NP_001008383.1"
                     /db_xref="GeneID:363603"
                     /db_xref="RGD:1306401"
                     /translation="MPAALVENSQVICEVWASNLEEEMRKIRETVLSYSYIAMDTEFP
                     GVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFN
                     LTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGY
                     DFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDL
                     QRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDS
                     AQEKMSILAMINNMQQ"
     exon            343..536
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            537..698
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            699..843
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            844..954
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2145
                     /gene="Cnot8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccgctgc cgcccgcact cggcggggcc gccagccagg ggtcgcagct ggttgtggtg
       61 gtacttgcct ttaaccccag cagttggagg ctgaggcagt tggatctccg aatccaaggc
      121 ctgtttggtg tacacgattg gatccagtgt ggaagattaa atcaagcaga agggggcttg
      181 ttcttttcat agttggctca cagtggctcc tcaggtgcct tcaggatgcc tgcggcactt
      241 gtagaaaaca gtcaggtcat ctgtgaggtg tgggccagca atcttgagga ggagatgcgg
      301 aagatccggg agactgtcct cagctacagc tacatcgcca tggacacaga gtttccaggt
      361 gttgttgtac gaccgattgg tgaatttcga agctccatag attaccagta tcagcttttg
      421 cggtgcaatg ttgaccttct aaaaatcatc cagctgggcc ttacattcac aaatgagaag
      481 ggggagtacc cttctggaat caacacgtgg cagttcaact tcaagttcaa cctgacagag
      541 gacatgtact cccaggattc catagacctg ctagccaact cagggctgca gttccagaag
      601 cacgaggagg aagggatcga tacgttgcac tttgcagagc tgcttatgac gtcgggagtg
      661 gtcctctgtg acaacgtcaa gtggctttca tttcacagtg gttatgattt tggctacatg
      721 gtgaagctgc tcacggattc tcgcctgcca gaagaagagc acgagttttt tcacatcctg
      781 aatcttttct tcccatccat ttatgatgtg aaatacctga tgaagagctg caaaaatctt
      841 aagggaggcc ttcaggaggt ggctgatcag ttggatttgc agaggattgg aaggcagcat
      901 caagcaggct cagactctct gctgacaggg atggctttct tcaggatgaa agagctattc
      961 tttgaggaca gtattgatga tgccaagtat tgtgggcgcc tctatggcct gggcacagga
     1021 gtggcccaga agcagaatga ggatgtggac tctgcccagg agaagatgag catcttggcc
     1081 atgatcaaca acatgcagca gtgatggtgc gtgcaccgtg ctgcttgcgt tgtctgccca
     1141 gccattgacc tgcatctgct ccgagcagag actttggggt tttgtttaaa gatgccttta
     1201 ttttagatcc aggaggggct ttgctctgaa tttgtaaaca agtcttcctt gtcctcatgc
     1261 ccataccctt ctgctgcttc ctgccaccag catccatagc tccatggaca cctttttaaa
     1321 gctccaggat gtctcaaact aaccagtaaa acgtatctga ctcttgtgtg ttgtcattct
     1381 tcttttggct ttgctgctct catgaagatg ctcaggtgag ctgagactgc cagagaacaa
     1441 ggtgtatatt cttgggaagc aggtctgtgc cagcaggctc ttttgccttg tttgtgcttc
     1501 ttcaggacag agcagtcctg atgatacagt aagtgatccc ttgtgctgaa gtctggacac
     1561 aattctgtct ccttccatgt cgttaggctg gcccaagcct caccttgttc accttggttt
     1621 tcagatgatg aactgttcta gactagatca taccgcaagt ccatcttgtt ctcagcaggg
     1681 tgatctgtcc gctgtgctct tagcctccat ttccccgcct gtatttagca agcctgagat
     1741 gtcaacaggt ggtagagctg agctctggaa ctggagtctt aggaaaggca caggagtcaa
     1801 ctgtgagcag gacagtaggg gattcacctt ggaacccgtg gagtcatccc cacagctgtg
     1861 cttggaagcc tgttgactat tatttttaag gttaggcatt taggaagcac actgcttttt
     1921 aaatgtttac agaaggacaa ctgtaagaaa gtaagaactt gtttggaagg cagaggcaga
     1981 tggcagcagc tcacttaggc aggaatggtc ttacctttta aaagcttgtg ggaaactgaa
     2041 tttgaaataa caaaatgtca agtattaaag ctggtattta agatgcttgt aaatattatt
     2101 tatgttttta attttgtaaa ataaagattg ctttttaacc attggaaaaa aaaaaaaaaa
     2161 aaaaaaaaaa a
//
