LOCUS       NM_001415094            9221 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex, subunit 6-like
            (Cnot6l), transcript variant 3, mRNA.
ACCESSION   NM_001415094 XM_006250709
VERSION     NM_001415094.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9221)
  AUTHORS   Wahle E and Winkler GS.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   2  (bases 1 to 9221)
  AUTHORS   Mittal S, Aslam A, Doidge R, Medica R and Winkler GS.
  TITLE     The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the
            human Ccr4-Not complex contribute to the prevention of cell death
            and senescence
  JOURNAL   Mol Biol Cell 22 (6), 748-758 (2011)
   PUBMED   21233283
REFERENCE   3  (bases 1 to 9221)
  AUTHORS   Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ
            and Timmers HT.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9221)
  AUTHORS   Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T and Yamamoto
            T.
  TITLE     Depletion of mammalian CCR4b deadenylase triggers elevation of the
            p27Kip1 mRNA level and impairs cell growth
  JOURNAL   Mol Cell Biol 27 (13), 4980-4990 (2007)
   PUBMED   17452450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000248.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415094.2.
            
            On Dec 21, 2022 this sequence version replaced XM_006250709.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132268,
                              SAMD00132273 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               JACYVU010000248.1  8872635-8873219
            586-707             JACYVU010000248.1  8900585-8900706
            708-894             JACYVU010000248.1  8903392-8903578
            895-980             JACYVU010000248.1  8905432-8905517
            981-1070            JACYVU010000248.1  8926154-8926243
            1071-1139           JACYVU010000248.1  8935036-8935104
            1140-1297           JACYVU010000248.1  8938907-8939064
            1298-1452           JACYVU010000248.1  8941179-8941333
            1453-1604           JACYVU010000248.1  8947690-8947841
            1605-1832           JACYVU010000248.1  8950905-8951132
            1833-2035           JACYVU010000248.1  8954582-8954784
            2036-9221           JACYVU010000248.1  8957462-8964647
FEATURES             Location/Qualifiers
     source          1..9221
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..9221
                     /gene="Cnot6l"
                     /note="CCR4-NOT transcription complex, subunit 6-like"
                     /db_xref="GeneID:360917"
                     /db_xref="RGD:1309128"
     exon            1..585
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            586..707
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..2248
                     /gene="Cnot6l"
                     /EC_number="3.1.13.4"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 6-like
                     isoform 1"
                     /protein_id="NP_001402023.1"
                     /db_xref="GeneID:360917"
                     /db_xref="RGD:1309128"
                     /translation="MPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLS
                     TSLWSLTHLTALHLNDNNLARIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL
                     LLNDNYLRVLPYELGRLFQLQTLGLTGNPLSQDIMSLYQDPDGTRKLLNFMLDNLAVH
                     PEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKG
                     IMEEIVNWDADIISLQEVETEQYFTLFLPALKDRGYDGFFSPKSRAKIMSEQERKHVD
                     GCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELF
                     GTGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPT
                     ADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCSGKNGS
                     SEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLV
                     ENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR"
     exon            708..894
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            895..980
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1070
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1139
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1297
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1452
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1604
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1832
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2035
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..9221
                     /gene="Cnot6l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctctaaa gcgatagcgc ccggactcct ctccccggcc ctcggggttg tgagcgtgtg
       61 tgaattagag cgaaggcacc gaaagctcgc gtctctcttc tctccctgtc tttctctctc
      121 tgctcggccc cggcctcggc aaccacccgg ctcggcagca acccccgcag cggcggcagc
      181 ctcagcgcca gaaggccaag gccaagggcg ggctccgcga ggctctcgca gcagcggcag
      241 ccgcgtctcc ggcgaccgcg ggccctctcc tgcgcgcccg ggtcgcccag gtccggcgcg
      301 gcgcggcccg cgttcccctt ccccgccccc tgatccgtct gctctgcgct cccttcggca
      361 gccctccgcc gcctcggtgg ttcctcaggc ggcccggccc ggcccacccg ccccgcgtcc
      421 cctccggccg gtgcctctcc ccccggcggg ctgcctgcat gtctttactg ccctcagccc
      481 cgccgccacc gccgccgccg cctcccccgc cgccgcagcc ccagcagcag ccgccccgcc
      541 gccgccgtcg tcgccgccgc ccggaccctg gcgcgctgaa tgcagactaa tagggatgcc
      601 aaaggaaaaa tatgaccctc cagaccctcg cagaatttac accatcatgt cagcagagga
      661 ggtagccaat gggaaaaaat ctcactgggc agaattagaa atctcgggta gagtgcggag
      721 cttaagtaca tcactctggt cattgacaca cttgacagca ctgcacctaa atgacaataa
      781 ccttgctcgc attccacctg acattgccaa gcttcataat ctggtttacc tggatctgtc
      841 gtccaataaa ctcagaagtt taccagcaga actaggaaac atggtgtctc tcagggaatt
      901 gcttttaaat gacaattatt tacgggtttt gccttatgaa cttggccggc tcttccagct
      961 acaaactcta ggtttaacag gcaatccttt atcacaggat attatgagct tataccagga
     1021 cccagatgga acccgaaagc tactgaactt catgcttgac aatcttgcag ttcatccaga
     1081 gcagcttcct ccgaggccat ggattacatt aaaagaacga gaccaaattc tgccatcagc
     1141 atcgttcacg gtcatgtgtt acaatgtgtt atgtgataaa tatgctaccc ggcagctcta
     1201 tggctattgt ccgtcctggg cattaaactg ggagtacagg aagaagggaa ttatggaaga
     1261 gattgttaac tgggacgcag atatcattag tcttcaggaa gtggaaacag agcaatactt
     1321 tactctcttt ctgccagcat tgaaggatcg tggatatgat ggattttttt ctccaaagtc
     1381 acgtgccaaa atcatgtctg agcaggaaag aaagcatgtg gatggttgtg caatattctt
     1441 caaaacagaa aaatttacat tggtgcagaa gcatacagtg gaattcaacc aggtagcaat
     1501 ggcaaattca gatggatccg aagcaatgct aaacagagta atgacaaaag ataacattgg
     1561 tgttgctgtg gtgttagagg tccacaaaga actctttgga acaggtatga agcctattca
     1621 tgctgcagac aaacagctgc ttatagtggc aaatgcccac atgcattggg acccagagta
     1681 ttctgatgtg aagcttattc agaccatgat gtttgtctca gaggttaaaa acattctgga
     1741 gaaagcctca agtaggcctg gcagcccaac tgcagatccc aattccatcc cgctggtgct
     1801 atgtgcagat cttaactcat tgccagattc aggtgttgtg gaatatttaa gcaacggagg
     1861 agtagcagac aaccacaaag acttcaagga actaaggtac aatgagtgtc ttatgaactt
     1921 cagctgtagt ggaaagaacg gaagctcaga agggagaatc acacatggct tccaacttaa
     1981 gagcgcctat gaaaataact tgatgcctta taccaattac acctttgatt tcaaaggcgt
     2041 gattgactac attttctatt ccaagactca catgaacgtg cttggtgtcc tggggccttt
     2101 agatcctcaa tggctggttg agaacaacat cactgggtgt ccacaccctc acatcccttc
     2161 agaccacttc tcactgttaa cacaacttga actccaccct ccactcctgc ctctagtcaa
     2221 cggtgttcac ttgcctaatc ggaggtagtg gagtacagtc ccgcagagac ggggatctgg
     2281 ctatggacct gtacagttgt aaatcaaagt atgtaggagt gaagtatggc catctttaac
     2341 gctgcttctt caggttcctt tcactatgtg tttgctgtaa gactttgtat atttttgtgc
     2401 atactgatat catttggcac tagggctgga accaaagtat tactgtctgt ctctatccaa
     2461 aagcttaata tactttaaaa ttggacttat tttcctattg tattaggaac caacattcac
     2521 aactgataaa tcactaattt gagaccccac accaatgttg ttctctaaaa acaaatacat
     2581 tcttttgaat gttttcaaat aagccaatca tttttgtaaa aagtgatttt taaaaactcc
     2641 aaatacaaga ttttcaattg aatgatggta tgccttatag gaaaaacttt gagtttctgt
     2701 tttgtttcat aacaagctga tttttggctc tcaagtcatt tgcacattaa caaagcactt
     2761 aaatttgctt gatttgtaca ttaaatatga tatagccact agccctaaca agacaatttg
     2821 agaaatgaaa ggtaattgca taacatgctt taaaatcaag cataggatgt gacagttggt
     2881 tggccagatg ctggctgttt tgaggaatct ttcttttctt ttctctagtc ttttcttttt
     2941 tgtcttacta ttagtcctaa tctttttaga agtattaact ccaagcccat ctctcaagtt
     3001 cattgataag gaaatagcag ataatactgc catacatctt gaaactaaaa tttggttttt
     3061 ttttagtatg cccacaaaat tagtgtctgg tatttttcat tttcgtgccc accctttttt
     3121 ttttttttgg tctggttgta ctggaaaaat atgatctata tctttaccac tactgttaaa
     3181 catttaaaga aaattgctga atgaaaagcc cctggacaga gtttcagaaa gggaaagcca
     3241 gataatatta tatatgtttt ccaaagtaag taaatttatt tgttgttttg ggttttttgt
     3301 ttcattttaa gataacagta gaaaggattt tgaggaaaga acagatttgg ggaagtaatt
     3361 gaaaaccttg gatcattttt ttctgactct agctgccaaa tggccatcat atgcttttaa
     3421 tcttcgttgc catttgtcta gatctgaatt aagctactgt tttattccca aagtttgatg
     3481 cctctagatg tattggaaac cccccaccat ttgttgttgt tggccaggag gtgccacttg
     3541 aaaatcttaa gaggcagaga gcatgaacac cattttgtgg ggagaaaatt tgttggcaaa
     3601 attagaaaat gttaattatg gcacagtaac attggaaaag gttgtgtctg tgtttttaag
     3661 tttttcttta ttctgctttt ttgctgctat aagagttttc tgaaatttat attttaaact
     3721 tttcatgcac tttactgttt ctagtatcaa aatgtgatat ttttaataaa caagaaattt
     3781 tccattatgt gatgaaattt taaaagaaaa tagcctatat ttgtgtctaa tatataaagt
     3841 acaagtcaaa tttaaattat ttaattagtt ttaaatatat acaaattgtc tcctctttca
     3901 aacgtgacaa cttaggctgt tttattagtc ttaaacgata catttcctgt ggtcatttta
     3961 tactaatttc ttccatagtt taccgatcag gctatataaa agaatatttc cccgaagggt
     4021 aattttagtg gggcgagggt ggtgggatga tgtagtatca cacaggactg catctggaag
     4081 agctctgtaa agcctaaact cccttttaaa agtgcctagt gacagaggcg tcgtcatcta
     4141 ttgtgattgg aatgtcactg tagttcagca aagtttgatg taaataaaat attcttttaa
     4201 aaatgttaaa gcacctgaat aaacaaacaa aagaaaccct tgatgacaga ttttcctcag
     4261 tgttcaggta tcccttctta tatacctcaa gcatccaaca tctagccatg cagattgatt
     4321 acctgaagcg catagtactg gaaagtggaa tagcatgaaa aacttaactt tgtggacatt
     4381 acctttttct gtaatcagct actgtatgtt tagcttttga tcttttgttt cgggtgggtt
     4441 ttctgctctg gaggtaaatg cactaacaga acattcttct tctttcatag acgcatgtta
     4501 attagcaatg tgagcaatat ttcctaccat acttcactcc caatattttt gagatgtttg
     4561 tataaaatga aatttaaagt tcatttatga ttgtatatga accacagagg agcccattta
     4621 ttaatacaaa tcttttttaa tagttaaatg tggaggggaa aataaaaaaa aacattggga
     4681 aacattgtaa acagtttaag tttattttgt gtatgatcaa ggcactctgt tgcaagaagg
     4741 aaggtgtgta cttgggtctc tctgcttcca aatgcactct ttcaaaccat cattatcctg
     4801 tgtattttaa tgtggttttc gtaaatgttg gtagtagctc tgttgaagta ggtgattgtg
     4861 ttttgttttg ggtggcacac acctagggca tggtatccca aatttcatgt gcacggtttc
     4921 cctttagcct cttgcccaaa tctcacacac tgtttccccc tgttcccttt gtaaaaggag
     4981 tggtatcttg ttttgagctg ccagttcaga tgatcagaaa tgctgctgtc ctcagcattg
     5041 tcttgttaaa tgcatgccat ttggaacttt ggcagtgaga agcccaaagg acaaggtgaa
     5101 tgacatggta tatattcaat aaaagtgaaa tatatgtgct catatacttt ctagttctca
     5161 gaataagtta ataagcttta cgcctttggg ctgctgcata ttttatctga tgagagaaaa
     5221 tttgggcatt tttagattgc tatgtatttt tttaaatgtt aaatatgatt tctggtaatt
     5281 gtcttaagaa ctggaatgtt aagtttatta aaatggtgtt gtttgaagaa ggggaaactg
     5341 cactgtttgc catttcaaaa gtcatacaag tgcatgtcaa gtcacccact gtcaagcatc
     5401 agtatcctca tagctttaca cactttgatg gggaatattg cagcatcctc aggactgaca
     5461 tctggaaaag gctcaaatca cttactgctc cttgcttgtt gactttgttt tacaatattg
     5521 tgcctggtgt caacttttaa gcaacagcac tgcctaaaag caagcagaga acagaatccc
     5581 agcaccattc tataggcaac tttttagaat tcagatacag taaatctgtt caagatttat
     5641 gatgttttat gtaaaaaatt ttgtacaaca tagctgaata tttttgtttt gatttatttg
     5701 atgtaaggcg tgtgaacatt catttgaata tcacatgtta aagtcaggta tggcacaatg
     5761 ggttctgaga ccagcttccc taccccctcc catttgcctc gttctaatcg ctttcttttc
     5821 aaattacatt tcgggtgttc ataggcagat atttaatttt actaataagc atcctttgtg
     5881 aatgtacttt aaaagccact atgttttaat gttaaagttt gtgaaattat gacacttatc
     5941 cccctacccc ttttttcttt ttgtcttaaa gtcacaaatc actgagaagg aagaaagtta
     6001 aaatctatcc aagactcata tcacttgaat ctgtggcaga ttatgttaaa attgagggtg
     6061 tggcaattaa agctagaaca tggacaatat tgtgctgttt aaaaattctg tcttctgagt
     6121 atgtcttgtg aataggtgaa attttaagtc tgtattgtac tcccaagaat tcgtaaaaat
     6181 cacaaacacc acctgtatac tgagtaacaa atcacaaagg gaagggagaa caaagggaca
     6241 ataggttgag tgtgctcctt caaggggcca ggagcgtaga atgccatttc taacacaggc
     6301 taaatctagt gttaaaattt catgtcggcc taacactgat ttaaaatttc atctttcata
     6361 ttcttgagtt tttgaaatat tttaatagtt ttgaaaagta tactactaac tggtttgtag
     6421 cttcagtcac agaaaacaaa ttgtatttca gtaagggtcc tgtagcaagc aagaactctt
     6481 tgtcacatgt tcaaagtaac aaaccttttt actgaaatgt gagctgtcat gtttgtaagg
     6541 ttgttttctt ctctccccca taaaacccaa agtaacacct ttctaatgtg ttaaaaattt
     6601 gtttaccgct tccgtttggc ttgtggtcta tttgtatgac ttttatgtat tagaagtaga
     6661 taaattaggt agagacgtta gacttatttt tctaagtcag gaacttaaac tgaagttttg
     6721 aatttgtaga cagaagagaa catttatgct tacgattgct ctggaagatt ttaatttctg
     6781 taaatgcacc atgattccta aatttgaaac ccaagtaaat gctagtccat ctttagcctg
     6841 cttattacca aagttttaag gacagggtgc caagagcacc tttcataact gtcacccgaa
     6901 tgcttaaaaa tataaaagaa aaacccatat gtgttctgag caagagccgt agagagaaaa
     6961 ccaggaaggg aagcagaagg gcaggacccc gctcaggaag atgaaaagaa agagcatgca
     7021 tgcttgttct gaccaaatgc attcatgtaa atgtctcagg taaaaggccg taggaagaag
     7081 cagactccag ggaacgtctt atcaatatag taattttgac ataagtttgg ttaacttggt
     7141 ttatgctaga cttgttttat tcttggatcc aaaggacaga ctgaaagtac tttttagcaa
     7201 gataagctaa ctttcaaagg atatgaatta agggtatgtc tattaaatgt tgattttttt
     7261 ttttttatgg tgcagcctat aagataaata gcattgaact gaaattcaaa gtgtgccatc
     7321 agaagccatg acgcctggca tggtgtacct ttcagaatga cacccgttaa ttaactggtt
     7381 attttcttca gcaggatccc cgcctttgtt tgatttccct gtttgtctgt cccttggaaa
     7441 agcataggag ttgtggtagc agctctctga aaactgatcc ctgctcatta ttcagagtac
     7501 tcccatattt tcttagctag ccgttgttct gtgtaccaca tttgtttaat ttgtgtgtag
     7561 ttacttgaac tcagaatatt tgctcagtat tggtgtgcca aacaatggct ctgcttctta
     7621 tggtacagac tgagtgttct gcttactgtt tcaactttaa tgcggtaagt gttacagtgt
     7681 gtgggttgct ctctattcag aaactactgt cctttctctg tgcttggctt gctaaaagta
     7741 catttcctta cctgtgtaat tcctgagcgg tgctttgctg acttttgagg gaggagggat
     7801 ttggatgact gttactacac actagaactg gaattgttca gtgttgtgaa tggcagattt
     7861 cttaaacacc agcagcactg agaagtgcac tatgggcatt cgtacagttg tccaaacgta
     7921 agcagtactt ttatccaaaa gaagccgaga tgtgttgggg tcaataggag tactttgagt
     7981 atctcaagga gggcaaatga ttaactttgt cgtatctgaa gtggagtagc cctttctctc
     8041 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tctctccttc
     8101 cctctctccc ttcttccctt cccccctccc tcctcctccc tctctctcct ctcttctctc
     8161 tcctttctcc tctcccctcc cccctctctc ttctctcttc tctctttatt tttcagtttt
     8221 taaagagaag gaaatatata catacttttt ctcaaagacc aggatgtttg attatattga
     8281 ccagagatta agtcgtatct agtttttaac tgtataagtg ccaagttatt gtccatggac
     8341 tttttaccat ttgattagga aagagattat ttttgtttcc tggcattaag ttgattaatt
     8401 tattgttttg catacatttg agtcattctg tggcctatat agtgttttta taactataca
     8461 gtggtctaaa atcaaagcac atgatcctaa aactaagcaa gatgttttag taaatttccc
     8521 catgagtact tgctaatttc tattaatatt gttctaagca gacactactg ttttaggttg
     8581 tgtatttttt tttttttaat ttttccccta agaaaaagcc aagcactaaa tcagcttgtg
     8641 ttctggtaat cacttgcaag ctaagctttt ctctttcttc ctttcttaga ggatttaatg
     8701 aagtgccatg taattgtagc ttattaatta atgtttgata gactggttct gtgatattct
     8761 aaacatttag ctctttcttg tcatctctgg agaagatggt tctactctca ttctctgata
     8821 aaatcaccag ctgctttatt tttctattta ttaaacagtt gataaggtct ggatcatgac
     8881 caaactgctc agctgagatg ttttcatagt ggacactgta gaaaatgtgt gtgcaaaagg
     8941 acacagttga gtgatggtat tctttttcat taatgtgaac attgactaaa caaagcagtc
     9001 ctgcctttta aatcttgtgg cagctcagaa gggaggtgct taagaacctt aactattatg
     9061 tcagatgaca aaatactttt tttccatttt ggagattggg tactgctcac acatgatgta
     9121 tagggctaaa tatatgcttg tttccttgca cctgtgtact ctccccttct ctcccacttt
     9181 tcctttccct gtaggcaata aatggccatt ttgcaaccgc a
//
