LOCUS       NM_001107471            2869 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex, subunit 3
            (Cnot3), mRNA.
ACCESSION   NM_001107471 XM_001066271 XM_218187
VERSION     NM_001107471.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2869)
  AUTHORS   Li,X., Morita,M., Kikuguchi,C., Takahashi,A., Suzuki,T. and
            Yamamoto,T.
  TITLE     Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy
  JOURNAL   FEBS Lett 591 (2), 358-368 (2017)
   PUBMED   28032897
REFERENCE   2  (bases 1 to 2869)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   3  (bases 1 to 2869)
  AUTHORS   Zheng,X., Dumitru,R., Lackford,B.L., Freudenberg,J.M., Singh,A.P.,
            Archer,T.K., Jothi,R. and Hu,G.
  TITLE     Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and
            inhibit extraembryonic differentiation
  JOURNAL   Stem Cells 30 (5), 910-922 (2012)
   PUBMED   22367759
REFERENCE   4  (bases 1 to 2869)
  AUTHORS   Suzuki,A., Igarashi,K., Aisaki,K., Kanno,J. and Saga,Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   5  (bases 1 to 2869)
  AUTHORS   Lau,N.C., Kolkman,A., van Schaik,F.M., Mulder,K.W., Pijnappel,W.W.,
            Heck,A.J. and Timmers,H.T.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 8, 2010 this sequence version replaced NM_001107471.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.847.1, SRR26643429.830.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               JAXUCZ010000001.1  74487248-74487527   c
            281-355             JAXUCZ010000001.1  74481871-74481945   c
            356-423             JAXUCZ010000001.1  74481697-74481764   c
            424-498             JAXUCZ010000001.1  74481408-74481482   c
            499-588             JAXUCZ010000001.1  74481176-74481265   c
            589-717             JAXUCZ010000001.1  74480824-74480952   c
            718-813             JAXUCZ010000001.1  74480631-74480726   c
            814-1033            JAXUCZ010000001.1  74479351-74479570   c
            1034-1167           JAXUCZ010000001.1  74479126-74479259   c
            1168-1224           JAXUCZ010000001.1  74478511-74478567   c
            1225-1606           JAXUCZ010000001.1  74476525-74476906   c
            1607-1730           JAXUCZ010000001.1  74476321-74476444   c
            1731-1929           JAXUCZ010000001.1  74475389-74475587   c
            1930-2029           JAXUCZ010000001.1  74474303-74474402   c
            2030-2228           JAXUCZ010000001.1  74474012-74474210   c
            2229-2361           JAXUCZ010000001.1  74473663-74473795   c
            2362-2487           JAXUCZ010000001.1  74472895-74473020   c
            2488-2869           JAXUCZ010000001.1  74471284-74471665   c
FEATURES             Location/Qualifiers
     source          1..2869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2869
                     /gene="Cnot3"
                     /note="CCR4-NOT transcription complex, subunit 3"
                     /db_xref="GeneID:308311"
                     /db_xref="RGD:1304771"
     exon            1..280
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            281..355
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2586
                     /gene="Cnot3"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 3"
                     /protein_id="NP_001100941.2"
                     /db_xref="GeneID:308311"
                     /db_xref="RGD:1304771"
                     /translation="MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKY
                     EADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKA
                     YSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDK
                     DKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPD
                     FEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPAN
                     CTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPATSAL
                     SSTPGNNGASTPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPS
                     AQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVALSSSGGSSASS
                     QALGPTSGPHNPAPSTLKESSTAAPSGAGSVASGSGNNSGGPSLLVPLPVNPPSSPTP
                     SFSEAKAAGTLLNGPPQFSTTPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTDR
                     DIILSSTSAPPTSSQPPLQLSEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMP
                     HPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQ
                     YLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTF
                     EYRYLEDRDLQ"
     exon            356..423
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..498
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..588
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..717
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..813
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1033
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1167
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1224
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1606
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1730
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1929
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2029
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2228
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2361
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2487
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2869
                     /gene="Cnot3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgttca gcttccgtgg agccgtcggc agccgctgcc aggcctttcc ttgatccctg
       61 aatcccctac tcggtcgtct agaacaatcc cgggctcact tcctctatca acaacccaac
      121 cccacttccg gctttcgcgc cctcttatcg cgatagcgcc cggactcggg gcgcgaggaa
      181 agaggaaaaa aaaaaaaagg cggcgggcgg gcgctcgcct ctctctcccc cctcctcgcc
      241 tgtcgcgata cgctccgcag cggcggcgcc agctcctgcg cgtccgtttc taagagagta
      301 tgaagagagt gcgtctgtag ggcagggaag atggcggaca agcgcaaact ccaaggtgag
      361 attgatcgct gcctcaagaa ggtgtccgaa ggtgtggagc agtttgaaga tatttggcaa
      421 aagctccaca atgcagccaa cgcgaaccag aaagaaaagt atgaggctga cctaaagaag
      481 gagattaaga agctacaacg gctgagggac cagatcaaga catgggtagc atccaatgag
      541 atcaaggaca aaaggcagct tatcgaaaac cgcaagctca ttgaaacgca aatggaacgg
      601 ttcaaagttg tggaacgaga gaccaaaacc aaagcctata gcaaggaggg tctcggtctg
      661 gctcagaagg tggaccctgc ccagaaggag aaggaagagg ttggccagtg gctcacgaac
      721 accattgaca ccttaaatat gcaggtggac cagtttgaga gtgaggtgga gtcactgtca
      781 gtacagacgc gcaagaagaa aggcgataag gataagcagg accggattga gggcttgaag
      841 cggcacatcg agaagcaccg ctaccatgta cgtatgctgg agaccatcct gcgcatgctg
      901 gacaatgact ccatcctggt tgatgccatc cgcaagatca aggatgatgt agagtactac
      961 gttgactcat cccaggaccc cgactttgaa gagaatgagt tcctctatga cgacctggac
     1021 ctcgaggaca ttccacaggc gctggtcgcc acctcccccc ccagccacag ccacatggag
     1081 gacgagatct tcaaccagtc tagcagtaca cccacctcaa caacctccag ctctcccatc
     1141 ccacccagcc cagctaactg cactacggaa aactctgaag atgataagaa gagaggccgc
     1201 tctacagata gtgaagtcag ccagtctcca gccaaaaatg gctccaagcc tgtccacagc
     1261 aaccagcacc cccagtcccc agctgtgccg cccacctacc cctctggccc cccacctgcc
     1321 acttctgcct tgagctccac ccctggcaac aatggggcct ctaccccagc agcacctcca
     1381 agtgccctgg gccctaaggc cagtccagct cccagccaca actcgggtac tcctgccccc
     1441 tatgcccagg ctgtggcccc acccaatgcc agcgggccca gcaatgccca gccccggccc
     1501 cccagtgccc agccaagcgg gggaagtggt ggtggcagcg gagggagcag cagcaatagt
     1561 aacagtggca caggcggagg ggctggcaag cagaacggtg ccaccagcta tagttcggtt
     1621 gtggcagaca gccctgcaga ggtggccctg agtagcagtg ggggcagcag tgccagcagc
     1681 caagccctgg ggcccacatc gggccctcat aacccagctc ccagcacctt aaaggaatcc
     1741 agtacagcag ccccatccgg ggctgggagt gtggcttcag gctcagggaa caactcaggg
     1801 ggacccagcc tcttggtgcc actgcctgta aatcccccca gttctccaac gcccagcttc
     1861 agtgaagcca aggcagctgg cactcttctt aatggtcccc cacagtttag caccacccca
     1921 gaaatcaagg cccctgaacc tctgagctct ctgaaatcca tggcagaacg ggcagctatc
     1981 agctctggta ttgaggaccc tgtgccaacg ttacacctaa ctgatagaga catcatcctg
     2041 agcagcacat cagcaccacc cacctcatcc cagccacccc tgcagctatc agaggtgaac
     2101 ataccattgt cactgggcgt ctgtccattg gggccagtgt ccctcaccaa ggagcagcta
     2161 taccaacagg ccatggaaga ggccgcctgg caccacatgc cccacccctc tgactccgag
     2221 cgcattcggc agtaccttcc ccggaaccct tgcccgacac ccccctacca ccaccagatg
     2281 ccacccccgc actcggacac tgtggagttc taccagcgcc tgtcaactga gacgctcttc
     2341 ttcatcttct actatctgga gggaaccaag gcacagtact tggcagccaa ggccctaaag
     2401 aagcagtcct ggcgattcca caccaagtat atgatgtggt ttcagaggca tgaggagccc
     2461 aagaccatca cagatgagtt tgagcagggc acctacatct actttgacta cgagaagtgg
     2521 ggccagcgga agaaggaagg cttcaccttt gagtatcgct acctggagga ccgggacctc
     2581 cagtgacacc ggcccccttt accctccccc tcccccgcat gctgatcccc ctgcccaggt
     2641 gagggccctg ccctggaaga ctgggggagg cccaaggcca tgggacaccc tcccgcccca
     2701 ggaagcagag aagggatagg gaagttttct cttcctctct gccctaccct gggggcctgg
     2761 gggcaagggc tgccccctcc tcccctcccc agtgagggac attttttggt aaacctattt
     2821 tcattttgga aaatatttat gaataaatag ttttatatga cggctggca
//
