LOCUS       NM_001399553            3080 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex, subunit 2
            (Cnot2), transcript variant 1, mRNA.
ACCESSION   NM_001399553 XM_006241363
VERSION     NM_001399553.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Zheng,X., Dumitru,R., Lackford,B.L., Freudenberg,J.M., Singh,A.P.,
            Archer,T.K., Jothi,R. and Hu,G.
  TITLE     Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and
            inhibit extraembryonic differentiation
  JOURNAL   Stem Cells 30 (5), 910-922 (2012)
   PUBMED   22367759
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Ito,K., Inoue,T., Yokoyama,K., Morita,M., Suzuki,T. and Yamamoto,T.
  TITLE     CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase
            complex and induces apoptotic cell death
  JOURNAL   Genes Cells 16 (4), 368-379 (2011)
   PUBMED   21299754
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Lau,N.C., Kolkman,A., van Schaik,F.M., Mulder,K.W., Pijnappel,W.W.,
            Heck,A.J. and Timmers,H.T.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Jayne,S., Zwartjes,C.G., van Schaik,F.M. and Timmers,H.T.
  TITLE     Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional
            repression by the CNOT2 subunit of the human Ccr4-Not complex
  JOURNAL   Biochem J 398 (3), 461-467 (2006)
   PUBMED   16712523
REFERENCE   7  (bases 1 to 3080)
  AUTHORS   Winkler,G.S., Mulder,K.W., Bardwell,V.J., Kalkhoven,E. and
            Timmers,H.T.
  TITLE     Human Ccr4-Not complex is a ligand-dependent repressor of nuclear
            receptor-mediated transcription
  JOURNAL   EMBO J 25 (13), 3089-3099 (2006)
   PUBMED   16778766
REFERENCE   8  (bases 1 to 3080)
  AUTHORS   Zwartjes,C.G., Jayne,S., van den Berg,D.L. and Timmers,H.T.
  TITLE     Repression of promoter activity by CNOT2, a subunit of the
            transcription regulatory Ccr4-not complex
  JOURNAL   J Biol Chem 279 (12), 10848-10854 (2004)
   PUBMED   14707134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006241363.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2180854.1,
                                           SRR26643292.29313.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               JAXUCZ010000007.1  54107567-54107960   c
            395-467             JAXUCZ010000007.1  54077584-54077656   c
            468-590             JAXUCZ010000007.1  54057106-54057228   c
            591-657             JAXUCZ010000007.1  54047240-54047306   c
            658-805             JAXUCZ010000007.1  54037386-54037533   c
            806-988             JAXUCZ010000007.1  54036583-54036765   c
            989-1068            JAXUCZ010000007.1  54034358-54034437   c
            1069-1194           JAXUCZ010000007.1  54031891-54032016   c
            1195-1319           JAXUCZ010000007.1  54030051-54030175   c
            1320-1440           JAXUCZ010000007.1  54029043-54029163   c
            1441-1597           JAXUCZ010000007.1  54028791-54028947   c
            1598-1659           JAXUCZ010000007.1  54025935-54025996   c
            1660-1709           JAXUCZ010000007.1  54025793-54025842   c
            1710-1810           JAXUCZ010000007.1  54024616-54024716   c
            1811-1955           JAXUCZ010000007.1  54023207-54023351   c
            1956-3080           JAXUCZ010000007.1  54016447-54017571   c
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3080
                     /gene="Cnot2"
                     /note="CCR4-NOT transcription complex, subunit 2"
                     /db_xref="GeneID:299805"
                     /db_xref="RGD:1311672"
     exon            1..394
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..2042
                     /gene="Cnot2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 2 isoform
                     1"
                     /protein_id="NP_001386482.1"
                     /db_xref="GeneID:299805"
                     /db_xref="RGD:1311672"
                     /translation="MRTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVD
                     SDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNN
                     TPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIG
                     IPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSL
                     SSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPA
                     NEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLSTSGKTTSSTDGPKFPGDKSST
                     TQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDL
                     TTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYG
                     EDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGT
                     YYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF"
     exon            395..467
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..590
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..657
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..805
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..988
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1068
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1194
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1319
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1440
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1597
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1659
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1709
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1810
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1955
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..3080
                     /gene="Cnot2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatttcccc gcccccgccc ccgaggccgc tctcggaccc caggccgcag ctcctggtgt
       61 ggcggtctgg cttgggaagc ccggcgaggc ctcggaggcc ccactttccg taatcgccac
      121 aaggcagcgc cgcacctccg cgggaggtgg cgggacgcct ggcggaagcc cgggaaggct
      181 cctgaggagc gccgtgcttc tcaccgtcga ccggcgttcg ggaaacactc tgtccttgag
      241 gcgagcatcg ctcgccacct tctgccgccg ccttagagcg aagtcggagc gacgggggtc
      301 acggcggggg tcagagggta aaggtcttgc tcccagcagc ctccgcggtg gatacgtcgc
      361 catcttggat ccgcgggaca agaaaattca tgcgtactgt gaggaaagga cacgactcta
      421 tggtgaggac tgatggacat acattatctg agaaaagaaa ctaccaggtg acaaacagca
      481 tgtttggtgc ttcaagaaag aagtttgtag agggggtgga cagcgactac catgatgaaa
      541 acatgtacta cagccagtct tctatgttcc cacatcggtc agagaaagat atgctggcat
      601 caccatctac atcaggtcag ctgtctcaat ttggggcaag tttatacggg caacaaagtg
      661 cactaggcct tccaatgagg gggatgagca acaatacccc tcagttaaat cgcagcttat
      721 cacaaggcac tcagttaccg agccacgtca cgccaacaac aggggtacca acaatgtcac
      781 ttcacacgcc tccatctcca agcaggggta ttttgcctat gaatcctagg aatatgatga
      841 accactccca ggttggtcag ggcattggaa ttcctagcag gacaaatagc atgagcagtt
      901 cagggttagg tagccccaac agaagctcgc caagcataat atgtatgcca aagcagcagc
      961 cttctcgaca gccttttact gtgaacagta tgtctggatt tggaatgaac aggaatcagg
     1021 catttggaat gaataactcc ttatcaagta acatttttaa tggaacagat ggcagtgaaa
     1081 atgtgacagg attggacctt tcagatttcc cagcattagc agaccggaat agaagggaag
     1141 gaagtggcaa cccaactcca ttaataaacc ccttggctgg aagagcccct tacgttggaa
     1201 tggtaacaaa acctgcaaat gagcaatccc aggacttctc aatacacaac gaagatttcc
     1261 cagcactacc tggctccagc tataaagacc caacgtcgag taatgacgac agcaagtcta
     1321 atttgagtac atcggggaag acgacttcaa gtacagatgg gcccaaattt cctggagata
     1381 aaagttcaac aacacaaaac aataatcagc agaaaaaggg gatccaggtg ttacctgatg
     1441 gtcgagttac taacattcct caagggatgg tgacggacca atttggaatg attggcctgt
     1501 taacatttat cagggcagca gagacagacc cgggaatggt acatcttgct ttaggaagtg
     1561 acttaacaac attaggcctc aatctgaact cacccgaaaa tctctacccc aaatttgcat
     1621 caccctgggc ttcttcacct tgtcgacctc aagatataga cttccatgtt ccgtcagaat
     1681 atttaacaaa cattcacatt agggataagc tggctgcaat caaacttggc cgatatggag
     1741 aagacctcct cttctatctc tattacatga acggaggaga cgtattacaa ctcttagctg
     1801 cagtagagct ttttaaccgt gattggagat accacaagga ggagcgggta tggattacca
     1861 gggcaccagg catggagcca acgatgaaaa ccaacacata tgagcgagga acctactact
     1921 tctttgactg tctcaactgg aggaaagtag ctaaggagtt ccatctggaa tatgacaagt
     1981 tagaagagcg gcctcacctg ccgtccacct tcaactacaa ccctgctcag caagccttct
     2041 gaaaagactc ccttttcttg gggtatggct gtctcagcac aatactcgac ataactgcag
     2101 aactgatgtg gctcaggcac cctggtttaa ttccttgagg atctggcaat tggcttacat
     2161 aaagggtcac catttgaggt cctgccttac caattatgtg ctgcccaaca actaaatttg
     2221 tactttgttt tctctagttt gagcagggtc tgaattttct catttatttt ctttttgcca
     2281 gcagacagac ttgggtctat aaagacaagc aagtacactg acagaagtta ccatttagtt
     2341 tcttaaatgt aaaaaaagaa aacccacaaa agactcaaca aaattagacc acaaaatttg
     2401 cattgttcat tgtagcacta ttggtaataa aagagcagat gtttgtgcgt tttgatgtgg
     2461 agatccttct cgtatttcat ttggaaagat gagcaaggtc tgcttctttc tttttacttc
     2521 cccttgtgtt tctgaaaggc agtttctcca ggcttactgc aagaatatga ctgtagagag
     2581 attaccacag tctctggtgg ctccagggct gtgttgttac tgagcttcat ctttccagaa
     2641 tgagcaaaac actgtccagt ctttgttacg attttgtaat aaatgtgtac atttttttta
     2701 aattttggac atcacatgaa taaaggtatg tatgtacgaa tgtgtatata ttatatatat
     2761 gacatctatt ttggaaaatg tttgccctgc tgtacctcat ttttaggagg tgtgcatgga
     2821 tgcaatatat gaaaatggga cattctggaa ctgctggtca ggggactttg tcgccctgtg
     2881 cactaaaggg ccagattttc agcagccaag gacatccata cccaagtgaa tgtgatgggg
     2941 cttcaagacg tgaactgaga caattcactc tggctgtgtg aacagcagcg tttcatagga
     3001 agagaaaaaa gatcaatctt gtattttctg accacataaa ggcttcttct ctttgtaata
     3061 aagtagaaaa gctctcctca
//
