LOCUS       NM_001134840            7714 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus CCR4-NOT transcription complex, subunit 1
            (Cnot1), mRNA.
ACCESSION   NM_001134840 XM_001060702
VERSION     NM_001134840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7714)
  AUTHORS   Chen,Y., Boland,A., Kuzuoglu-Ozturk,D., Bawankar,P., Loh,B.,
            Chang,C.T., Weichenrieder,O. and Izaurralde,E.
  TITLE     A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct
            links between miRNA target recognition and silencing
  JOURNAL   Mol Cell 54 (5), 737-750 (2014)
   PUBMED   24768540
REFERENCE   2  (bases 1 to 7714)
  AUTHORS   Bhandari,D., Raisch,T., Weichenrieder,O., Jonas,S. and
            Izaurralde,E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   3  (bases 1 to 7714)
  AUTHORS   Fabian,M.R., Frank,F., Rouya,C., Siddiqui,N., Lai,W.S.,
            Karetnikov,A., Blackshear,P.J., Nagar,B. and Sonenberg,N.
  TITLE     Structural basis for the recruitment of the human CCR4-NOT
            deadenylase complex by tristetraprolin
  JOURNAL   Nat Struct Mol Biol 20 (6), 735-739 (2013)
   PUBMED   23644599
REFERENCE   4  (bases 1 to 7714)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   5  (bases 1 to 7714)
  AUTHORS   Huntzinger,E., Kuzuoglu-Ozturk,D., Braun,J.E., Eulalio,A.,
            Wohlbold,L. and Izaurralde,E.
  TITLE     The interactions of GW182 proteins with PABP and deadenylases are
            required for both translational repression and degradation of miRNA
            targets
  JOURNAL   Nucleic Acids Res 41 (2), 978-994 (2013)
   PUBMED   23172285
REFERENCE   6  (bases 1 to 7714)
  AUTHORS   Sandler,H., Kreth,J., Timmers,H.T. and Stoecklin,G.
  TITLE     Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted
            for degradation by tristetraprolin
  JOURNAL   Nucleic Acids Res 39 (10), 4373-4386 (2011)
   PUBMED   21278420
REFERENCE   7  (bases 1 to 7714)
  AUTHORS   Suzuki,A., Igarashi,K., Aisaki,K., Kanno,J. and Saga,Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   8  (bases 1 to 7714)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 7714)
  AUTHORS   Lau,N.C., Kolkman,A., van Schaik,F.M., Mulder,K.W., Pijnappel,W.W.,
            Heck,A.J. and Timmers,H.T.
  TITLE     Human Ccr4-Not complexes contain variable deadenylase subunits
  JOURNAL   Biochem J 422 (3), 443-453 (2009)
   PUBMED   19558367
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7714)
  AUTHORS   Winkler,G.S., Mulder,K.W., Bardwell,V.J., Kalkhoven,E. and
            Timmers,H.T.
  TITLE     Human Ccr4-Not complex is a ligand-dependent repressor of nuclear
            receptor-mediated transcription
  JOURNAL   EMBO J 25 (13), 3089-3099 (2006)
   PUBMED   16778766
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 9, 2008 this sequence version replaced XM_001060702.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.78226.1,
                                           SRR26643297.50829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000019.1  9261294-9261426
            134-408             JAXUCZ010000019.1  9276962-9277236
            409-516             JAXUCZ010000019.1  9291963-9292070
            517-615             JAXUCZ010000019.1  9292598-9292696
            616-684             JAXUCZ010000019.1  9293517-9293585
            685-739             JAXUCZ010000019.1  9293675-9293729
            740-943             JAXUCZ010000019.1  9294616-9294819
            944-1112            JAXUCZ010000019.1  9295806-9295974
            1113-1239           JAXUCZ010000019.1  9296693-9296819
            1240-1350           JAXUCZ010000019.1  9296976-9297086
            1351-1521           JAXUCZ010000019.1  9301862-9302032
            1522-1649           JAXUCZ010000019.1  9302395-9302522
            1650-1890           JAXUCZ010000019.1  9303754-9303994
            1891-2010           JAXUCZ010000019.1  9305565-9305684
            2011-2133           JAXUCZ010000019.1  9306347-9306469
            2134-2285           JAXUCZ010000019.1  9306901-9307052
            2286-2436           JAXUCZ010000019.1  9309238-9309388
            2437-2638           JAXUCZ010000019.1  9310433-9310634
            2639-2785           JAXUCZ010000019.1  9311727-9311873
            2786-2910           JAXUCZ010000019.1  9313515-9313639
            2911-3197           JAXUCZ010000019.1  9313884-9314170
            3198-3276           JAXUCZ010000019.1  9315021-9315099
            3277-3507           JAXUCZ010000019.1  9317649-9317879
            3508-3648           JAXUCZ010000019.1  9318330-9318470
            3649-3828           JAXUCZ010000019.1  9319629-9319808
            3829-3945           JAXUCZ010000019.1  9321030-9321146
            3946-4056           JAXUCZ010000019.1  9327913-9328023
            4057-4134           JAXUCZ010000019.1  9328312-9328389
            4135-4312           JAXUCZ010000019.1  9328563-9328740
            4313-4443           JAXUCZ010000019.1  9329922-9330052
            4444-4740           JAXUCZ010000019.1  9331463-9331759
            4741-4881           JAXUCZ010000019.1  9332782-9332922
            4882-4986           JAXUCZ010000019.1  9333017-9333121
            4987-5106           JAXUCZ010000019.1  9333991-9334110
            5107-5298           JAXUCZ010000019.1  9337212-9337403
            5299-5441           JAXUCZ010000019.1  9337827-9337969
            5442-5550           JAXUCZ010000019.1  9338805-9338913
            5551-5720           JAXUCZ010000019.1  9339005-9339174
            5721-5952           JAXUCZ010000019.1  9339826-9340057
            5953-6201           JAXUCZ010000019.1  9342574-9342822
            6202-6365           JAXUCZ010000019.1  9343879-9344042
            6366-6483           JAXUCZ010000019.1  9344385-9344502
            6484-6585           JAXUCZ010000019.1  9345540-9345641
            6586-6759           JAXUCZ010000019.1  9346790-9346963
            6760-6909           JAXUCZ010000019.1  9348180-9348329
            6910-7090           JAXUCZ010000019.1  9349192-9349372
            7091-7223           JAXUCZ010000019.1  9351124-9351256
            7224-7358           JAXUCZ010000019.1  9351996-9352130
            7359-7714           JAXUCZ010000019.1  9352281-9352636
FEATURES             Location/Qualifiers
     source          1..7714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..7714
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /note="CCR4-NOT transcription complex, subunit 1"
                     /db_xref="GeneID:291841"
                     /db_xref="RGD:1308009"
     exon            1..133
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            134..408
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..7437
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /note="adrenal gland protein AD-005"
                     /codon_start=1
                     /product="CCR4-NOT transcription complex subunit 1"
                     /protein_id="NP_001128312.1"
                     /db_xref="GeneID:291841"
                     /db_xref="RGD:1308009"
                     /translation="MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEAD
                     RHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQ
                     KSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSPDLRGFAAQFIKQKLPDLLRSY
                     IDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQER
                     CPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNI
                     IMQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSEGAQAH
                     TWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPV
                     DFIYRPWKHAEGQLSFIQHSLINPEVFCFADYPCHTVATDILKAPPEDDNREIATWKS
                     LDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMP
                     IFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQD
                     LKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRC
                     PSILGGLAPEKDQPKSAQLPAETLATMLACLQACAGSVSQELSETILTMVANCSNVMN
                     KARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMASLSIGGSAAPHTQSMQGFPPNL
                     GSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPA
                     VNSDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIY
                     NHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITA
                     CLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYC
                     QHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKA
                     PLAGQVNTMVTTSTTTTVAKTVTVTKPTGVSFKKDVPPSINTTNIDTLLVATDQTERI
                     VEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFH
                     SLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITL
                     AKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSLVFRPPNPWTMAI
                     MNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPK
                     KDVKQPEELPAITTTTTSTTPATSTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNP
                     TIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESR
                     MRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQ
                     LAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAER
                     MPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQ
                     IYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEG
                     LLDATSGADADLLLRYRECHLLVLKGLQDGRAYGSPWCNKQITRCLIECRDEYKYNVE
                     AVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHITEADL
                     FHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEY
                     DDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFR
                     LCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVT
                     KINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTL
                     TAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKY
                     LAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLI
                     LSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPV
                     TFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHM
                     DIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITR
                     VLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQK
                     QAQQVMEGTGAS"
     exon            409..516
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            517..615
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            616..684
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            685..739
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            740..943
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1112
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1239
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1350
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1521
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1649
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1890
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2010
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2133
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2285
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2436
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2638
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2785
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2910
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3197
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3276
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3507
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3648
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3828
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3945
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4056
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4134
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4312
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4313..4443
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4444..4740
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4881
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4986
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5106
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5107..5298
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5441
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5442..5550
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..5720
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5721..5952
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            5953..6201
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6202..6365
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6366..6483
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6484..6585
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6586..6759
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6760..6909
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            6910..7090
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            7091..7223
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            7224..7358
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
     exon            7359..7714
                     /gene="Cnot1"
                     /gene_synonym="RGD1308009"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacgtgag cgcgcgacct cgggcgccat tttgtcgaga aacaagcgga gttaaccgaa
       61 gaggggggtc gaggagagcc ggagtcgagg acccaggagt ttcctgtgtc cagcgctgcc
      121 ggagccgcct gaggtgccat gtttcagaac agagtaagac acttggtaaa gaagaactga
      181 agacatttat agataccaga gatagcctga ttacaaagaa agcattaacc tgcctctgag
      241 gtgactaaag gggaataatg gtgattttgc gccgggctcg gccgcctgct tccgccccaa
      301 ccagcaatga atcttgactc gctctcgctg gccttgtctc aaatcagcta cctggtggac
      361 aatttaacca agaaaaacta ccgagccagc cagcaggaaa tacagcatat tgtaaatcgg
      421 cacggtcctg aggcagacag gcatttatta cgctgcctat tttcacatgt ggatttcagt
      481 ggcgatggta aaagcagtgg caaagatttc catcagacac agtttctgat tcaggagtgt
      541 gcctcgctga ttacaaagcc aaattttatc tcgacattgt catatgccat tgataatcct
      601 ttgcactacc agaagagttt aaaacctgca ccccacttat ttgcccagct gagtaaagtt
      661 ctcaagttaa gtaaagtaca agaggtaatt tttggtcttg cccttttgaa ttcttctagc
      721 ccagatctca ggggatttgc tgcccagttt attaagcaga agcttccaga tcttctgcgt
      781 tcttacattg acgcagacgt cagtggaaat caagaaggtg gcttccaaga tatagcaata
      841 gaggtcctgc acctcctgct ctcccacctc ctctttgggc agaagggggc ctttggagtc
      901 gggcaggagc agatagacgc ctttctcaag acgctgcgca gagattttcc ccaagagcgt
      961 tgtcctgtgg tgcttgcacc actcctatac cctgaaaaac gggacattct aatggacagg
     1021 attctgcctg actctggagg ggtagctaag accatgatgg agagctctct ggctgatttc
     1081 atgcaagaag tgggctatgg cttttgtgca agtattgaag aatgtcgcaa tataatcatg
     1141 cagtttggtg ttcgggaggt gacagctgcc caggttgcca gggtcttggg aatgatggct
     1201 cggactcact caggattaac agatggtatt ccattacaga gcatctctgc tcccggcagt
     1261 gggatctgga gtgatgggaa agataaaagc gagggggcac aggcacacac gtggaatgta
     1321 gaggttttga tcgatgttct taaagaactg aacccgagtt tgaatttcaa ggaagtaact
     1381 tatgaactgg accatcctgg atttcaaatt cgtgatagca aagggcttca caatgtggtg
     1441 tatggcattc agaggggtct gggcatggaa gtgttcccag tggactttat atataggccc
     1501 tggaaacatg cggaaggcca gctctccttc atccagcatt ccctgataaa cccagaagtc
     1561 ttctgctttg ccgactaccc ctgtcacact gttgccactg atattttgaa agcaccacca
     1621 gaggatgaca atcgagaaat tgccacatgg aaaagcttgg atttgattga atctctgctg
     1681 aggcttgcag aggttgggca gtatgagcaa gtgaaacaac tcttcagctt ccctatcaaa
     1741 cactgtccag acatgttggt attggcctta cttcaaatca acacctcctg gcacacccta
     1801 cgccatgaac tcatttctac tttgatgcca attttccttg gaaaccatcc taactctgcc
     1861 attattttgc actatgcatg gcatgggcag ggacagtctc catcaattcg ccaacttata
     1921 atgcatgcaa tggcagaatg gtacatgaga ggggagcagt atgaccaggc caaattgtct
     1981 cgaatacttg atgtggccca ggacttgaag gccctgtcga tgctgctgaa cggcactcca
     2041 tttgcctttg ttattgacct tgctgcactc gcttctcggc gtgaatacct caaacttgac
     2101 aagtggctaa cagataagat aagagagcat ggggagcctt ttatacaagc atgtatgact
     2161 tttttaaaaa gaaggtgccc ttctattttg ggtggacttg ccccagagaa agatcagccc
     2221 aaaagtgctc aacttcctgc tgaaacacta gcgacaatgt tggcctgtct acaggcttgt
     2281 gcagggagtg tttctcagga gttatccgag actatcctca ccatggtagc caattgcagt
     2341 aatgtaatga ataaggccag acagccacca cctggagtta tgcccaaagg ccgccctcct
     2401 agtgctagca gcttagatgc catttctcct gttcagattg accctcttgc tggaatggca
     2461 tctcttagta taggtggttc agctgcccct cacacccaga gcatgcaggg ttttcctcca
     2521 aatttgggtt ctgcgttcag tacacctcag tcaccagcaa aagcatttcc accactttca
     2581 accccaaatc aaacaacggc attcagtggt attgggggac tttcatcaca gcttccagta
     2641 ggtggtcttg gcacaggaag cctgactggc ataggaactg gggcccttgg acttcctgca
     2701 gtgaacagtg atccttttgt acagaggaaa ctgggcacct ctggactcaa ccagcctaca
     2761 ttccagcaga gtaagatgaa accttccgac ttgtctcagg tgtggccaga ggcaaatcag
     2821 cactttagta aagaaataga tgacgaagca aacagctatt tccagcgaat atataatcac
     2881 cccccacatc caaccatgtc tgttgatgag gtactagaaa tgctacagag atttaaagac
     2941 tctacaataa aaagggagcg agaagtattt aactgtatgc taaggaactt atttgaagaa
     3001 taccggtttt ttccccagta ccctgataaa gaattacata taacagcctg cttgtttggt
     3061 ggcataattg aaaaaggact ggtcacttac atggcattgg gtctggccct gcgatatgtt
     3121 cttgaagcct tacggaagcc ttttgggtcc aaaatgtatt attttggtat tgctgcacta
     3181 gatagattta aaaatagatt gaaggactat cctcagtatt gtcaacacct ggcttctatc
     3241 agtcacttta tgcagttccc acaccatttg caggagtaca tcgaatatgg acaacagtct
     3301 cgagatcctc ctgtgaaaat gcagggctct atcactaccc ctggaagtat tgcactggct
     3361 caggcccagg cccaggccca ggttccagca aaagcccctc ttgcgggtca ggttaacaca
     3421 atggtgacca cctcaacaac caccactgtt gctaaaacgg ttacagtcac caagccaaca
     3481 ggagtcagct ttaagaaaga tgtgccacct tccataaaca caacgaatat cgatacactg
     3541 cttgtggcca cagatcaaac tgagaggatt gtggagcccc cagagaatat tcaagagaaa
     3601 attgctttta ttttcaacaa tctctcacag tcaaatatga cacaaaaggt tgaagagctt
     3661 aaagaaactg tgaaggaaga atttatgcct tgggtttccc agtatctagt tatgaaaaga
     3721 gtcagtattg agccaaactt tcatagcttg tattcaaact ttcttgatac attgaagaat
     3781 cctgaattta acaagatggt tctgaatgaa acctacagaa acattaaagt gctgctgact
     3841 tctgataaag ctgcggccaa tttctcagat cgttctttgc tgaagaactt gggacattgg
     3901 ttaggaatga tcacattagc taaaaataaa cccatcttac acacggactt ggatgtgaaa
     3961 tcccttctgt tagaggctta cgttaaagga caacaggagc tgctttatgt agtgcccttt
     4021 gttgccaaag ttctagagtc cagcattcgt agtctggttt ttagaccacc caatccctgg
     4081 acgatggcca ttatgaatgt cttggcagag ctgcaccagg agcatgacct gaagttaaac
     4141 ttgaagtttg agattgaggt gctctgtaag aacctcgcat tagacatcaa cgagctcaaa
     4201 cctggaaacc tgctgaaaga caaagatcgc ctgaagaatt tagatgaaca gctctctgct
     4261 ccaaagaaag atgtcaaaca gccagaagag cttcctgcca tcacaacaac aacgacttct
     4321 acaacaccag ctaccagcac tacgtgcaca gccaccgttc cgccacagcc gcagtacagc
     4381 taccatgaca ttaatgtcta ttctctagca ggcctggcac ctcacattac tctaaaccct
     4441 acaatccctt tatttcaggc tcatccacag ttgaagcagt gtgtgcgaca agcaattgaa
     4501 cgagctgtcc aggagctagt ccaccccgtg gtggatcggt ccattaagat tgctatgact
     4561 acatgtgaac agatagttag aaaggacttt gctctggatt ctgaagaatc tagaatgaga
     4621 atagcagctc atcacatgat gcggaacttg acagctggaa tggctatgat tacttgcagg
     4681 gaacctttac tgatgagcat atctaccaac ctcaaaaaca gcttcgcttc agctctccgt
     4741 actgcgtccc cacaacaaag ggagatgatg gaccaggccg ccgctcagtt agctcaggac
     4801 aattgtgaat tagcttgctg ctttattcag aaaactgcag tggagaaagc aggccctgag
     4861 atggacaaga gattggcaac tgaatttgag ctgaggaaac acgctcggca agaaggccgt
     4921 cggtactgtg atcctgttgt gcttacatac caagccgaac ggatgcccga gcagatcagg
     4981 ctgaaagttg gtggtgtgga cccaaagcag ctagccgtct atgaagagtt tgcgcgaaat
     5041 gtgcctggct tcttacctac aaatgactta agtcagccta cagggttttt agcacagccc
     5101 atgaagcaag cttgggcaac agatgacgtc gctcagattt atgataagtg tattacagaa
     5161 ctggagcagc acctgcatgc catcccacca actttggcca tgaatcccca agcccaggct
     5221 ctacgaagtc tcttagaggt tgtagtattg tctcggaatt ctcgggatgc tatagctgct
     5281 cttggattac tacagaaggc tgtggagggc ctattggatg ccacaagtgg tgctgacgct
     5341 gacctgctgc tgcgctacag ggagtgccac ctgctggtgc tgaaagggct gcaggacggc
     5401 agggcgtacg ggtctccatg gtgcaacaag cagatcacaa ggtgcctaat cgaatgccga
     5461 gatgaataca agtataatgt ggaggccgtg gagttgttaa tccgaaacca tctggtcaac
     5521 atgcagcagt atgaccttca tcttgctcag tcgatggaga atggcttaaa ctacatggcc
     5581 gtggcatttg ctatgcaact ggtaaaaatt ctgctggtgg acgaaaggag tgttgcccat
     5641 attactgagg cagatctgtt ccacaccatt gaaaccctca tgagaattaa tgctcattcc
     5701 agaggcaatg ctccagaagg attgccccag ctgatggaag tggtgagatc taactatgaa
     5761 gcaatgattg atcgtgctca tggaggccct aactttatga tgcattctgg gatctctcaa
     5821 gcctcagaat atgatgaccc tccaggcctg agggagaagg cagagtatct tctgagggaa
     5881 tgggtgaatc tgtaccattc agcagcagct ggccgtgaca gtaccaaagc attctctgcg
     5941 tttgttggac agatgcacca acaaggaata cttaaaactg atgacctcat aacaaggttt
     6001 tttcgacttt gcactgaaat gtgtgttgaa atcagttacc gtgctcaggc agagcagcag
     6061 cacaatcctg ctgccaaccc caccatgatc cgggccaagt gttaccacaa cctggatgcc
     6121 tttgtccgcc tcattgcact gttagtgaag cactctgggg aggccaccaa cactgtcaca
     6181 aagatcaacc tgcttaataa ggttctcggt atagtagtgg gagttctcct gcaggaccac
     6241 gatgtccggc agagcgagtt tcagcagctt ccctaccata ggattttcat catgctgctg
     6301 ctggagctca atgcacctga gcacgtgttg gagaccatca atttccagac ccttacagct
     6361 ttctgcaata cattccacat cttgaggcct accaaagctc ctggctttgt atatgcttgg
     6421 cttgaattga tctcgcatcg gatctttatt gcaagaatgc tggcacacac gccacagcag
     6481 aaggggtggc ctatgtatgc acagctgttg attgatttat tcaaatattt agcacctttc
     6541 cttagaaatg tggaactcac taaacctatg caaatcctct acaagggtac tctgagagtg
     6601 ctgctagttc ttttgcatga tttcccagag ttcctttgtg attaccatta tgggttctgt
     6661 gatgtgatcc ctcctaattg tatccagtta agaaatttga tcctgagtgc cttcccaaga
     6721 aatatgaggc tcccagaccc attcacgcct aatctgaagg tggacatgct gagcgaaatt
     6781 aacattgcac ctcggatcct caccaacttc actggagtga tgccacctca gttcaaaaaa
     6841 gatttggatt cttatcttaa aactcgatca ccggtcactt ttctgtctga tctgcgtagt
     6901 aacctacagg tatctaatga acctgggaat cgctacaacc tccagcttat caatgcattg
     6961 gtgctctatg tagggactca ggccatcgcg cacatccaca acaagggcag cacgccttca
     7021 atgagcacca tcacccactc agcacacatg gacatcttcc agaatctggc tgtggaccta
     7081 gataccgagg gccggtatct ctttttaaac gcaattgcaa accagctgcg gtacccaaac
     7141 agccacacgc actacttcag ctgcaccatg ctgtaccttt ttgccgaggc gaacactgag
     7201 gcaatccagg aacagatcac aagggttctc ttggaacggt tgattgtaaa taggccgcat
     7261 ccttggggtc ttctcatcac cttcattgag ctgattaaaa acccagcatt taagttctgg
     7321 aaccatgaat ttgtacactg tgccccagag atcgaaaagc tgttccagtc tgttgcgcag
     7381 tgctgcatgg gacagaagca ggctcagcaa gtgatggagg ggaccggtgc cagttagatg
     7441 aactgtgtat atcccttgca gaggcatcaa ccttggtccc actgaaccaa gttcataaac
     7501 tgaagaatcc tttcagctcc tcctgacttt cctagccctt tggttctcag gcgtctgccc
     7561 caacaactgc tggggttggt tctcctgtct atgtgggcaa gttccaaagt ttaaatgcat
     7621 tttttttttt gactcttggc caaaatttag aagatgctgt gaatatcatt ttgaacttgt
     7681 gtaaatatat gaaagagaaa acttttgtct ggaa
//
