LOCUS       NM_001271050            4599 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cyclin and CBS domain divalent metal cation
            transport mediator 4 (Cnnm4), mRNA.
ACCESSION   NM_001271050 XM_001056626 XM_343554
VERSION     NM_001271050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4599)
  AUTHORS   Yamazaki,D., Funato,Y., Miura,J., Sato,S., Toyosawa,S.,
            Furutani,K., Kurachi,Y., Omori,Y., Furukawa,T., Tsuda,T.,
            Kuwabata,S., Mizukami,S., Kikuchi,K. and Miki,H.
  TITLE     Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+
            transport across epithelia: a mouse model
  JOURNAL   PLoS Genet 9 (12), e1003983 (2013)
   PUBMED   24339795
REFERENCE   2  (bases 1 to 4599)
  AUTHORS   Guo,D., Ling,J., Wang,M.H., She,J.X., Gu,J. and Wang,C.Y.
  TITLE     Physical interaction and functional coupling between ACDP4 and the
            intracellular ion chaperone COX11, an implication of the role of
            ACDP4 in essential metal ion transport and homeostasis
  JOURNAL   Mol Pain 1, 15 (2005)
   PUBMED   15840172
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Aug 31, 2012 this sequence version replaced
            XM_001056626.3, XM_343554.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.25223.1,
                                           SRR26643288.37129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1396              JAXUCZ010000009.1  46207704-46209099
            1397-1540           JAXUCZ010000009.1  46235773-46235916
            1541-1675           JAXUCZ010000009.1  46236182-46236316
            1676-1845           JAXUCZ010000009.1  46237153-46237322
            1846-1942           JAXUCZ010000009.1  46237621-46237717
            1943-2121           JAXUCZ010000009.1  46243470-46243648
            2122-4599           JAXUCZ010000009.1  46244340-46246817
FEATURES             Location/Qualifiers
     source          1..4599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..4599
                     /gene="Cnnm4"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 4"
                     /db_xref="GeneID:363216"
                     /db_xref="RGD:1305571"
     CDS             1..2319
                     /gene="Cnnm4"
                     /note="metal transporter CNNM4; cyclin-M4; ancient
                     conserved domain-containing protein 4"
                     /codon_start=1
                     /product="metal transporter CNNM4 precursor"
                     /protein_id="NP_001257979.1"
                     /db_xref="GeneID:363216"
                     /db_xref="RGD:1305571"
                     /translation="MAPGGGGGRRDGWPARGRLLLAALLLLLWTRAASGQSSPQQSVI
                     LGMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHRLGEISSNLISFTEVDDAETVHN
                     STNCLELTKDLVVQRLVNVSRGNTSGMLVVITKFLRRSENMKLYALCTRTRADGPWLK
                     WTDKDSLLFMVEEHGRFLPLWLHILLVLVLLVLSGIFSGLNLGLMALDPMELRIVQNC
                     GTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIG
                     IVIFGEILPQALCSRHGLAVGANTIVLTKIFMLLTFPLSFPISKLLDFVLGQEIRTVY
                     NREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDF
                     NTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFV
                     FHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILD
                     ESDTYTDNRTRKRVSMKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVPQFSPS
                     LMSEKILLRLLKYPDVIQELRFDEHNKHCTRHYLYTRNKPADCFILILQGKVEVEAGK
                     ENMKFETGAFSYYGTMALSLAPPDRSPAHPTPLSRSASLSYPDRNTDMTPSSLAGSNQ
                     FGSCILGQYVSDFSVRALTDLQYIKVTRQQYQNGLLASRMDNSPQLTLDGCATCTENL
                     SERPELPVVDETTTLLNERNLLLHRASQEGTI"
     exon            1..1396
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1540
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1675
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1845
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1942
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2121
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..4599
                     /gene="Cnnm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgccgg ggggcggggg cgggcggcgg gacggctggc cggcccgagg gcgcctcctc
       61 ctggccgcgc tgctgctgct gctatggacg cgggcggcca gcggccagag cagcccccag
      121 cagagcgtga tcctaggcat gaggctggcg agctgcaaca agtcgtgcgg gatgaacccg
      181 gatggcatca tcttcgtgtc cgagggcagc acggtgaact tgaggctcta cggccacaga
      241 ctgggcgaga tctctagcaa cctgatctcc ttcaccgagg tggacgacgc cgagacggtc
      301 cacaactcca ccaactgcct ggagctcacc aaggacttag tggtccagcg gctggtcaac
      361 gtgagccgcg ggaacacgtc ggggatgcta gtggtgatta ccaagttcct gcggaggagt
      421 gagaacatga agctgtacgc gctgtgcacc cggacccggg ccgacgggcc ctggctcaaa
      481 tggacggaca aggactccct gctcttcatg gtggaggagc atgggaggtt tctgccgctc
      541 tggctgcaca tccttcttgt tttggtgctg ttggtgctgt cgggcatctt ttctggcctc
      601 aacttggggc ttatggccct ggacccgatg gagttgcgca tcgtgcagaa ctgtggaact
      661 gagaaggaga gaaggtacgc tcgcaagata gagcccatca ggcgcaaggg caactacctg
      721 ctctgctcgc tgctcctggg gaatgtgcta gtcaacacct ccctcaccat ccttctagac
      781 aacctcatcg gttctggcat catggcagtg gcctcctcca ccattggcat tgtcatcttt
      841 ggggagatct tacctcaagc cctgtgctcc aggcatgggc tggctgtggg tgccaacact
      901 attgttctca ccaaaatctt tatgttactc actttccccc tgagtttccc cattagcaaa
      961 ctcctggact tcgtcttggg tcaggagatt cgcactgttt acaatcggga gaaactgatg
     1021 gagatgttga aggtgacaga gccctataat gacctggtga aggaggagtt aaacatgatc
     1081 cagggtgctc tggaactaag gaccaaaact gtggaggata tcatgaccca gctacacgac
     1141 tgcttcatga tccgcagtga tgccattctg gacttcaaca ccatgtcgga gattatggag
     1201 agtggctata ctcgcattcc tgtgtttgaa gatgagcagt ccaatatcgt agatatcctt
     1261 tacgtcaaag acctggcttt tgttgaccca gatgactgca ccccgctcaa gacgatcact
     1321 cgcttctaca accacccggt ccattttgtt tttcatgaca ccaagctgga tgccatgctg
     1381 gaggaattca agaagggcaa gtcccacctg gccatcgtgc agaaggtgaa caatgagggc
     1441 gagggcgacc ccttctacga ggtgctgggc ctggtcaccc tggaggacgt catcgaggag
     1501 atcatcaagt ctgagatcct ggatgagtcg gacacgtaca ctgacaatcg aacccggaaa
     1561 cgggtgtcca tgaagaacaa gcgtgacttc tctgccttca aggatgctga caatgaactc
     1621 aaagtgaaaa tctcacctca gcttcttctg gccgctcacc gcttcctggc cacagaggtg
     1681 ccgcagttca gtccctccct gatgtcagag aagatcctgc tccggctgct caagtaccct
     1741 gacgtcattc aggagctcag gttcgacgag cacaacaagc actgcacccg ccactacctg
     1801 tacacccgga acaagccagc cgactgcttc attctcatcc tgcaggggaa ggtggaggtg
     1861 gaagcaggca aggagaacat gaagtttgag accggtgcct tctcgtacta tgggaccatg
     1921 gctctgtccc tggcgccccc agaccggtcc ccagcccacc caactccact cagccgttca
     1981 gcctccctca gttacccgga ccgcaacaca gacatgacac cctcctccct ggcaggcagc
     2041 aaccagtttg gcagctgcat tctgggccag tatgtctctg acttcagtgt gcgggcgctc
     2101 acagacctgc agtacattaa ggtcacaaga cagcagtacc agaacgggct gctggcctcc
     2161 cgcatggaca acagccccca gctcaccttg gatggctgtg ccacctgcac agagaactta
     2221 tccgagaggc ctgagctgcc cgtggtggac gagacgacga ctcttctcaa tgaacgcaac
     2281 ttgttgctgc acagagcctc ccaagagggc accatctgac aggagggccc ggggactccc
     2341 gcccaccctg cggggtctcc ccagtgggcc cacatgaagt cagggagcct attaggctag
     2401 aaggggtgca ggtagatatc ctgcatgact gagcaaccag acgtccctgc ccaggggctc
     2461 tggctgcaga tggggacctc tgaacagctc tgacgtgaaa cctacccagt ccagctagtg
     2521 agcaaaggct gtggggtttt gttttttaaa acactgagag aagttttaag ctaggcgcat
     2581 tgctcctctt tttaaatatc attttgggaa gggaagacag ggttaaggaa ctttatgtaa
     2641 aaaaacaaaa ttttttttca agaagcccca caaactgtaa aaggggagga gggctcctca
     2701 ctccaggaag caatagccat aacctgtttc cagcagagac cttgcagcct gtgcctgttg
     2761 ctccaggagg cgctcttctg cagcagtggg ggcctggagc ccactggagg ggattcctgg
     2821 gaggaagcag ggatccaggt cataacatcg actgccggga cacacgagca gaagtcatag
     2881 agaagtgctg ggcaacggat cagggacacg gtgaccccag catcagagag ggatacatct
     2941 gctcttatca actgccggat ccagtgatct cctagaaccc tgcccagggc ctctcttggt
     3001 gaggcgggac tcggccgaga accagacctg gctctcatct acctaccact ttggacagtt
     3061 ctcccctgga agggtctggc cccaagagtt aggcgtggtc tttggctctg cagttgctta
     3121 tctgcttcct ggctctggtt tcactcttac caaaggtttc ctctcagagg ggagagcatc
     3181 aacattagag gtgacttatt gggcactcct ggtagtctca ggctatctga taataggtag
     3241 atctgtgtca gcagtcattc ctacccaacc acctgctgga agagtcaggg ctcagtagtc
     3301 cgcccaggaa ggtctctttc ctgactcccc attcttatct atcctggtcc ttctggggac
     3361 tggaagcccc ccaagctcag tcattgtgtc cttgcctgtg tagtgggcag aggaccacct
     3421 gagctctgag ctcttttcca cttaaggacc ccaagaaagg agggttccct aaggacaagc
     3481 agcagatggc ctggttctct ctgcctgagg cctgtgctgg tgagaggtat ttgatgagca
     3541 taggctgaag ctcttggtac tgcagggcaa tccacaccat gtgaaatcct accccagttc
     3601 cacctgggaa acctgagtgc aatcagtcca tgggactgag ctgcacactt ctattgtagg
     3661 gagactgtat gaccaagggc cacatctacc ttttgttggg acaaatggag ctgcagtata
     3721 agagccaggc cagcgggagc acgggcgagt gggagcacag gccatctgtg tttgttcact
     3781 tcattcctca gccagcggag tcctgtcaca ccaggtactc tgctgtctgt gtacccagag
     3841 aatcctaact cctaggatga tgcaccaagg tgtcctgtac ccctggccaa tctgaagtct
     3901 cctccactca caaaatttac tctgagaagc ctggagatgg cggctttcaa cgataaggga
     3961 aaaagacatc agacctctcg ttccttaaga aactcttagt tctctgtagg tgcggcatgc
     4021 tcctgagtct gtagatgagg tgcctagctg tgttactgtg agacctaagt gccaggtaga
     4081 gcaaaaccct gtggtgggtg tgaggcaaac gtagcaggtg cacacacttc cacagctacc
     4141 tctctgcata cacagtcacc gacagccggg ccccgcccct cccctcctca cttagaatca
     4201 cttcttgcag agggtcataa ttatttccaa atattactgt tctgatgact tcctcctcct
     4261 agtgcaattt ttcacttctt ccaacctctg gttcctgggc agagccatac cctggaactg
     4321 gcctggtctg cgtgtcttcc cagcagggga ggactccaca gacggcgtcc aagtgggtag
     4381 gcaagtcaca gccgccatag cagatgactc ctatttattt tgcattaaga ttttaatttg
     4441 tatatttttg tgatttattt tggcattgtt atgagtttga ctctcgggga gttttgttgt
     4501 tatgactctt gtgtcttttg tcacaaaaca atgataatat ttgctaaaca atatatggaa
     4561 tttatttttg attggtaata aaaaatgaaa tgcacatac
//
