LOCUS       NM_001011942            3300 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus cyclin and CBS domain divalent metal cation
            transport mediator 2 (Cnnm2), mRNA.
ACCESSION   NM_001011942 XM_219962
VERSION     NM_001011942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Hirata,Y., Funato,Y., Takano,Y. and Miki,H.
  TITLE     Mg2+-dependent interactions of ATP with the
            cystathionine-beta-synthase (CBS) domains of a magnesium
            transporter
  JOURNAL   J Biol Chem 289 (21), 14731-14739 (2014)
   PUBMED   24706765
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Stuiver,M., Lainez,S., Will,C., Terryn,S., Gunzel,D., Debaix,H.,
            Sommer,K., Kopplin,K., Thumfart,J., Kampik,N.B., Querfeld,U.,
            Willnow,T.E., Nemec,V., Wagner,C.A., Hoenderop,J.G., Devuyst,O.,
            Knoers,N.V., Bindels,R.J., Meij,I.C. and Muller,D.
  TITLE     CNNM2, encoding a basolateral protein required for renal Mg2+
            handling, is mutated in dominant hypomagnesemia
  JOURNAL   Am J Hum Genet 88 (3), 333-343 (2011)
   PUBMED   21397062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085930.1.
            
            On Feb 11, 2005 this sequence version replaced XM_219962.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3300
                     /gene="Cnnm2"
                     /note="cyclin and CBS domain divalent metal cation
                     transport mediator 2"
                     /db_xref="GeneID:294014"
                     /db_xref="RGD:1308162"
     exon            1..1730
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2737
                     /gene="Cnnm2"
                     /note="cyclin-M2; ancient conserved domain-containing
                     protein 2"
                     /codon_start=1
                     /product="metal transporter CNNM2"
                     /protein_id="NP_001011942.1"
                     /db_xref="GeneID:294014"
                     /db_xref="RGD:1308162"
                     /translation="MIGCGACEPEVKMAGGQAAAALPTWKMAARRSLSARGRGVLQAA
                     AGRLLPLLLLSCCCSAGGCTAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVK
                     LRVYGQNINNETWSRIAFTEHERRRHTPGERGLGGPAPPEPDSGPQRCGIRTSDIIIL
                     PHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSASGTVGGKGGA
                     GVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLN
                     LGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILL
                     DDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYP
                     VSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVM
                     TPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDC
                     TPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGI
                     VTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSETKVKISPQL
                     LLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPECYLYQRNKP
                     VDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTEVLA
                     AGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSSFLQVYIPDYSVRA
                     LSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTEMHDGLPDETANLLNE
                     QNCVSHNKANHSLHSEGAI"
     exon            1731..1874
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2012
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2182
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2276
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2342
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2527
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..3277
                     /gene="Cnnm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgaggg ctgggcgcga acgcgcggtt gcagtcccgc tcgggcgccg gtgcctgcgc
       61 tcgcgccgcc gggtgggaag gatgaagcct cagctggagc agccacccta tgattggctg
      121 tggagcttgt gaacccgaag taaagatggc gggcgggcag gcagccgccg cactgcccac
      181 ttggaagatg gcggcgcgcc gcagcctcag tgcccgcggc cggggggtcc tgcaggcagc
      241 tgcgggccgg ctgctgccgc tgctactgct gagctgctgc tgcagcgcgg gcggctgcac
      301 agcggccggc gagaacgagg agactgtgat catcggactg cggctggagg atacgaacga
      361 cgtgtcgttc atggaagggg gtgctctgcg ggtgagcgag cggacccggg tcaagctgcg
      421 ggtgtacggg cagaacatca acaacgagac atggtcccgc atcgccttca ctgagcacga
      481 gcggcgccgg cacacacccg gcgagcgtgg gctggggggc cccgcgcctc cggagccgga
      541 cagtggcccc cagcgctgcg gcatccgcac ctcagacatc atcatcttgc cccacatcat
      601 tctcaatcgc cgcacatcgg gcatcattga gatcgagatc aaaccgctgc gcaagatgga
      661 gaagagcaag tcttattacc tgtgcacgtc tctctccacg cccgcattgg gcgccggcgg
      721 ctccgggtct gcgagtggca ccgtcggggg caagggtggc gcgggggtgg ctggactccc
      781 gcctcctccc tgggccgaga ccacctggat ttaccacgac ggtgaggaca ccaagatgat
      841 agtgggcgag gagaagaagt tcttgctgcc cttctggctg caagtgatct tcatctcgct
      901 gctgctgtgc ctgtccggca tgttcagcgg cctcaacctg gggctcatgg ctctggaccc
      961 gatggagctg cgcatcgtgc aaaactgcgg cacggagaaa gagaagaatt atgccaagcg
     1021 catcgagccg gtgcgcaggc agggcaacta cctgctgtgc tcgctgctgc tgggaaacgt
     1081 actagtcaac accacgctca ccatcctgct cgacgacatt gcgggctcag gccttgtggc
     1141 ggtggtggtc tccaccattg gcatcgtcat cttcggagaa atcgtgcccc aagccatttg
     1201 ctcccgacac ggcctggcgg taggggccaa taccatcttc ctcaccaagt ttttcatgat
     1261 gatgaccttc cccgcttctt acccggttag caaactgctg gactgcgtcc tgggccagga
     1321 gataggcact gtctataacc gggaaaaact gctagagatg ctccgggtta ctgaccccta
     1381 caacgacctc gttaaggagg agctgaacat catccaaggg gcgctggagc tccgcaccaa
     1441 gacggtggag gacgtgatga ctcccctcag ggactgcttc atgatcaccg gcgaggctat
     1501 cctggacttc aacaccatgt ctgagatcat ggagagtggc tacactcgaa tcccagtgtt
     1561 cgagggagaa cggtccaaca tcgtggatct gctctttgtc aaagacttgg ccttcgtgga
     1621 tccagatgac tgtactccct tgaaaaccat caccaaattt tacaaccacc ctttgcactt
     1681 tgttttcaat gacaccaagt tggacgctat gctggaagaa tttaagaaag gtaaatccca
     1741 cctggccatt gtgcagcgag tgaacaatga gggcgaaggg gacccgtttt atgaagttct
     1801 gggaattgtc accttggaag atgtgattga agaaatcatc aaatctgaaa tcttggatga
     1861 gacagacttg tacaccgaca acagaacaaa gaagaaagtg gcccaccgtg aaagaaagca
     1921 agatttctct gcctttaagc agacggacag cgagacgaag gttaaaatat caccgcagct
     1981 tctcctggcc atgcaccgtt tcctagcaac agaagtagaa gcatttagcc catcccagat
     2041 gtcagagaag atcctcctaa ggctgctaaa gcaccccaat gtcatccagg aactgaagta
     2101 cgacgagaag aacaagaaag cccccgaatg ctacctctac cagcggaaca agcccgtaga
     2161 ctacttcgtc ctcattctgc agggaaaggt ggaggtagaa gctgggaaag aaggcatgaa
     2221 gtttgaagcc agtgcgtttt catactacgg tgtgatggcc ctcacagcct ctccagttcc
     2281 tttgtccctg tctcgcacct ttgttgtcag caggacagag gtgttagctg cgggctctcc
     2341 aggtgaaaat aagtcacctc ctcgcccctg cggcctgaat cactcggact ctctcagtcg
     2401 gagcgaccgg attgatgcca tgacacccac cttggggagc agcaacaacc agctcagctc
     2461 ttcattccta caagtctaca tccccgatta ctcagtgcga gccctctccg acctacagtt
     2521 cgtcaagatc tccagacagc aataccaaaa tgccttgatg gcgtcccgga tggacaaaac
     2581 gcctcagtct tcagacagtg aaaacactaa aattgaattg actcttacgg agatgcatga
     2641 cggcttgcca gacgagacgg ccaacttgct caatgaacag aactgtgtgt cacacaataa
     2701 ggccaaccac agcctgcaca gtgaaggcgc catctagggc ccctcgggcc cccttgtcct
     2761 gccctcctgg acttggtctg accgtgactt ccactagtgt gagcttgtct gccatgctgc
     2821 gtcctacagc attgagacca aagactttgc ccccttccct ggaagctgcg gaggacggct
     2881 tggggaggga tggaaaccgg acacgtgaca tccacagctg gggcatggct ttcaagaatt
     2941 cagagacaaa cttcttccgc ccaaatagaa tcatgtttat tttttcagaa ccttttatcg
     3001 tttctttcat ccctcaattt gcatgaattt aaaaatcgtt gcatttattt tttttccaag
     3061 agatcatgtt tttgttttta agtgtctttt gcagagtttg aagttggtct ttctgagcta
     3121 actctgctgt agccccacca tgtgaccctg acaggatgga cttgtccctt tagtggcctt
     3181 ccttggccat ccctaggagg aatacctttc ctccgtgccc ggtgggtgtc gctgtcgaac
     3241 ttgaaggatg aatgaagaaa atcctgtcac tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
