LOCUS       NM_019359               1931 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus calponin 3 (Cnn3), mRNA.
ACCESSION   NM_019359 XM_346635
VERSION     NM_019359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Appel,S., Allen,P.G., Vetterkind,S., Jin,J.P. and Morgan,K.G.
  TITLE     h3/Acidic calponin: an actin-binding protein that controls
            extracellular signal-regulated kinase 1/2 activity in nonmuscle
            cells
  JOURNAL   Mol Biol Cell 21 (8), 1409-1422 (2010)
   PUBMED   20181831
  REMARK    GeneRIF: h3/acidic calponin controls fibroblast migration by
            regulation of ERK1/2-mediated l-caldesmon phosphorylation.
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Agassandian,K. and Cassell,M.D.
  TITLE     Co-localization of caldesmon and calponin with cortical afferents,
            metabotropic glutamate and neurotrophic receptors in the lateral
            and central nuclei of the amygdala
  JOURNAL   Brain Res 1226, 39-55 (2008)
   PUBMED   18582438
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Rami,G., Caillard,O., Medina,I., Pellegrino,C., Fattoum,A.,
            Ben-Ari,Y. and Ferhat,L.
  TITLE     Change in the shape and density of dendritic spines caused by
            overexpression of acidic calponin in cultured hippocampal neurons
  JOURNAL   Hippocampus 16 (2), 183-197 (2006)
   PUBMED   16358313
  REMARK    GeneRIF: acidic calponin is a key factor in the regulation of spine
            plasticity and synaptic activity
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Fattoum,A., Roustan,C., Smyczynski,C., Der Terrossian,E. and
            Kassab,R.
  TITLE     Mapping the microtubule binding regions of calponin
  JOURNAL   Biochemistry 42 (5), 1274-1282 (2003)
   PUBMED   12564930
  REMARK    GeneRIF: calponin undergoes a concomitant binding to both F-actin
            and microtubules by interaction at the former site with actin and
            at the second site with microtubules
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Agassandian,C., Plantier,M., Fattoum,A., Represa,A. and der
            Terrossian,E.
  TITLE     Subcellular distribution of calponin and caldesmon in rat
            hippocampus
  JOURNAL   Brain Res 887 (2), 444-449 (2000)
   PUBMED   11134639
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Represa,A., Trabelsi-Terzidis,H., Plantier,M., Fattoum,A.,
            Jorquera,I., Agassandian,C., Ben-Ari,Y. and der Terrossian,E.
  TITLE     Distribution of caldesmon and of the acidic isoform of calponin in
            cultured cerebellar neurons and in different regions of the rat
            brain: an immunofluorescence and confocal microscopy study
  JOURNAL   Exp Cell Res 221 (2), 333-343 (1995)
   PUBMED   7493632
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Applegate,D., Feng,W., Green,R.S. and Taubman,M.B.
  TITLE     Cloning and expression of a novel acidic calponin isoform from rat
            aortic vascular smooth muscle
  JOURNAL   J Biol Chem 269 (14), 10683-10690 (1994)
   PUBMED   8144658
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019359.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U06755.1, BC062020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               JAXUCZ010000002.1  212203661-212203948
            289-410             JAXUCZ010000002.1  212226755-212226876
            411-477             JAXUCZ010000002.1  212227055-212227121
            478-615             JAXUCZ010000002.1  212228767-212228904
            616-732             JAXUCZ010000002.1  212229255-212229371
            733-879             JAXUCZ010000002.1  212231620-212231766
            880-1931            JAXUCZ010000002.1  212233721-212234772
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1931
                     /gene="Cnn3"
                     /note="calponin 3"
                     /db_xref="GeneID:54321"
                     /db_xref="RGD:71044"
     exon            1..288
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1224
                     /gene="Cnn3"
                     /note="acidic calponin h3; calponin 3, acidic"
                     /codon_start=1
                     /product="calponin-3"
                     /protein_id="NP_062232.1"
                     /db_xref="GeneID:54321"
                     /db_xref="RGD:71044"
                     /translation="MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGMGI
                     GTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHD
                     IFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAG
                     QSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAG
                     MSAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAP
                     TEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDEYPREYQYGDDQGIDY"
     exon            289..410
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..477
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..615
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..732
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     exon            733..879
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1931
                     /gene="Cnn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagggcag ccggtcccac tccagtgcga cccggagcct ccgcgggact cgagtccgag
       61 cgaacctcga agcatcatcc gcgtccgtct gccgcgttcc ggcttctgcg ccgcgcagag
      121 tagcgagctt gtgcatcacc cgcgcggcca cagctggggg ctaagagcag ggacaccgag
      181 ggtgactgac cccgactccg agcgcagccc cttcctgtgg tccgaacagc catgacccac
      241 ttcaacaagg gcccttccta cgggctctcc gccgaggtca agaacaagat cgcatccaag
      301 tatgaccagc aggccgagga ggatctgcgc aactggatag aagaggtgac aggcatgggc
      361 attgggacca acttccagct gggcctgaag gacggcatca tcctctgcga actcataaac
      421 aagctacagc caggctctgt gaagaaagtc aacgagtcct cactaaactg gccgcagttg
      481 gagaacatcg gcaactttat taaagccatc caggcttacg gtatgaagcc ccatgacata
      541 tttgaggcaa acgacctttt tgagaatggc aacatgaccc aggttcagac tacgctggtg
      601 gctctagcag gtctggcgaa aacaaaagga ttccatacaa ccattgacat cggcgttaag
      661 tacgcagaaa aacagacacg acgcttcgat gaaggcaagc taaaggctgg ccaaagtgta
      721 atcggtttac agatggggac caacaaatgt gccagccagg cgggtatgac agcctatggg
      781 actcggaggc atctttatga tcccaaaatg cagactgaca aaccctttga ccagaccacc
      841 atcagcctgc agatgggcac caacaaagga gccagccagg ctggcatgtc ggcaccgggt
      901 accagaagag acatctatga ccagaagcta acattacagc cggtggacaa ctcgaccatt
      961 tctctacaga tgggcaccaa caaagttgct tcccagaaag gaatgagcgt gtatgggctt
     1021 gggcggcaag tgtatgaccc caagtactgt gccgcaccca cagaacctgt cattcacaac
     1081 ggaagccagg gcacgggaac aaatgggtca gaaatcagtg atagcgatta ccaggcagaa
     1141 taccccgatg agtatcatgg cgagtaccca gatgagtacc ctcgagagta ccagtatggt
     1201 gacgaccagg gcatcgatta ctagagtcac acacaggagt gcagtattta gtccattgtt
     1261 tatccagtga gacccaagct agccttgagt aattcttatc tcgtcttcct aaacactatt
     1321 acgcttactg tacctttaaa gaatgcctta cgtacattcc tttctccctt tcctgcctcc
     1381 tccctaaatt gccttctagt gctgtagcga gggaagccta cagcctaacc agtaactcgc
     1441 gttggaagaa gtgagaagga acgctgtgcg agggcagcca gctctttcgt tgaagatcta
     1501 tgcatttttt tacacttaca cgtaaactgg tattttcaaa caataggaaa ctattttttt
     1561 cttttttaca gtttattatg tatctggctt gtacacggaa gactaagaag ttgatttgct
     1621 aagtgtggtc tttgccaagt aatctaacat gcagctttag aacctgacac gtggatgctt
     1681 ctgcacagtg ttgtctgcta agttttaaat aaagtcgtga tcagtgtgat tcgtgattac
     1741 atgtgtactc attctttccc gaagctgaca aggtctctcc cgagtggcgc tctaaaggcg
     1801 cgtctacaga aatggccgca gacatgtagg tgtgggtggc gtgcctgcag acttcatttg
     1861 tgccaatgta ttactgtaga gtcgctgttc ccttcaactg tatttattgc tgcatttctc
     1921 agcataaact t
//
