LOCUS       NM_001399010            1876 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus calponin 2 (Cnn2), mRNA.
ACCESSION   NM_001399010 XM_006241038
VERSION     NM_001399010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Huang,Q.Q., Hossain,M.M., Wu,K., Parai,K., Pope,R.M. and Jin,J.P.
  TITLE     Role of H2-calponin in regulating macrophage motility and
            phagocytosis
  JOURNAL   J Biol Chem 283 (38), 25887-25899 (2008)
   PUBMED   18617524
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Hossain,M.M., Crish,J.F., Eckert,R.L., Lin,J.J. and Jin,J.P.
  TITLE     h2-Calponin is regulated by mechanical tension and modifies the
            function of actin cytoskeleton
  JOURNAL   J Biol Chem 280 (51), 42442-42453 (2005)
   PUBMED   16236705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 29, 2021 this sequence version replaced XM_006241038.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2767883.1,
                                           SRR26643292.28508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000007.1  10370187-10370312   c
            127-248             JAXUCZ010000007.1  10367089-10367210   c
            249-315             JAXUCZ010000007.1  10366163-10366229   c
            316-453             JAXUCZ010000007.1  10365927-10366064   c
            454-570             JAXUCZ010000007.1  10365303-10365419   c
            571-717             JAXUCZ010000007.1  10365059-10365205   c
            718-1876            JAXUCZ010000007.1  10363141-10364299   c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1876
                     /gene="Cnn2"
                     /note="calponin 2"
                     /db_xref="GeneID:690976"
                     /db_xref="RGD:1589807"
     exon            1..126
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..984
                     /gene="Cnn2"
                     /codon_start=1
                     /product="calponin-2"
                     /protein_id="NP_001385939.1"
                     /db_xref="GeneID:690976"
                     /db_xref="RGD:1589807"
                     /translation="MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRSWIEGLTGL
                     SIGPDFQKGLKDGVILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNP
                     VDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMK
                     AGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCASQ
                     VGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQ
                     GSAVDGAPTGGDGQGEAPEYLSYCQEEASY"
     exon            127..248
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..315
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..453
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..570
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..717
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1876
                     /gene="Cnn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcagcc ggtccctctg ccggtccctc tggtctgcct gtcccgcgcc agggtcccgc
       61 gccatgagct ccacgcagtt caacaagggt ccgtcctacg ggctctcggc cgaggtcaag
      121 aaccggctcc tgtctaaata tgacccccag aaggaagctg agctccggag ctggatagaa
      181 ggactcacgg gcctctccat tggccctgac ttccagaagg gtctgaaaga tggggttatc
      241 ctatgcacac tcatgaacaa gttgcagccg ggctccgtcc ccaaaatcaa ccgctctatg
      301 cagaactggc accagctaga aaacctctcc aacttcatca aagccatggt cagctatggc
      361 atgaaccccg tggacctgtt tgaagccaac gacctgtttg agagtgggaa tatgacacag
      421 gtgcaggtgt ctctgcttgc gttggcggga aaggccaaga ccaaggggct acagagtggt
      481 gtggacatcg gggtcaaata ttcagagaaa caggagcgaa actttgacga tgccaccatg
      541 aaggccggcc agtgcgtcat cgggctgcag atgggcacca acaaatgtgc cagccagtcc
      601 ggcatgacag cctatggtac caggagacat ctctacgacc ccaagaacca catcctgccc
      661 cccatggacc actgcaccat cagcctccag atgggcacca ataagtgtgc cagccaggtg
      721 ggcatgacag caccagggac ccggaggcac atctatgaca ccaagctggg caccgacaag
      781 tgcgacaact cctccatgtc cctgcagatg ggctacacac agggcgccaa ccagagcggc
      841 caggtcttcg gactggggcg gcagatatat gaccccaagt attgcccaca gggctctgca
      901 gttgacgggg ctcctaccgg gggtgatggc caaggcgagg cccctgaata cctgtcctac
      961 tgccaggagg aagccagcta ctgagcaccc aggggtgcca gctccccgcc ttgcatcagc
     1021 agccctgtgt gggtttgggg gttttcattg tgttgttttg tgttttgaaa ctggtcatct
     1081 ctttgtagct atctctggcc tggaactcat gcaatccttc tgcctcagct tcctgaggac
     1141 tggggtgaca gctccctcct cacccaccat gcctcgcttc cttcccagga ctgacccacc
     1201 aggcagggaa catgggtttc cttggtggga tagcgaggca gtgcatttcc tagtgggagg
     1261 ggcggtggga ggtgccggcc caaagagctt tcggtttttt cctctctttt acatggtttt
     1321 tgtggtttgt gaaccaagga aattacaggc agtttctttt ttttttcttt tttttttttt
     1381 tttctttttc ggagctgggg actgaaccca gggccttgca cttgctaggc aagtgctcta
     1441 ccactgagct aaatccccaa cccctacagg cagtttcaat gaaagaagag aaggaatttt
     1501 gtgctttgtt tgctcccaaa ggtatcgggt tcaccaggct ttaatatact gcgggcattc
     1561 cgagggatta aatttgcttt cccaacaccc tcagacttca ccctcctgtg cccagtgggg
     1621 aaactgaggc aaaccccagt acctgcagcc agccctccct cgtccctctg gtctatgaag
     1681 gtctcagttt tccctgcatc cctgagcaag cccaattagc tgtgctaggt ccctgggtct
     1741 ctgaaaatgc cccacgtgac catgtgaccc acaggggccc ctgcgctgcc agataatgtg
     1801 aaattccctg tgtggaccaa aaaaataaat aaataaataa ataaataaaa taaaaataaa
     1861 acctcctttt ctaaga
//
