LOCUS       NM_031747               1452 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus calponin 1 (Cnn1), mRNA.
ACCESSION   NM_031747
VERSION     NM_031747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Blascke de Mello,M.M., Parente,J.M., Schulz,R. and Castro,M.M.
  TITLE     Matrix metalloproteinase (MMP)-2 activation by oxidative stress
            decreases aortic calponin-1 levels during hypertrophic remodeling
            in early hypertension
  JOURNAL   Vascul Pharmacol 116, 36-44 (2019)
   PUBMED   30339939
  REMARK    GeneRIF: Oxidative stress may contribute to the increase in aortic
            MMP-2 activity, possibly by S-glutathiolation, and this may result
            in calponin-1 loss and maladaptive vascular remodeling in early
            hypertension.
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Parente,J.M., Pereira,C.A., Oliveira-Paula,G.H., Tanus-Santos,J.E.,
            Tostes,R.C. and Castro,M.M.
  TITLE     Matrix Metalloproteinase-2 Activity is Associated with Divergent
            Regulation of Calponin-1 in Conductance and Resistance Arteries in
            Hypertension-induced Early Vascular Dysfunction and Remodelling
  JOURNAL   Basic Clin Pharmacol Toxicol 121 (4), 246-256 (2017)
   PUBMED   28374979
  REMARK    GeneRIF: MMP-2 activity is increased in both conductance and
            resistance arteries in hypertension and contributes to early
            vascular dysfunction and remodelling. These maladaptive effects
            were related to the divergent regulation of calponin-1, which is
            decreased in aortas while is increased in resistance arteries.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Xu,H., Wu,F., Zhang,H., Yang,C., Li,K., Wang,H., Yang,H., Liu,Y.,
            Ding,B., Tan,Y., Yuan,M., Li,Y. and Dai,Z.
  TITLE     Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in
            preosteoblast under simulated microgravity
  JOURNAL   Biochimie 138, 184-193 (2017)
   PUBMED   28457943
  REMARK    GeneRIF: Actin cytoskeleton depolymerization inhibites BMP2
            signaling via blocking of Smad by dephosphorylated CNN1 in
            osteoblast cells under simulated microgravity.
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Belo,V.A., Parente,J.M., Tanus-Santos,J.E. and Castro,M.M.
  TITLE     Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and
            contributes to arterial remodeling in early hypertension
  JOURNAL   Biochem Pharmacol 118, 50-58 (2016)
   PUBMED   27531060
  REMARK    GeneRIF: Data suggest that proteolysis of calponin-1 by Mmp2
            (matrix metallopeptidase 2) contributes to the down-regulation of
            calponin-1 in cytoplasm of endothelium and smooth muscle of
            aorta/arteries in early (1-week) hypertension; however, at 2-weeks,
            calponin-1 is up-regulated.
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Zeng,L., Li,Y., Yang,J., Wang,G., Margariti,A., Xiao,Q.,
            Zampetaki,A., Yin,X., Mayr,M., Mori,K., Wang,W., Hu,Y. and Xu,Q.
  TITLE     XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via
            Cross Talk With the PDGF Signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (10), 2134-2144 (2015)
   PUBMED   26315405
  REMARK    Erratum:[Arterioscler Thromb Vasc Biol. 2024 Oct;44(10):e263. doi:
            10.1161/ATV.0000000000000179.. PMID: 39321272]
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Kaneko,M., Takeoka,M., Oguchi,M., Koganehira,Y., Murata,H.,
            Ehara,T., Tozuka,M., Saida,T. and Taniguchi,S.
  TITLE     Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1
            cells in association with a decrease in angiogenesis
  JOURNAL   Jpn J Cancer Res 93 (8), 935-943 (2002)
   PUBMED   12716472
  REMARK    GeneRIF: CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by
            decreasing VEGF expression and angiogenesis in vivo and partially
            through reducing cellular proliferative potential and cell motility
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Burgstaller,G., Kranewitter,W.J. and Gimona,M.
  TITLE     The molecular basis for the autoregulation of calponin by
            isoform-specific C-terminal tail sequences
  JOURNAL   J Cell Sci 115 (Pt 10), 2021-2029 (2002)
   PUBMED   11973344
  REMARK    GeneRIF: The molecular basis for the autoregulation of calponin by
            isoform-specific C-terminal tail sequences
REFERENCE   8  (bases 1 to 1452)
  AUTHORS   Shah,N.M., Groves,A.K. and Anderson,D.J.
  TITLE     Alternative neural crest cell fates are instructively promoted by
            TGFbeta superfamily members
  JOURNAL   Cell 85 (3), 331-343 (1996)
   PUBMED   8616889
REFERENCE   9  (bases 1 to 1452)
  AUTHORS   Nishida,W., Kitami,Y. and Hiwada,K.
  TITLE     cDNA cloning and mRNA expression of calponin and SM22 in rat aorta
            smooth muscle cells
  JOURNAL   Gene 130 (2), 297-302 (1993)
   PUBMED   8359698
REFERENCE   10 (bases 1 to 1452)
  AUTHORS   Shanahan,C.M., Weissberg,P.L. and Metcalfe,J.C.
  TITLE     Isolation of gene markers of differentiated and proliferating
            vascular smooth muscle cells
  JOURNAL   Circ Res 73 (1), 193-204 (1993)
   PUBMED   8508530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14437.1, X71071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000008.1  28908437-28908559
            124-245             JAXUCZ010000008.1  28910343-28910464
            246-312             JAXUCZ010000008.1  28912176-28912242
            313-450             JAXUCZ010000008.1  28913410-28913547
            451-561             JAXUCZ010000008.1  28913848-28913958
            562-708             JAXUCZ010000008.1  28916123-28916269
            709-1452            JAXUCZ010000008.1  28916356-28917099
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1452
                     /gene="Cnn1"
                     /note="calponin 1"
                     /db_xref="GeneID:65204"
                     /db_xref="RGD:621883"
     exon            1..123
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..954
                     /gene="Cnn1"
                     /note="calponin 1, smooth muscle; basic calponin; calponin
                     H1, smooth muscle; calponin 1, basic, smooth muscle"
                     /codon_start=1
                     /product="calponin-1"
                     /protein_id="NP_113935.2"
                     /db_xref="GeneID:65204"
                     /db_xref="RGD:621883"
                     /translation="MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGR
                     RIGSNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKP
                     HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREG
                     RNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAG
                     MTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTP
                     EYPELDEPTHNHHPHNYYNSA"
     exon            124..245
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..312
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..450
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..561
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..708
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1452
                     /gene="Cnn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgttgaac ttgtctgggt catctcggca cccccgcttt gccagagccc cctggccagc
       61 atgtcttccg cacactttaa ccgaggtcct gcctacggcc tgtctgctga ggtaaagaac
      121 aagctggccc agaaatacga ccaccagcgt gagcaggagc tgagagagtg gatcgaaggg
      181 gtgacaggcc gccgcatcgg gagcaacttc atggatggcc tcaaggacgg gatcattctt
      241 tgcgaattta tcaacaagct ccagccggga tctgtgaaga aggtcaatga gtcaacccag
      301 aactggcacc agctggagaa cataggaaat ttcatcaaag ccattaccaa gtatggggtg
      361 aaaccccacg acatttttga ggccaatgac ctgtttgaaa acaccaatca tacacaagtt
      421 cagtctactc tcttggctct ggccagcatg gccaagacaa aaggaaacaa agtcaatgtg
      481 ggggtcaaat atgcagagaa acaagagcgg agatttgagc ctgagaagct gagagaaggc
      541 aggaacatca ttggcctaca gatgggcacc aataagtttg ccagtcagca gggcatgaca
      601 gcctatggta cccggcgtca cctctatgat cccaaactgg gtacagatca acccctggat
      661 caggcaacta tcagtctaca gatgggtacc aacaagggcg ccagccaggc tggcatgact
      721 gcaccgggca ccaagcggca gatctttgag ccaggtctgg gcatggaaca ctgtgacacg
      781 ctcaacgtca gcttgcagat gggcagcaac aagggggcct cacagagggg catgacggtg
      841 tatgggctgc cccgccaggt gtatgatccc aagtactgcc tgaccccgga atatccagag
      901 ctggacgagc ccacccacaa tcaccaccca cacaactact ataactctgc ctaggggccc
      961 ccaaggggct ggctgctgct cttggctgga cccagctggc ccagccaacc ccatctcctg
     1021 catggcgtcc tccagccccc tggcacctgc ctatagggtt acagtttggg gagatcaggc
     1081 cgaggggggc agtgggaaga agggggcccc ctcatccctg gagctttccc agggcccaac
     1141 atagaattgg gtgtccccaa caacacccaa aggaagcact gagtaaagcc atttcagctt
     1201 ccccctttat tccctcacaa gtaagtacct cccagaacca gaaacccttc aagcgaagcc
     1261 cccagaaccc aggcttggcc tgccccctgc ccccttcctg caatgggagc ggaatgcatg
     1321 cctggaaatg cagtggacac acacgcagtt tggttttgca gtgactggcg tttgtggatg
     1381 tgacagcagc gtttgtaact tgaacacttt ctttttctat ttcactggag cacaataaat
     1441 ggctgtgaca tc
//
