LOCUS       NM_030854               1421 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus chondromodulin (Cnmd), mRNA.
ACCESSION   NM_030854
VERSION     NM_030854.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Xing,S.C., Du,L.X., Zhou,W., Hu,Y.Q., Feng,Y., Liang,H.F., Sang,L.,
            Qi,M., Zhai,L.J. and Wang,Z.Q.
  TITLE     Proteomic analysis of chondromodulin-I-induced differentiation of
            mesenchymal stem cells into chondrocytes
  JOURNAL   J Proteomics 159, 1-18 (2017)
   PUBMED   28263889
  REMARK    GeneRIF: These results demonstrate novel information about the
            molecular mechanism by which ChM-I induce MSCs to differentiate
            into chondrocytes.
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Miura,S., Kondo,J., Takimoto,A., Sano-Takai,H., Guo,L.,
            Shukunami,C., Tanaka,H. and Hiraki,Y.
  TITLE     The N-terminal cleavage of chondromodulin-I in growth-plate
            cartilage at the hypertrophic and calcified zones during bone
            development
  JOURNAL   PLoS One 9 (4), e94239 (2014)
   PUBMED   24710035
  REMARK    GeneRIF: intact 20-25 kDa ChM-I is stored as a component of
            extracellular matrix in the avascular cartilage zones, but it is
            inactivated by a single N-terminal proteolytic cleavage in the
            hypertrophic zone of growth-plate cartilage
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Watahiki,J., Yamaguchi,T., Enomoto,A., Irie,T., Yoshie,K.,
            Tachikawa,T. and Maki,K.
  TITLE     Identification of differentially expressed genes in mandibular
            condylar and tibial growth cartilages using laser microdissection
            and fluorescent differential display: chondromodulin-I (ChM-1) and
            tenomodulin (TeM) are differentially expressed in mandibular
            condylar and other growth cartilages
  JOURNAL   Bone 42 (6), 1053-1060 (2008)
   PUBMED   18337200
  REMARK    GeneRIF: Data show that chondromodulin-I (ChM-1) and tenomodulin
            (TeM) are differentially expressed in mandibular condylar and other
            growth cartilages.
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Yoshioka,M., Yuasa,S., Matsumura,K., Kimura,K., Shiomi,T.,
            Kimura,N., Shukunami,C., Okada,Y., Mukai,M., Shin,H., Yozu,R.,
            Sata,M., Ogawa,S., Hiraki,Y. and Fukuda,K.
  TITLE     Chondromodulin-I maintains cardiac valvular function by preventing
            angiogenesis
  JOURNAL   Nat Med 12 (10), 1151-1159 (2006)
   PUBMED   16980969
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Amil,B., Fernandez-Fuente,M., Molinos,I., Rodriguez,J.,
            Carbajo-Perez,E., Garcia,E., Yamamoto,T. and Santos,F.
  TITLE     Chondromodulin-I expression in the growth plate of young uremic
            rats
  JOURNAL   Kidney Int 66 (1), 51-59 (2004)
   PUBMED   15200412
  REMARK    GeneRIF: In experimental uremia, expansion of growth cartilage does
            not result from increased or persistent expression of ChM-I or from
            reduced VEGF expression at the cartilage-metaphyseal bone
            interphase.
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Kitahara,H., Hayami,T., Tokunaga,K., Endo,N., Funaki,H.,
            Yoshida,Y., Yaoita,E. and Yamamoto,T.
  TITLE     Chondromodulin-I expression in rat articular cartilage
  JOURNAL   Arch Histol Cytol 66 (3), 221-228 (2003)
   PUBMED   14527163
  REMARK    GeneRIF: Chm-1 expression was studied in articular cartilage and
            compared with that in the growth plate.
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Oshima,Y., Shukunami,C., Honda,J., Nishida,K., Tashiro,F.,
            Miyazaki,J., Hiraki,Y. and Tano,Y.
  TITLE     Expression and localization of tenomodulin, a transmembrane type
            chondromodulin-I-related angiogenesis inhibitor, in mouse eyes
  JOURNAL   Invest Ophthalmol Vis Sci 44 (5), 1814-1823 (2003)
   PUBMED   12714610
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Funaki,H., Sawaguchi,S., Yaoeda,K., Koyama,Y., Yaoita,E.,
            Funaki,S., Shirakashi,M., Oshima,Y., Shukunami,C., Hiraki,Y.,
            Abe,H. and Yamamoto,T.
  TITLE     Expression and localization of angiogenic inhibitory factor,
            chondromodulin-I, in adult rat eye
  JOURNAL   Invest Ophthalmol Vis Sci 42 (6), 1193-1200 (2001)
   PUBMED   11328727
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF051425.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF051425.1, BC127493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKY"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q12"
     gene            1..1421
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /note="chondromodulin"
                     /db_xref="GeneID:81512"
                     /db_xref="RGD:620176"
     exon            1..198
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1131
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /note="chM-I; chondromodulin-I; chondromodulin-1;
                     leukocyte cell derived chemotaxin 1"
                     /codon_start=1
                     /product="leukocyte cell-derived chemotaxin 1"
                     /protein_id="NP_110481.1"
                     /db_xref="GeneID:81512"
                     /db_xref="RGD:620176"
                     /translation="MTENSDKVPITMVGPEDVEFCSPPAYATVTVKPSGSPTRLLKVG
                     AVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYTMSINGRLQDASMEIDAANNLETF
                     KMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVSTGTKQSISELEGKI
                     MPVKYEENSLIWVAVDQPVKDNSFLSSKILEFCGDLPIFWLKPMYPKEIPRERREVVR
                     SSAPSTTRRPHSEPRGNAGPGRLSNRTRPSVQDDEEPFNPDNPYHQQEGESMTFDPRL
                     DHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV
                     "
     exon            199..342
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..483
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..594
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..748
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..915
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1405
                     /gene="Cnmd"
                     /gene_synonym="Chm-1; Lect1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctactgctgc tgctgctact gctgccgctg tgtgcagggg gcattcactg tagggacaac
       61 gggacagttg ggacagttag gacagcaaga cgggaccttt gagtatcttt ttctccgtct
      121 tcagtcatga cagagaactc ggacaaagtt cctatcacca tggtaggacc tgaagacgtt
      181 gagttttgca gtcccccggc atatgccact gtgaccgtga agccctccgg gagccctaca
      241 cggctgctca aggtgggagc tgtggttctc atttctggcg cggtgctgct gctcttcggg
      301 gccattgggg ccttctactt ctggaaggga aatgacaatc acatttacaa cgtccattac
      361 accatgagta tcaatgggag actacaagac gcgtccatgg agatagatgc tgccaacaac
      421 ttggagacct ttaaaatggg aagcggagcg gaggaagcga ttgaagttaa tgatttccaa
      481 aatggcatca ctgggatccg ttttgctgga ggagagaagt gctacatcaa agcacaggtg
      541 aaggctcgca tccctgaggt cagcactggg accaagcaga gcatctctga actggaaggc
      601 aagatcatgc cagtcaaata tgaagagaat tctctgattt gggtggccgt ggaccagcct
      661 gtaaaggaca acagcttcct gagttctaaa atcctcgaat tctgtggcga cctgcctatt
      721 ttctggctta agcccatgta tccgaaagaa atcccaagag agagaagaga agtagtgaga
      781 agcagtgctc cctctaccac aaggagacca cacagcgaac ctcgaggcaa cgcaggccct
      841 ggaagactga gtaacagaac cagacccagc gttcaggatg acgaagaacc tttcaaccct
      901 gacaatcctt accaccagca ggaaggagag agcatgacct ttgaccctag actggatcac
      961 gaaggaatct gctgtataga gtgcagacgg agctacaccc actgccagaa gatctgcgaa
     1021 ccgctgggag gttactaccc gtggccttat aattaccaag ggtgtcgctc agcctgcaga
     1081 gtggtcatgc cgtgcagctg gtgggttgcc cgcatcttgg gcatggtgta aatccatttc
     1141 atctatcagc actgccaagc aagaattagc acgagagttg agaaccaaag aaccatgcca
     1201 agggaccgca aagtatttta tactcaacct gaataacgtt atcctaaacg ctgcagcaga
     1261 accttggttg tgcaccgctg tgtgcaaatg tactgaaagg gtagttttaa gtctacagtt
     1321 actatccctt tactatttgc tttaccaata aagtctactg caagtcttta aaagctactt
     1381 ttgaaataaa catgaagtta tttacaaaaa aaaaaaaaaa a
//
