LOCUS       NM_001012061            3350 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus Cnksr family member 3 (Cnksr3), mRNA.
ACCESSION   NM_001012061 XM_217819
VERSION     NM_001012061.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Soundararajan,R., Ziera,T., Koo,E., Ling,K., Wang,J., Borden,S.A.
            and Pearce,D.
  TITLE     Scaffold protein connector enhancer of kinase suppressor of Ras
            isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial
            sodium channel (ENaC)-regulatory complex
  JOURNAL   J Biol Chem 287 (39), 33014-33025 (2012)
   PUBMED   22851176
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Ziera,T., Irlbacher,H., Fromm,A., Latouche,C., Krug,S.M., Fromm,M.,
            Jaisser,F. and Borden,S.A.
  TITLE     Cnksr3 is a direct mineralocorticoid receptor target gene and plays
            a key role in the regulation of the epithelial sodium channel
  JOURNAL   FASEB J 23 (11), 3936-3946 (2009)
   PUBMED   19567370
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY328890.1.
            
            On Feb 11, 2005 this sequence version replaced XM_217819.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY328890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..3350
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /note="Cnksr family member 3"
                     /db_xref="GeneID:308113"
                     /db_xref="RGD:1307544"
     exon            1..571
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..2187
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /note="maguin-like protein; CNK3; CNK homolog protein 3;
                     connector enhancer of KSR 3; parturition-related protein
                     4; membrane-associated guanylate kinase-interacting
                     protein-like 1"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras
                     3"
                     /protein_id="NP_001012061.1"
                     /db_xref="GeneID:308113"
                     /db_xref="RGD:1307544"
                     /translation="MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKIS
                     HQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSR
                     RKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLC
                     LDLTTAVQKDCLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLPNVR
                     PGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVK
                     KLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASL
                     KKEKPAILDLYIPPPPAVPYSPRDENVSFSYRGHTKSKQPLPGRKGSESPNSFLDQES
                     QRRRFTITDSDQLPGYSVGTNILPIKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKP
                     RGHGRKGEDALCRYFSNERITPIIEESASPVYRFSRPLTERHLVRGADYIRGSRCYIN
                     SDLHSSATIPFQEEGPKKKSASSSAKASSGEPSLLVSWLTRLKLLTH"
     exon            572..735
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..938
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1026
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1068
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1188
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1248
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1317
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1464
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1589
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1798
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1888
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..3337
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3338
                     /gene="Cnksr3"
                     /gene_synonym="Magi1; Prp4"
ORIGIN      
        1 ccgagcgcgc aggctctgcg tttttcccct cccgggcggc ccgcgacggt ggcgcaggag
       61 gtgggacccg ctggcgggaa ggctcgaggc accggcgcac gcggagtgag gacctcggga
      121 gcggacacag ctcgcagggg ctgcggaggg ccagccgacc tagaagttcc cggccaggag
      181 agttccacgc ctgagcagcc ccgggcctgg ggtctgaggt tgcaatcttg cgcccgctgc
      241 tgcggtggtc acggagaagc agctgtatcc cagagctgcg tgggggagaa ctgcagctgg
      301 acggcggtag ctgcggggag cagccgtacc ggacacagct gtcccgtacg tagggaccca
      361 gggccgcact cccctcgctg agccgctgcg cgatggctgg ctgactgcgg ccatgcaggc
      421 ttgagcggac gcccgggaca cgcaagggac aactgcgggc gcaagtttca ggactccgcc
      481 gtcgactccc cagcccagcg ggtagagaag catcttacca tggagcccgt gaccaagtgg
      541 agccccaaac aagtggtgga ctggactaga gggttggatg actgcctgca gccgtacgtc
      601 cacaagtttg agcgggagaa gatagatggg gagcagttgc taaagatctc ccaccaggat
      661 ctcgaggaac tgggggtcac gcggatcgga caccaagagc tggtgttgga ggctgtggac
      721 cttctctgcg cactgaatta tggccttgaa actgataaca tgaagaactt ggttctgaag
      781 ctgcgggcat cctcccataa tctgcagaat tacataagta gccggcggaa gagcccagcc
      841 tacgatggga acacgtcccg caagcccccc aatgagttcc tgacttctgt ggtagagctc
      901 attggtgctg ccaaggccct gctggcttgg ctggatcggg ctccattcac agggatcacg
      961 gatctgtcgg taacaaagaa caaaatcatc caactgtgcc tggacctgac cacagcagtc
     1021 cagaaggatt gcctcgtagc agaaatggag gataaagttt taaatgtggt caaggtcttg
     1081 aatggcatct gtgacaaaat gatgcactct actacggacc ctgtgatgag ccagtgcgca
     1141 tgcctggagg aagttcactt accgaatgtt agacccgggg aaggcctggg catgtacatc
     1201 aagtcaacct atgatggact gcatgtgatt actggaacca cagaaaattc tcctgcagac
     1261 agatctcaaa agattcatgc tggtgacgag gtcattcaag tcaatcggca aacagtggtc
     1321 gggtggcagt tgaagaatct ggtgaagaag ttgagagaga atcccacagg cgtggtgctg
     1381 ctgctgaaga agaggcccac gggctcattc agcttcactc cagccccgct gaagaacctg
     1441 aggtggaagc cacccctcgt gcagacctca cccccgccca ccacaaccca gtccccagag
     1501 agcaccatgg atgcctccct gaagaaggag aagccagcca tcctggacct atacattcct
     1561 cccccacctg ctgttcccta ctctccccgg gatgagaacg tgagtttcag ctatagagga
     1621 cacactaaga gtaaacagcc actgcctggg cgcaagggtt ccgagtcccc taactccttc
     1681 ctggaccagg agagccagag acgcagattc accatcacag actccgatca gctacccggg
     1741 tactcggtgg ggaccaatat tctgcccata aaaatgagag ggaagacgcc gtcctatggc
     1801 aaaccccggc ctctgtccat gcctgcagat gggaactgga tggggattgt ggaccctttt
     1861 gctaaacctc gaggtcatgg gaggaaaggg gaagacgccc tgtgccggta cttcagcaat
     1921 gagcgcatta cacccatcat tgaagaaagt gcctctcccg tgtaccggtt ctccagaccc
     1981 ctgactgagc ggcatctggt tcgaggtgcg gactacatcc gagggagcag gtgctatatc
     2041 aactctgatc tacacagcag cgccaccatt ccattccagg aggaagggcc caagaagaag
     2101 tcggcctcct catcggccaa ggcgtcttct ggggagccgt cgctgttggt cagctggctg
     2161 actcgcctca agctgttgac tcactgaggt tgctgctgcg ccagcttcct gcctgtctcc
     2221 tgctagcaag tgccttcttc ctcagtggac agcttgtcca gactcctgcc acagtgctcc
     2281 atggcgacct tacttcattc cattttgttt ttaaggttgt atattgccct tcctggagtt
     2341 ttgaagtcac cagagggcaa caaatccggt ggatcttagg gtgctgttcg tggaggcaga
     2401 aggaaggacg gacatggcac acgtttagtt tttgccttcc cactgtggga gcgtggagac
     2461 atactcttta aagtgtcagg agttggcagc attgttcact tttgttttct tgggcagtgg
     2521 ggactaaaat tgatgggttt tgtcacatag atatgttggt ttgtggtcca acttctgtat
     2581 ctgaaaaagc tgaaggagga aaacttctgt tttgattttt taaagctgta gagcatattt
     2641 atcagggtgg cagcgcccac tgcagagtgt gaggctgttt ggagcagagc ttacctgcag
     2701 gtcagctctt atgtgtgttc accccccctt cagtaacagc ctccgtgtag gggagccagt
     2761 cacaagctca cgagcacgct ttgatggaac cttgcgtata caaagacgtg tgtgcgtttt
     2821 tgagaggtgt cgcagttacg tgtacgaggg aaagaagcta taagatttgc tgacagccaa
     2881 agcgtagttc cggaagctga agcaaccgga tttagaggca tcggtcagtt tgcggtattg
     2941 gcctgtttga tgtctgtgtt ctagggggga aaagccttca ggccttccca ggtgtgcaca
     3001 gttttgctag ttagaaatat cttggaaggc ctcatggtca ctgatttttc aactagcatc
     3061 aggtattttg aaaatgtatg tctgggtatt aactcttgtt taaaaccaaa tgtacaatat
     3121 tttgctagaa tggaaaaacc ctttcttgtt aatttaagtg ttttaaatag agttgtatat
     3181 ttttcttact cttagtcaca tgtaattgaa atatttctgt tttgcgttat acgtgaaacc
     3241 caggggaaag agcattaaat gttttcagat ttacacgtga cccagtgtgg ccgttggcag
     3301 cctgggcgcg catattaaag atggaaataa accctccaaa aaaaaaaaaa
//
