LOCUS       NM_001039011            2512 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus connector enhancer of kinase suppressor of Ras 1
            (Cnksr1), mRNA.
ACCESSION   NM_001039011 XM_216548
VERSION     NM_001039011.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Rodrigues-Ferreira S and Nahmias C.
  TITLE     An ATIPical family of angiotensin II AT2 receptor-interacting
            proteins
  JOURNAL   Trends Endocrinol Metab 21 (11), 684-690 (2010)
   PUBMED   20889352
  REMARK    Review article
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca
            M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J and Seed B.
  TITLE     The scaffold protein CNK1 interacts with the tumor suppressor
            RASSF1A and augments RASSF1A-induced cell death
  JOURNAL   J Biol Chem 279 (28), 29247-29254 (2004)
   PUBMED   15075335
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Jaffe AB, Aspenstrom P and Hall A.
  TITLE     Human CNK1 acts as a scaffold protein, linking Rho and Ras signal
            transduction pathways
  JOURNAL   Mol Cell Biol 24 (4), 1736-1746 (2004)
   PUBMED   14749388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099788.1.
            
            On Jan 12, 2006 this sequence version replaced XM_216548.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2512
                     /gene="Cnksr1"
                     /note="connector enhancer of kinase suppressor of Ras 1"
                     /db_xref="GeneID:298545"
                     /db_xref="RGD:1311879"
     exon            1..79
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2142
                     /gene="Cnksr1"
                     /codon_start=1
                     /product="connector enhancer of kinase suppressor of ras
                     1"
                     /protein_id="NP_001034100.1"
                     /db_xref="GeneID:298545"
                     /db_xref="RGD:1311879"
                     /translation="MEPVETWTPGKVAAWLRGLDDVLQDYPFEDWELPGKYLLQLCPQ
                     NLEALTVWPLGHQELILHGVEQLRALGSKLQTENLKSLAQGLLDRTQAFQSLVQGRLR
                     DCAETPADVLNAAVELVREAHALLSWLNRYLFTHLNDFSACQEIGVLCGELGQVLQED
                     CLEAEKESNTLRICGRVAGICHNILGCSPEELLEQRAVLELVQLDDPSGLEIHTTSNC
                     LHFVSRVGVQAATGSQILPGDEIIQINEQVVVGWPHKNMLRELLREPARVSLVLKKIP
                     VPETPSKTPPDSPQRLSQSLPLNPPSPRVPREGLFDFKLFTDGNPSPSPAWTDSTSLD
                     AQPTPTPPGPPGTLPEETAEPLEASGHLDKSPTVGRKNSKGIATRLSRRRVSCRELGL
                     PDCDGWLLLRKVPGGFMGARWRRCWFVLKGHTLYWYRQPQDEKAEGLINISNYSLECG
                     HDQKKKYVFQLTHDVYKPFIFASETLSDLSMWVRHLVTCISKYQTLGRAPSAREEDCY
                     SETEAEDPDEEAGSRSASPGPAQAWNDTSPSASPLQSPRTSFGSSLDSSDRALEGMVQ
                     GLRQGGVSLLGQPQPLTHEQWRSSFMRRNRDPHLNEHVHRVRALQSTLKAKLQELQVL
                     EEVLGDPELTGAKFRQWKEQNHELYSEGLRTWGGMWAQTSSPDPNTDSRGQSPQPLPS
                     DPEEPSQLFPSTPENSLQPPDL"
     exon            80..237
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..419
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..504
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..546
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..651
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..711
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..774
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..876
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..938
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1012
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1119
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1150
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1323
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1397
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1469
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1543
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1605
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1690
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1872
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2476
                     /gene="Cnksr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctggacgc tgcgggcgga gctcagtatg gagcccgtgg agacctggac ccccgggaag
       61 gtggcagctt ggctgagagg ccttgatgac gtcctacagg actatccctt cgaggactgg
      121 gagctgcctg gaaagtacct gctgcagctc tgtccccaaa acctcgaggc tctgaccgtg
      181 tggcctctgg gccaccagga gctcattcta catggagtgg aacagctccg ggccctgggc
      241 tctaagttac agaccgagaa cctcaagagc ctagcccagg ggctgctgga caggacccag
      301 gccttccaaa gcttggtcca aggccgtctg agagactgtg ctgagacacc cgccgatgtc
      361 ctcaatgctg ctgtagagct ggtacgggag gctcatgccc tgctctcttg gctcaacagg
      421 tacctcttca ctcacttaaa tgacttctcc gcctgccaag agattggtgt gctgtgcgga
      481 gagctgggcc aagtcttgca ggaggattgc ctagaggctg agaaagaaag caacaccctg
      541 aggatttgcg gccgtgtggc tgggatctgt cacaacatcc tgggctgcag cccggaggag
      601 ctgctggaac agagggccgt gttggagctg gtgcagctgg acgacccttc cggcctagaa
      661 attcacacca ccagcaactg cctacacttt gtgtctcgag taggcgtcca ggctgccacc
      721 ggctcccaga tcctgcccgg agatgagatc atccaaatca atgagcaggt ggtggtcggc
      781 tggccccata aaaacatgct gagggagctg ctgagggagc cagcaagggt cagccttgta
      841 ctaaagaaga ttcccgtgcc agagaccccc tcaaagacgc ccccggactc ccctcagcgg
      901 ctaagccaat cgctgcccct gaacccaccg tctcccaggg ttccacgcga aggtcttttt
      961 gacttcaagc tgtttacaga tggaaacccc agccccagcc ctgcgtggac agactctacc
     1021 tcccttgacg ctcagcccac gcccactccc cctgggccac caggcactct tccagaagaa
     1081 acagcagaac ctctggaggc ttcgggacac cttgacaaga gtcccaccgt tggtcggaag
     1141 aattcaaaag gtatagctac aaggctgagc cgccggcggg tgtcctgccg agagctgggt
     1201 ctgccggact gtgatggatg gcttctactg cggaaggtac ccggtggttt tatgggcgct
     1261 cgctggcgtc gctgctggtt cgtgctcaag ggacacaccc tatactggta ccgccaaccg
     1321 caggatgaaa aggcggaagg acttatcaac atctccaatt acagcctgga gtgcgggcat
     1381 gaccagaaga aaaaatatgt gttccagctg acccacgatg tgtacaagcc cttcatcttt
     1441 gcctcggaga ccctgtctga tctgagcatg tgggtgcggc atcttgtcac ctgcatttcc
     1501 aagtatcaga ctctaggtcg ggccccctcc gccagagagg aagactgcta cagtgagacc
     1561 gaagcagaag accctgatga agaggcaggg tcccgctcag cttctcctgg tccagctcaa
     1621 gcttggaatg acacatcgcc ctcggcttca cccctgcaga gtcctaggac ctcctttggc
     1681 tcttcattag atagcagtga cagagccctg gaaggaatgg tacaggggct gaggcaggga
     1741 ggcgtgtccc tcctgggcca gccacagccc ttgacccatg aacagtggcg gagttctttc
     1801 atgcggcgaa accgtgaccc tcatctcaat gagcatgtgc accgtgtccg ggcactacag
     1861 agcacactca aggcaaagct acaggaactg caggtcctgg aggaagtcct gggtgatcct
     1921 gaactcacag gagcaaaatt tcgccagtgg aaggaacaga accacgagct gtactcagaa
     1981 ggcctgagga cctggggagg gatgtgggcc cagaccagct ccccagaccc aaacactgac
     2041 tccaggggtc aatccccaca gcctctaccc tctgaccctg aagagccctc ccagcttttt
     2101 ccctcgaccc cagagaacag cctccaacct cctgacctct gaccctggct gaggactact
     2161 tcatccccag tctctgatgt gcttaaaaca tgtccaaggg gtctgtgaga gaccggaagg
     2221 agcattagcc ctcagcttac ctccaaaccg gtccctctat gctgggcttc cacactttct
     2281 gctcacaagt ccctcatagt ggaaggaaag ttcctctctt ctctgtgagg tagaaatccc
     2341 tcaacccatc ctcagatttg ggatgtacct gcctccctgg gtcattcaaa aaggtttccc
     2401 agaccttcct aggtaggtgt ttattttaca tgagagatag ttttccacca aataaagttg
     2461 atttttctga agtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
