LOCUS       NM_001166578            1968 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus cornichon family AMPA receptor auxiliary protein
            3 (Cnih3), mRNA.
ACCESSION   NM_001166578 XM_001062823 XM_001073856
VERSION     NM_001166578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Nakagawa,T.
  TITLE     Structures of the AMPA receptor in complex with its auxiliary
            subunit cornichon
  JOURNAL   Science 366 (6470), 1259-1263 (2019)
   PUBMED   31806817
  REMARK    GeneRIF: reports high-resolution cryo-electron microscopy
            structures of AMPAR in complex with CNIH3. Contrary to its
            predicted membrane topology, CNIH3 lacks an extracellular domain
            and instead contains four membrane-spanning helices
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Shanks,N.F., Cais,O., Maruo,T., Savas,J.N., Zaika,E.I.,
            Azumaya,C.M., Yates,J.R. 3rd, Greger,I. and Nakagawa,T.
  TITLE     Molecular dissection of the interaction between the AMPA receptor
            and cornichon homolog-3
  JOURNAL   J Neurosci 34 (36), 12104-12120 (2014)
   PUBMED   25186755
  REMARK    GeneRIF: Residues in the membrane-proximal region of CNIHs that
            contribute to AMPAR binding and a segment in the CNIH-2/3
            extracellular loop required for both physical interaction and
            gating modulation of the AMPAR, are identified.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Herring,B.E., Shi,Y., Suh,Y.H., Zheng,C.Y., Blankenship,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Cornichon proteins determine the subunit composition of synaptic
            AMPA receptors
  JOURNAL   Neuron 77 (6), 1083-1096 (2013)
   PUBMED   23522044
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Shi,Y., Suh,Y.H., Milstein,A.D., Isozaki,K., Schmid,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Functional comparison of the effects of TARPs and cornichons on
            AMPA receptor trafficking and gating
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16315-16319 (2010)
   PUBMED   20805473
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Schwenk,J., Harmel,N., Zolles,G., Bildl,W., Kulik,A., Heimrich,B.,
            Chisaka,O., Jonas,P., Schulte,U., Fakler,B. and Klocker,N.
  TITLE     Functional proteomics identify cornichon proteins as auxiliary
            subunits of AMPA receptors
  JOURNAL   Science 323 (5919), 1313-1319 (2009)
   PUBMED   19265014
  REMARK    GeneRIF: findings show that the majority of AMPARs in the brain are
            coassembled with CNIH-2 & CNIH-3; cornichons increase surface
            expression of AMPARs, & alter channel gating by markedly slowing
            deactivation & desensitization kinetics
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 20, 2022 this sequence version replaced NM_001166578.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.550711.1,
                                           SRR26360176.1843892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               JAXUCZ010000013.1  95631469-95632377
            910-978             JAXUCZ010000013.1  95682764-95682832
            979-1026            JAXUCZ010000013.1  95686979-95687026
            1027-1139           JAXUCZ010000013.1  95728577-95728689
            1140-1283           JAXUCZ010000013.1  95733574-95733717
            1284-1968           JAXUCZ010000013.1  95738816-95739500
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1968
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /note="cornichon family AMPA receptor auxiliary protein 3"
                     /db_xref="GeneID:690252"
                     /db_xref="RGD:1582859"
     exon            1..909
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             829..1311
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /note="cornichon 3; cornichon homolog 3"
                     /codon_start=1
                     /product="protein cornichon homolog 3"
                     /protein_id="NP_001160050.1"
                     /db_xref="GeneID:690252"
                     /db_xref="RGD:1582859"
                     /translation="MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQ
                     CNPVHARERLRNIERICFLLRKLVLPEYSIHSLFCVMFLCAQEWLTLGLNVPLLFYHF
                     WRYFHCPADSSELAYDPPVVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS
                     "
     exon            910..978
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1026
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1139
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1283
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1968
                     /gene="Cnih3"
                     /gene_synonym="CNIH-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaatcctcg cggcgcccgc gacagcagca gcagcagcgg cagtagcagc agcagcagca
       61 gcagcaggtg gagccccgct cagctgcgag cagcacttgg ccggaaatct gcgccgcagc
      121 cgctgggctg ggagctggcc atctaggctg gagcccacgc cgtcccggtc cgacccagtt
      181 tcccaggcac cgggttaccg aagccggcgg ccggggaacg cggttggggc cggggacgga
      241 tgcatctcag tacgcatagc tgcattggga gaccctaccc cggggcgcgg ggctaacggg
      301 acctggccca cctcggccac ctaaagactt gtgctctggg gacagagcag ctgtgggatc
      361 cggagcccgg gcacctggcc ccgcactgtt gaagtctggg tggcgtgctc gccccacctc
      421 tttgcttggg cacggacaga gagggctctt tccaggggac cagacctcct tgcctagtcc
      481 tgagtggagt cctcgcaccc gatgtctgtt ggtctggaga acctctttag ttgacaccgg
      541 tctggaggtg ttctttgttg gttaggtttc ttcttcggct aggggaacag tagtcgccag
      601 tgacattctg tgcctatggg cgctccaggt cctgggtctc cagccttgcc ggaatcgtcc
      661 tggcttcgct gaccctcaac tctgtctctg cttgtcgtgg gtgctcctag ccgtttgttt
      721 gttttttgac gagactgtgc agactacaca tctttctggc tctcatttgg gaaggcactg
      781 gtctccaagg tgcggctttg tgtgtggtgg gatcagtggt cctcagccat ggccttcact
      841 ttcgctgctt tctgctacat gctgtccctg gtgctctgcg ctgcgctcat cttcttcgct
      901 atctggcaca taatcgcctt cgatgagcta aggacagatt tcaagagtcc catagaccag
      961 tgcaaccctg tccatgcgag ggagcggctg aggaacatcg aacgcatctg cttccttctg
     1021 agaaagctgg tgctgccgga gtactccatc cacagcctct tctgcgtcat gtttctgtgt
     1081 gcacaggagt ggctcaccct ggggctcaat gttcctctgc ttttctatca cttctggagg
     1141 tatttccact gtccagcaga tagctcagaa ctagcctacg acccaccagt tgtcatgaat
     1201 gccgacacct tgagctactg tcagaaggag gcctggtgta agctggcctt ctatctcctc
     1261 tccttcttct actacctgta ctgcatgatt tacaccttag tgagctccta actcagaccc
     1321 tgctggtgga gagaccaagg ctgggaacca ctgcggttgt ggctagcgga gcaccaggtg
     1381 gggatgatga agagacccgg ctggcagaga ctgaatggaa ggaacggagt tgcaccacgg
     1441 acagggccgt gttacccatg catatgcgtt tctgccttcg cctttcacct cccacatggg
     1501 ttgcagagcc cccctgagca tgggggtggc agcctgtagc tgatgaaaca ttcaacctcc
     1561 ggagatgcgg ttactttctt catccacttc ttcagtgggc agcagaacgg tacgagttca
     1621 cgaagagctc gaccagaggg tagaaatgag gccagaagcc gggaaggtgt cgatcaagga
     1681 acagaatggc tctgggtcag tgccagatct tcagggatgg ctgagaccca caaggacacc
     1741 atgggctgcc caagactctt gtcatatttt ttccagagct gtggccacat gctttgctca
     1801 gtgcaaagct aaaagccgca gggactgccc tgagccacct ctcatgtcac ttttatgctt
     1861 tgtctgggag cctgagcatt ggcttcctga gctgggtgtg ggcagcaagt cctgtccagt
     1921 gggaactggg gaggggagaa aatggatttc taaaatgttt gcaacatg
//
