LOCUS       NM_001025132            1365 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cornichon family AMPA receptor auxiliary protein
            2 (Cnih2), mRNA.
ACCESSION   NM_001025132 XM_341989
VERSION     NM_001025132.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Boudkkazi,S., Brechet,A., Schwenk,J. and Fakler,B.
  TITLE     Cornichon2 dictates the time course of excitatory transmission at
            individual hippocampal synapses
  JOURNAL   Neuron 82 (4), 848-858 (2014)
   PUBMED   24853943
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Brockie,P.J., Jensen,M., Mellem,J.E., Jensen,E., Yamasaki,T.,
            Wang,R., Maxfield,D., Thacker,C., Hoerndli,F., Dunn,P.J.,
            Tomita,S., Madsen,D.M. and Maricq,A.V.
  TITLE     Cornichons control ER export of AMPA receptors to regulate synaptic
            excitability
  JOURNAL   Neuron 80 (1), 129-142 (2013)
   PUBMED   24094107
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Harmel,N., Cokic,B., Zolles,G., Berkefeld,H., Mauric,V., Fakler,B.,
            Stein,V. and Klocker,N.
  TITLE     AMPA receptors commandeer an ancient cargo exporter for use as an
            auxiliary subunit for signaling
  JOURNAL   PLoS One 7 (1), e30681 (2012)
   PUBMED   22292017
  REMARK    GeneRIF: Mammalian AMPARs commandeer CNIH-2 for use as a bona fide
            auxiliary subunit that is able to modify receptor signaling.
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Gill,M.B., Kato,A.S., Roberts,M.F., Yu,H., Wang,H., Tomita,S. and
            Bredt,D.S.
  TITLE     Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor
            regulatory protein assembly to dictate gating and pharmacology
  JOURNAL   J Neurosci 31 (18), 6928-6938 (2011)
   PUBMED   21543622
  REMARK    GeneRIF: CNIH-2 modulates neuronal AMPA receptor auxiliary subunit
            assembly by regulating the number of transmembrane AMPA receptor
            regulatory proteins within an AMPA receptor complex to modulate
            receptor gating and pharmacology.
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Shi,Y., Suh,Y.H., Milstein,A.D., Isozaki,K., Schmid,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Functional comparison of the effects of TARPs and cornichons on
            AMPA receptor trafficking and gating
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16315-16319 (2010)
   PUBMED   20805473
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Schwenk,J., Harmel,N., Zolles,G., Bildl,W., Kulik,A., Heimrich,B.,
            Chisaka,O., Jonas,P., Schulte,U., Fakler,B. and Klocker,N.
  TITLE     Functional proteomics identify cornichon proteins as auxiliary
            subunits of AMPA receptors
  JOURNAL   Science 323 (5919), 1313-1319 (2009)
   PUBMED   19265014
  REMARK    GeneRIF: findings show that the majority of AMPARs in the brain are
            coassembled with CNIH-2 & CNIH-3; cornichons increase surface
            expression of AMPARs, & alter channel gating by markedly slowing
            deactivation & desensitization kinetics
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091325.1.
            
            On Jul 1, 2005 this sequence version replaced XM_341989.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091325.1, DY311867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1365
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /note="cornichon family AMPA receptor auxiliary protein 2"
                     /db_xref="GeneID:361705"
                     /db_xref="RGD:1304930"
     exon            1..332
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..734
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /note="cornichon-like protein; cornichon homolog 3;
                     cornichon homolog 2"
                     /codon_start=1
                     /product="protein cornichon homolog 2"
                     /protein_id="NP_001020303.1"
                     /db_xref="GeneID:361705"
                     /db_xref="RGD:1304930"
                     /translation="MAFTFAAFCYMLTLVLCASLIFFVIWHIIAFDELRTDFKNPIDQ
                     GNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHL
                     WRYFHRPADGSEVMYDAVSIMNADILNYCQKESWCKLAFYLLSFFYYLYSMVYTLVSF
                     "
     exon            333..401
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
     exon            402..449
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
     exon            450..562
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
     exon            563..706
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1337
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnih3; RGD1304930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccgcgg gcgagggatc gcaggatgag cgatcggggc ccgggcagcc ggcagcggac
       61 gcgccccccg agccccacgg cccgcgcccc gcgtccccca cggccccgtg gcccaggtcc
      121 cggacgcgct gcctgtgtcc ctcgagtccg gtgggccatg cccggccggc cctaagtgtg
      181 ggccgggggg cgtccccttg cgcccagacc ccgcgctggc gccccccggg ccaccgcccg
      241 gcgcgggggc catggcgttc accttcgcag cattctgcta catgctcacc ctggtgctgt
      301 gcgcctccct catcttcttt gtcatctggc acatcatagc ctttgatgag ctgcggactg
      361 acttcaagaa ccccatcgac caggggaacc cagcgcgggc acgcgagcgt ttgaaaaaca
      421 tcgaacgcat ctgctgcctc ctgaggaagc tggtggtccc ggaatattcc atccacggcc
      481 tcttctgtct gatgtttctg tgtgcagcag agtgggtgac cctgggcctc aacatccccc
      541 tcctcttcta ccacctctgg aggtacttcc accgtcctgc ggatggctct gaggtcatgt
      601 atgatgcggt ctctatcatg aatgctgaca tcctcaacta ctgccagaag gagtcctggt
      661 gcaaactcgc cttctacctg ctctccttct tctattacct gtacagtatg gtttatacgt
      721 tggtgagctt ctaaggggga agccggccag ggagcaagcc cagaacggac cggacgcctg
      781 tgcaccccca gccctgcccc tctggccaca gaggcctcag ccctggggag ggaggaggca
      841 ctggtgcctc cagcctctcc acccccccaa actgctgctg cggggacccc cgccctcaga
      901 gctctcccct tccgactagg gccaggcaaa gctctaaaca ggggtggggg ctcctctgct
      961 agccggcagc taggcatggc agttgtcctg gaaggggtag gacttccggt cttgtccgtt
     1021 tcaggggaat ttgggccctg ccaacaggca gaccttgatc ctggaaattc tgggcagccc
     1081 accttggccc tcaccctgaa gctccccctg caggtggggg ggcacctgca ccaggaatga
     1141 gcaggctcaa catgggggca gccccacccc tagtctgccc tcttcccctc cccaggctct
     1201 ctttccaacc cagtctctac ttatcacaaa tccagcccac cctgtccctt ggacctattt
     1261 tctatgttgc ctggaggagt ccagtaccct atccccggac atttgtgaca aaatatgaat
     1321 aaactactga aaacacaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
