LOCUS       NM_001271238            3092 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit beta 3
            (Cngb3), mRNA.
ACCESSION   NM_001271238 XM_001057513
VERSION     NM_001271238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Meighan,S.E., Meighan,P.C., Rich,E.D., Brown,R.L. and Varnum,M.D.
  TITLE     Cyclic nucleotide-gated channel subunit glycosylation regulates
            matrix metalloproteinase-dependent changes in channel gating
  JOURNAL   Biochemistry 52 (46), 8352-8362 (2013)
   PUBMED   24164424
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Berridge,M.J.
  TITLE     Calcium signalling remodelling and disease
  JOURNAL   Biochem Soc Trans 40 (2), 297-309 (2012)
   PUBMED   22435804
  REMARK    Review article
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Carvalho,L.S., Xu,J., Pearson,R.A., Smith,A.J., Bainbridge,J.W.,
            Morris,L.M., Fliesler,S.J., Ding,X.Q. and Ali,R.R.
  TITLE     Long-term and age-dependent restoration of visual function in a
            mouse model of CNGB3-associated achromatopsia following gene
            therapy
  JOURNAL   Hum Mol Genet 20 (16), 3161-3175 (2011)
   PUBMED   21576125
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Wiszniewski,W., Lewis,R.A. and Lupski,J.R.
  TITLE     Achromatopsia: the CNGB3 p.T383fsX mutation results from a founder
            effect and is responsible for the visual phenotype in the original
            report of uniparental disomy 14
  JOURNAL   Hum Genet 121 (3-4), 433-439 (2007)
   PUBMED   17265047
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Huttl,S., Michalakis,S., Seeliger,M., Luo,D.G., Acar,N., Geiger,H.,
            Hudl,K., Mader,R., Haverkamp,S., Moser,M., Pfeifer,A., Gerstner,A.,
            Yau,K.W. and Biel,M.
  TITLE     Impaired channel targeting and retinal degeneration in mice lacking
            the cyclic nucleotide-gated channel subunit CNGB1
  JOURNAL   J Neurosci 25 (1), 130-138 (2005)
   PUBMED   15634774
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Kaupp,U.B. and Seifert,R.
  TITLE     Cyclic nucleotide-gated ion channels
  JOURNAL   Physiol Rev 82 (3), 769-824 (2002)
   PUBMED   12087135
  REMARK    Review article
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Kohl,S., Baumann,B., Broghammer,M., Jagle,H., Sieving,P.,
            Kellner,U., Spegal,R., Anastasi,M., Zrenner,E., Sharpe,L.T. and
            Wissinger,B.
  TITLE     Mutations in the CNGB3 gene encoding the beta-subunit of the cone
            photoreceptor cGMP-gated channel are responsible for achromatopsia
            (ACHM3) linked to chromosome 8q21
  JOURNAL   Hum Mol Genet 9 (14), 2107-2116 (2000)
   PUBMED   10958649
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Gerstner,A., Zong,X., Hofmann,F. and Biel,M.
  TITLE     Molecular cloning and functional characterization of a new
            modulatory cyclic nucleotide-gated channel subunit from mouse
            retina
  JOURNAL   J Neurosci 20 (4), 1324-1332 (2000)
   PUBMED   10662822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 8, 2012 this sequence version replaced XM_001057513.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN14984036, SAMN16676807
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000005.1  37543903-37544013
            112-187             JAXUCZ010000005.1  37546577-37546652
            188-314             JAXUCZ010000005.1  37584172-37584298
            315-472             JAXUCZ010000005.1  37669511-37669668
            473-607             JAXUCZ010000005.1  37670756-37670890
            608-816             JAXUCZ010000005.1  37672038-37672246
            817-867             JAXUCZ010000005.1  37680000-37680050
            868-954             JAXUCZ010000005.1  37684052-37684138
            955-1019            JAXUCZ010000005.1  37687197-37687261
            1020-1142           JAXUCZ010000005.1  37687942-37688064
            1143-1284           JAXUCZ010000005.1  37697637-37697778
            1285-1444           JAXUCZ010000005.1  37721279-37721438
            1445-1542           JAXUCZ010000005.1  37724454-37724551
            1543-1626           JAXUCZ010000005.1  37745028-37745111
            1627-1745           JAXUCZ010000005.1  37769063-37769181
            1746-1892           JAXUCZ010000005.1  37787770-37787916
            1893-2067           JAXUCZ010000005.1  37788467-37788641
            2068-3092           JAXUCZ010000005.1  37791006-37792030
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3092
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /note="cyclic nucleotide gated channel subunit beta 3"
                     /db_xref="GeneID:500418"
                     /db_xref="RGD:1565364"
     CDS             1..2073
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /note="cyclic nucleotide gated channel beta 3"
                     /codon_start=1
                     /product="cyclic nucleotide-gated cation channel beta-3"
                     /protein_id="NP_001258167.1"
                     /db_xref="GeneID:500418"
                     /db_xref="RGD:1565364"
                     /translation="MLKSLTVKCNKVKPMEGRTEKQPCPHLSSGSQPSIAQGENQSEN
                     ESLMSRTPATVEKSHSKEDNSTGENSLRGSTTNPDTECPAELTGTISEMEQTRTRKEK
                     PASIKTKVFETSIINEYTDAHLHNLVERMRERTAFYKRTLTEGENSPELEASSHTATS
                     TDISPRQEINSKPKEHHHKLQRVPVKEYLRSMRLPRSIDSYTDRIYLLWLLLVTIAYN
                     WNCWLLPVRLVFPCQTPDNRNYWIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSN
                     ELKRHYRSSTKFQMDVASLLPFEVLYIFFGVNPIFRTNRILKYTSFFEFNHHLESIMD
                     RAYVYRIIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRT
                     LITIGGLPEPQTSFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNNFHVCMDHI
                     IAYMNKYSIPQSTQHRVRTWLEYTWHSQRILDESNLLETLPTAMQLSVAIDINFNIID
                     KVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGA
                     QVLVTLKAGAVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKK
                     LLMKKAKVLLSQKGKNTQAIPPRTRPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKG
                     KRKQTTQK"
     exon            1..111
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            112..187
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            188..314
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            315..472
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            473..607
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            608..816
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            817..867
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            868..954
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1019
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1142
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1284
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1444
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1542
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1626
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1745
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1892
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2067
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..3092
                     /gene="Cngb3"
                     /gene_synonym="Cng6; RGD1565364"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttaaaat ctctgacagt aaaatgcaac aaagtgaagc ccatggaagg gaggaccgag
       61 aagcaaccct gcccccacct gagcagtggg tctcagccat ccatagcaca gggagaaaac
      121 caaagtgaaa acgaatctct gatgagcagg acaccagcca cagttgaaaa atcacacagc
      181 aaagaagaca acagcactgg ggagaactcc ctcaggggtt ctaccacaaa tcctgacact
      241 gaatgtcctg cagaactcac gggaacaata tcggagatgg agcaaactag gactaggaaa
      301 gaaaagccag ccagcattaa gaccaaagta tttgaaactt caattataaa tgaatatact
      361 gatgcccatc tacacaacct agtggagaga atgcgtgaaa ggactgcttt ctacaagaga
      421 acactgacag agggagagaa ctcccccgaa ttagaagcca gctctcatac tgcaacgtct
      481 acagatatat caccaagaca agagatcaat tctaagccaa aagaacacca ccacaaactc
      541 cagagagtac ctgtgaaaga gtacctaaga agcatgagac ttccgagaag catagattcc
      601 tacacagatc ggatttatct cctgtggctc ctgcttgtca ccattgccta caactggaac
      661 tgttggctgc taccggtacg ccttgtcttt ccatgccaaa caccagacaa caggaactac
      721 tggatcatta ctgacatcat atgtgatatc atctaccttg gtgatatatt attgatccaa
      781 ccaagacttc aattcgtaag aggaggagaa attatcgtag attcaaatga gctgaagagg
      841 cactacagga gttctacaaa atttcagatg gatgtggcat ctctactgcc atttgaagtt
      901 ctctacatct tcttcggagt caatccaata ttcagaacaa atcggatatt aaagtacact
      961 tcattctttg agtttaacca tcacctggag tctataatgg acagagcata tgtctacagg
     1021 ataatccgaa caactggcta cttgctgttt cttctgcaca ttaacgcctg tgtttattac
     1081 tgggcttcag actatgaagg aattggctca actaaatggg tctataatgg ggaaggaaac
     1141 aagtatctgc gatgttttta ttgggcagtt cgaactttaa ttacaattgg gggccttcca
     1201 gagccacaga cttcatttga aattgttttt caactcttga atttcttttc gggagttttt
     1261 gtgttctcca gcttaattgg tcagatgcgt gatgtaattg gggcagcaac agccaatcag
     1321 aacaacttcc atgtctgcat ggaccatatc attgcctaca tgaacaaata ctccattcct
     1381 cagagtacgc agcatcgagt tcggacttgg ctggaatata cgtggcattc tcagagaatc
     1441 ctagatgagt ccaacttgct tgagaccctc ccaacagcaa tgcagttgtc tgttgccatt
     1501 gacataaact tcaatatcat cgacaaagtg gagctgttca agggctgtga cacccagatg
     1561 atttatgacc tgctactaag actgaaatcc actatttatt tacctggtga ctttgtctgc
     1621 aaaaagggag aaattggaaa agaaatgtac atcatcaagc atggagaagt ccaagttctt
     1681 ggaggccctg atggtgctca agttctggtt actctgaaag ctggggcagt gtttggagaa
     1741 ataagccttc tggcaaaagg aggaggaaac cgccggacag cggatgtggt ggcccacggg
     1801 tttgccaatc ttttaactct ggacaaaaag actctccagg aaattttgct gcattatcca
     1861 acttctaaaa agcttctcat gaagaaagcc aaagttcttt taagccagaa gggaaagaac
     1921 acacaggcaa tccctccaag aacaagacct gcctttcttt tcccaccaaa agaagagaca
     1981 ccacgaatgc ttaaagtcct cctgggaaac acaggaaagg tggaccttgg aagactcctt
     2041 aaaggaaaga gaaaacaaac cactcagaaa taaaggtgaa agctccaaag gaagaaaaag
     2101 aagaggaaaa gaatatgaag ataaaggaac agagccagca gaaagataaa aaccattgga
     2161 caggtcaaaa ggcacaacaa gtttcattac agtggaggaa attccccagt caattaaaaa
     2221 ggcagttttt cccaaccgac ctgcctatca atcattcttc agcaacatag cccctgatgc
     2281 tgggactggg ggagagattc tgattatcaa agtcaaagaa aggctaagca ataagtgatt
     2341 gtcttttaaa tataatctag cttattccca aagagattcc tggaaattgt agcttaaatt
     2401 aatgagggaa actcacctca ctgggaccct gggaaactcc aggcaaatcc ttagcttcac
     2461 ttccaggact ttgaattcat caataagatt attaaaaact gtcctcttac tcactgtcag
     2521 cagatttgag caattgctat ttcttttaaa tgtctgcagg aggtaatttt ttttcttctt
     2581 tcctggtgaa tttccatggt ccaccttagt aaacttgatt ttaatgctcc tgtgatttac
     2641 tgtcctttct gcttacaatt ttgtggtaca taatttctgg caaaacactt tggtcaaatg
     2701 tctaaaatag actcatctgt ccagggtaga ctcatcttac ttcttgtgta tagtgaaaga
     2761 gtgtgaattt tttaataaaa taggtcataa atcaagtggt ttctatttaa ataagaaagt
     2821 tgggtcacta aatccagcac ctgatgttga cacaggctga cgtcatggat gaaaccttct
     2881 gaatgagaac tgtgattttc actcaaggcc aatgccagtt agcaagatta gctagcatgt
     2941 agacaaaagg ccgaatcaaa aacaaagttc cctcactaac aactgtgccg ccagcttctt
     3001 agagcctcac ccctgtgaca tccaacatct taccggaacc tttcaagcct cactctgcca
     3061 actgacgatt tccttttcaa tcggcccatt gc
//
