LOCUS       NM_031809               4231 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit beta 1
            (Cngb1), transcript variant 1, mRNA.
ACCESSION   NM_031809 XM_346517
VERSION     NM_031809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4231)
  AUTHORS   Nache,V., Wongsamitkul,N., Kusch,J., Zimmer,T., Schwede,F. and
            Benndorf,K.
  TITLE     Deciphering the function of the CNGB1b subunit in olfactory CNG
            channels
  JOURNAL   Sci Rep 6, 29378 (2016)
   PUBMED   27405959
  REMARK    GeneRIF: CNGB1b subunit participates in ligand-gated activation of
            olfactory CNG channels and, particularly, contributes to rapid
            termination of odorant signal in an olfactory sensory neuron.
            Erratum:[Sci Rep. 2018 Jun 28;8:47000. doi: 10.1038/srep47000..
            PMID: 29952375]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4231)
  AUTHORS   Meighan,S.E., Meighan,P.C., Rich,E.D., Brown,R.L. and Varnum,M.D.
  TITLE     Cyclic nucleotide-gated channel subunit glycosylation regulates
            matrix metalloproteinase-dependent changes in channel gating
  JOURNAL   Biochemistry 52 (46), 8352-8362 (2013)
   PUBMED   24164424
REFERENCE   3  (bases 1 to 4231)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   4  (bases 1 to 4231)
  AUTHORS   Gilliam,J.C., Chang,J.T., Sandoval,I.M., Zhang,Y., Li,T.,
            Pittler,S.J., Chiu,W. and Wensel,T.G.
  TITLE     Three-dimensional architecture of the rod sensory cilium and its
            disruption in retinal neurodegeneration
  JOURNAL   Cell 151 (5), 1029-1041 (2012)
   PUBMED   23178122
REFERENCE   5  (bases 1 to 4231)
  AUTHORS   Nache,V., Zimmer,T., Wongsamitkul,N., Schmauder,R., Kusch,J.,
            Reinhardt,L., Bonigk,W., Seifert,R., Biskup,C., Schwede,F. and
            Benndorf,K.
  TITLE     Differential regulation by cyclic nucleotides of the CNGA4 and
            CNGB1b subunits in olfactory cyclic nucleotide-gated channels
  JOURNAL   Sci Signal 5 (232), ra48 (2012)
   PUBMED   22786723
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4231)
  AUTHORS   Bareil,C., Hamel,C.P., Delague,V., Arnaud,B., Demaille,J. and
            Claustres,M.
  TITLE     Segregation of a mutation in CNGB1 encoding the beta-subunit of the
            rod cGMP-gated channel in a family with autosomal recessive
            retinitis pigmentosa
  JOURNAL   Hum Genet 108 (4), 328-334 (2001)
   PUBMED   11379879
REFERENCE   7  (bases 1 to 4231)
  AUTHORS   Bonigk,W., Bradley,J., Muller,F., Sesti,F., Boekhoff,I.,
            Ronnett,G.V., Kaupp,U.B. and Frings,S.
  TITLE     The native rat olfactory cyclic nucleotide-gated channel is
            composed of three distinct subunits
  JOURNAL   J Neurosci 19 (13), 5332-5347 (1999)
   PUBMED   10377344
REFERENCE   8  (bases 1 to 4231)
  AUTHORS   Dzeja,C., Hagen,V., Kaupp,U.B. and Frings,S.
  TITLE     Ca2+ permeation in cyclic nucleotide-gated channels
  JOURNAL   EMBO J 18 (1), 131-144 (1999)
   PUBMED   9878057
REFERENCE   9  (bases 1 to 4231)
  AUTHORS   Sautter,A., Zong,X., Hofmann,F. and Biel,M.
  TITLE     An isoform of the rod photoreceptor cyclic nucleotide-gated channel
            beta subunit expressed in olfactory neurons
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4696-4701 (1998)
   PUBMED   9539801
REFERENCE   10 (bases 1 to 4231)
  AUTHORS   Sautter,A., Biel,M. and Hofmann,F.
  TITLE     Molecular cloning of cyclic nucleotide-gated cation channel
            subunits from rat pineal gland
  JOURNAL   Brain Res Mol Brain Res 48 (1), 171-175 (1997)
   PUBMED   9379842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 7, 2020 this sequence version replaced NM_031809.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000496.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000019.1  9732646-9732695
            51-253              JAXUCZ010000019.1  9735767-9735969
            254-311             JAXUCZ010000019.1  9739468-9739525
            312-378             JAXUCZ010000019.1  9739810-9739876
            379-496             JAXUCZ010000019.1  9740781-9740898
            497-539             JAXUCZ010000019.1  9741005-9741047
            540-585             JAXUCZ010000019.1  9741671-9741716
            586-661             JAXUCZ010000019.1  9742709-9742784
            662-701             JAXUCZ010000019.1  9743578-9743617
            702-849             JAXUCZ010000019.1  9744465-9744612
            850-925             JAXUCZ010000019.1  9745983-9746058
            926-962             JAXUCZ010000019.1  9747485-9747521
            963-1122            JAXUCZ010000019.1  9753140-9753299
            1123-1506           JAXUCZ010000019.1  9754963-9755346
            1507-1594           JAXUCZ010000019.1  9761606-9761693
            1595-1721           JAXUCZ010000019.1  9762057-9762183
            1722-1878           JAXUCZ010000019.1  9769625-9769781
            1879-1986           JAXUCZ010000019.1  9771225-9771332
            1987-2144           JAXUCZ010000019.1  9773469-9773626
            2145-2300           JAXUCZ010000019.1  9775508-9775663
            2301-2509           JAXUCZ010000019.1  9776804-9777012
            2510-2560           JAXUCZ010000019.1  9779036-9779086
            2561-2647           JAXUCZ010000019.1  9779501-9779587
            2648-2712           JAXUCZ010000019.1  9780473-9780537
            2713-2835           JAXUCZ010000019.1  9781354-9781476
            2836-2977           JAXUCZ010000019.1  9784951-9785092
            2978-3137           JAXUCZ010000019.1  9785747-9785906
            3138-3235           JAXUCZ010000019.1  9786750-9786847
            3236-3319           JAXUCZ010000019.1  9786935-9787018
            3320-3438           JAXUCZ010000019.1  9789506-9789624
            3439-3585           JAXUCZ010000019.1  9790128-9790274
            3586-3805           JAXUCZ010000019.1  9795900-9796119
            3806-4231           JAXUCZ010000019.1  9796736-9797161
FEATURES             Location/Qualifiers
     source          1..4231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..4231
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /note="cyclic nucleotide gated channel subunit beta 1"
                     /db_xref="GeneID:83686"
                     /db_xref="RGD:621809"
     exon            1..50
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            51..253
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..4075
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide-gated channel beta subunit 1; cyclic
                     nucleotide gated channel beta 1; cyclic nucleotide-gated
                     cation channel beta-1; CNG channel 4; cyclic
                     nucleotide-gated cation channel 4"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel beta-1 isoform
                     1"
                     /protein_id="NP_113997.2"
                     /db_xref="GeneID:83686"
                     /db_xref="RGD:621809"
                     /translation="MLGWVQRVLPQPPGTPQKTEEGAGPQPETESKPEANPQPEPEVQ
                     PEPEPEPEPAPEEAAPEVQTLPPEEPVEGEDVAEAGPSLQETQEADPPQPTSQAQVAV
                     VKVNRPSSWMLSWFWKGMEKVVPQPVYSSSGGQNLAAGEGGPDQDGAQTLEPCGTGDP
                     GSEDGSDKTSKTQDTEPSLWLLRWLELNLEKVLPQPPTPSQAWKVEPEGAVLEPDPPG
                     TPMEVEPTENPSQPNPGPVEPEEEPAAEPQPGFQASSLPPPGDPVRLIEWLLHRLEMA
                     LPQPVLHGKAAEQEPSCPGTCDVQTISILPVEQAEHDLVLEDVDSCWEDTQQEDGASL
                     QETELAPIYEDESEAMVEMPRELPQIQEEQEEENEEKEEEEEEKEEKEEKEEEEEKEE
                     EEKREEEKKKEKEEEKKEKEEEEKGEEEEKEEKEEKEEEEGKEEKEEKEEKEEEEKEE
                     KEEEEKEEKEEEEKEEKEEEEEEEEEEEEEEPIVLLDSCLVVQADVDQCQLERAQPET
                     ASIQELPEEEEEKEEEKKEEEEEKEEEEEKEEEEEKEEEGEATNSTVPATKEHPELQV
                     EDTDAEAGPLIPEETIPPPERPPVSPAKSDTLAVPGAATHRKKLPSQDDEAEELKALS
                     PAESPVVAWSDPTTPQEADGEDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLI
                     DPDVTSDEESPKPSPAKKAPDSAPAQKPAEAEAAEEEHYCDMLCCKFKRRPWKMYQFP
                     QSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHLWLLMDYLCDFIYL
                     LDITVFQMRLQFVKGGDIITDKKEMRNNYLKSQRFKMDLLCLLPLDFLYLKLGVNPLL
                     RLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIG
                     STHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIG
                     QMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESE
                     LMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKG
                     EIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGF
                     TNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLF
                     NAALAAAGKMGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGS
                     GATDQPAPQEPSEPKEPPEPPAPSSPPPASAKPEGSTEEAAGPPEPSVRIRVSPGPDP
                     GEQTLSVEMLEEKKEEVE"
     exon            254..311
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            312..378
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            497..539
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            540..585
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            586..661
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            662..701
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            702..849
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            850..925
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            926..962
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1122
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1506
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1594
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1721
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1878
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1986
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2144
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2300
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2509
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2560
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2647
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2712
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2835
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2977
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3137
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3235
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3319
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3438
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3585
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3805
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..4231
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Gm1959"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggggcat tgagaagaca attcctggct agccgctgac atctgaacag gtgtcaggat
       61 gttgggctgg gtccaaaggg tgctgcctca gcctccgggg accccccaga agactgaaga
      121 gggagcagga ccacagccag aaacagagtc aaagcctgag gcaaatccac aacccgagcc
      181 agaggttcag ccggaaccag agccggaacc ggaaccagca cctgaagagg ctgcaccaga
      241 ggtccagacc ctgccaccag aggaaccagt ggaaggagag gatgtggctg aggctggccc
      301 tagccttcaa gagacccagg aagctgaccc tcctcagccc acctcccagg cccaggttgc
      361 tgttgtcaag gtgaacaggc ccagctcctg gatgttgagt tggttctgga agggcatgga
      421 gaaggtcgtg ccacagcctg tctacagcag cagtgggggc cagaacctgg ctgccggaga
      481 gggaggccca gatcaggatg gagcacagac cctggagccc tgtggcactg gagacccagg
      541 gtctgaagat ggctcagata aaacttccaa gactcaagac actgagccca gcctgtggct
      601 actcaggtgg cttgagctga atctggagaa ggtgctacct cagcccccta cgccttccca
      661 ggcctggaaa gttgaacctg agggtgctgt cttggaacca gatcctccag gaacccctat
      721 ggaagtggag cccacagaga acccctccca gcctaatcct ggacccgtgg agcctgagga
      781 ggagccagcc gcagagcccc agcctggctt tcaagcctct tccctgccac cacctgggga
      841 ccctgtcagg ctgatcgagt ggctcctaca caggctggag atggccctgc ctcagcctgt
      901 gctccatggg aaggctgcag agcaggagcc cagctgccct gggacgtgtg acgtacagac
      961 catcagcatc ctccctgtgg aacaggcgga acatgatctt gtcctcgagg atgtggactc
     1021 ttgctgggag gacacccagc aggaagatgg tgccagcctg caggagacag agttggctcc
     1081 catttatgaa gacgagagtg aggccatggt ggagatgccc agggagctgc cacagattca
     1141 agaggagcag gaagaggaga atgaagagaa ggaagaagag gaagaagaga aggaagagaa
     1201 ggaagagaag gaagaggagg aagagaagga agaggaggag aagagggagg aagagaagaa
     1261 gaaagagaag gaagaggaga agaaagagaa ggaagaagag gagaaagggg aggaagaaga
     1321 gaaggaagag aaggaagaaa aggaagagga ggaggggaag gaagagaagg aagagaagga
     1381 agaaaaagaa gaggaggaga aggaagaaaa agaagaggag gagaaggaag aaaaagaaga
     1441 ggaggagaag gaagaaaaag aagaggagga agaggaggag gaggaagagg aggaagagga
     1501 gcctattgtc ctgctggata gctgtttggt ggtgcaggct gatgtggacc agtgccagct
     1561 agaaagggca cagccagaga cagcatcgat ccaggagtta ccagaagaag aagaggagaa
     1621 ggaggaagag aagaaggagg aggaagagga gaaggaggag gaggaagaga aggaagagga
     1681 agaggagaag gaggaggagg gggaggccac aaactcaaca gtaccagcca cgaaagagca
     1741 cccagagctc caggtggaag acacagatgc cgaagctggc cccctcatcc cagaggagac
     1801 gatcccgcca cctgagagac caccagtgtc tcccgccaag tctgacaccc tcgcggttcc
     1861 cggcgcagca acccacagga agaagctacc ttctcaggac gatgaggctg aagaactcaa
     1921 ggccctgtca ccggctgagt ccccagtggt tgcctggtca gaccccacca ccccacagga
     1981 ggctgatggc gaggaccgtg cggcctccac agccagccag aacagtgcca tcatcaacga
     2041 ccggctccag gagctggtga agatgttcaa ggagcggaca gagaaggtga aggagaagct
     2101 cattgaccct gacgtcacct ccgatgagga gagccccaag ccctccccag ccaagaaggc
     2161 cccagactca gccccagccc agaagccggc ggaggcagag gcggcagagg aggagcacta
     2221 ctgtgacatg ctctgctgca agttcaagcg caggccctgg aagatgtacc agttccccca
     2281 gagcatcgac ccactgacca acctcatgta catcctgtgg ctgttcttcg tggtgctggc
     2341 ctggaactgg aactgctggc tgattcctgt gcgctgggcc ttcccgtacc agcgggcaga
     2401 caacatccac ctctggctgc tcatggacta cttgtgcgac ttcatctacc tcctggacat
     2461 caccgtgttc cagatgcgtc tccagtttgt caaaggcggg gacatcatta cagataagaa
     2521 ggagatgcgt aataattacc tgaagtctca acgatttaag atggacttgc tctgcctttt
     2581 gcctttggat tttctctact tgaaacttgg cgtgaacccc cttcttcgcc tgccccgctg
     2641 cctgaagtac atggccttct ttgagtttaa taaccgtctg gaagccatcc tcagcaaagc
     2701 ctacgtttac agggttatca ggaccaccgc ctacctgctg tatagcttgc atctcaactc
     2761 ctgtctttac tactgggcgt cggccttcca gggcatcggt tccactcact gggtttatga
     2821 cggcgtgggg aacagctaca ttcgatgcta ctactgggct gtgaaaactc tcatcaccat
     2881 cggaggactg cccgaccccc agacgctctt tgagatcgtc ttccagctgc tgaattattt
     2941 tacaggtgtc ttcgctttct ctgtgatgat tggacagatg agagatgtgg tgggggccgc
     3001 cacggcaggg cagacgtact accgcagctg catggacagc acggtgaagt acatgaactt
     3061 ctacaagatc cccaggtctg tgcagaaccg cgtcaagacc tggtatgagt acacctggca
     3121 ttcacaaggc atgctggatg agtcagagct gatggttcag cttccggaca agatgcgtct
     3181 ggacctggcc attgacgtaa actacaacat tgtcagcaaa gtggcgctct tccagggctg
     3241 cgaccggcag atgatcttcg acatgctcaa gcgacttcgc tcagtcgtct acctacccaa
     3301 tgactatgtg tgcaagaagg gggagattgg ccgagagatg tatattatcc aggcggggca
     3361 ggtgcaggtg ctgggcggcc cagatggaaa ggctgtactg gtgacactca aagccggatc
     3421 ggtgtttgga gagataagct tgctggctgt cgggggcggt aacaggcgca cggccaatgt
     3481 ggtggcccac ggcttcacca atctcttcat tctggataag aaggacttga atgagatttt
     3541 ggtgcattac cctgaatctc agaagctgct ccggaagaag gccaggcgca tgctcagaaa
     3601 caacaacaaa cccaaggagg agaagagtgt gctcatcctg cccccacgtg cgggcacccc
     3661 gaagctcttc aatgctgccc tggctgcagc aggaaagatg ggccccaggg gagccaaggg
     3721 cggcaagctc gcccacctga gagccaggct caaagaactg gctgcactgg aggcagccgc
     3781 acgacagcag cagctgctgg aacaggccaa gagctcgcaa gaagccgggg gagaggaggg
     3841 ctctggagcc acagaccaac ctgcacccca ggagccgtca gagcccaagg agcccccgga
     3901 gcccccagcc ccgagttctc caccgccagc ctcagcaaag cccgagggaa gcacggagga
     3961 ggccgcaggg ccgccggagc cttcagtgag gatccgtgtg agtccaggcc ctgatcccgg
     4021 ggaacagaca ctatcggtgg agatgctgga agagaagaag gaggaggtgg agtgaggtgc
     4081 attcagcacc ctgatcccat ccctaggtgc ggaccagacc tttgaaccac ctgcctcacc
     4141 aagcatctta gcctaaaggc gccttctcac cggcttatag aaactctcaa atttcatcaa
     4201 gtagtggtgg tgacctcgag ctcctaacat t
//
