LOCUS       NM_053496               2355 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit alpha 4
            (Cnga4), mRNA.
ACCESSION   NM_053496 XM_346555
VERSION     NM_053496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Nache,V., Wongsamitkul,N., Kusch,J., Zimmer,T., Schwede,F. and
            Benndorf,K.
  TITLE     Deciphering the function of the CNGB1b subunit in olfactory CNG
            channels
  JOURNAL   Sci Rep 6, 29378 (2016)
   PUBMED   27405959
  REMARK    Erratum:[Sci Rep. 2018 Jun 28;8:47000. doi: 10.1038/srep47000..
            PMID: 29952375]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Nache,V., Zimmer,T., Wongsamitkul,N., Schmauder,R., Kusch,J.,
            Reinhardt,L., Bonigk,W., Seifert,R., Biskup,C., Schwede,F. and
            Benndorf,K.
  TITLE     Differential regulation by cyclic nucleotides of the CNGA4 and
            CNGB1b subunits in olfactory cyclic nucleotide-gated channels
  JOURNAL   Sci Signal 5 (232), ra48 (2012)
   PUBMED   22786723
  REMARK    GeneRIF: cGMP activated olfactory CNG channels by binding to the
            two CNGA2 subunits and the CNGA4 subunit.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Berridge,M.J.
  TITLE     Calcium signalling remodelling and disease
  JOURNAL   Biochem Soc Trans 40 (2), 297-309 (2012)
   PUBMED   22435804
  REMARK    Review article
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Zheng,J. and Zagotta,W.N.
  TITLE     Stoichiometry and assembly of olfactory cyclic nucleotide-gated
            channels
  JOURNAL   Neuron 42 (3), 411-421 (2004)
   PUBMED   15134638
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Kelliher,K.R., Ziesmann,J., Munger,S.D., Reed,R.R. and Zufall,F.
  TITLE     Importance of the CNGA4 channel gene for odor discrimination and
            adaptation in behaving mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4299-4304 (2003)
   PUBMED   12649326
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Bonigk,W., Bradley,J., Muller,F., Sesti,F., Boekhoff,I.,
            Ronnett,G.V., Kaupp,U.B. and Frings,S.
  TITLE     The native rat olfactory cyclic nucleotide-gated channel is
            composed of three distinct subunits
  JOURNAL   J Neurosci 19 (13), 5332-5347 (1999)
   PUBMED   10377344
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Dzeja,C., Hagen,V., Kaupp,U.B. and Frings,S.
  TITLE     Ca2+ permeation in cyclic nucleotide-gated channels
  JOURNAL   EMBO J 18 (1), 131-144 (1999)
   PUBMED   9878057
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Bradley,J., Zhang,Y., Bakin,R., Lester,H.A., Ronnett,G.V. and
            Zinn,K.
  TITLE     Functional expression of the heteromeric 'olfactory' cyclic
            nucleotide-gated channel in the hippocampus: a potential effector
            of synaptic plasticity in brain neurons
  JOURNAL   J Neurosci 17 (6), 1993-2005 (1997)
   PUBMED   9045728
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Bradley,J., Li,J., Davidson,N., Lester,H.A. and Zinn,K.
  TITLE     Heteromeric olfactory cyclic nucleotide-gated channels: a subunit
            that confers increased sensitivity to cAMP
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 8890-8894 (1994)
   PUBMED   7522325
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Liman,E.R. and Buck,L.B.
  TITLE     A second subunit of the olfactory cyclic nucleotide-gated channel
            confers high sensitivity to cAMP
  JOURNAL   Neuron 13 (3), 611-621 (1994)
   PUBMED   7522482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U12623.1 and JAXUCZ010000001.1.
            
            On Oct 12, 2007 this sequence version replaced NM_053496.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12425.1, SRR26360181.360156.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               U12623.1           2-560
            560-1389            JAXUCZ010000001.1  169167389-169168218
            1390-1421           U12623.1           562-593
            1422-2251           JAXUCZ010000001.1  169167389-169168218
            2252-2952           U12623.1           595-1295
            2953-3782           JAXUCZ010000001.1  169167389-169168218
            3783-4012           U12623.1           1297-1526
            4013-4842           JAXUCZ010000001.1  169167389-169168218
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2355
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /note="cyclic nucleotide gated channel subunit alpha 4"
                     /db_xref="GeneID:85258"
                     /db_xref="RGD:619844"
     exon            1..169
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1835
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /note="cyclic nucleotide gated cation channel; olfactory
                     cyclic nucleotide-gated channel subunit 2; cyclic
                     nucleotide gated channel alpha 4; cyclic nucleotide-gated
                     cation channel alpha-4; CNCalpha4 C; CNG channel alpha-4;
                     cyclic nucleotide-gated olfactory channel subunit OCNC2"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel alpha-4"
                     /protein_id="NP_445948.2"
                     /db_xref="GeneID:85258"
                     /db_xref="RGD:619844"
                     /translation="MSQDGKVKTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFP
                     IMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTGFLEQGILVVDK
                     GMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRFLRVPRLFEAFDRTETR
                     TAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQY
                     LYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTAD
                     AAFYPDHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEV
                     AVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQ
                     LAVVADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDL
                     REVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQ
                     TKFARLLAELESSALKIAYRIERLEWQTREWPMPEDMGEADDEAEPGEGTSKDGEGKA
                     GQEGPSDIE"
     exon            170..271
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..378
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..1024
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1374
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2355
                     /gene="Cnga4"
                     /gene_synonym="Cgn2; CNG-4; CNG4; CNG5; OCNC2; rOCNC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggagccc gagggcagcc tcttccagga agccaggcac tttcccaagc cacctataat
       61 cggagaatca ctggatagtc tacagactag aaccacacta cggaaacatg agccaggacg
      121 gcaaagtgaa gaccacagag tccacgcccc cagccccaac caaagccagg aagtggctgc
      181 cagtcctaga cccatctggg gattactact actggtggct gaacacaatg gtcttcccaa
      241 tcatgtacaa cctcatcatc gttgtatgca gggcctgctt tcctgacttg cagcacagtt
      301 acctggtggc ctggttcgtg ctggactaca cgagtgacct gctgtaccta ctagatattg
      361 gggtacgctt ccacacagga ttcctagagc agggcatcct ggtggtagac aaaggcatga
      421 tcgccagtcg ctacgtccgc acctggagct tcctgttgga cctggcgtcc ctggtcccca
      481 cagatgcggc ctatgtgcag ctgggccccc acatccctac actccggcta aaccgctttc
      541 tccgagtgcc ccgcctcttt gaggcttttg atcgtacaga gacccgcacg gcatacccaa
      601 atgccttccg catagccaag ctgatgcttt acatttttgt tgtcatccat tggaacagtt
      661 gcttatactt cgccctgtcc aggtacctgg gctttggacg ggatgcgtgg gtatacccag
      721 accctgcgca acctggcttt gagcgcttgc ggcgccagta tctctacagc ttctacttct
      781 ccactctgat cctgaccaca gtgggtgaca cgccgctgcc agaccgagag gaagagtacc
      841 tcttcatggt gggtgacttc ctgctggccg tcatgggttt cgccaccatc atgggtagca
      901 tgagctctgt catttacaac atgaacactg cagatgcggc cttctaccca gaccatgcgc
      961 tggtaaagaa gtacatgaag ctgcagcatg tcaacaagag gctggagcgg cgagttattg
     1021 actggtacca gcatcttcag atcaacaaga agatgaccaa cgaggtagcc atcttgcagc
     1081 acctgcctga gcggctgcgg gcggaggttg ctgtgtccgt gcacctgtct accctgagcc
     1141 gagtacagat cttccagaac tgtgaagcca gcctgctgga agagctggtg ctgaagctac
     1201 agccccagac ctactcgcca ggcgaatatg tgtgccgcaa aggggacatt ggccgagaga
     1261 tgtacatcat ccgtgagggc cagctggctg tggtagccga tgatggtgtc acacagtatg
     1321 ctgtgcttgg tgcagggctc tactttgggg agatcagtat catcaacatc aaagggaaca
     1381 tgtctggaaa ccgacgaaca gccaacatca agagcctagg ttattcagac ctgttctgcc
     1441 tcagcaagga ggatctgcgg gaggtactga gtgagtaccc acaggcccag gcggtcatgg
     1501 aggagaaggg ccgagaaatc ttgcttaaaa tgaataagtt ggatgtgaat gctgaggcag
     1561 ctgagatcgc cctccaggag gccacagagt ctcggctcaa aggcctcgac cagcagcttg
     1621 atgatctgca gaccaagttt gctcgcctac tggctgagct ggagtccagt gcactgaaga
     1681 tagcttaccg catcgaaagg ctcgagtggc agactcgaga gtggccaatg ccagaggaca
     1741 tgggtgaggc tgatgatgag gctgagcctg gagaagggac gtccaaggat ggagagggaa
     1801 aggctggcca ggagggaccc tcagacatag aatgaccccg tcctgaccct aggactccca
     1861 gctcaaataa atccagagtg gtgggaaagt ctgcctgcag gaactgtcat cctctttgct
     1921 aggttacaga atgtaggtaa attggtctat agatgcctag ctagggatgt gggtcacagc
     1981 atccattaaa tcccatactc accagcaaat gtacacacac acacacacac acacacacac
     2041 acacacacac acacacacac acacaaacac gcgcacgcac acgctcaaga ctgagttcta
     2101 cataatgttc ctgtcttctg cacacatgtg caccatgatc acagagaaca attgaatgca
     2161 ctgggactct tgaggtaagc tttacacatc ttaaaggagg tctgctggtt tagggcaagg
     2221 acagtgttgg agctacaggg aaagtagaca gatacaattc ctgaactcta ggtcaccact
     2281 tcagctgctt cagggtatgg cccgacttca ggtctgagct gggccaggcg gtattttgaa
     2341 atgaacctga tgtgt
//
