LOCUS       NM_001398686            3861 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit alpha 3
            (Cnga3), transcript variant 1, mRNA.
ACCESSION   NM_001398686 XM_008767042
VERSION     NM_001398686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3861)
  AUTHORS   Meighan,S.E., Meighan,P.C., Rich,E.D., Brown,R.L. and Varnum,M.D.
  TITLE     Cyclic nucleotide-gated channel subunit glycosylation regulates
            matrix metalloproteinase-dependent changes in channel gating
  JOURNAL   Biochemistry 52 (46), 8352-8362 (2013)
   PUBMED   24164424
REFERENCE   2  (bases 1 to 3861)
  AUTHORS   Selvakumar,D., Drescher,M.J. and Drescher,D.G.
  TITLE     Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with
            stereocilia tip-link cadherin 23 + exon 68 or alternatively with
            myosin VIIa, two proteins required for hair cell
            mechanotransduction
  JOURNAL   J Biol Chem 288 (10), 7215-7229 (2013)
   PUBMED   23329832
  REMARK    GeneRIF: Data indicate that CNGA3 interacts with cadherin 23 and
            with cadherin 23 binding partner, myosin VIIa.
REFERENCE   3  (bases 1 to 3861)
  AUTHORS   Selvakumar,D., Drescher,M.J., Dowdall,J.R., Khan,K.M.,
            Hatfield,J.S., Ramakrishnan,N.A. and Drescher,D.G.
  TITLE     CNGA3 is expressed in inner ear hair cells and binds to an
            intracellular C-terminus domain of EMILIN1
  JOURNAL   Biochem J 443 (2), 463-476 (2012)
   PUBMED   22248097
  REMARK    GeneRIF: Pull-down assays indicated that the binding to organ of
            Corti CNGA3 was attributable to the EMILIN1 intracellular sequence
            that follows a predicted transmembrane domain in the C-terminus
REFERENCE   4  (bases 1 to 3861)
  AUTHORS   Berridge,M.J.
  TITLE     Calcium signalling remodelling and disease
  JOURNAL   Biochem Soc Trans 40 (2), 297-309 (2012)
   PUBMED   22435804
  REMARK    Review article
REFERENCE   5  (bases 1 to 3861)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   6  (bases 1 to 3861)
  AUTHORS   Meyer,M.R., Angele,A., Kremmer,E., Kaupp,U.B. and Muller,F.
  TITLE     A cGMP-signaling pathway in a subset of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10595-10600 (2000)
   PUBMED   10984544
REFERENCE   7  (bases 1 to 3861)
  AUTHORS   Hirano,A.A., Hack,I., Wassle,H. and Duvoisin,R.M.
  TITLE     Cloning and immunocytochemical localization of a cyclic
            nucleotide-gated channel alpha-subunit to all cone photoreceptors
            in the mouse retina
  JOURNAL   J Comp Neurol 421 (1), 80-94 (2000)
   PUBMED   10813773
REFERENCE   8  (bases 1 to 3861)
  AUTHORS   Gerstner,A., Zong,X., Hofmann,F. and Biel,M.
  TITLE     Molecular cloning and functional characterization of a new
            modulatory cyclic nucleotide-gated channel subunit from mouse
            retina
  JOURNAL   J Neurosci 20 (4), 1324-1332 (2000)
   PUBMED   10662822
REFERENCE   9  (bases 1 to 3861)
  AUTHORS   Misaka,T., Kusakabe,Y., Emori,Y., Gonoi,T., Arai,S. and Abe,K.
  TITLE     Taste buds have a cyclic nucleotide-activated channel, CNGgust
  JOURNAL   J Biol Chem 272 (36), 22623-22629 (1997)
   PUBMED   9278419
REFERENCE   10 (bases 1 to 3861)
  AUTHORS   Bradley,J., Zhang,Y., Bakin,R., Lester,H.A., Ronnett,G.V. and
            Zinn,K.
  TITLE     Functional expression of the heteromeric 'olfactory' cyclic
            nucleotide-gated channel in the hippocampus: a potential effector
            of synaptic plasticity in brain neurons
  JOURNAL   J Neurosci 17 (6), 1993-2005 (1997)
   PUBMED   9045728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 21, 2021 this sequence version replaced XM_008767042.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ272428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               JAXUCZ010000009.1  46943353-46943940
            589-727             JAXUCZ010000009.1  46957930-46958068
            728-841             JAXUCZ010000009.1  46967367-46967480
            842-1021            JAXUCZ010000009.1  46970445-46970624
            1022-1129           JAXUCZ010000009.1  46979316-46979423
            1130-1236           JAXUCZ010000009.1  46981881-46981987
            1237-3861           JAXUCZ010000009.1  46987238-46989862
FEATURES             Location/Qualifiers
     source          1..3861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..3861
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /note="cyclic nucleotide gated channel subunit alpha 3"
                     /db_xref="GeneID:85257"
                     /db_xref="RGD:70948"
     exon            1..588
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     exon            589..727
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     CDS             624..2636
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide-gated cation channel alpha-3; cyclic
                     nucleotide gated channel alpha 3"
                     /codon_start=1
                     /product="cyclic nucleotide-gated cation channel alpha-3
                     isoform 1"
                     /protein_id="NP_001385615.1"
                     /db_xref="GeneID:85257"
                     /db_xref="RGD:70948"
                     /translation="MAKVNTQCSQPSPRQLSVKDAADRDLDQVENGLGRSHSPCEETS
                     STVHQGIVMETGELAGAAQSLFTSQGPARVSRFIISIRAWAARHLHHEDPTPDSFLDR
                     FHGAELKEVSSQERNAQPNPGGQEPPEGGKGRKKDPIVVDPSSNIYYRWLTAIALPVF
                     YNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQGLMVRDTKR
                     LWKHYTKTLHFKLDILSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTN
                     YPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIY
                     SLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRAE
                     FQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAI
                     NVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLA
                     VVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLME
                     TLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKVEYLESSLDGLQTRF
                     ARLLAEYSASQMKLKQRLSQLESQMTRRGHGFSPDRENSEDASKAD"
     exon            728..841
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1021
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1129
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1236
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..3861
                     /gene="Cnga3"
                     /gene_synonym="CNGgust"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccaaaggg gtcgttactc acaagttgag aaccactggt ctggaatata gagtggtaga
       61 aaaaaagcca aaaaatgaag aatatgcatc ccaagaaaag cttgtttcta gaagcatcgc
      121 taagagtata gattatacaa ttgcacattg tagataagtg tagtgtatac acacacacac
      181 acacacacac acacacacac acacacacac acacttcagg ccgcatgatt cttactgttc
      241 tgacttagtg tgaactactg gaagctgtct atggtgtcca cgagatcagg agaaaagtcc
      301 aaagttgaca gctggacttt tgctttcttg cttcctgcta cctcctcctc ctttggatac
      361 aatcgagcag tggcttctgc ctttctccag gctgcctttg aatctcaggc gcctcagctg
      421 actctcccag tcaaaggagg caacgggcta ctccgcccac ctattggccc cagaagacct
      481 tcctgaagag ctgaggagca ggagaaagaa gtccgagctt ctctgagacc aaagagtgga
      541 gtcgctcttc cagatccagg tgcaccgaga agcccaaact ttgacgggct accaccctgg
      601 ggctgaaggt gaccagcgta cagatggcca aggtcaatac ccaatgctca cagccctccc
      661 cgagacaact ttcagtaaag gacgccgcag acagagacct cgatcaagtg gagaatggcc
      721 tcggcaggtc tcactcacca tgtgaggaga catcttccac agtgcatcag gggatcgtca
      781 tggagaccgg agaactggct ggagccgcac agagtttatt cacaagccag gggccagcca
      841 gggtgtcacg cttcatcatc tccattcgtg cgtgggccgc caggcactta caccatgaag
      901 acccgacgcc tgactccttt ttggatcgtt ttcatggagc tgagcttaag gaagtatcca
      961 gccaggaaag gaatgcccag cccaacccag gaggacagga accaccagag ggagggaaag
     1021 gcaggaagaa ggatcccatt gtggtggacc cctccagcaa catctactac cgctggctga
     1081 ctgccatcgc cctcccggtc ttctataact ggtgtctact tgtgtgcagg gcctgttttg
     1141 atgagctaca gtcagaacac ctgacactgt ggctggtcct ggactactct gcagatgccc
     1201 tgtatgttgt ggacatgctg gttcgtgccc ggacaggttt ccttgaacaa ggcctaatgg
     1261 tcagggatac caagaggctg tggaaacatt acacaaagac cttgcacttc aagctggaca
     1321 tcctgtctct catccccaca gacctggctt atttgaagtt gggcatgaac tacccggaac
     1381 tgaggttcaa tcgcctcctg aggttctctc ggctctttga gttctttgac cgcacggaga
     1441 caaggaccaa ctaccccaat gtgttcagga tagggaactt ggttctgtac accctcatta
     1501 tcatccactg gaacgcctgc atctactttg ccatttccaa gttcatcggt tttggaacag
     1561 attcctgggt ctatccaaac acctccaagc cggagtatgg acgcctctcc aggaagtaca
     1621 tttacagcct ctactggtcc accttgaccc tgaccaccat tggggagacc ccgccccccg
     1681 tgaaggatga ggagtatctc tttgtggtca tagacttcct ggtgggcgtc ctgatcttcg
     1741 ccactatagt aggcaatgtg ggctccatga tttccaacat gaacgcttcc cgggcggagt
     1801 tccaggctaa gatagattcc atcaagcagt acatgcagtt ccggaaggta accaaggact
     1861 tggagactcg ggttatccgg tggtttgact atctgtgggc taacaggaag acggtggatg
     1921 aaaaggaagt gctcaaaaac ctcccagaca agctgaaggc cgagatcgcc atcaacgtgc
     1981 acctggacac actgaagaaa gtccgaatct tccaggactg cgaggcaggg cttctggtgg
     2041 agctggtgct gaagcttcgt cctgctgtgt tcagccctgg ggactacatt tgcaaaaagg
     2101 gggacattgg aagggagatg tacatcatca aggagggcaa gctggctgtc gtggctgacg
     2161 atggggtcac ccagtttgtg gtcctcagtg atggcagtta ctttggggag atcagcatct
     2221 taaacattaa ggggagcaag tcggggaacc gcaggacagc caacatcagg agcatcggct
     2281 actcggacct gttctgcctc tccaaggatg acttgatgga gaccctcacg gagtacccgg
     2341 atgctaagag ggctctggag gaaaagggtc ggcagattct gatgaaggac aacctaatcg
     2401 atgacgacct ggtgacggcc agggcagatg ccaggaacat cgaggagaag gtggagtacc
     2461 tggagtcatc cttggacggc ctgcagacga ggttcgcccg actcctggct gagtacagtg
     2521 cctcccagat gaagctgaaa cagcggctca gccagctgga gagccagatg accaggaggg
     2581 gtcatggctt ctcacctgac agggagaatt ccgaggatgc ttcaaaagct gactgaaaat
     2641 gcaggtggct ctgcctcctg cttcccaggg ccagctgcca gtgagacact ttacagcctc
     2701 gtggtgaaga gtttgactgt gcttttgcct cagtgttact cgtcctttgg ttgtaggaca
     2761 gcaagggaga gccttcattt cctcacctag gaaatgggac tcatgcctgc caaccccatg
     2821 aagttccaga ttatcatgag gtctacttga tacaaggaca agggttgcag ctttggaaag
     2881 agtgaagggt tccaaaccaa gtgtatgaat gcacatgcgc gattctaatg ttcgtaatta
     2941 tgtttgtgta tgtgaatgtt gggttacctg tggaggtcag gagagagtgt tgttggatcc
     3001 cctgggctgt tgtaagctac ccagcgtggg ggctggggtc gtcctgtctt cactagggtt
     3061 actattgctg tgatgaaaca ccatagccaa agcaagtcgg ggaggaaagg gtttattcag
     3121 tttacattcc acatcatagg ccatcactga aggaaagtga ggacaggttc tcaaacaggg
     3181 caagaatctg gaagcgggag ctgggatgca gaggccatga aggggagctg cttactggct
     3241 tgctcttttt agcttgctaa gcctgctttc ttatagaatc cagaaccacc agcacaggag
     3301 tggtccttcc taccacggac tgggtcttct tacatccatc actagttaag gaaatgctca
     3361 caggcctgcc tgcctacagc tggatcttag ggagccattt tctcagtcat cctctcagct
     3421 gactaacttg tgtcaaggtg acataaaaat tgaccagcac agacccaaac gtgtcccgta
     3481 tttattgagg tgagggtcct gctctgtgac tcggtccagc tgtcaactcc cgtgcccaag
     3541 tgcggttccc acactagcct tccaagtagc agagaccaca ggcacactcc actgtttgca
     3601 gcccaattaa ttttttacaa aaccatgaga tgtttaagcc tctcagccta gctatcgtat
     3661 aaatagacat ttatggggct ggtgaaatgg ctcggcactt aagagcactg gctgctcttc
     3721 caagaagtca tgagttcaat tcccagcaac cacatggtgg cacacaacca tctacagggg
     3781 aatctggtgc cctcttcagg caggtggata tatatgcaac ataagactca taaataaata
     3841 aaataaaaat atataaacgg a
//
