LOCUS       NM_012928               3017 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit alpha 2
            (Cnga2), mRNA.
ACCESSION   NM_012928 XM_003751618 XM_008771338
VERSION     NM_012928.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3017)
  AUTHORS   Nache,V., Wongsamitkul,N., Kusch,J., Zimmer,T., Schwede,F. and
            Benndorf,K.
  TITLE     Deciphering the function of the CNGB1b subunit in olfactory CNG
            channels
  JOURNAL   Sci Rep 6, 29378 (2016)
   PUBMED   27405959
  REMARK    Erratum:[Sci Rep. 2018 Jun 28;8:47000. PMID: 29952375]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3017)
  AUTHORS   Goncalves,I., Hubbard,P.C., Tomas,J., Quintela,T., Tavares,G.,
            Caria,S., Barreiros,D. and Santos,C.R.
  TITLE     'Smelling' the cerebrospinal fluid: olfactory signaling molecules
            are expressed in and mediate chemosensory signaling from the
            choroid plexus
  JOURNAL   FEBS J 283 (9), 1748-1766 (2016)
   PUBMED   26934374
  REMARK    GeneRIF: The major components of the olfactory transduction pathway
            in the rat choroid plexus have been determined, including odorant
            receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
REFERENCE   3  (bases 1 to 3017)
  AUTHORS   Irene,D., Huang,J.W., Chung,T.Y., Li,F.Y., Tzen,J.T., Lin,T.H. and
            Chyan,C.L.
  TITLE     Binding orientation and specificity of calmodulin to rat olfactory
            cyclic nucleotide-gated ion channel
  JOURNAL   J Biomol Struct Dyn 31 (4), 414-425 (2013)
   PUBMED   22877078
  REMARK    GeneRIF: Data indicate that the two distinct CaM/OLFp complexes
            existed simultaneously with stable structures.
REFERENCE   4  (bases 1 to 3017)
  AUTHORS   Nache,V., Zimmer,T., Wongsamitkul,N., Schmauder,R., Kusch,J.,
            Reinhardt,L., Bonigk,W., Seifert,R., Biskup,C., Schwede,F. and
            Benndorf,K.
  TITLE     Differential regulation by cyclic nucleotides of the CNGA4 and
            CNGB1b subunits in olfactory cyclic nucleotide-gated channels
  JOURNAL   Sci Signal 5 (232), ra48 (2012)
   PUBMED   22786723
  REMARK    GeneRIF: cGMP activated olfactory CNG channels by binding to the
            two CNGA2 subunits and the CNGA4 subunit.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3017)
  AUTHORS   Berridge,M.J.
  TITLE     Calcium signalling remodelling and disease
  JOURNAL   Biochem Soc Trans 40 (2), 297-309 (2012)
   PUBMED   22435804
  REMARK    Review article
REFERENCE   6  (bases 1 to 3017)
  AUTHORS   Zheng,C., Feinstein,P., Bozza,T., Rodriguez,I. and Mombaerts,P.
  TITLE     Peripheral olfactory projections are differentially affected in
            mice deficient in a cyclic nucleotide-gated channel subunit
  JOURNAL   Neuron 26 (1), 81-91 (2000)
   PUBMED   10798394
REFERENCE   7  (bases 1 to 3017)
  AUTHORS   Strijbos,P.J., Pratt,G.D., Khan,S., Charles,I.G. and Garthwaite,J.
  TITLE     Molecular characterization and in situ localization of a
            full-length cyclic nucleotide-gated channel in rat brain
  JOURNAL   Eur J Neurosci 11 (12), 4463-4467 (1999)
   PUBMED   10594674
REFERENCE   8  (bases 1 to 3017)
  AUTHORS   Bonigk,W., Bradley,J., Muller,F., Sesti,F., Boekhoff,I.,
            Ronnett,G.V., Kaupp,U.B. and Frings,S.
  TITLE     The native rat olfactory cyclic nucleotide-gated channel is
            composed of three distinct subunits
  JOURNAL   J Neurosci 19 (13), 5332-5347 (1999)
   PUBMED   10377344
REFERENCE   9  (bases 1 to 3017)
  AUTHORS   Dzeja,C., Hagen,V., Kaupp,U.B. and Frings,S.
  TITLE     Ca2+ permeation in cyclic nucleotide-gated channels
  JOURNAL   EMBO J 18 (1), 131-144 (1999)
   PUBMED   9878057
REFERENCE   10 (bases 1 to 3017)
  AUTHORS   Dhallan,R.S., Yau,K.W., Schrader,K.A. and Reed,R.R.
  TITLE     Primary structure and functional expression of a cyclic
            nucleotide-activated channel from olfactory neurons
  JOURNAL   Nature 347 (6289), 184-187 (1990)
   PUBMED   1697649
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by NM_012928.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012928.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55519.1, AF126808.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000021.1  154741766-154742074
            310-445             JAXUCZ010000021.1  154753078-154753213
            446-541             JAXUCZ010000021.1  154753605-154753700
            542-712             JAXUCZ010000021.1  154754557-154754727
            713-820             JAXUCZ010000021.1  154755802-154755909
            821-927             JAXUCZ010000021.1  154757332-154757438
            928-3017            JAXUCZ010000021.1  154757725-154759814
FEATURES             Location/Qualifiers
     source          1..3017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..3017
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /note="cyclic nucleotide gated channel subunit alpha 2"
                     /db_xref="GeneID:25411"
                     /db_xref="RGD:2367"
     exon            1..309
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     exon            310..445
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2327
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /note="CNG channel alpha-2; cyclic nucleotide-gated cation
                     channel 2; cyclic nucleotide gated channel alpha 2; cyclic
                     nucleotide-gated olfactory channel subunit OCNC1; CNG2;
                     CNG-2; cyclic nucleotide gated channel 4; cyclic
                     nucleotide-gated olfactory channel-like"
                     /codon_start=1
                     /product="cyclic nucleotide-gated olfactory channel"
                     /protein_id="NP_037060.2"
                     /db_xref="GeneID:25411"
                     /db_xref="RGD:2367"
                     /translation="MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAA
                     DDDTSSELQRLAEMDTPRRGRGGFQRIVRLVGVIRDWANKNFREEEPRPDSFLERFRG
                     PELQTVTTHQGDDKGGKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLL
                     VARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYI
                     HTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFR
                     ISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWST
                     LTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKID
                     AVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLST
                     LKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDG
                     VTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP
                     DAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMDTLYTRFARLLAEY
                     TGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPTAAE"
     exon            446..541
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     exon            542..712
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     exon            713..820
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     exon            821..927
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
     exon            928..3017
                     /gene="Cnga2"
                     /gene_synonym="Cncg4; OLFCH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattgaaga tggcttctcc aggggccggg gcaccctgat aggctctcaa gctcacctag
       61 ctgtgttatg tgctccattg ggcctctgtc agctgctatc agacagcgtg ggctagatct
      121 ctgattggga agctgctgct gtttgttggg gtctcagaga accttccctg gctggacaac
      181 agaagaaaca ggaaatctct tcagctttca gtgctcatga gctcccaaga gcttctcttt
      241 gattggagct ggtgtggaca gaacaacaga tgttgactgt gacctcagga ctctgaaacc
      301 atctgactgg tgagagccct ggatttacat ggatgatgac cgaaaaatcc aatggtgtga
      361 aaagctctcc agctaataac cataaccatc atcctcctcc ttctatcaag gccaatggca
      421 aagatgacca cagggcagga agcagaccac agtctgtggc agctgatgat gacacttcct
      481 cagaactaca aaggctggca gagatggata cccctcggag ggggaggggt ggcttccaaa
      541 ggattgttcg cctggtgggg gtcatcaggg actgggccaa caagaatttc cgtgaagagg
      601 aaccaaggcc tgactccttc ctagagcgtt tccgtgggcc agaactccag actgtgacaa
      661 cccatcaggg ggatgacaaa ggcggcaagg acggcgaggg aaagggcacc aaaaagaaat
      721 ttgaactgtt tgttttggac ccagccggag actggtatta ccgttggttg tttgtcattg
      781 ccatgcctgt tctttacaac tggtgcctgt tggtggccag agcctgcttc agtgatctac
      841 agagaaacta ttttgtggta tggctggtgc tggactactt ctcagacact gtctatatcg
      901 cagacctcat cattcggctg cgcacaggct tcctagaaca ggggctcttg gtcaaagatc
      961 ccaagaaatt gcgagacaac tatattcaca ctttgcagtt caaattggat gtggcttcta
     1021 tcattcccac tgaccttatc tattttgctg tgggtatcca cagccctgag gtacgcttca
     1081 accgtctatt acactttgcc cgtatgtttg agttctttga ccgcactgag acacgcacca
     1141 gctaccccaa catcttccga atcagcaatc tggtccttta catcttggtc atcatccact
     1201 ggaatgcttg tatttattat gttatttcta agtccattgg ctttggagtt gacacctggg
     1261 tttaccccaa cattactgac cctgaatatg gctacctggc tagagagtac atttactgtc
     1321 tttactggtc cacactgacc ctcaccacca ttggagagac accaccccct gtaaaggatg
     1381 aggagtacct atttgtcatc tttgacttct tgattggtgt cctcatcttt gccactattg
     1441 tgggaaatgt gggctccatg atctccaaca tgaatgccac acgagcagag ttccaggcca
     1501 agattgatgc tgtcaaacac tacatgcagt tccgaaaggt cagcaaagac atggaagcca
     1561 aggtcatcaa atggtttgac tacttgtgga ccaataagaa gacagtagat gaacgagaag
     1621 tcctcaagaa cctgccagca aagctcaggg ctgagatagc cattaatgtt cacttgtcca
     1681 ctctgaagaa agtgcgcata ttccaggatt gtgaagctgg cctactggtg gaactggtac
     1741 tgaagcttcg tcctcaggtc tttagtcctg gagattatat ttgccgtaag ggggacattg
     1801 gcaaggaaat gtacatcatc aaggagggca agttggcagt ggtagctgat gatggcgtga
     1861 ctcagtatgc cttgctctca gctgggagct gctttggtga gattagtatc cttaacatta
     1921 agggtagcaa aatgggcaat cgacgtactg ctaatatccg tagcctgggc tactcagatc
     1981 tcttctgctt gtccaaggac gatcttatgg aagctgtaac tgagtatcct gatgccaaga
     2041 aggtcctgga ggaacggggt agggagatcc tgatgaagga aggtctactg gatgagaatg
     2101 aagtggcagc tagtatggag gtagatgttc aggagaagct ggaacagttg gagacaaaca
     2161 tggatacctt gtacactcgc tttgcccgcc tgctggctga gtacactggg gcccagcaga
     2221 agctcaagca acgcatcaca gtgctagaga ccaagatgaa acagaaccat gaggatgatt
     2281 atctatcaga tgggataaac actcctgagc caactgctgc tgaataacca taagtgacta
     2341 tccagccttg gtctgactcc aggagttaga agtgctgtat agaactttac atttacacac
     2401 attatgctca tgtccctctg aactctcccc aaagccatgc tgaggcttaa ggttttgact
     2461 acatcttgaa gtccccctct aagtccagct aacagtcaag cttgtggaca atgcagatca
     2521 tgtgggttga atttccaaga gcttgacctc ctatgtctga aaagggatca gagactagct
     2581 aaattgtcct tcctggggct tttctggtac tagataccta gacagtgttc tctgaagaac
     2641 actgtgcaca atgcctgact ccctttagtt tctttatatc tagtcactcc ctactgtatt
     2701 ctgccccaaa tacctttttt aatgtgttct ctaagcagcc tgtttccatg tacatgtata
     2761 aatttaagaa ttggctgcaa acactgggcc ccctaaactg tctcccaagg catgcaaggg
     2821 ccgtgagggg agtggtaggg tgggtttgag tgtgtgtgct cagggtcata cttccttgtc
     2881 agacaatgtc actatgagaa gaggtggctg gcagctttgg ccatcacacc tttatgcaca
     2941 caagttctga agagtttgtg aatgctgaga tactgtgaat tagagccact taaaagttaa
     3001 taaattcttt tcagcta
//
