LOCUS       NM_053497               2755 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus cyclic nucleotide gated channel subunit alpha 1
            (Cnga1), mRNA.
ACCESSION   NM_053497
VERSION     NM_053497.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2755)
  AUTHORS   Wu,J., El-Hassar,L., Datta,D., Thomas,M., Zhang,Y., Jenkins,D.P.,
            DeLuca,N.J., Chatterjee,M., Gribkoff,V.K., Arnsten,A.F.T. and
            Kaczmarek,L.K.
  TITLE     Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal
            Cell Excitability in Working Memory Circuits
  JOURNAL   Mol Neurobiol 61 (4), 2430-2445 (2024)
   PUBMED   37889366
  REMARK    GeneRIF: Interaction Between HCN and Slack Channels Regulates mPFC
            Pyramidal Cell Excitability in Working Memory Circuits.
REFERENCE   2  (bases 1 to 2755)
  AUTHORS   Zhang,J., Zhuang,Q.X., Li,B., Wu,G.Y., Yung,W.H., Zhu,J.N. and
            Wang,J.J.
  TITLE     Selective Modulation of Histaminergic Inputs on Projection Neurons
            of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels
  JOURNAL   Mol Neurobiol 53 (2), 1386-1401 (2016)
   PUBMED   25633097
  REMARK    GeneRIF: Histamine depolarizes projection neurons but not
            interneurons in the cerebellar nuclei via the
            hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
            coupled to histamine H2 receptors.
REFERENCE   3  (bases 1 to 2755)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   4  (bases 1 to 2755)
  AUTHORS   Gupta,V.K., Rajala,A. and Rajala,R.V.
  TITLE     Insulin receptor regulates photoreceptor CNG channel activity
  JOURNAL   Am J Physiol Endocrinol Metab 303 (11), E1363-E1372 (2012)
   PUBMED   23032687
  REMARK    GeneRIF: Insulin receptor (IR), an integral membrane protein,
            directly phosphorylates the CNGA1 subunit of CNG channels that in
            turn affects the function of these channels negatively. CNGA1 is a
            direct substrate of IR.
REFERENCE   5  (bases 1 to 2755)
  AUTHORS   Gracelli,J.B., Souza-Menezes,J., Barbosa,C.M., Ornellas,F.S.,
            Takiya,C.M., Alves,L.M., Wengert,M., Feltran Gda,S.,
            Caruso-Neves,C., Moyses,M.R., Prota,L.F. and Morales,M.M.
  TITLE     Role of estrogen and progesterone in the modulation of CNG-A1 and
            Na/K+-ATPase expression in the renal cortex
  JOURNAL   Cell Physiol Biochem 30 (1), 160-172 (2012)
   PUBMED   22759964
  REMARK    GeneRIF: estrogen and progesterone act in renal tissues modulating
            CNG-A1 and Na/K ATPase gene expression
REFERENCE   6  (bases 1 to 2755)
  AUTHORS   Hong,D.H., Pawlyk,B.S., Shang,J., Sandberg,M.A., Berson,E.L. and
            Li,T.
  TITLE     A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse
            model for X-linked retinitis pigmentosa (RP3)
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3649-3654 (2000)
   PUBMED   10725384
REFERENCE   7  (bases 1 to 2755)
  AUTHORS   Ding,C., Potter,E.D., Qiu,W., Coon,S.L., Levine,M.A. and
            Guggino,S.E.
  TITLE     Cloning and widespread distribution of the rat rod-type cyclic
            nucleotide-gated cation channel
  JOURNAL   Am J Physiol 272 (4 Pt 1), C1335-C1344 (1997)
   PUBMED   9142860
REFERENCE   8  (bases 1 to 2755)
  AUTHORS   Bradley,J., Zhang,Y., Bakin,R., Lester,H.A., Ronnett,G.V. and
            Zinn,K.
  TITLE     Functional expression of the heteromeric 'olfactory' cyclic
            nucleotide-gated channel in the hippocampus: a potential effector
            of synaptic plasticity in brain neurons
  JOURNAL   J Neurosci 17 (6), 1993-2005 (1997)
   PUBMED   9045728
REFERENCE   9  (bases 1 to 2755)
  AUTHORS   Dryja,T.P., Finn,J.T., Peng,Y.W., McGee,T.L., Berson,E.L. and
            Yau,K.W.
  TITLE     Mutations in the gene encoding the alpha subunit of the rod
            cGMP-gated channel in autosomal recessive retinitis pigmentosa
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10177-10181 (1995)
   PUBMED   7479749
REFERENCE   10 (bases 1 to 2755)
  AUTHORS   Barnstable,C.J. and Wei,J.-Y.
  TITLE     Isolation and characterization of the alpha-subunit of the rat rod
            photoreceptor cGMP-gated cation channel
  JOURNAL   J Mol Neurosci 6 (4), 289-302 (1995)
   PUBMED   8860239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 24, 2020 this sequence version replaced NM_053497.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U93851.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000014.1  35920948-35921202
            256-376             JAXUCZ010000014.1  35943366-35943486
            377-478             JAXUCZ010000014.1  35944218-35944319
            479-541             JAXUCZ010000014.1  35945797-35945859
            542-583             JAXUCZ010000014.1  35949911-35949952
            584-691             JAXUCZ010000014.1  35950042-35950149
            692-799             JAXUCZ010000014.1  35952076-35952183
            800-906             JAXUCZ010000014.1  35953394-35953500
            907-2755            JAXUCZ010000014.1  35957217-35959065
FEATURES             Location/Qualifiers
     source          1..2755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2755
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /note="cyclic nucleotide gated channel subunit alpha 1"
                     /db_xref="GeneID:85259"
                     /db_xref="RGD:621815"
     exon            1..255
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            256..376
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..2321
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /note="cGMP-gated cation channel alpha-1; CNG1; CNG-1; CNG
                     channel alpha-1; cyclic nucleotide-gated cation channel 1;
                     cyclic nucleotide-gated channel, photoreceptor; rod
                     photoreceptor cGMP-gated channel subunit alpha; cyclic
                     nucleotide gated channel alpha 1; rod photoreceptor
                     cGMP-gated cation channel subunit alpha"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel alpha-1"
                     /protein_id="NP_445949.2"
                     /db_xref="GeneID:85259"
                     /db_xref="RGD:621815"
                     /translation="MKTNIINTWHSFVNIPNVVVPAIEKEIRRMENGACSSFSDNDNG
                     SLSEESENEDSLFRSNSYRRRGPSQREHYLPGTMALFNVNNSSNKDQDPKEKKKKKKE
                     KKSKADDKKESKKDPEKKKKKEKEKEKKKEEKPKEKKEEEKKEVVVIDPSGNMYYNWL
                     FCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQG
                     LLVKDKLKLIEKYKANLQFKLDVLSVIPTDLLYFKFGWNYPEIRLNRLLRISRMFEFF
                     QRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFG
                     RLARKYVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFLIGVLIFATIVGNIGSMIS
                     NMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPD
                     KLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMY
                     IIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFC
                     LSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANLGSDPKDLEEKVTRMEGS
                     VDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESEPTESLQ
                     G"
     exon            377..478
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            479..541
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            542..583
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            584..691
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            692..799
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            800..906
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
     exon            907..2755
                     /gene="Cnga1"
                     /gene_synonym="Cncg; HCN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaaatcca gtactgagcc atgaacatcc tctcgagcca acgccatgga ctgcctgcct
       61 tttctaagga ataattaata aaaaccatcc atttgtgctg cttaaggagg ggagagacaa
      121 cgtcatagtt attactaaag aaaacttgca tctggatttt gacaatgcca agactaacca
      181 tatacctgcg tctgttttgg atgtaccact gattggccct gcaggaagac agacatctca
      241 tttagacaag aacagatatt aaactaacca tgaagacaaa tattatcaat acgtggcact
      301 ccttcgtaaa tatccccaac gtggttgtac cagctatcga aaaggaaatt cgacgcatgg
      361 aaaatggggc gtgcagctca ttttctgaca atgacaatgg ctctctgtct gaagaatcag
      421 agaatgagga ctctctcttt agaagcaact catacagaag gcgaggacca tcccagaggg
      481 agcattactt gccaggcacc atggctcttt tcaatgttaa caacagcagc aacaaagacc
      541 aagacccaaa ggagaaaaag aaaaagaaaa aggaaaagaa gagcaaggcc gatgataaaa
      601 aggaaagtaa aaaggaccca gagaagaaaa aaaagaagga aaaggaaaaa gagaagaaaa
      661 aggaggagaa acccaaagaa aagaaagaag aggagaaaaa agaggtggtt gttattgacc
      721 cttcaggaaa catgtactac aactggctgt tttgtatcac tttacctgtg atgtacaact
      781 ggacgatgat tattgcaaga gcatgttttg atgaactcca gtctgattac ctagaatatt
      841 ggctcatttt tgattacgta tcagatgtag tctaccttgc tgatatgttt gtacggacaa
      901 ggacaggtta cctggaacaa gggttgctag tgaaagacaa actgaaactc atagagaagt
      961 acaaagcaaa cctgcagttt aaacttgacg ttctgtcagt gataccgacc gacctgctgt
     1021 atttcaagtt tgggtggaac tatccagaaa tcaggttgaa ccggctgtta agaatctctc
     1081 ggatgtttga gttcttccag aggacagaga caaggaccaa ctacccgaac atctttagga
     1141 tctcaaacct tgtgatgtac attgtcatca tcatccactg gaacgcgtgt gtgtactact
     1201 ccatctcaaa agctattgga tttgggaatg acacatgggt ctaccctgat gttaatgatc
     1261 ctgaatttgg ccgtttggct agaaaatacg tctacagcct ttattggtct accttgactt
     1321 tgacgaccat tggagaaacc ccaccccccg tgctggattc cgagtatgtc tttgtggtgg
     1381 tagacttctt aattggagtt ttaatttttg ccaccattgt cggtaacata ggctccatga
     1441 tttccaatat gaatgcagcc cgggcagaat ttcaatcaag agttgatgct atcaaacagt
     1501 acatgaattt tcgaaatgtg agcaaagaca tggaaaagag agttattaaa tggtttgact
     1561 acctgtggac taacaaaaag acagtcgatg agagagaagt tctgagatac ctccctgaca
     1621 aactcagggc agagattgcc atcaatgttc acctagacac gttaaaaaag gttcgtatct
     1681 ttgctgactg tgaggctggt ctgttggtgg agttggtgtt gaaattacaa ccccaggtgt
     1741 acagtcctgg agattacata tgcaagaaag gggacattgg gcgggagatg tacatcatca
     1801 aggaaggcaa acttgctgtg gtggcagacg acggaatcac acagtttgtg gtgttgagtg
     1861 acggcagcta ctttggcgag atcagcattc ttaacatcaa aggcagcaag gctggcaacc
     1921 gaagaacagc caatattaag agcattggct actcggacct gttctgcctc tcaaaggatg
     1981 acctcatgga agctcttaca gagtacccag atgccaaaac tatgttggag gagaaaggga
     2041 ggcagatctt aatgaaagac ggtctactgg atataaacat tgcgaatttg ggcagtgacc
     2101 ctaaagacct ggaagagaag gtcactcgaa tggaggggtc agtggacctc ctgcaaacac
     2161 gatttgcccg aatcttggct gagtatgaat cgatgcagca gaaactcaag caaagattaa
     2221 ccaaggttga gaaattcttg aaaccactta ttgaaactga attttcagcc cttgaggaac
     2281 ccggaggaga aagtgaaccc acagagtcgc tacagggcta aaaaaaaacc tgcccaatag
     2341 caaaaaccat gcacgccgtg tgatcctttt gagcgcttga ccagagacaa ttgagaattg
     2401 ggagaaaaag agttctctgg gaaatttttc tatattgaaa aagtgtgtgg gtagatgaca
     2461 caaatctgtt gtgcaacact gcaacaaaag tatcatctta tcctgggact tttcacaatg
     2521 gacactgtgc gaggacatga attgattaat gtgtctgtgt caggatccgt ttattctctt
     2581 tcccacagat gctcctttta tgaagtaatc tgtaaaaatg aacacgtatc tctcactttc
     2641 aggccacctg catcattgag tcaaacgtat tcagtgcaac tgcgtccctt gtgcttgaga
     2701 cacagttatc agaagaagta gaacgcaata aagtgaaatt gattacaaaa ccaga
//
